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| 1 | Breakthrough of extracellular vesicles in pathogenesis, diagnosis and treatment of osteoarthritis显示文摘Osteoarthritis(OA)is a highly prevalent whole-joint disease that causes disability and pain and affects a patient’s quality of life.However,currently,there is a lack of effective early diagnosis and treatment.Although stem cells can promote cartilage repair and treat OA,problems such as immune rejection and tumorigenicity persist.Extracellular vesicles(EVs)can transmit genetic information from donor cells and mediate intercellular communication,which is considered a functional paracrine factor of stem cells.Increasing evidences suggest that EVs may play an essential and complex role in the pathogenesis,diagnosis,and treatment of OA.Here,we introduced the role of EVs in OA progression by influencing inflammation,metabolism,and aging.Next,we discussed EVs from the blood,synovial fluid,and joint-related cells for diagnosis.Moreover,we outlined the potential of modified and unmodified EVs and their combination with biomaterials for OA therapy.Finally,we discuss the deficiencies and put forward the prospects and challenges related to the application of EVs in the field of OA. | Zichang Liu Yu Zhuang Lianfei Fang Changyong Yuan Xudong Wang Kaili Lin | 2023 | Bioactive Materials2023，，4： | 3 |
| 2 | An Approach of Three-Dimensional Vector Radiative Transfer (3-D-VRT) Equation for Inhomogeneous Scatter Media显示文摘 | JIN Yaqiu LIANG Zichang | 2004 | IEEE Transactions on Geosciences and Remote Sensing2004，42，2： | 1 |
| 3 | Model reference control for bulkhead pressure of EPB shield in tunneling显示文摘 | Zichang Shangguan Shouju Li | 2010 | Journal of Convergence Information Technology2010，5，1： | 1 |
| 4 | The experiences of TCM in the treatment of prostatitis and prostatic hyperplasia 显示文摘 | Huang Maosheng Huang Zichang | 2012 | Journal of clinical re- search of TCM2012，18，4： | 1 |
| 5 | Multiple forms of vitamin B_(6) regulate salt tolerance by balancing ROS and abscisic acid levels in maize root显示文摘Salt stress causes osmotic stress,ion toxicity and oxidative stress,inducing the accumulation of abscisic acid(ABA)and excessive reactive oxygen species(ROS)production,which further damage cell structure and inhibit the development of roots in plants.Previous study showed that vitamin B_(6)(VB_(6))plays a role in plant responses to salt stress,however,the regulatory relationship between ROS,VB_(6) and ABA under salt stress remains unclear yet in plants.In our study,we found that salt stress-induced ABA accumulation requires ROS production,in addition,salt stress also promoted VB_(6)(including pyridoxamine(PM),pyridoxal(PL),pyridoxine(PN),and pyridoxal 5′-phosphate(PLP))accumulation,which involved in ROS scavenging and ABA biosynthesis.Furthermore,VB_(6)-deficient maize mutant small kernel2(smk2)heterozygous is more susceptible to salt stress,and which failed to scavenge excessive ROS effectively or induce ABA accumulation in maize root under salt stress,interestingly,which can be restored by exogenous PN and PLP,respec-tively.According to these results,we proposed that PN and PLP play an essential role in balancing ROS and ABA levels under salt stress,respectively,it laid a foundation for VB_(6) to be better applied in crop salt resistance than ABA. | Chongchong Lu Yuan Tian Xuanxuan Hou Xin Hou Zichang Jia Min Li Mingxia Hao Yanke Jiang Qingbin Wang Qiong Pu Ziyi Yin Yang Li Baoyou Liu Xiaojing Kang Guangyi Zhang Xinhua Ding Yinggao Liu | 2022 | Stress Biology2022，2，1： | 1 |
| 6 | Yield, grain quality and water use efficiency of rice under non-flooded mulching cultivation显示文摘 | Zichang Zhang Shenfeng Zhang Jianchnag Yang Jianhua Zhang | 2008 | Field Crops Research2008，，1： | 1 |
| 7 | Iterative inversion from the multi-order Mueller matrix solution of vector radiative transfer equation for a layer of random spheroids显示文摘 | Ya-Qiu Jin Zichang Liang | 2003 | Journal of Quantitative Spectroscopy and Radiative Transfer2003，，3： | 1 |
