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| 1 | Hepatic echinococcosis:Clinical and therapeutic aspects显示文摘Echinococcosis or hydatid disease(HD)is a zoonosis caused by the larval stages of taeniid cestodes belonging to the genus Echinococcus.Hepatic echinococcosis is a life-threatening disease,mainly differentiated into alveolar and cystic forms,associated with Echinoccus multilocularis(E.multilocularis)and Echinococcus granulosus(E.granulosus)infection,respectively.Cystic echinococcosis(CE)has a worldwide distribution,while hepatic alveolar echinococcosis(AE)is endemic in the Northern hemisphere,including North America and several Asian and European countries,like France,Germany and Austria.E.granulosus young cysts are spherical,unilocular vesicles,consisting of an internal germinal layer and an outer acellular layer.Cyst expan-sion is associated with a host immune reaction and the subsequent development of a fibrous layer,called the pericyst;old cysts typically present internal septations and daughter cysts.E.multilocularis has a tumorlike,infiltrative behavior,which is responsible for tissue destruction and finally for liver failure.The liver is the main site of HD involvement,for both alveolar and cystic hydatidosis.HD is usually asymptomatic for a long period of time,because cyst growth is commonly slow;the most frequent symptoms are fatigue and abdominal pain.Patients may also present jaundice,hepatomegaly or anaphylaxis,due to cyst leakage or rupture.HD diagnosis is usually accomplished with the combined use of ultrasonography and immunodiagnosis;furthermore,the improvement of surgical techniques,the introduction of minimally invasive treatments[such as puncture,aspiration,injection,re-aspiration(PAIR)]and more effective drugs(such as benzoimidazoles)have deeply changed life expectancy and quality of life of patients with HD.The aim of this article is to provide an up-todate review of biological,diagnostic,clinical and therapeutic aspects of hepatic echinococcosis. | Giuseppe Nunnari Marilia R Pinzone Salvatore Gruttadauria Benedetto M Celesia Giordano Madeddu Giulia Malaguarnera Piero Pavone Alessandro Cappellani Bruno Cacopardo | 2012 | World Journal of Gastroenterology2012，18，13： | 72 |
| 2 | Incidental gallbladder cancer during laparoscopic cholecystectomy:Managing an unexpected finding显示文摘AIM:To evaluate the impact of incidental gallbladder cancer on surgical experience.METHODS:Between 1998 and 2008 all cases of cholecystectomy at two divisions of general surgery,one university based and one at a public hospital,were retrospectively reviewed.Gallbladder pathology was diagnosed by history,physical examination,and laboratory and imaging studies [ultrasonography and computed tomography(CT)].Patients with gallbladder cancer(GBC) were further analyzed for demographic data,and type of operation,surgical morbidity and mortality,histopathological classification,and survival.Incidental GBC was compared with suspected or preoperatively diagnosed GBC.The primary endpoint was diseasefree survival(DFS).The secondary endpoint was the difference in DFS between patients previously treated with laparoscopic cholecystectomy and those who had oncological resection as first intervention.RESULTS:Nineteen patients(11 women and eight men) were found to have GBC.The male to female ratio was 1:1.4 and the mean age was 68 years(range:45-82 years).Preoperative diagnosis was made in 10 cases,and eight were diagnosed postoperatively.One was suspected intraoperatively and confirmed by frozen sections.The ratio between incidental