| 1 | Current systematic reviews and meta-analyses of COVID-19显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million deaths.While the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of life.AIM To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be performed.METHODS We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS coronavirus-2.The included studies were extracted from Embase,Medline,and Cochrane databases.The publication timeframe of included studies ranged between January 01,2020,to October 30,2020.Studies that were published in languages other than English were not considered for this systematic review.The finalized full-text articles are freely accessible in the public domain.RESULTS Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 studies.The inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 studies.After screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and treatment.Subsequently,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stroke,thrombosis,anosmia and dysgeusia,ocular manifestations,nephrology,cutaneous manifestations,D-dimer,lymphocyte,anticoagulation,antivirals,convalescent plasma,immunosuppressants,corticosteroids,hydroxychloroquine,renin-angiotensin-aldosterone system,technology,diabetes mellitus,obesity,pregnancy,children,mental health,smoking,cancer,and transplant.CONCLUSION Among the included articles,it is clear that further research is needed regarding treatment options and vaccines.With more studies,data will be less heterogeneous,and statistical analysis can be better applied to provide more robust clinical evidence.This study was not designed to give recommendations regarding the management of COVID-19. | Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo | 2021 | World Journal of Virology2021，10，4： | 2 |
| 17 | Isolated micropenis reveals partial androgen insensitivity syndrome confirmed by molecular analysis显示文摘部分雄激素 insensitivity 症候群(白族) 是雄激素受体(AR ) 的更温和的变体缺点。AR 变化的微妙的效果与 micropenis 在一个病人介绍, peno 阴囊的 hypospadias,不孕, clitoromegaly 并且以后的唇音熔化。我们学习了孤立的 micropenis 的协会,基因缺点导致雄激素抵抗,也就是说, AR 基因缺点和 5- 伪 reductase 打 2 (SRD5A2 ) 缺乏。我们描述孤立的 micropenis 的二个盒子:在在被跟随直到他是 10 岁的一个 3 岁的男孩的一个 3 岁的男孩和其它的。没有在也的 hypospadias, cryptorchidism 或这些病人的 gynecomastia 的调查结果。浆液 gonadotrophin 和雄激素层次被获得, karyotyping 被做。测试的人的 chorionic gonadotropin (hCG ) 刺激估计了睾丸的功能的能力。DNA 从外部白血球被提取,并且 SRD5A2 和 AR 基因的所有 exons 被聚合酶链反应放大并且定序。在两个病人,基线睾丸激素(T) 水平是低的,价值在测试的 hCG 以后被提高。SRD5A2 基因的顺序是在病人 1 的正常,和异质接合的多型性, V89L,在病人 2 被发现。二个已知的变化, P390S 和 A870V,在病人被识别 1 和 2 分别地。没有白族的另外的特征,在 AR 基因的变化能与孤立的 micropenis 被联系,例如 hypospadias 或 gynecomastia。这加重与正常血浆 T 在孤立的 micropenis 的评估包括 AR 基因分析保证病人并且为家庭的适当基因建议的合适的管理的重要性。 | Amrit Bhangoo Francoise Paris Pascal Philibert Francoise Audran Svetlana Ten Charles Sultan | 2010 | Asian Journal of Andrology2010，12，4： | 1 |
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