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| 1 | Prognostic value of increased carbohydrate antigen in patients with heart failure显示文摘AIM:To study the prognostic value of carbohydrateantigen 125(CA125) and whether it adds prognostic information to N-terminal pro-brain natriuretic peptide(NT-proBNP) in stable heart failure(HF) patients.METHODS:The predictive value of CA125 was retrospectively assessed in 156 patients with stable HF remitted to the outpatient HF unit for monitoring from 2009 to 2011.Patients were included in the study if they had a previous documented episode of HF and received HF treatment.CA125 and NT-proBNP concentrations were measured.The independent association between NT-proBNP or CA125 and mortality was assessed with Cox regression analysis,and their combined predictive ability was tested by the integrated discrimination improvement(IDI) index.RESULTS:The mean age of the 156 patients was 72 ± 12 years.During follow-up(17 ± 8 mo),27 patients died,1 received an urgent heart transplantation and 106 required hospitalization for HF.Higher CA125 values were correlated with outcomes:58 ± 85 KU/L if hospitalized vs 34 ± 61 KU/L if not(P < 0.05),and 94 ± 121 KU/L in those who died or needed urgent heart transplantation vs 45 ± 78 KU/L in survivors(P < 0.01).After adjusting for propensity scores,the highest risk was observed when both biomarkers were elevated vs not elevated(HR = 8.95,95%CI:3.11-25.73; P < 0.001) and intermediate when only NT-proBNP was elevated vs not elevated(HR = 4.15,95%CI:1.41-12.24; P < 0.01).Moreover,when CA125 was added to the clinical model with NT-proBNP,a 4%(P < 0.05) improvement in the IDI was found.CONCLUSION:CA125 > 60 KU/L identified patients in stable HF with poor survival.Circulating CA125 level adds prognostic value to NT-proBNP level in predicting HF outcomes. | Ana B Méndez Jordi Ordonez-Llanos Andreu Ferrero Mariana Noguero Teresa Mir Josefina Mora Antoni Bayes-Genis Sònia Mirabet Juan Cinca Eulàlia Roig | 2014 | World Journal of Cardiology2014，6，4： | 13 |
| 2 | Outcome in obscure gastrointestinal bleeding after capsule endoscopy显示文摘AIM: To investigate the clinical impact of capsule endoscopy(CE) after an obscure gastrointestinal bleeding(OGIB) episode, focusing on diagnostic work-up, followup and predictive factors of rebleeding. METHODS: Patients who were referred to Hospital del Mar(Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid antiinflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings(significant or non-significant), work-up and patient out-comes were analyzed from electronic charts. Variables were compared by χ 2 analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model. RESULTS: There were 105 patients [45.7% women, median age of 72 years old(interquartile range 56-79)] and a median follow-up of 326 d(interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1%(55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients(69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios(HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above(HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE(HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding. CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions. | Alex Caas-Ventura Lucia Márque Xavier Bessa Josep Maria DedeuDepartment of Gastroenterology Hospital del Mar Research Institute Pompeu Fabra University Marc Puigvehí Sílvia Delgado-Aros Ines Ana Ibáez Agustin Seoane Luis Barranco Felipe Bory Montserrat Andreu Begoa González-Suárez | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 4 |
| 3 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 4 | Blockade of the Bcr - abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5 - dependent expression of Bcl - X1 显示文摘 | Horita M Andreu E J Benito A | 2000 | J Exp Med2000，191，6： | 1 |
| 5 | Satisfaction and destination loyality a comparison between non-repeat and repeat tourists 显示文摘 | Kozak M Bigne Enrique Andreu Luisa | 2004 | Journal of Quality Assurance in Hospitality & Tourism2004，5，1： | 1 |
| 6 | Immunogenitity and T cell recognition in swine of foot-and-mouth disease virus Polymerase 3D 显示文摘 | Garcia-Briones M M Blanco E Andreu D | 2004 | Virology2004，322，： | 1 |
| 7 | Zn-Mn alloys obtained using pulse,reverse and superimposed current modulations显示文摘 | MULLER C SARRET M ANDREU T | 2003 | Electrochimica Acta2003，48，15： | 1 |
| 8 | Psychological variables and temporomandibular disorders: distress, coping, and personality 显示文摘 | Ferrando M Andreu Y Gald6n M J | 2004 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2004，98，2： | 1 |
| 9 | Blockade, of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5- dependent expression of Bcl-XI显示文摘 | Horita M Andreu EJ Benito A | 2000 | J Exp Med2000，191，6： | 1 |
| 10 | Daphnia magna feeding behavior after exposure to tetradifon and recovery from intoxication 显示文摘 | Villarroel M J Ferrando M D Andreu E | 1999 | Ecotoxicol Environ Saf1999，44，： | 1 |
| 11 | Accumulation of cytosolic glyceraldehydes-3-phosphate dehydrogenase RNA under biological stress conditions and elicitor treatments in potato显示文摘 | Laxalt A M Cassia R O Sanllorenti P M Madrid E A Andreu A B Daleo GR Conde R D Lamattina L | | 0，，： | 1 |
| 12 | Radiological manifestations of pulmonary tuberculosis显示文摘 | Andreu J Caceres J Pallisa E Martinez-Rodriguez M | 2004 | Eur J Radiol2004，51，： | 1 |
| 13 | Acute cellular rejection in liver transplant recipients under cyclosporine immunosuppression:predictive factors of response to antirejection therapy显示文摘 | Andreu H Rimola A Bruguera M Navasa M Cirera I Grande L | 2002 | Transplantation2002，73，： | 1 |
| 14 | Dielectric Saturation Of Water In A Membrane Protein Channel显示文摘 | Aguilella-Arzo Marcel Andrio Andreu Vicente M Aguilella | 2009 | PhysChem Chem Phys2009，11，2： | 1 |
| 15 | Pneumonia presentation of an endobronchial chondroma 显示文摘 | Pastir E Andreu A Llombart M | 2004 | An Med Interna2004，21，11： | 1 |
| 16 | Exercise intolerance due to mutations in the cytochrome b gene of mitochondrial DNA 显示文摘 | ANDREU A L HANNA M G REICHMANN H | 1999 | N EnglJMed1999，341，14： | 1 |
| 17 | Argument structure and the representation of abstract semantics 显示文摘 | Rodriguez-Ferreiro J Andreu L Sanz-Torrent M | 2014 | PloS one2014，9，8： | 1 |
| 18 | CT in nontraumaticacute thoracic aortic disease: typical and atypical features andcomplications显示文摘 | Castafier E Andreu M Gallardo X | 2003 | Radiographics2003，，93： | 1 |
| 19 | CT in nontraumatic acute thoracic aortic disease: typical and atypical features and complications显示文摘 | Castaner E Andreu M Gallardo X | 2003 | RadioGraphics2003，23，10： | 1 |
| 20 | CT in nontraumatic acute thoracic aortic disease: typical and atypical features and complications显示文摘 | Castaner E Andreu M Gallardo X | 2003 | Radiographics2003，23，1： | 1 |
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