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| 1 | Endoscopic submucosal dissection training with pig models in a Western country显示文摘AIM:To test a strategy for endoscopic submucosal dissection(ESD) training in animal models designed to overcome the initial learning curve.METHODS:ESD was attempted in ex vivo and in vivo pig models.Thirty ESD procedures were attempted in the esophagus(n=9) or the stomach(n=21).The ex vivo model was used until initial competence was achieved.In the in vivo model,several ESD procedures were performed in up to 3 sessions.The following variables were analyzed:specimen size,complete and en bloc resection rate,time for circumferential incision,time for submucosal dissection,total ESD duration,and complications.RESULTS:Complete resection was achieved in 28 cases(en bloc 27);2 could not be completed(one perforation,one technical diff iculty).The mean ± SD time for circumferential incision was 36.2±16.8 min(range:8-87 min),and the mean±SD time for submucosal dissection was 45.1±35.7 min(range:9-196 min).The mean±SD size of the resected specimens was 45.2±17.8 mm.The mean±SD total resection time was signif icantly increased for the gastric cases performed in the f irst half of the study(n=13) than in the second half(n=8)(98.9±62.4 min vs 61.7±17.6 min,P=0.04),although the specimen size did not differ.CONCLUSION:Training in animal models could help endoscopists overcome the learning curve before starting ESD in humans. | Adolfo Parra-Blanco María Rosa Arnau David Nicolás-Pérez Antonio Z Gimeno-García Nicolás González Juan A Díaz-Acosta Alejandro Jiménez Enrique Quintero | 2010 | World Journal of Gastroenterology2010，16，23： | 9 |
| 2 | Pharmacomicrobiomics: a novel route towards personalized medicine?显示文摘在药反应的内部个人的异质是影响病人幸福并且在社会水平上提出庞大的临床、金融的负担的一个严重问题。Pharmacogenomics 在关于药反应可变性或药毒性的对单个基因背景的影响的研究的最前线,并且最近,内脏 microbiome,也被称为第二个染色体,在这个方面作为一个重要播放器被认出了。而且, microbiome 是为由于机会改进药功效和安全操作它的作文的一个很吸引人的目标。Pharmacomicrobiomics 是调查 microbiome 变化和药反应和布置(吸收,分发,新陈代谢和排泄) 的相互影响的一个新兴的领域。在这评论,我们提供历史的概述并且在在内脏 microbiome,主人和药之间的复杂相互作用上检验当前的最先进的知识。我们主张那联合 pharmacogenomics 和 pharmacomicrobiomics 将为在个性化的药做主要进展提供一个重要基础。 | Marwah Doestzada Arnau Vich Vila Alexandra Zhernakova Debby P.Y. Koonen Rinse K. Weersma Daan J. TOUW Folkert Kuipers Cisca Wijmenga Jingyuan Fu | 2018 | Protein & Cell2018，9，5： | 7 |
| 3 | Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury:An update显示文摘Aldehyde dehydrogenase 2(ALDH2) is best known for its critical detoxifying role in liver alcohol metabolism. However, ALDH2 dysfunction is also involved in a wide range of human pathophysiological situations and is associated with complications such as cardiovascular diseases, diabetes mellitus, neurodegenerative diseases and aging. A growing body of research has shown that ALDH2 provides important protection against oxidative stress and the subsequent loading of toxic aldehydes such as 4-hydroxy-2-nonenal and adducts that occur in human diseases, including ischemia reperfusion injury(IRI). There is increasing evidence of its role in IRI pathophysiology in organs such as heart, brain, small intestine and kidney; however, surprisingly few studies have been carried out in the liver, where ALDH2 is found in abundance. This study reviews the role of ALDH2 in modulating the pathways involved in the pathophysiology of IRI associated with oxidative stress, autophagy and apoptosis. Special emphasis is placed on the role of ALDH2 in different organs, on therapeutic 'preconditioning' strategies, and on the use of ALDH2 agonists such as Alda-1, which may become a useful therapeutic tool for preventing the deleterious effects of IRI in organ transplantation. | Arnau Panisello-Roselló Alexandre Lopez Emma Folch-Puy Teresa Carbonell Anabela Rolo Carlos Palmeira René Adam Marc Net Joan Roselló-Catafau | 2018 | World Journal of Gastroenterology2018，24，27： | 6 |
