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| 1 | Numerical investigation of particle saltation in the bed-load regime显示文摘This paper numerically investigates particle saltation in a turbulent channel flow having a rough bed consisting of 2–3 layers of densely packed spheres.In this study,we combined three the state-of-the-art technologies,i.e.,the direct numerical simulation of turbulent flow,the combined finite-discrete element modelling of the deformation,movement and collision of the particles,and the immersed boundary method for the fluid-solid interaction.Here we verify our code by comparing the flow and particle statistical features with the published data and then present the hydrodynamic forces acting on a particle together with the particle coordinates and velocities,during a typical saltation.We found strong correlation between the abruptly decreasing particle stream-wise velocity and the increasing vertical velocity at collision,which indicates that the continuous saltation of large grain-size particles is controlled by collision parameters such as particle incident angle,local rough bed packing arrangement,and particle density,etc.This physical process is different from that of particle entrainment in which turbulence coherence structures play an important role.Probability distribution functions of several important saltation parameters and the relationships between them are presented.The results show that the saltating particles hitting the windward side of the bed particles are more likely to bounce off the rough bed than those hitting the leeside.Based on the above findings,saltation mechanisms of large grain-size particles in turbulent channel flow are presented. | JI ChunNing ANTE Munjiza ELDAD Avital XU Dong JOHN Williams | 2014 | Science China(Technological Sciences)2014，57，8： | 10 |
| 2 | Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in treatment of gastric cancer with peritoneal carcinomatosis显示文摘Although gastric cancer with peritoneal carcinomatosis is associated with poor prognosis and is generally treated with palliative systemic therapy, recent studies have shown that cytoreductive surgery(CRS) and hyperthermic intraperitoneal chemotherapy(HIPEC) may prove to be an efficacious treatment option. In addition to reviewing the natural history of gastric cancer with peritoneal carcinomatosis, this mini-review examines literature on the efficacy of CRS and HIPEC as compared to chemotherapy and surgical options. Both randomized and nonrandomized studies were summarized with the emphasis focused on overall survival. In summary, CRS and HIPEC are indeed a promising treatment option for gastric cancer with peritoneal carcinomatosis and large randomized clinical trials are warranted. | Lynne M.Ellison Yangao Man Alexander Stojadinovic Hongwu Xin Itzhak Avital | 2017 | Chinese Journal of Cancer Research2017，29，1： | 5 |
| 3 | Effect of No-Reflow During Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction on Six-Month Mortality显示文摘 | David Brosh Abid R. Assali Aviv Mager Avital Porter David Hasdai Igal Teplitsky Eldad Rechavia Shmuel Fuchs Alexander Battler Ran Kornowski | 2007 | The American Journal of Cardiology2007，，4： | 4 |
| 4 | Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders显示文摘Neurodegenerative diseases are progressive conditions that affect the neurons of the central nervous system(CNS)and result in their damage and death.Neurodevelopmental disorders include intellectual disability,autism spectrum disorder,and attention-deficit/hyperactivity disorder and stem from the disruption of essential neurodevelopmental processes.The treatment of neurodegenerative and neurodevelopmental conditions,together affecting~120 million people worldwide,is challenged by the blood—brain barrier(BBB)and the blood—cerebrospinal fluid barrier that prevent the crossing of drugs from the systemic circulation into the CNS.The nose-to-brain pathway that bypasses the BBB and increases the brain bioavailability of intranasally administered drugs is promising to improve the treatment of CNS conditions.This pathway is more efficient for nanoparticles than for solutions,hence,the research on intranasal nano-drug delivery systems has grown exponentially over the last decade.Polymeric nanoparticles have become key players in the field owing to the high design and synthetic flexibility.This review describes the challenges faced for the treatment of neurodegenerative and neurodevelopmental conditions,the molecular and cellular features of the nasal mucosa and the contribution of intranasal nano-drug delivery to overcome them.Then,a comprehensive overview of polymeric nanocarriers investigated to increase drug bioavailability in the brain is introduced. | Rania Awad Avi Avital Alejandro Sosnik | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 2 |
| 5 | Isolation characterization and transplantation of bone marrow-derived hepatocyte stem cells显示文摘 | Avital I Inderbitzin D Aoki T | | 0，，： | 2 |
| 6 | Cytoreductive surgeryand intraperitoneal hyperthermic chemotherapy in peritoneal car-cinomatosis显示文摘 | Nesher E Greenberg R Avital S | 2007 | Isr Med Assoc J2007，9，11： | 1 |
| 7 | Can peak expiratory flow measurements estimate small airway function in asthmatic children显示文摘 | Goldberg S Springer C Avital A | 2001 | Chest2001，120，2： | 1 |
| 8 | Laparoscoplc splenectomy for solitary splenic tumors显示文摘 | Makrin V Avital S White I | 2008 | Surg Endosc2008，22，9： | 1 |
| 9 | Can Peak Expiratory Flow Measurements Estimate Small Airway Function in Asthmatic Children显示文摘 | Goldberg S Springer C Avital A | 2001 | Chest2001，120，2： | 1 |
| 10 | Asymmetric instability of a viscid capillary jet in an inviscid media显示文摘 | Avital E | 1995 | Phys Fluids1995，7，5： | 1 |
| 11 | CK levels in unmedicated bipolar patients显示文摘 | Segal M Avital A Drobot M | 2007 | Eur Neuropsychopharmacol2007，17，21： | 1 |
| 12 | The SSRIs drug fluoxetine, but not the noradrenergic tricyclic drug desipramine,improves memory performance during acute major depression 显示文摘 | Levkovitz Y Caftori R Avital A etal | 2002 | Brain Res Bull2002，58，4： | 1 |
| 13 | Hemodynamic and cate- cholamine response to tracheal intubation : direct laryngoscopy com- pared with fiberoptic intubation 显示文摘 | Michal B Avishai Z Avital G | 2003 | J Clin Anesth2003，15，8： | 1 |
| 14 | Isolation, characterization and transplantation of bone marrow-derived hepatocyte stem cells 显示文摘 | Avital I Inderbitzin D Aoki T | 2001 | Biochem Biophys Res Commun2001，288，： | 1 |
| 15 | Isolation,characterization and transplantation of bone marrow-derived hepatocytes stem cell显示文摘 | Avital I Inderbitzin D Aoki T | 2001 | Biochem Biophy Res Commu2001，288，1： | 1 |
| 16 | Reversible modulations of neuronal plasticity by VEGF显示文摘 | Licht T Goshen I Avital A | 2011 | PNAS2011，108，12： | 1 |
| 17 | Isolation, characterization, and t ransplantation of bone marrow-derived hepatocyte stem cells显示文摘 | AVITAL I INDERBITZIN D AOKI T | 2001 | Biochem Biophys Res Commun2001，288，： | 1 |
| 18 | Aminoterminal pro-brain- type natriuretic peptide: heart or lung disease in pediatric respira- tory distress 显示文摘 | Cohen S Springer C Avital A | 2005 | Pediatrics2005，115，5： | 1 |
| 19 | Yield from flexible bronchoscopy in children显示文摘 | Godfrey S Avital A Maayan C | 1997 | Pediatr Pulmonol1997，23，4： | 1 |
| 20 | Obesity and the risk of heart failure显示文摘 | Jenny Avital ER | 2002 | N Engl J Med2002，347，23： | 1 |
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