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| 1 | Failure mechanism and coupled static-dynamic loading theory in deep hard rock mining: A review显示文摘Rock failure phenomena,such as rockburst,slabbing(or spalling) and zonal disintegration,related to deep underground excavation of hard rocks are frequently reported and pose a great threat to deep mining.Currently,the explanation for these failure phenomena using existing dynamic or static rock mechanics theory is not straightforward.In this study,new theory and testing method for deep underground rock mass under coupled static-dynamic loading are introduced.Two types of coupled loading modes,i.e.'critical static stress + slight disturbance' and 'elastic static stress + impact disturbance',are proposed,and associated test devices are developed.Rockburst phenomena of hard rocks under coupled static-dynamic loading are successfully reproduced in the laboratory,and the rockburst mechanism and related criteria are demonstrated.The results of true triaxial unloading compression tests on granite and red sandstone indicate that the unloading can induce slabbing when the confining pressure exceeds a certain threshold,and the slabbing failure strength is lower than the shear failure strength according to the conventional Mohr-Column criterion.Numerical results indicate that the rock unloading failure response under different in situ stresses and unloading rates can be characterized by an equivalent strain energy density.In addition,we present a new microseismic source location method without premeasuring the sound wave velocity in rock mass,which can efficiently and accurately locate the rock failure in hard rock mines.Also,a new idea for deep hard rock mining using a non-explosive continuous mining method is briefly introduced. | Xibing Li Fengqiang Gong Ming Tao Longjun Dong Kun Du Chunde Ma Zilong Zhou Tubing Yin | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，4： | 68 |
| 2 | Generation of a monkey with MECP2 mutations by TALEN-based gene targeting显示文摘Gene editing in model organisms has provided critical insights into brain development and diseases. Here, we report the generation of a cynomolgus monkey(Macaca fascicularis) carrying MECP2 mutations using transcription activator-like effector nucleases(TALENs)-mediated gene targeting. After injecting TALENs mRNA into monkey zygotes achieved by in vitro fertilization and embryo transplantation into surrogate monkeys, we obtained one male newborn monkey with an MECP2 deletion caused by frameshifting mutation in various tissues. The monkey carrying the MECP2 mutation failed to survive after birth, due to either the toxicity of TALENs or the critical requirement of MECP2 for neural development. The level of MeCP2 protein was essentially depleted in the monkey's brain. This study demonstrates the feasibility of introducing genetic mutations in non-human primates by site-specific gene-editing methods. | Zhen Liu Xue Zhou Ying Zhu Zhi-Fang Chen Bin Yu Yan Wang Chen-Chen Zhang Yan-Hong Nie Xiao Sang Yi-Jun Cai Yue-Fang Zhang Chen Zhang Wen-Hao Zhou Qiang Sun Zilong Qiu | 2014 | Neuroscience Bulletin2014，30，3： | 17 |
| 3 | Geochemical characteristics,cooling history and mineralization significance of Zhangtiantang pluton in South Jiangxi Province,P.R. China显示文摘The zircon SHRIMP dating of the Zhangtiantang granite gave an age of 159±7 Ma.,which shows that the granite was produced at the early Late Jurassic.The Ar-Ar plateau ages of biotite and K-feldspar from the Zhangtiantang pluton are 153.2±1.1 Ma and 135.8±1.2 Ma,respectively.The Ar-Ar anti-isochrone ages of biotite and K-feldspar are 152.5±1.7Ma and 135.4±2.7Ma,respectively.The ages represent the isotopic closure ages of minerals in the pluton.The Zhangtiantang granites are regarded as peraluminous crust-derived type granites to possess the typical geochemical characteristics of calc-alkaline rocks on continental margin,with enriched Si,K,Al(average value of A/CNK as 1.18),HREE,Rb,U,and Th,heavily depleted V,Cr,Co,Ni,Ti,Nb-Ta,Zr,Sr,P,and Ba,strongly negative Eu and common corundum normative(average value of C as 1.84).The εNd(t) values of the Zhangtiantang granite are-5.84 to-7.79,and t2DM values are 1.69 to 1.83 Ga,which indicates partial melting of continental-crust metamorphic sedimentary rocks during the Middle Proterozoic.The cooling history of the Zhangtiantang granitic pluton indicates that the cooling velocity of pluton was faster(about 67℃ /Ma) from zircon(158 Ma) to biotite(152 Ma),and was slower(about12℃ /Ma) from biotite(152.5 Ma) to K-feldspar(135.8 Ma).It can be deduced that the temporal gap(about 10 Ma) between the granite formmation and W-Sn mineralization in South China may be related to ordinary magma-hydrothermal processes by the variational cooling curve of the pluton.The Zhangtiantang pluton was formed in a compressive setting,with differentiation evolution and mineralization occurring in a relative relaxation setting. | MAO Jianren LI Zilong ZHAO Xilin ZHOU Jie YE Haimin ZENG Qitao | 2010 | Chinese Journal Of Geochemistry2010，29，1： | 11 |