| 4 | Ubiquitin-proteasome system and oxidative stress in liver transplantation显示文摘A major issue in organ transplantation is the development of a protocol that can preserve organs under optimal conditions. Damage to organs is commonly a consequence of flow deprivation and oxygen starvation following the restoration of blood flow and reoxygenation. This is known as ischemia-reperfusion injury(IRI): a complex multifactorial process that causes cell damage. While the oxygen deprivation due to ischemia depletes cell energy, subsequent tissue oxygenation due to reperfusion induces many cascades, from reactive oxygen species production to apoptosis initiation. Autophagy has also been identified in the pathogenesis of IRI, although such alterations and their subsequent functional significance are controversial. Moreover, proteasome activation may be a relevant pathophysiological mechanism. Different strategies have been adopted to limit IRI damage, including the supplementation of commercial preservation media with pharmacological agents or additives. In this review, we focus on novel strategies related to the ubiquitin proteasome system and oxidative stress inhibition, which have been used to minimize damage in liver transplantation. | Norma Alva Arnau Panisello-Roselló Marta Flores Joan Roselló-Catafau Teresa Carbonell | 2018 | World Journal of Gastroenterology2018，24，31： | 5 |
| 5 | Relevance of proteolysis and proteasome activation in fatty liver graft preservation: An Institut Georges Lopez-1 vs University of Wisconsin appraisal显示文摘AIM To compare liver proteolysis and proteasome activation in steatotic liver grafts conserved in University of Wisconsin(UW) and Institut Georges Lopez-1(IGL-1)solutions.METHODS Fatty liver grafts from male obese Zücker rats were conserved in UW and IGL-1 solutions for 24 h at 4 ℃and subjected to 'ex vivo ' normo-thermic perfusion(2 h; 37 ℃). Liver proteolysis in tissue specimens and perfusate was measured by reverse-phase high performance liquid chromatography. Total free amino acid release was correlated with the activation of the ubiquitin proteasome system(UPS: measured as chymotryptic-like activity and 20 S and 19 S proteasome), the prevention of liver injury(transaminases), mitochondrial injury(confocal microscopy) and inflammation markers(TNF 1 alpha, high mobility group box-1(HGMB-1) and PPAR gamma), and liver apoptosis(TUNEL assay, cytochrome c and caspase 3).RESULTS Profiles of free AA(alanine, proline, leucine, isoleucine, methionine, lysine, ornithine, and threonine, among others) were similar for tissue and reperfusion effluent. In all cases, the IGL-1 solution showed a significantly higher prevention of proteolysis than UW(P < 0.05) after cold ischemia reperfusion. Livers conserved in IGL-1 presented more effective prevention of ATP-breakdown and more inhibition of UPS activity(measured as chymotryptic-like activity). In addition, the prevention of liver proteolysis and UPS activation correlated with the prevention of liver injury(AST/ALT) and mitochondrial damage(revealed by confocal microscopy findings) as well as with the prevention of inflammatory markers(TNF1alpha and HMGB) after reperfusion. In addition, the liver grafts preserved in IGL-1 showed a significant decrease in liver apoptosis, as shown by TUNEL assay and the reduction of cytochrome c, caspase 3 and P62 levels. CONCLUSION Our comparison of these two preservation solutions suggests that IGL-1 helps to prevent ATP breakdown more effectively than UW and subsequently achieves a higher UPS inhibition and reduced liver proteolysis. | Mohamed Amine Zaouali Arnau Panisello-Roselló Alexandre Lopez Carlos Castro Benítez Emma Folch-Puy Agustín García-Gil Teresa Carbonell RenéAdam Joan Roselló-Catafau | 2017 | World Journal of Gastroenterology2017，23，23： | 3 |
| 6 | Polyethylene glycols: An effective strategy for limiting liver ischemia reperfusion injury显示文摘Liver ischemia-reperfusion injury(IRI) is an inherent feature of liver surgery and liver transplantation in which damage to a hypoxic organ(ischemia) is exacerbated following the return of oxygen delivery(reperfusion). IRI is a major cause of primary nonfunction after transplantation and may lead to graft rejection, regardless of immunological considerations. The immediate response involves the disruption of cellular mitochondrial oxidative phosphorylation and the accumulation of metabolic intermediates during the ischemic period, and oxidative stress during blood flow restoration. Moreover, a complex cascade of inflammatory mediators is generated during reperfusion, contributing to the extension of the damage and finally to organ failure. A variety of pharmacological interventions(antioxidants, anticytokines, etc.) have been proposed to alleviate graft injury but their usefulness is limited by the local and specific action of the