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| 1 | Targeted therapy in advanced metastatic colorectal cancer: Current concepts and perspectives显示文摘The introduction of new cytotoxic substances as well as agents that target vascular endothelial growth factor(VEGF)and epidermal growth factor receptor(EGFR)signaling has improved clinical outcome of patients withmetastatic colorectal cancer(mCRC).In this review we summarize the most relevant clinical data on VEGF and EGFR targeting regimens in mCRC.The effects of available treatment strategies for mCRC are often temporary,with resistance and disease progression developing in most patients.Thus,new treatment strategies are urgently needed.Some GI peptides including gastrin and gastrin releasing peptide,certain growth factors such as insulin-like growth factor-ⅠandⅡand neuropeptides such as growth hormone releasing hormone(GHRH)are implicated in the growth of CRC.Experimental investigations in CRC with antagonistic analogs of bombesin/gastrin-releasing peptide,GHRH,and with cytotoxic peptides that can be targeted to peptide receptors on tumors,are summarized in the second part of the review. | Florian Hohla Thomas Winder Richard Greil Ferenc G Rick Norman L Block rew V Schally | 2014 | World Journal of Gastroenterology2014，20，20： | 3 |
| 2 | 发展中国家的可再生能源:沼气的机遇和挑战显示文摘能源对于现代社会至关重要,是社会经济发展最重要的指标之一。尽管科技不断发展,但仍然有约30亿人(主要集中在发展中国家的农村地区),继续通过在传统的炉灶中燃烧生物质资源(如柴薪、秸秆、动物粪便)的方式来满足烹饪的能源需求。这种方式对环境、社会、经济、公众健康都带来极大负面影响。这些地区要实现可持续性发展,开发干净清洁、价格低廉的可再生能源就势在必行。把现有的生物质资源(动物粪便、秸秆、餐厨垃圾、绿色废弃物)提炼成更加清洁高效的能源载体(例如厌氧发酵产生的沼气),不仅具有提供清洁、可靠能源的独特潜力,同时又能保护当地和全球的环境。尽管沼气对发展中国家来说意义重大,但其面临着成本高、设备安装和维护专业知识缺乏等问题,因而在地理位置分散的社区难以广泛推广应用。因此,政府和非政府层面的通力协作就显得至关重要,从而促进沼气技术的更新改造和传播,开发尚未被开发的潜力。文章旨在通过分析沼气技术的现状、挑战和潜力,明确它在发展中国家未来的研究方向和发展传播路径。 | K C Surendra Devin Takara rew G Hashimoto Samir Kumar Khanal 李谦 | 2015 | 中国沼气2015，33，1： | 3 |
| 3 | Sonic testing a simple nondestructive testing for verifying casting quality 显示文摘 | Fuller A G Emerson P J Rew R | 1963 | BCIRA Journal1963，，11： | 1 |
| 4 | The role of cationic antimicrobial peptides in innate host defences 显示文摘 | Hancock REW Diamond G | 2000 | Trends Microbiol2000，8，9： | 1 |
| 5 | Modelling ofThermal Radiation from External Hydrocarbon Poor Fires显示文摘 | REW P J HULBERT W G DAVES D M | 1997 | TransIchemE1997，75，： | 1 |
| 6 | NetCDF:An Interface for Scien- tific Data Access显示文摘 | Rew R Davis G | 1990 | Computer Graphics and Ap- plications IEEE1990，10，4： | 1 |
| 7 | A trading strategy based on the lead-lag relationship between the spot index and futures contract for the FTSE 100显示文摘 | Brooks C Rew A G Ritson S | 2001 | International Journal of Forecasting2001，，17： | 1 |
| 8 | Cell production rates in human tissues and tumours and their significance,Part Ⅱ:clinical data显示文摘 | Rew D A Wilson G D | 2000 | Eur J Surg Oncol2000，26，4： | 1 |
| 9 | Model of thermal radiation from external hydrocarbon pool fires显示文摘 | REW P J HULBERT W G DEAVES D M | 1997 | Process Safety and Environmental Protection1997，75，2： | 1 |
| 10 | Net CDF:an interface for scientific data access显示文摘 | Rew R Davis G | 1990 | Computer Graphics and Applications1990，10，4： | 1 |
| 11 | Modeling of thermal radiation from external hydrocarbon pool fires显示文摘 | Rew P J Hulbert W G Deaves D M | 1997 | Process Safety and Environmental Protection1997，，75： | 1 |
| 12 | NetCDF: An interface for scientific data access显示文摘 | Rew R K Davis G P | 1990 | Computer Graphics and Applications IEEE1990，10，4： | 1 |
| 13 | The role of cationic antimicrobial peptides in innate host defences显示文摘 | Hancock REW Diamond G | 2000 | Trends Microbiol2000，8，： | 1 |
| 14 | Long-term per- formance of active fixation pacing leads:a p rospeclive study显示文摘 | Kistler PMI rew G Mond HG | 2006 | PACE2006，29，3： | 1 |
| 15 | Cell production rates in human tissues and tumours and their significance, Part II : clinical data显示文摘 | Rew D A Wilson G D | 2000 | Eur J Surg Oncol2000，26，4： | 1 |
| 16 | The role of cationic antimicrobial peptides in innate host defences显示文摘 | Hancock REW Diamond G | 2000 | Trends Microbiol2000，8，： | 1 |
| 17 | Sonic testing a simple nondestructive test for verifying casting quality显示文摘 | Emerson P J Rew R | 1963 | BCIRA Journal1963，11，： | 1 |
| 18 | A trading strategy based on the lead-lag relationship between the spotindex and futures contract for the FTSE 100显示文摘 | Brooks C Rew A G Ritson S | 2001 | Intemational Journal of Forecasting2001，，17： | 1 |
| 19 | Sonic testing a simple nondestructive test for verifying casting quality 显示文摘 | Fuller A G Emerson P J Rew R | 1963 | BCIRA Jounal1963，11，： | 1 |
| 20 | A Trading Strategy Based on the Lead - lag Relationship between the Spot Index and Futures Contract for the ElSE 100显示文摘 | Brooks C Rew A G Ritson S | 2001 | International journal of Forecasting2001，17，1： | 1 |
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