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| 1 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 2 | Accuracy of Magnetic Resonance Enterography in Assessing Response to Therapy and Mucosal Healing in Patients With Crohn’s Disease显示文摘 | Ingrid Ordás Jordi Rimola Sonia Rodríguez José M. Paredes María J. Martínez-Pérez Esther Blanc Juan A. Arévalo Marta Aduna Montserrat Andreu Alexander Radosevic Anna M. Ramírez-Morros Susana Pinó Marta Gallego Aranzazu Jauregui-Amezaga Elena Ricart Julián | 2013 | Gastroenterology2013，，： | 3 |
| 3 | Evaluation of 5 versus 10 granulocyteaphaeresis sessions in steroid-dependent ulcerative colitis: A pilot, prospective, multicenter, randomized study显示文摘瞄准:与活跃类固醇依赖者 ulcerative 在病人与 10 个 granulocyteaphaeresis 会议相比评估 5 的功效。方法:在这名飞行员,未来,多集中使随机化的试用,有中等活跃的类固醇的 20 个病人 -- 依赖 ulcerative 被使随机化到 5 或 10 个 granulocyteaphaeresis 会议。主要目的是在 wk 的临床的宽恕 17。第二等的措施包括了内视镜的宽恕和类固醇消费。结果:九个病人被使随机化到 5 个 granulocyteaphaeresis 会议(组 1 ) 和 11 个病人到 10 个 granulocyteaphaeresis 会议(组 2 ) 。在 wk 17,在在组 2 的组 1 病人和 45.45% 的 37.5% 病人在临床的宽恕。临床的宽恕被内视镜的宽恕在所有情况中伴随。完成宽恕的百分之 86 个病人在 wk 是没有类固醇的 17。每日的类固醇要求在组 2 是显著地更低的。病人的 89% 在一年后续期间留在宽恕。一个严肃的不利事件不与学习治疗有关,被报导。结论:Granulocyteaphaeresis 为类固醇依赖者 ulcerative 的治疗安全、有效。在这张人口,增加 aphaeresis 会议的数字没与更高的宽恕率被联系,但是负担得起重要类固醇圆材效果。 | Elena Ricart Maria Esteve Montserrat Andreu Francesc Casellas David Monfort Miquel Sans Natalia Oudovenko Raúl Lafuente Julián Panés | 2007 | World Journal of Gastroenterology2007，13，15： | 3 |
| 4 | Wiskott-Aldrich syndrome in a female with skewed X-chromosome inactivation显示文摘 | Andreu N Pujol-Moix N Martinez-Lostao L | 2003 | Blood Cells Mol Dis2003，31，3： | 1 |
| 5 | Cloning,mapping and expression analysis of VPS33B,the human orthologue of rat Vps33 b显示文摘 | Carim L Sumoy L Andreu N | | 0，，： | 1 |
| 6 | Disease severity in familial cases of IBD显示文摘 | M. Andreu L. Márquez E. Domènech J.P. Gisbert V. García I. Marín-Jiménez M. Pe?alva F. Gomollón X. Calvet O. Merino E. Garcia-Planella N. Vázquez-Romero M. Esteve P. Nos A. Gutiérrez I. Vera J.L. Cabriada M.D. Martín A. Ca?as-Ventura J. Panés | 2014 | Journal of Crohn’s and Colitis2014，，3： | 1 |
| 7 | Stress relaxation of five different soil samples whenuniaxially compacted at different water contents显示文摘 | SáNCHEZ-GIRóN V ANDREU E HERNANZ J L | 2001 | Soil&Tillage Research2001，62，： | 1 |
| 8 | Local injection versus surgery in carpal tunnel syndrome : neurophysiologic outcomes of a randomized clinical trial 显示文摘 | Andreu JL Ly-Pen D Mill 6 n I | 2014 | Clin Neurophysiol2014，125，7： | 1 |
| 9 | Mangiferin, a naturally occurring glueoxilxanthone improves long - texan object recognition memory in rats 显示文摘 | Pardo Andreu GL Maurmann N Reolon GK | 2010 | Eur J Pharmaeol2010，635，13： | 1 |
| 10 | Mangiferin, a naturally occurring giucoxilxanthone improves long-term object recognition memory in rats显示文摘 | PARD() ANDREU GL MAURMANN N REOLON GK et ol | 2010 | Eur J Pharmaco]2010，635，1： | 1 |
| 11 | Mangiferin,a natural y occurring glucoxilxanthone improves long-term object recognition memory in rats显示文摘 | Pardo Andreu GL Maurmann N Reolon GK | | 0，，07： | 1 |
| 12 | Mangiferin, a naturally occurring glueoxilxanthone improves long-term object reeogni-tion memory in rats 显示文摘 | Pardo Andreu G L Maurmann N Reolon G K | 2010 | Eur J Pharm2010，635，13： | 1 |
| 13 | Struc- ture of the major antigenic loop of foot-and-mouth disease virus complexed with a neutralizing antibod- y : direct involvement of the Arg-Gly-Asp motif in the interaction显示文摘 | Verdaguer N Mateu M G9 Andreu D etal | 1995 | Embo J1995，14，8： | 1 |
| 14 | Role of leukemia inhibitor factor (LIF) in decidualisation of murine uterine stromal cells in vitro 显示文摘 | Fouladi Nashta AA Andreu CV Nijjar N | 2004 | J Endocrinol2004，181，： | 1 |
| 15 | Direct determination of uric acid in serum by a fluorometric-enzymatic method based on uricase显示文摘 | Javier Galbán Yolanda Andreu M.J Almenara Susana de Marcos Juan R Castillo | 2001 | Talanta2001，，5： | 1 |
| 16 | Mycobacterium smegmatis displays the mycobacterium tuberculosis virulence-related neutral red character when expressing the Rv0577 gene显示文摘 | ANDREU N SOTO C Y ROCA I | 2004 | FEMS Microbiol Let2004，231，2： | 1 |
| 17 | First principle study of the surface reactivity of layered lithium oxides LiMO2 (M=Ni, Mn, Co)显示文摘 | VALLVERDU G MINVIELLE M ANDREU N | 2016 | Surface Science2016，649，： | 1 |
| 18 | Simulating the impact of ir-rigation management on the water and salt balance in drained marsh soils(Marismas,Spain)显示文摘 | ANDREU L JARVIS N J MORENO F | 1996 | Soil Use and Management1996，12，3： | 1 |
| 19 | Parabolic quasilinear equations minimizing linear growth functionals显示文摘 | Andreu F Caselles V Mazón J M | | 0，，223： | 1 |
| 20 | Wiskott-Aldrich syndrome in a female with skewed X-chromosome inactivation显示文摘 | Andreu N Pujol-Moix N Martinez-Lostao L Oset M Muniz-Diaz E Estivill X | 2003 | Blood Cells Mol Dis2003，31，3： | 1 |
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