and nonincidental cases was 9/19.The tumor node metastasis stage was:pTis(1),pT1a(2),pT1b(4),pT2(6),pT3(4),pT4(2);five cases with stageⅠa(T1 a-b);two with stageⅠb(T2 N0);one with stage Ⅱa(T3 N0);six with stage Ⅱb(T1-T3 N1);two with stage Ⅲ(T4 Nx Nx);and one with stage Ⅳ(Tx Nx Mx).Eighty-eight percent of the incidental cases were discovered at an early stage(≤Ⅱ).Preoperative diagnosis of the 19 patients with GBC was:GBC with liver invasion diagnosed by preoperative CT(nine cases),gallbladder abscess perforated into hepatic parenchyma and involving the transversal mesocolon and hepatic hilum(one case),porcelain gallbladder(one case),gallbladder adenoma(one case),and chronic cholelithiasis(eight cases).Every case,except one,with a T1b or more advanced invasion underwent Ⅳb + Ⅴ wedge liver resection and pericholedochic/hepatoduodenal lymphadenectomy.One patient with stage T1b GBC refused further surgery.Cases with Tis and T1a involvement were treated with cholecystectomy alone.One incidental case was diagnosed by intraoperative frozen section and treated with cholecystectomy alone.Six of the nine patients with incidental diagnosis reached 5-year DFS.One patient reached 38 mo survival despite a port-site recurrence 2 years after original surgery.Cases with non incidental diagnosis were more locally advanced and only two patients experienced 5-year DFS.CONCLUSION:Laparoscopic cholecystectomy does not affect survival if implemented properly.Reoperation should have two objectives:R0 resection and clearance of the lymph nodes. | Andrea Cavallaro Gaetano Piccolo Vincenzo Panebianco Emanuele Lo Menzo Massimiliano Berretta Antonio Zanghì Maria Di Vita Alessandro Cappellani | 2012 | World Journal of Gastroenterology2012，18，30： | 33 |
| 3 | Use of biological meshes for abdominal wall reconstruction in highly contaminated fields显示文摘Abdominal wall defects and incisional hernias represent a challenging problem. In particular, when a synthetic mesh is applied to contaminated wounds, its removal is required in 50%-90% of cases. Biosynthetic meshes are the newest tool available to surgeons and they could have a role in ventral hernia repair in a potential-ly contaminated field. We describe the use of a sheet of bovine pericardium graft in the reconstruction of abdominal wall defect in two patients. Bovine pericardium graft was placed in the retrorectus space and secured to the anterior abdominal wall using polypropylene sutures in a tension-free manner. We experienced no evidence of recurrence at 4 and 5 years follow-up. | Andrea Cavallaro Emanuele Lo Menzo Maria Di Vita Antonio Zanghì Vincenzo Cavallaro Pier Francesco Veroux Alessandro Cappellani | 2010 | World Journal of Gastroenterology2010，16，15： | 9 |
| 4 | Intrahepatic Cholangiocarcinoma: Prognostic Factors After Surgical Resection显示文摘 | Alfredo Guglielmi Andrea Ruzzenente Tommaso Campagnaro Silvia Pachera Alessandro Valdegamberi Paola Nicoli Alessandro Cappellani Giulio Malfermoni Calogero Iacono | 2009 | World Journal of Surgery2009，，6： | 3 |
| 5 | Adjuvant radiotherapy on older and oldest breast cancer patients after conservative surgery: A retrospective analysis显示文摘 | Francesco Fiorica Massimiliano Berretta Stefano Ursino Rossella Fisichella Arben Lleshi Gerlando Fiorica Antonio Stefanelli Giampaolo Zini Umberto Tirelli Antonio Zanghi Alessandro Cappellani Salvatore Berretta Francesco Cartei | 2011 | Archives of Gerontology and Geriatrics2011，，2： | 1 |