| 8 | A Preparing Process of Quick-moving Leaf for TiNi Alloy显示文摘This paper reports a preparing process of quick moving leaf for TiNi shape memory alloy. Using the process. a series of quick moving leaves having different points of temperature. from 58 to 100℃. at which they jump up have been made. The quick moving leaves will be fully qualified as the electric switches that open and close themselves at proper temperatures. | Zichang SHAO Jingcheng WANG and Wei ZHANG (No. 1 Materials Research Dept., Shanghai Iron and Steel Research Institute, Shanghai, 200940, China)(To whom correspondence should be addressed) | 1994 | Journal of Materials Science & Technology1994，10，5： | 0 |
| 9 | Fierce Competition in China's Ethyl Acetate Market | Wang Zichang | 2007 | China Chemical Reporter2007，，23： | 0 |
| 10 | Identification Method for Single-line-to-ground Faults with Line Break Based on Phasor Measurement in Distribution Networks显示文摘The single-line-to-ground faults with line breaks(SLGFs-LBs)occur more and more frequently in distribution networks and can cause major safety accidents.It is difficult to distinguish the single-line-to-ground faults(SLGFs)in resonant grounding systems and ungrounding systems due to the same electrical characteristics on the source side and uncertain operation conditions of distribution networks.This paper proposes a method for distinguishing SLGFs-LBs and SLGFs.First,the source-side and load-side voltage characteristics of SLGFs and SLGFs-LBs are analyzed,and the phase difference between the voltages of the fault phase and non-fault phase on the load side is selected as the identification criterion.Phasor measurement units(PMUs)are selected as measuring devices.Then,the effects of operation conditions and external devices in distribution networks on the proposed method are discussed,and the phase errors caused by them are calculated to correct the identification method.Finally,the field testing and simulation experiments are conducted to verify the effectiveness and robustness of the proposed method. | Yadong Liu Zichang Li Yingjie Yan Guanghui He Jian Fang Kejun Li Xiuchen Jiang | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，3： | 0 |
| 11 | Hertz-rate metropolitan quantum teleportation显示文摘Quantum teleportation can transfer an unknown quantum state between distant quantum nodes,which holds great promise in enabling large-scale quantum networks.To advance the full potential of quantum teleportation,quantum states must be faithfully transferred at a high rate over long distance.Despite recent impressive advances,a high-rate quantum teleportation system across metropolitan fiber networks is extremely desired.Here,we demonstrate a quantum teleportation system which transfers quantum states carried by independent photons at a rate of 7.1±0.4 Hz over 64-km-long fiber channel.An average single-photon fidelity of≥90.6±2.6%is achieved,which exceeds the maximum fidelity of 2/3 in classical regime.Our result marks an important milestone towards quantum networks and opens the door to exploring quantum entanglement based informatic applications for the future quantum internet. | Si Shen Chenzhi Yuan Zichang Zhang Hao Yu Ruiming Zhang Chuanrong Yang Hao Li Zhen Wang You Wang Guangwei Deng Haizhi Song Lixing You Yunru Fan Guangcan Guo Qiang Zhou | 2023 | Light(Science & Applications)2023，12，6： | 0 |
| 12 | EFFECT OF γ-IRRADIATION ON CuZnAl SHAPE MEMORY ALLOY显示文摘Effect of γ-irradiation on the shape memory alloy CuZnAl has been studied by the techniquesof TEM,positron annihilation etc..The martensitic transformation temperature of the alloyincreases obviously ofter γ-irradiation at a dose of 2×10~7 Gy but not for a dose of 1×10~7 Gy.The shape memory effect in both irradiated alloys remains unaffected. | ZHANG Guilin XU Feng LIU Wenhong YU Fanghua Shanghai Institute of Nuclear Research,Academia Sinica,Shanghai,ChinaWANG Jingcheng SHAO Zichang Shanghai Iron and Steel Research Institute,Shanghai,China | 1992 | Acta Metallurgica Sinica(English Letters)1992，5，5： | 0 |
