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| 1 | Preoperative rectosigmoid endoscopic ultrasonography predicts the need for bowel resection in endometriosis显示文摘BACKGROUND Rectosigmoid endometriosis is an underdiagnosed disease responsible for abdominal pain, transit disorders and rectal bleeding. Two surgical approaches,rectosigmoid bowel resection(segmental or patch) or intramuscular layer dissection(shaving), are available.AIM To assess whether the lesion features observed via preoperative rectosigmoid endoscopic ultrasonography(RS-EUS) might predict the need for bowel resection.METHODS This multicentric retrospective study was conducted on patients with rectosigmoid endometriosis who underwent a curative surgical procedure,evaluated by RS-EUS performed by two trained operators, between January 2012 and March 2018. A univariate statistical analysis was performed on nodules' RSEUS features(thickness, width, infiltration of the submucosae, presence of a bump into the digestive lumen and presence of multiple rectosigmoid localizations). A multivariate logistic regression was then performed on the significant results.RESULTS Of the 367 patients, 73 patients with rectosigmoid endometriosis were evaluated by RS-EUS and underwent rectosigmoid surgery. After the univariate analysis was completed, thickness, width and infiltration of the submucosae were identified as potential predictive factors for bowel resection. In a multivariate logistic regression model, only thickness appeared to be a significant [odds ratio(OR) = 1.49, 95% confidence interval(CI): 1.04-2.12, P = 0.028] predictive factor for bowel resection. Receiver operating characteristic analysis performed showed that a thickness over 5.20 mm might be used as cut-off with a sensitivity of 76%, a specificity of 81%, and an area under carve = 0.82. The cut-off values for 100%sensitivity and 100% specificity were 0.90 mm and 10.00 mm, respectively. A trend concerning width to predict the need for resection was also observed(OR1.12, 95%CI: 1.00-1.26, P = 0.054)CONCLUSION The presence of a rectosigmoid nodule of endometriosis greater than 5.20 mm thick on RS-EUS might predict the need for bowel resection. | Victor Desplats René-Louis Vitte Joseph du Cheyron Gilles Roseau Arnaud Fauconnier Frédérick Moryoussef | 2019 | World Journal of Gastroenterology2019，25，6： | 9 |
| 2 | Mapping of long-range chromatin interactions by proximity ligation-assisted ChlP-seq显示文摘 | Rongxin Fang Miao Yu Guoqiang Li Sora Chee Tristin Liu Anthony D Schmitt Bing Ren | 2016 | Cell Research2016，26，12： | 8 |
| 3 | 反蛋白石结构的g-C_(3)N_(4)可控合成及其优异的光催化产氢性能显示文摘日渐严重的能源短缺和环境失衡问题已经阻碍了人类社会的进一步和长远可持续发展。能够将太阳能转化为可储存化学能的半导体基光催化技术被广泛的理解为一种经济和清洁的解决方式,比如光催化分解水。虽然被认为是有前途的光催化剂,g-C_(3)N_(4)低的比表面积极大地限制了其光催化性能。大孔-介孔结构可以为物质的传输和光的充分利用提供有效通道,从而提高光催化反应效率。本文中,具有反蛋白石(IO)结构的g-C_(3)N_(4)合理地通过紧密堆积的SiO_(2)作为模板来制备得到。并且显示出超高比表面积(450.2 m~2·g^(-1)),表现出更好的光催化产氢速率(21.22μmol·h^(-1)),约为体相g-C_(3)N_(4) (3.65μmol·h^(-1))的六倍。相对于体相g-C_(3)N_(4),IO g-C_(3)N_(4)表现了更好的可见光吸收能力,这得益于3D多孔结构的多重光散射效应。同时,较低的荧光强度、更长的荧光寿命、更小的Nyquist半圆环和更强的光电流响应协同地抑制了光生载流子的复合,降低了界面电荷传输的电阻,促进了光生电子的形成。此外,氮空位的存在能够增强局部电子密度,氮气吸-脱附测试揭示了IO g-C_(3)N_(4)中存在丰富的中孔和大孔,高比表面积暴露更多的活性边界和催化中心。正如光学性质、电子顺磁共振和电化学表征结果所揭示的那样,那些有利因素,包括增强的光利用率、提高的光生电荷的分离、延长的荧光寿命都赋予具有反蛋白石结构的IO g-C_(3)N_(4)优越的光催化性能。这项工作为结构设计和光催化性能调制做出了重要贡献。 | 陈一文 李铃铃 徐全龙 Tina Düren 范佳杰 马德琨 | 2021 | 物理化学学报2021，37，6： | 7 |