drugs and by their potential undesirable toxic effects. Polyethylene glycols(PEGs), which are non-toxic water-soluble compounds approved by the FDA, have been widely used as a vehicle or a base in food, cosmetics and pharmaceuticals, and also as adjuvants for ameliorating drug pharmacokinetics. Some PEGs are also currently used as additives in organ preservation solutions prior to transplantation in order to limit the damage associated with cold ischemia reperfusion. More recently, the administration of PEGs of different molecular weights by intravenous injection has emerged as a new therapeutic tool to protect liver grafts from IRI. In this review, we summarize the current knowledge concerning the use of PEGs as a useful target for limiting liver IRI. | Gianfranco Pasut Arnau Panisello Emma Folch-Puy Alexandre Lopez Carlos Castro-Benítez Maria Calvo Teresa Carbonell Agustín García-Gil RenéAdam Joan Roselló-Catafau | 2016 | World Journal of Gastroenterology2016，22，28： | 3 |
| 7 | 经翼点入路两骨瓣开颅法保留脑膜中动脉的解剖学研究显示文摘目的研究脑膜中动脉在颅骨额颞区走行的解剖特点,探讨通过两骨瓣颅骨成形方式保留脑膜中动脉的效果。方法收集成人尸头标本5具(10侧),采用标准经翼点入路显露骨窗,同时增加1个以翼点区蝶鳞缝前5 mm处为中心的骨孔,首先用铣刀成形一'凹'字形额颞蝶骨瓣,然后剥离硬脑膜和脑膜中动脉,绕蝶骨大翼再成形一'V'字形骨瓣。观察脑膜中动脉在颅骨额颞区的走行特点并测量其在翼点处的管径。结果脑膜中动脉的前支在翼点区主要沿蝶鳞缝走行,此处脑膜中动脉的直径为(1.4±0.2)mm,其最前方的主要分支上行至颞上线水平时,位于冠状缝后方约(13.3±1.5)mm处。10侧标本中,通过采取两骨瓣法开颅,9侧脑膜中动脉可保持完整。结论根据脑膜中动脉走行的解剖学特点,采取改良经翼点入路两骨瓣开颅法可有效保留脑膜中动脉。 | 刘勇 冯学泉 刘云阳 马光铄 李牧 Benet Arnau Lawton Michael | 2020 | 中华神经外科杂志2020，36，12： | 2 |
| 8 | Hope and the interpersonal-psychological theory of suicidal behavior: replication and extension of prior findings 显示文摘 | ANESTIS M D MOBERG F B ARNAU R C | 2013 | Suicide Life Threat Behav2013，11，4： | 1 |
| 9 | Methodology for characterisation and simulation of turbocharged diesel engines combustion during transient operation. Part 1: Data acquisition and post-processing显示文摘 | J.R. Serrano F.J. Arnau V. Dolz P. Piqueras | 2008 | Applied Thermal Engineering2008，，1： | 1 |
| 10 | Evidence based medical treatment of heart failure显示文摘 | Agusti Escasany A Duran Dalmau M Arnau De Bolos JM | 2001 | Rev Esp Cardiol2001，54，： | 1 |
| 11 | A review of interface electronic systems for AT-cut quartz crystal microbalance applications in liquids 显示文摘 | ARNAU A | 2008 | Sensors2008，，8： | 1 |
| 12 | Lipoprotein(a) in young individuals as a marker of the presence of ischemich eart disease and the severity of coronary lesions显示文摘 | Zorio E Falco C Arnau M A | 2006 | Haemato logica2006，91，4： | 1 |
| 13 | Nosocomial pneumonia: Comparative multicentre trial between monotherapy with cefotaxime and treatment with antibiotic combinations显示文摘 | Dr. M. Fernández-Guerrero M. D. C. Arnau Ph. D. L. Valdés M. D. C. Vallvé M. D. F. Gudiol A. Rodríguez-Torres M. D | 1991 | Infection1991，，6： | 1 |
| 14 | The effect of glycerol mixed substrate on the heterologous production of a Rhizopus oryzae lipase in Pichia pastoris system显示文摘 | Arnau C Casas C Valero F | 2011 | Biochem Eng J2011，57，： | 1 |
| 15 | Beta-adrenergic blocking agents in heartfailure:benefits of vasodilating and non-vasodilating agents according to patients′characteristics:a meta-analysis of clinical trails显示文摘 | Bonet S Agusti A Arnau JM | 2000 | Arch Intern Med2000，160，： | 1 |
| 16 | Optimization of the heterologous production of a Rhizopus oryzae lipase in Pichia pastoris system using mixed substrates on controlled fed-batch bioprocess显示文摘 | Arnau C Ramon R Casas C | 2010 | Enzyme and Microbial Technology2010，46，6： | 1 |
| 17 | Analysis of the capabilities of a two-stage turbocharging system to fulfill the US 2007 anti-pollution directive for heavy duty diesel engines 显示文摘 | Serrano J R Arnau F J V Dolz | 2008 | International Journal of Automotive Tech- nology2008，9，3： | 1 |
| 18 | Effect of the inoculation of a starter culture and vacuum packaging during the resting stage on sensory waits of dry-cured ham显示文摘 | SANCHEZ-MOLINERO F ARNAU J | 2008 | Meat Science2008，80，4： | 1 |
| 19 | Analysis of the capabilities of a two-stage turbocharging syetem to fulfil the US2007 anti-pollution directive for heavy duty diesel engines显示文摘 | Serrano J Arnau F Dolz V | 2008 | International Journal of Automotive Technology2008，9，3： | 1 |
| 20 | Fast and reliable strawberry cultivar identification using inter simple sequence repeat(ISSR)amplification显示文摘 | ARNAU G LALLEMAND J BOURGOIN M | | 0，，01： | 1 |
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