| 13 | An ANN-Based Short-Term Temperature Forecast Model for Mass Concrete Cooling Control显示文摘Concrete temperature control during dam construction(e.g.,concrete placement and curing)is important for cracking prevention.In this study,a short-term temperature forecast model for mass concrete cooling control is developed using artificial neural networks(ANN).The development workflow for the forecast model consists of data integration,data preprocessing,model construction,and model application.More than 80000 monitoring samples are collected by the developed intelligent cooling control system in the Baihetan Arch Dam,which is the largest hydropower project in the world under construction.Machine learning algorithms,including ANN,support vector machines,long short-term memory networks,and decision tree structures,are compared in temperature prediction,and the ANN is determined to be the best for the forecast model.Furthermore,an ANN framework with two hidden layers is determined to forecast concrete temperature at intervals of one day.The root mean square error of the forecast precision is 0.15∘C on average.The application on concrete blocks verifies that the developed ANN-based forecast model can be used for intelligent cooling control during mass concrete construction. | Hide Author's Information Ming Li Peng Lin Daoxiang Chen Zichang Li Ke Liu Yaosheng Tan | 2023 | Tsinghua Science and Technology2023，28，3： | 0 |
| 14 | Stability and Thermal Property Optimization of Propylene Glycol-Based MWCNT Nanofluids显示文摘Propylene glycol-based MWCNT(multi-walled carbon nanotubes)nanofluids were prepared in the framework of a two-step method and by using a suitable PVP(polyvinyl pyrrolidone)dispersant.The BBD(Box-Behnken design)model was exploited to analyze 17 sets of experiments and examine the sensitivity of the absorbance to three parameters,namely the concentration of MWCNT,the SN ratio(mass ratio of carbon nanotubes to sur-factants)and the sonication time.The results have revealed that,while the SN ratio and concentration of MWCNT have a strong effect on the absorbance,the influence of the sonication time is less important.The sta-tistical method of analysis of variance(ANOVA)was further used to determine the F-and p-values of the model.Five experiments were run to validate this approach.Since sample 2 was found to display the greatest absorbance,it was selected for stability monitoring as well as thermal conductivity and viscosity measurements.This sample has been found to be stable;the viscosity decreased with increasing temperature;the addition of MWCNT nano-particles was more effective in improving the thermal conductivity of propylene glycol than other methods in the literature.Moreover,the MWCNT nanofluid based on propylene glycol exhibited higher thermal conductivity at low temperatures. | Xi Wang Shan Qing Zhumei Luo Yiqin Liu Zichang Shi Jiachen Li | 2023 | Fluid Dynamics & Materials Processing2023，19，9： | 0 |
| 15 | Competitiveness of Formic Acid Sector Needs to Be Improved | Wang Zichang | 2009 | China Chemical Reporter2009，，15： | 0 |
| 16 | WGCNA and LASSO algorithm constructed an immune infiltration-related 5-gene signature and nomogram to improve prognosis prediction of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is a common immunogenic malignant tumor.Although the new strategies of immunotherapy and targeted therapy have made considerable progress in the treatment of HCC,the 5-year survival rate of patients is still very low.The identification of new prognostic signatures and the exploration of the immune microenvironment are crucial to the optimization and improvement of molecular therapy strategies.We studied the potential clinical benefits of the inflammation regulator miR-93-3p and mined its target genes.Weighted gene coexpression network analysis(WGCNA),univariate and multivariate COX regression and the LASSO COX algorithm are employed to identify prognostic-related genes and construct multi-gene signature-based risk model and nomogram for survival prediction.Support vector machine(SVM)based Cibersort’s deconvolution algorithm and gene set enrichment analysis(GSEA)is used to evaluate the changes in tumor immune microenvironment and pathway differences.The study found the favorable prognostic performance of miR-93-3p and identified 