| 4 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 5 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 6 | Clinical pharmacology considerations in biologics development显示文摘Biologics 包括 monoclonal 抗体(mAbs ) 和象 cytokines 和生长荷尔蒙那样的另外的治疗学的蛋白质,与小分子相比有唯一的特征。这篇论文为阶段 II/III 临床的试用从一个机械学的观点,为 first-in-human (FIH ) 的剂量学习的开始的决心,和 dosing 政体优化从 biologics 的 pharmacokinetics (PK ) 的概述开始。随后,典型临床的药理学发出相应小径因为 biologics 开发被总结,包括在特定的人口的药药相互作用, QTc 延伸, immunogenicity,和研究。在 biologics,他们的 pharmacokinetic 和 pharmacodynamic 特征,和相应临床的药理学策略的分子的结构之间的关系在一张图解的图被总结并且描绘。 | Liang ZHAO Tian-hua REN Diane D WANG | 2012 | Acta Pharmacologica Sinica2012，33，11： | 5 |
| 7 | Establishment and Applications of Epstein-Barr Virus-based Episomal Vectors in Human Embryonic Stem Cells显示文摘 | Ren C Zhao M Yang X Li D Jiang X Wang L Shan W Yang H Zhou L Zhou W Zhang H | 2006 | 中国生物学文摘2006，20，7： | 4 |
| 8 | Preferential CTL targeting of Gag is associated with relative viral control in long-term surviving HIV-1 infected former plasma donors from China显示文摘它通常被相信细胞毒素的 T 淋巴细胞(CTL ) 玩的那 CD8 + 在限制人的免疫不全病毒类型 1 的复制(HIV-1 ) 并且在决定感染的结果,和这效果可以部分优先地取决于产品是哪个 HIV 的一个关键角色指向了。在以前的血浆施主(FPD ) 的一个队探讨在 HIV-1-specific CTL 回答和病毒复制之间的关联,天真的 FPD 与 HIV-1 clade B' 紧张感染了的 143 antiretroviral 治疗与 IFN-γ 为 HIV-1-specific CTL 回答被估计;在由使用盖住整个一致 clade B proteome 的重叠的肽(OLP ) 的单个肽水平的 Elispot 试金。由使用一个枪兵的等级关联分析,当是断然相关到 CD4 计数时,我们发现在全部的病毒特定的 CTL 活动之中的作呕特定的 CTL 回答的比例相反地与病毒的负担被相关,与与增加的病毒的负担被联系并且减少的Pol特定、Env特定的回答对比, CD4 数。另外, Vpr-specifc CTL 回答显示出类似的保护的效果与作呕回答,但是与识别的低得多的频率。显著地,我们也观察了在 HLA 之间的一个协会 --*30/B*13/Cw*06 haplotype 和可能由于的更低的病毒的负担限制了作呕特定的 CTL 回答。因此,我们的数据在疾病控制表明作呕特定的 CTL 回答的突出的角色。HLA 的优点 -- 在病毒的控制的 *30/B*13/Cw*06 haplotype 可以在学习个人与作呕特定的 CTL 回答的贡献被联系。 | Mingming Jia Kunxue Hong Jianping Chen Yuhua Ruan Zhe Wang Bing Su Guoliang Ren Xiaoqing Zhang Zhen Liu Quanbi Zhao Dan Li Hong Peng Marcus Altfeld Bruce D Walker Xu G Yu Yiming Shao | 2012 | Cell Research2012，22，5： | 3 |
| 9 | Synthesis, Crystal Structure and Calculated β Value of a Tetrahedral Zinc (II) Complex——Zn(2-NH_2py)_2Br_2显示文摘A new zinc(II) complex, Zn(2-NH2py)2Br2 (py=pyridine), has been synthesized, and its molecular structure has been confirmed by IR, elemental analysis and -ray crystal structure analysis. Its space group is P21/n with Mr=413.43 (C10H12Br2N4Zn), a=7.435(2), b=12.865(3), c=14.186(4)? b=94.08(2)? V=1353.5(5) 3, Z=4, Dc=2.029 g/cm3, F(000)=328, ?2.378mm-1, R=0.0283, wR=0.0501. The total observed reflections with I≥2?I) were 5314, of which the independent reflections were 3106. The complex structure contains a distorted tetrahedron formed by four atoms coordinated to zinc atom, namely two bromide atoms and two nitrogen atoms. The two ZnBr bond lengths within one molecule, 2.3763(6) and 2.4002(5)? respectively, are not equal; and so are the two ZnN bond lengths, which are 2.031(2) and 2.044(2)?respectively. The calculation results using PM3 method through MOPAC software package in Chem 3D show that its first molecular hyperpolarizability b value is 5.210-30esu, which is comparable with that of p-nitroaniline. No bulk SHG effect has been detected due to the centrosymmetric space group. | REN Peng a SU Nan-Bing a QIN Jin-Gui a Michael W. Day b CHEN Chuang-Tianc ( aDepartment of Chemistry, Wuhan University, Wuhan 43007, China) ( bBeckman Institute, California Institute of Technology, Pasadena, CA91125, USAQ ) ( cBeijing R & D Center | 2002 | Chinese Journal of Structural Chemistry2002，21，1： | 3 |
