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| 1 | PTEN in liver diseases and cancer显示文摘The phosphoinositide 3-kinase (PI3K)/phosphatase and tensin homolog (PTEN)/Akt axis is a key signal transduction node that regulates crucial cellular functions, including insulin and other growth factors signaling, lipid and glucose metabolism, as well as cell survival and apoptosis. In this pathway, PTEN acts as a phosphoinositide phosphatase, which terminates PI3Kpropagated signaling by dephosphorylating PtdIns(3,4)P2 and PtdIns(3,4,5)P3. However, the role of PTEN does not appear to be restricted only to PI3K signaling antagonism, and new functions have been recently discovered for this protein. In addition to the well-established role of PTEN as a tumor suppressor, increasing evidence now suggests that a dysregulated PTEN expression and/or activity is also linked to the development of several hepatic pathologies. Dysregulated PTEN expression/activity is observed with obesity, insulin resistance, diabetes, hepatitis B virus/hepatitis C virus infections, and abusive alcohol consumption, whereas mutations/deletions have also been associated with the occurrence of hepatocellular carcinoma. Thus, it appears that alterations of PTEN expression and activity in hepatocytes are common and recurrent molecular events associated with liver disorders of various etiologies. These recent f indings suggest that PTEN might represent a potential common therapeutic target for a number of liver pathologies. | Marion Peyrou Lucie Bourgoin Michelangelo Foti | 2010 | World Journal of Gastroenterology2010，16，37： | 16 |
| 2 | 经呼气末二氧化碳无创评估机械通气患儿动脉二氧化碳:GRAeDIENT先导性研究显示文摘背景PICU患儿呼气末二氧化碳分压( end-tidal partial pressure of carbon dioxide, PetCO2. )和动脉血二氧化碳分压(arterial partial pressure of carbon dioxide,PaCO2 )间差异显著。本次预试验旨在建立一项可通过包括容积二氧化碳图( volumetriccapnography, VCap )在内的无创参数推算机械通气患儿PaCO2的预测模型。 | Bandin F Bourgoin P Brossier D 方伯梁 钱素云 | 2016 | 中国小儿急救医学2016，23，9： | 2 |
| 3 | Small inhibitors of ADP-ribosylation factor activation and function in mammalian cells显示文摘Small GTP-binding proteins of the ADP-ribosylation factor(Arf)family control various cell functional responses including protein transport and recycling between different cellular compartments,phagocytosis,proliferation,cytoskeletal remodelling,and migration.The activity of Arfs is tightly regulated.GTPase-activating proteins(GAPs)inactivate Arfs by stimulating GTP hydrolysis,and guanine nucleotide exchange factors(GEFs)stimulate the conversion of inactive GDP-bound Arf to the active GTP-bound conformation.There is increasing evidence that Arf small GTPases contribute to cancer growth and invasion.Increased expression of Arf6 and of Arf-GEPs,or deregulation Arf-GAP functions have been correlated with enhanced invasive capacity of tumor cells and metastasis.The spatiotemporal specificity of Arf activation is dictated by their GEFs that integrate various signals in stimulated cells.Brefeldin A(BFA),which inactivates a subset of Arf-GEFs,has been very useful for assessing the function of Golgi-localized Arfs.However,specific inhibitors to investigate the individual function of BFA-sensitive and insensitive ArfGEFs are lacking.In recent years,specific screens have been developed,and new inhibitors with improved selectivity and potency to study cell functional responses regulated by BFA-sensitive and BFA-insensitive Arf pathways have been identified.These inhibitors have been instrumental for our understanding of the spatiotemporal activation of Arf proteins in cells and demonstrate the feasibility of developing small molecules interfering with Arf activation to prevent tumor invasion and metastasis. | Sylvain G Bourgoin Mohammed-Amine El Azreq | 2012 | World Journal of Pharmacology2012，1，4： | 2 |
| 4 | Role of glycopeptides in the treatment of septic complications after cardiac surgery 显示文摘 | Bourgoin A Leone M Martin C | 2001 | Chemother2001，1，1： | 1 |
| 5 | 18S rRNA secondary structure and phylogenetic position of Peloridiidae (Insecta: Hemiptera)显示文摘 | Ouvrard D Campbell BC Bourgoin T | 2000 | Mol Phylogenet Evol2000，16，3： | 1 |
| 6 | Lead content in 70 brands of dietary calcium supplements 显示文摘 | Bourgoin BP Evans DR Cornett JR | 1993 | Am J Public Health1993，83，： | 1 |
| 7 | Population pharmacokinetics and Bayesian estimation of mycophenol ic acid concentrations in stable renal transplant patients显示文摘 | LE-GUELLEC C BOURGOIN H BUCHLER M | 2004 | Clin Pharmacokinet2004，43，4： | 1 |
| 8 | Electron transport through a metal-molecule-metal junction显示文摘 | C Kerguefis J P Bourgoin S Palacin | 1999 | Phys Rev1999，59，12： | 1 |
| 9 | Microphytobenthos biomass at Kerguelen's Land (Subantarctic Indian Ocean):Repartition and variability during austral summers显示文摘 | Riaux-Gobin C Bourgoin P | | 0，，： | 1 |
| 10 | Factors influencing the duration of breastfeeding in the Sudbury region显示文摘 | Bourgoin GL | 1997 | Canadian Journal of Public Health1997，88，4： | 1 |
| 11 | Detection of the Metastable State of the EL2 Defect in GaAs显示文摘 | BOURGOIN J C NEFFATI T | 1997 | J Appl Phys1997，82，8： | 1 |
| 12 | The behaviour of control rod absorber under irra- diation显示文摘 | BOURGOIN J COUVREUR F GOSSET D | 1999 | J NuclMater1999，275，： | 1 |
| 13 | Are horizontal transfers involved in the evolution of the Streptococcus thermophilus exopolysaccharide synthesis loci显示文摘 | BOURGOIN F PLUVINET A DECARIS B | 1999 | Gene1999，233，： | 1 |
| 14 | Human papillomavirus infection of the cervix uteri in women attending a health examination center of the French Social Security显示文摘 | Beby DA Bourgoin A Ragot S | 2004 | J Med Virol2004，73，2： | 1 |
| 15 | interaction of low molecular weight group IIA phospholipase A2 with apop- totic human T cells: role of heparan sulfate proteoglycans显示文摘 | Boilard E Bourgoin SG Bernatchez C | 2003 | FASEB J2003，17，9： | 1 |
| 16 | Ikaros and GATA-1 combinatorial effect is required for silencing of human gamma-globin genes显示文摘 | BOTTARDI S ROSS J BOURGOIN V | 2009 | Mol Cell Biol2009，29，6： | 1 |
| 17 | Effects of sufentanil or ketamine administered in target-controlled infusion on the cerebral hemodynamics of severely brain-injured patients显示文摘 | Bourgoin A Albanese J Leone M | 2005 | Crit Care Med2005，33，5： | 1 |
| 18 | The agents used for sedation in neurointensive care unit显示文摘 | Albanese J Garnier F Bourgoin A | 2004 | Ann Fr Anesth Reanim2004，23，5： | 1 |
| 19 | Fast and reliable strawberry cultivar identification using inter simple sequence repeat(ISSR)amplification显示文摘 | ARNAU G LALLEMAND J BOURGOIN M | | 0，，01： | 1 |
| 20 | Electron transport through a metal-molecule-metal junction显示文摘 | Kergueris C Bourgoin J P Pasacin S | 1999 | Phys Rev B1999，59，12： | 1 |
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