| 4 | Size distribution and source of heavy metals in particulate matter on the lead and zinc smelting affected area显示文摘In order to understand the size distribution and the main kind of heavy metals in particulate matter on the lead and zinc smelting affected area, particulate matter(PM) and the source samples were collected in Zhuzhou, Hunan Province from December 2011 to January 2012 and the results were discussed and interpreted. Atmospheric particles were collected with different sizes by a cascade impactor. The concentrations of heavy metals in atmospheric particles of different sizes, collected from the air and from factories, were measured using an inductively coupled plasma mass spectrometry(ICP-MS). The results indicated that the average concentration of PM, chromium(Cr), arsenic(As), cadmium(Cd) and lead(Pb) in PM was177.3 ± 33.2 μg/m^3, 37.3 ± 8.8 ng/m^3, 17.3 ± 8.1 ng/m^3, 4.8 ± 3.1 ng/m^3 and 141.6 ± 49.1 ng/m^3,respectively. The size distribution of PM displayed a bimodal distribution; the maximum PM size distribution was at 1.1–2.1 μm, followed by 9–10 μm. The size distribution of As, Cd and Pb in PM was similar to the distribution of the PM mass, with peaks observed at the range of1.1–2.1 μm and 9–10 μm ranges while for Cr, only a single-mode at 4.7–5.8 μm was observed. PM(64.7%), As(72.5%), Cd(72.2%) and Pb(75.8%) were associated with the fine mode below 2.1 μm,respectively, while Cr(46.6%) was associated with the coarse mode. The size distribution characteristics, enrichment factor, correlation coefficient values, source information and the analysis of source samples showed that As, Cd and Pb in PM were the typical heavy metal in lead and zinc smelting affected areas, which originated mainly from lead and zinc smelting sources. | Kai Zhang Fahe Chai Zilong Zheng Qing Yang Xuecai Zhong Khanneh Wadinga Fomba Guangzhu Zhou | 2018 | Journal of Environmental Sciences2018，30，9： | 10 |
| 5 | Cellular microparticles and pathophysiolog, of traumatic brain injury显示文摘 | Zilong Zhao Yuan Zhou Ye Tian Min Li Jing-fei Dong Jianning Zhang | 2017 | Protein & Cell2017，8，11： | 9 |
| 6 | Mechanical properties of rock under coupled static-dynamic loads显示文摘Rock drilling machine,INSTRON testing system,and SHPB device are updated to investigate the characteristics of rocks at great depth,with high loads from overburden,tectonic stresses and dynamic impacts due to blasting and boring.It is verified that these testing systems can be used to study the mechanical properties of rock material under coupled static and dynamic loading condition and give useful guidance for the deep mining and underground cavern excavation.Various tests to determine the rock strength,fragmentation behavior,and energy absorption were conducted using the updated testing systems.It is shown that under coupled static-dynamic loads,if the axial prestress is lower than its elastic limit,the rock strength is higher than the individual static or dynamic strength.At the same axial prestress,rock strength under coupled loads rises with the increasing strain rates.Under coupled static and dynamic loads,rock is observed to fail with tensile mode.While shear failure may exist if axial prestress is high enough.In addition,it is shown that the percentage of small particles increases with the increasing axial prestress and impact load based on the analysis of the particle-size distribution of fragments.It is also suggested that the energy absorption ratio of a specimen varies with coupled loads,and the maximum energy absorption ratio for a rock can be obtained with an appropriate combination of static and dynamic loads. | Xibing Li Zilong Zhou Fujun Zhao Yujun Zuo Chunde Ma Zhouyuan Ye Liang Hong | 2009 | Journal of Rock Mechanics and Geotechnical Engineering2009，1，1： | 8 |
| 7 | Innovative testing technique of rock subjected to coupled static and dynamic loads显示文摘 | Xibing Li Zilong Zhou Tat-Seng Lok Liang Hong Tubing Yin | 2007 | International Journal of Rock Mechanics and Mining Sciences2007，，5： | 5 |