| 6 | Intrahepatic Cholangiocarcinoma: Prognostic Factors After Surgical Resection显示文摘 | Alfredo Guglielmi Andrea Ruzzenente Tommaso Campagnaro Silvia Pachera Alessandro Valdegamberi Paola Nicoli Alessandro Cappellani Giulio Malfermoni Calogero Iacono | 2009 | World Journal of Surgery2009，，6： | 1 |
| 7 | Intrahepatic Cholangiocarcinoma: Prognostic Factors After Surgical Resection显示文摘 | Alfredo Guglielmi Andrea Ruzzenente Tommaso Campagnaro Silvia Pachera Alessandro Valdegamberi Paola Nicoli Alessandro Cappellani Giulio Malfermoni Calogero Iacono | 2009 | World Journal of Surgery2009，，6： | 1 |
| 8 | The role of HIPEC in the treatment of peritoneal carcinomatosis from gastric cancer: between lights and shadows显示文摘 | Maria Di Vita Alessandro Cappellani Gaetano Piccolo Antonio Zanghì Andrea Cavallaro Giulio Bertola Antonio Bolognese Gaetano Facchini Carmine D’Aniello Raffaele Di Francia Francesco Cardì Massimiliano Berretta | 2015 | Anti-Cancer Drugs2015，，2： | 1 |
| 9 | Skin Cancers in Elderly Patients显示文摘 | Giulia Malaguarnera Maria Giordano Alessandro Cappellani Massimiliano Berretta Michele Malaguarnera Rosario Emanuele Perrotta | 2013 | Anti-Cancer Agents in Medicinal Chemistry2013，，9： | 1 |
| 10 | Peroxisome proliferator-activated receptor β/δ agonist GW0742 ameliorates cerulein- and taurocholate-induced acute pancreatitis in mice显示文摘 | Irene Paterniti Emanuela Mazzon Luisa Riccardi Maria Galuppo Daniela Impellizzeri Emanuela Esposito Placido Bramanti Alessandro Cappellani Salvatore Cuzzocrea | 2012 | Surgery2012，，1： | 1 |
| 11 | 结直肠癌标本切除长度与淋巴结转移度有关系吗?显示文摘背景:阳性淋巴结数量(LN+)和淋巴结切除总数(rLN)都会影响结直肠癌的预后,这两者的比值即淋巴结转移度(LNR)。本研究旨在评估标本切除长度(LR)对LNR预后价值的影响。方法:回顾性纳入本中心2000-2015年间的所有结直肠癌手术病例,对其病理结果进行全面分析,计算经RL调整的rLN、LN+及LNR。采用受试者操作特征(ROC)分析,评估上述指标对淋巴结转移患者的预后价值。结果:670例患者纳入研究,男性337例(50.3%),平均年龄69.2岁。无论是阳性淋巴结患者(n=312)还是所有患者(n=670),LNR与预后的相关性均强于经RL调整的LNR(LNR/RL)。ROC分析显示,除了肿瘤转移外,LNR对各个预后指标的预测价值均高于LNR/RL和RL,而LNR/RL对肿瘤转移的预测价值似乎更高一些。Kaplan-Meier生存曲线显示,LNR可有效区分不同生存时间的患者(P=0.043),而LNR/RL(P=0.373)和RL(P=0.314)都未能显示出统计学意义。结论:RL的增加在导致淋巴结获取数量的增多的同时并不会影响LN+数量,从而成为了可能改变LNR预后价值的干扰因素。但本研究结果并未发现将RL纳入考虑的LNR具有更优的预后价值,这一结果需要前瞻性大样本研究的进一步证实。 | Antonio Zanghi Andrea Cavallaro Emanuele Lo Menzo Serena Curella Botta Salvatore Lo Bianco Maria Di Vita Francesco Cardi Alessandro Cappellani | 2021 | Gastroenterology Report2021，9，3： | 0 |
| 12 | Gallbladder hemorrhage–An uncommon surgical emergency:A case report显示文摘BACKGROUND Gallbladder hemorrhage is a life-threatening disorder.Trauma(accidental or iatrogenic such as a percutaneous biopsy or cholecystectomy surgery),cholelithiasis,biliary tract parasitosis,vasculitis,vascular malformations,autoimmune and neoplastic diseases and coagulopathies have been described as causes of hemorrhage within the lumen of the gallbladder.The use of nonsteroidal anti-inflammatory drugs and anticoagulants may represent a risk factor.CASE SUMMARY We report the case of a 76-year-old male patient.An urgent contrast computed tomography scan demonstrated relevant distension of the gallbladder filled with hyperdense non-homogeneous content.The gallbladder walls were of regular thickness.Near the anterior wall a focus of suspected active bleeding was observed.Due to the progressive decrease in hemoglobin despite three blood transfusions,this was an indication for urgent surgery.CONCLUSION Early diagnosis of this potentially fatal pathology is essential in order to plan a strategy and eventually proceed with urgent surgical treatment. | Maria Rosaria Valenti Andrea Cavallaro Maria Di Vita Antonio Zanghi Giovanni Longo Trischitta Alessandro Cappellani | 2022 | World Journal of Clinical Cases2022，10，27： | 0 |
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