| 10 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 11 | Association between interleukin-21 gene rs907715 polymorphism and gastric precancerous lesions in a Chinese population显示文摘BACKGROUND The single nucleotide polymorphisms of interleukin-21(IL-21)gene were confirmed to be related to various diseases,but no studies have examined the possible role of IL-21 single nucleotide polymorphisms(SNPs)(rs907715,rs2221903,and rs12508721)in gastric precancerous lesions.AIM To explore the associations between SNPs of IL-21 gene(rs907715,rs2221903,and rs12508721)and gastric precancerous lesions in a Chinese population.METHODS Three SNPs of IL-21 were genotyped using polymerase chain reaction–ligase detection reaction in 588 cases and 290 healthy controls from May 2013 to December 2016 in northwestern China.Gastric precancerous lesions were confirmed by endoscopic examination and categorized as non-atrophic gastritis,atrophic gastritis,and intestinal metaplasia.Descriptive statistic and logistic regression were used for data analyses.RESULTS IL-21 rs907715 genotype CC and C frequencies were higher in in patients with gastric precancerous lesions than in the controls(OR=1.59,95%CI:1.06-2.38,P=0.013;OR=1.28,95%CI:1.01-2.22,P=0.044,respectively)after adjusting for confounding factors.For SNP rs907715 in intestinal metaplasia patients,significant differences between cases and controls were observed in the frequencies of genotype CC and C(OR=1.92,95%CI:1.24-2.98,P=0.004;OR=1.53,95%CI:1.04-2.24,P=0.028,respectively);for non-atrophic gastritis and atrophic gastritis patients,the CC and C genotypes showed no significant association with risk in all models.No association between either rs2221903 or rs12508721 and gastric precancerous lesions was found in the present study.In the haplotype analysis,the TC haplotype(rs907715 and rs12508721)and TT haplotype(rs2221903 and rs907715)were more frequent in the case group than control group(P<0.05).CONCLUSION Our findings indicate that SNP rs907715 of IL-21 gene is associated with gastric precancerous lesions.The TC haplotype(rs907715 and rs12508721)and TT haplotype(rs2221903 and rs907715)increased the risk of gastric precancerous lesions.If confirmed,these findings will shed light on the etiology of precancerous lesions. | Xiao-Qin Wang Yang Li Paul D Terry Wen-Jing Kou Yue Zhang Zhao-Zhao Hui Xiao-Han Ren Ming-Xu Wang | 2020 | World Journal of Gastrointestinal Oncology2020，12，3： | 2 |
| 12 | 近红外天文仪器的复消色差透镜显示文摘本文探讨的选择玻璃的赫伯格方法适用于近红外(NIR)波段的复消色差设计。此方法可避免复杂的代数计算,简化玻璃的选择过程。可从部分色散与V数关系曲线图上直接选择双合和三合透镜玻璃组合,本文还给出近红外双合和三合透镜的良好组合。设计样例表明此方法是实用而有效的。 | Ren,D 汪世祯 等 | 2001 | 云光技术2001，33，1： | 2 |
| 13 | Rapid, high throughput prenatal detection ofaneuploidy using a novel quantitative method (MLPA) 显示文摘 | Slater H R Bruno D L Ren H at al | 2003 | J Med Genet2003，40，12： | 1 |
| 14 | Esophageal imaging and strategies for avoiding injury during left atrial ablation for atrial fibrillation显示文摘 | REN J F LIN D MARCHLINSKI F E | 2006 | Heart Rhythm2006，3，： | 1 |
| 15 | A ffactal image coding algorithm research based on wavelet transformation显示文摘 | Xie Y Fu D Ren W | 2003 | Journal of Image and Graphics2003，7，8： | 1 |
| 16 | Quorum sensing inhibitors: a patent overview显示文摘 | Pan J Ren D | 2009 | Expert Opin Ther Pat2009，19，11： | 1 |
| 17 | The dependency of microstructure and properties of nanostructured coatings on plasma spray conditions 显示文摘 | Shaw L L Goberman D Ren R | 2000 | Surf Coat Technol2000，130，： | 1 |
| 18 | PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgammal reactivates adipogenesis 显示文摘 | Ren D Collingwood TN Rebar EJ | 2002 | Genes Dev2002，16，1： | 1 |
| 19 | The effect of electric field, annealing temperature and filler loading on the percolation threshold of polystyrene containing carbon nanotubes and graphene nanosheets 显示文摘 | Pang H Chen C Zhang Y C Ren P G Yan D X Li Z M | 2011 | Carbon2011，49，6： | 1 |
| 20 | Microbial community structure of ethanol type fermentation in bio-hydmgen production 显示文摘 | REN N Q XING D F ZHAO L H | 2007 | Environmental Microbiology2007，9，5： | 1 |
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