| 8 | Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer显示文摘Metformin is currently a strong candidate anti-tumor agent in multiple cancers.However,its anti-tumor effectiveness varies among different cancers or sub-populations,potentially due to tumor heterogeneity.It thus remains unclear which hepatocellular carcinoma(HCC)patient subpopulation(s)can benefit from met-formin treatment.Here,through a genome-wide CRISPR-Cas9-based knockout screen,we find that DOCK1 levels determine the anti-tumor effects of met-formin and that DOCK1 is a synthetic lethal target of metformin in HCC.Mechanistically,metformin promotes DOCK1 phosphorylation,which activates RAC1 to facilitate cell survival,leading to metformin resistance.The DOCK1-selective inhibitor,TBOPP,potentiates anti-tumor activity by metformin in vitro in liver cancer cell lines and patient-derived HCC organoids,and in vivo in xenografted liver cancer cells and immunocompetent mouse liver cancer models.Notably,metformin improves overall survival of HCC patients with low DOCK1 levels but not among patients with high DOCK1 expression.This study shows that metformin effective-ness depends on DOCK1 levels and that combining metformin with DOCK1 inhibition may provide a promising personalized therapeutic strategy for met-formin-resistant HCC patients. | Junru Feng Hui Lu Wenhao Ma Wenjing Tian Zhuan Lu Hongying Yang Yongping Cai Pengfei Cai Yuchen Sun Zilong Zhou Jiaqian Feng Jiazhong Deng Ying Shu Kun Qu Weidong Jia Ping Gao Huafeng Zhang | 2022 | Protein & Cell2022，13，11： | 5 |
| 9 | De Novo and Inherited SETD1A Variants in Early-onset Epilepsy显示文摘Early-onset epilepsy is a neurological abnormality in childhood, and it is especially common in the first2 years after birth. Seizures in early life mostly result from structural or metabolic disorders in the brain, and the genetic causes of idiopathic seizures have been extensively investigated. In this study, we identified four missense mutations in the SETD1 A gene(SET domain-containing 1 A, histone lysine methyltransferase): three de novo mutations in three individuals and one inherited mutation in a four-generation family. Whole-exome sequencing indicated that all four of these mutations were responsible for the seizures. Mutations of SETD1 A have been implicated in schizophrenia and developmental disorders, so we examined the role of the four mutations(R913 C, Q269 R, G1369 R, and R1392 H) in neural development. We found that their expression in mouse primary cortical neurons affected excitatory synapse development. Moreover, expression of the R913 C mutation also affected the migration of cortical neurons in the mouse brain.We further identified two common genes(Neurl4 and Usp39) affected by mutations of SETD1 A. These results suggested that the mutations of SETD1 A play a fundamental role in abnormal synaptic function and the development of neurons, so they may be pathogenic factors for neurodevelopmental disorders. | Xiuya Yu Lin Yang Jin Li Wanxing Li Dongzhi Li Ran Wang Kai Wu Wenhao Chen Yi Zhang Zilong Qiu Wenhao Zhou | 2019 | Neuroscience Bulletin2019，35，6： | 4 |
| 10 | The Epigenetic Switches for Neural Development and Psychiatric Disorders显示文摘The most remarkable feature of the nervous system is that the development and functions of the brain are largely reshaped by postnatal experiences,in joint with genetic landscapes.The nature vs.nurture argument reminds us that both genetic and epigenetic information is indispensable for the normal function of the brain.The epigenetic regulatory mechanisms in the central nervous system have been revealed over last a decade.Moreover,the mutations of epigenetic modulator genes have been shown to be implicated in neuropsychiatric disorders,such as autism spectrum disorders.The epigenetic study has initiated in the neuroscience field for a relative short period of time. In this review,we will summarize recent discoveries about epigenetic regulation on neural development,synaptic plasticity,learning and memory,as well as neuropsychiatric disorders.Although the comprehensive view of how epigenetic regulation contributes to the function of the brain is still not completed,the notion that brain,the most complicated organ of organisms,is profoundly shaped by epigenetic switches is widely accepted. | Jingwen Lv Yongjuan Xin Wenhao Zhou Zilong Qiu | 2013 | Journal of Genetics and Genomics2013，40，7： | 4 |
| 11 | Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis显示文摘Neonatal sepsis is common in neonatal intensive care units,often complicated by injury to the immature brain. Previous studies have shown that the expression of the gap junction protein connexin 43(Cx43) in the brain decreases when stimulated by neuro-infl ammatory drugs such as lipopolysaccharide(LPS). Here we showed that partial deletion of Cx43 in astrocytes resulted in weakened inflammatory responses. The up-regulation of pro-inflammatory cytokines was significantly reduced in mice with partial deletion of Cx43 in astrocytes compared with wild-type littermates after systemic LPS injection. Moreover,microglial activation was inhibited in mice with partial deletion of Cx43. These results showed that Cx43 in astrocytes plays a critical role in neuro-infl ammatory responses. This work provides a potential therapeutic target for inhibiting neuroinfl ammatory responses in neonatal sepsis. | Jing-Jing Zhou Cheng Cheng Zilong Qiu Wen-Hao Zhou Guo-Qiang Cheng | 2015 | Neuroscience Bulletin2015，31，6： | 2 |
| 12 | A guide to use fluorinated aromatic bulky cations for stable and high-performance 2D/3D perovskite solar cells:The more fluorination the better?显示文摘While serious stability issues impede the commercialization of perovskite solar cells(PSCs),two-dime nsional(2D)perovskites based on fluorinated bulky cations have emerged as more intrinsically stable materials.However,the influence of fluorination degree of the bulky aromatic cation on the per-formance of resulting PSCs has not been scrutinized.Here,2D perovskites(FxPEA)_(2)PbI_(4)(x=1,2,3,5)are grown in situ on the surface of the three-dime nsion al(3D)perovskite and dem on strate effective passivation of the surface defects of 3D perovskite.The power conversion efficiency(PCE)of the optimized devices were boosted from 20.75%for the control device to 21.09%,22.06%,22.74%and 21.86%for 2D/3D devices treated with 4-fluorophenethylamine iodide,3,5-difluorophenylethylamine iodide,2,4,5-trifluoroethylphenylethylamine iodide,and 1,2,3,4,5-pentafluorophenylethylamine iodide,respectively.We firstly reported two unexplored RP-type layered perovskites with F_(2)PEAI and F_(3)PEAI as bulky cations.The combined experimental and theoretical analysis revealed the reasons behind the various morphology,device performances,dynamic behavior,and humidity stability.The best performing F_(5)PEAI-treated device retaining 95.0%of its initial PCE under ambient atmosphere(with RH of 60%±5%)without encapsulation for 300 h storage.This work provides useful guidance for selecting fluorinated bulky cations with different molecular electronic properties,which will play an essential role in further improving the performance/stability of PSCs for the sake of further commercialization. | Lei Wang Qin Zhou Zilong Zhang Wenbo Li Xiaobing Wang Qi ng Tian Xiaoyan Yu Ting Sun Jihuai Wu Bao Zhang Peng Gao | 2022 | Journal of Energy Chemistry2022，31，1： | 2 |
| 13 | A Numerical Gas Fracturing Model of Coupled Thermal,Flowing and Mechanical Effects显示文摘Gas fracturing,which overcomes the limitation of hydraulic fracturing,is a potential alternative technology for the development of unconventional gas and oil resources.However,the mechanical principle of gas fracturing has not been learned comprehensively when the fluid is injected into the borehole.In this paper,a damage-based model of coupled thermal-flowing-mechanical effects was adopted to illustrate the mechanical principle of gas fracturing.Numerical simulation tools Comsol Multiphysics and Matlab were integrated to simulate the coupled process during the gas fracturing.Besides,the damage evolution of drilling areas under several conditions was fully analyzed.Simulation results indicate that the maximum tensile stress,which occurs in the upper and lower of the injection hole,decreases with the increase of the tectonic stress coefficient(TSC).As the TSC increases,shear fractures increase,a crushed area is gradually formed and the seepage area increases rapidly.The influence of TSC on fracture expansion is concluded as follows:with the decrease of TSC,the relative width of fractures decreases whilst the depth increases.It indicates that thermal stress and pore pressure promote the expansion of tensile fractures but restrain the expansion of shear fractures.Therefore,a relatively lower injection gas pressure is required to obtain the same degree of fracturing with a coupled thermal gradient. | Dan Ma Hongyu Duan Qi Zhang Jixiong Zhang Wenxuan Li Zilong Zhou Weitao Liu | 2020 | Computers, Materials & Continua2020，，12： | 2 |
| 14 | F-containing cations improve the performance of perovskite solar cells显示文摘Organic–inorganic halide perovskite solar cells(PSCs)have delivered power conversion efficiency(PCE)on par with that of crystalline silicon solar cells,due to the considerable effort on the optimization of perovskite materials and devices[1].The three-dimensional(3D)perovskite-based PSCs with the standard n–i–p architecture gave a certified PCE of25.5%[2].However,the poor device stability under operating conditions remains an obstacle to commercialization.The 3D hybrid perovskite materials are susceptible to oxygen,UV light,humidity,heat,and electric fields[3].To improve device stability,two main strategies are applied:(1)improving the intrinsic stability[4];(2)providing sufficient protection. | Qin Zhou Chuantian Zuo Zilong Zhang Peng Gao Liming Ding | 2022 | Journal of Semiconductors2022，43，1： | 1 |
| 15 | Obtaining Constitutive Relationship for Rate-Dependent Rock in SHPB Tests显示文摘 | Zilong Zhou Xibing Li Zhouyuan Ye Kewei Liu | 2010 | Rock Mechanics and Rock Engineering2010，，6： | 1 |
| 16 | Engineer Nanoscale Defects into Selective Channels:MOF-Enhanced Li^(+) Separation by Porous Layered Double Hydroxide Membrane显示文摘Two-dimensional(2D)membrane-based ion separation technology has been increasingly explored to address the problem of lithium resource shortage,yet it remains a sound challenge to design 2D membranes of high selectivity and permeability for ion separation applications.Zeolitic imidazolate framework functionalized modified layered double hydroxide(ZIF-8@MLDH)composite membranes with high lithium-ion(Li^(+)) permeability and excellent operational stability were obtained in this work by in situ depositing functional ZIF-8 nanoparticles into the nanopores acting as framework defects in MLDH membranes.The defect-rich framework amplified the permeability of Li^(+),and the site-selective growth of ZIF-8 in the framework defects bettered its selectivity.Specifically speaking,the ZIF-8@MLDH membranes featured a high permeation rate of Li^(+) up to 1.73 mol m^(−2) h^(−1) and a desirable selectiv-ity of Li^(+)/Mg^(2+) up to 31.9.Simulations supported that the simultaneously enhanced selectivity and permeability of Li+are attributed to changes in the type of mass transfer channels and the difference in the dehydration capacity of hydrated metal cations when they pass through nanochannels of ZIF-8.This study will inspire the ongoing research of high-performance 2D membranes through the engineering of defects. | Yahua Lu Rongkun Zhou Naixin Wang Yuye Yang Zilong Zheng Miao Zhang Quan-Fu An Jiayin Yuan | 2023 | Nano-Micro Letters2023，15，9： | 1 |
| 17 | Fractal characteristics of rock fragmentation at strain rate of 10°- 10^2s^-1 显示文摘 | Zhou Zilong Li Xi-bing Zuo Yujun | 2006 | Journal of Central South University of Technology2006，13，29： | 1 |
| 18 | Superior performance porous carbon nitride nanosheets for helium separation from natural gas:Insights from MD and DFT simulations显示文摘Increasing helium(He)demand in fundamental research,medical,and industrial processes necessitates efficient He purification from natural gas.However,most theoretically available membranes focus on the separation of two or three kinds of gas molecules with He and the underlying separation mechanism is not yet well understood.Using molecular dynamic(MD)and first-principle density function theory(DFT)simulations,we systematically demonstrated a novel porous carbon nitride membrane(g-C_(9)N_(7))with superior performance for He separation from natural gas.The structure of g-C_(9)N_(7) monolayer was optimized first,and the calculated cohesive energy confirmed its structural stability.Increasing temperature from 200 to 500 K,the g-C_(9)N_(7)membrane revealed high He permeability,as high as 1.48×10^(7) GPU(gas permeation unit,1 GPU=3.35×10^(-10) mol·s^(-1)·Pa^(-1)·m^(-2))at 298 K,and also exhibited high selectivity for He over other gases(Ar,N_(2),CO_(2),CH_(4),and H_(2)S).Then,the selectivity of He over Ne was found to decrease with increasing the total number of He and Ne molecules,and to increase with increasing He to Ne ratio.More interestingly,a tunable He separation performance can be achieved by introducing strain during membrane separation.Under the condition of 7.5%compressive strain,the g-C_(9)(N_(7)(membrane reached the highest He over Ne selectivity of 9.41×10^(2).It can be attributed to the low energy barrier for He,but increased energy barrier for other gases passing through the membrane,which was subject to a compressive strain.These results offer important insights into He purification using g-C_(9)N_(7)membrane and opened a promising avenue for the screening of industrial grade gas separation with strain engineering. | Zilong Liu Ge Zhao Xiao Zhang Lei Gao Junqing Chen Weichao Sun Guanggang Zhou Guiwu Lu | 2021 | Chinese Journal of Chemical Engineering2021，34，9： | 1 |
| 19 | Innovative testing technique of rock subjected to coupled static and dynamic loads显示文摘 | LI Xibing ZHOU Zilong Lok T S | 2000 | International Journal of Rock Mechanics and Mining Science2000，37，4： | 1 |
| 20 | Stress uniformity of split Hopkinson pressure bar under half-sine wave loads显示文摘 | Zilong Zhou Xibing Li Aihua Liu Yang Zou | 2010 | International Journal of Rock Mechanics and Mining Sciences2010，，4： | 1 |
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