389 prognostic-related target genes.The risk model based on a novel 5-gene signature(cct5,cdk4,cenpa,dtnbp1 and flvcr1)was developed and has prominent prognostic significance in the training cohort(P<0.0001)and validation cohort(P=0.0016).The nomogram constructed by combining the gene signature and the AJCC stage further improves the survival prediction ability of the gene signature.The infiltration level of multiple immune cells(especially T cells,B cells and macrophages)were positively correlated with the expression of prognostic signature.In addition,we found that gene markers of T cells and B cells is monitored and regulated by prognostic signature.Meanwhile,several GSEA pathways related to the immune system are enriched in the high-risk group.In general,we integrated the WGCNA,LASSO COX and SVM algorithms to develop and verify 5-gene signatures and nomograms related to immune infiltration to improve the survival prediction of patients. | MENG FANG JING GUO HAIPING WANG ZICHANG YANG HAN ZHAO QINGJIA CHI | 2022 | BIOCELL2022，46，2： | 0 |
| 17 | Co-planted barnyardgrass reduces rice yield by inhibiting plant above-and belowground-growth during post-heading stages显示文摘Barnyardgrass (Echinochloa spp.) is the most common noxious weed in rice paddies as it inhibits rice growth and reduces grain yield.To date,little information is available on above-and belowgroundgrowth changes in rice due to neighboring barnyardgrass.This study aimed to investigate the changes in root traits and shoot growth of rice when it is grown with different kinds of barnyardgrass.Japonica rice plants (var.Nanjing 9108) were co-cultured with two varieties of Echinochloa crusgalli (L.) Beauv.(EP,var.mitis (pursh) Petern;EH,var.zelayensis (H.B.K.) Hitchc),and E.colonum (L.) Link (EL) in the field in 2017 and 2018.Four treatments included control (i.e.,weed free rice plants) and co-cultures with each of three barnyardgrasses (EP,EH,and EL).The results revealed that EP,EH,and EL treatments significantly reduced rice grain yields by 30.6%–36.2%,42.5%–46.5%,and 10.6%–14.3%,respectively.Shoot growth including shoot dry weight,leaf photosynthetic rate,zeatin (Z) and zeatin riboside (ZR) in grains,and activities of key enzymes involved in sucrose-to-starch conversion in grains and root traits,such as length density,root dry weight,total absorbing surface area,active absorption surface area,oxidation activity,and Z+ZR contents in roots were dramatically reduced during post-heading stages of rice when grown with the three kinds of barnyardgrass.Moreover,above-mentioned rice shoot growth indices were strongly and positively correlated with root traits.These results suggested the decrease in rice shoot growth and root traits during post-heading stages contributes to the reduction in the rice yield when it grows with barnyardgrass neighbors. | Zichang Zhang Jingjing Cao Tao Gu Xia Yang Qiong Peng Lianyang Bai Yongfeng Li | 2021 | The Crop Journal2021，9，5： | 0 |
| 18 | A three-dimensional vector radiative transfer (3D-VRT) equation for inhomogeneous scatter media显示文摘To solve 3D-VRT equation for the model of spatially inhomogeneous scatter media, the finite enclosure of the scatter media is geometrically divided, in both the vertical z and horizontal (x,y) directions, to form very thin multi-boxes. The zero-th order emission, first-order Mueller matrix of each thin box and an iterative approach of high-order radiative transfer are applied to deriving high-order scattering and emission of whole inhomogeneous scatter media. Numerical results of polarized brightness temperature at microwave frequency from inhomogeneous scatter model such as vegetation canopy are calculated and discussed. | JIN Yaqiu* and LIANG Zichang (Center for Wave Scattering and Remote Sensing and School of Information Science and Engineering, Fudan University, Shanghai 200433, China) | 2003 | Progress in Natural Science:Materials International2003，13，11： | 0 |
| 19 | Steady Growth of DMAC Demand | Wang Zichang | 2009 | China Chemical Reporter2009，，20： | 0 |
| 20 | Spectrally multiplexed indistinguishable single-photon generation at telecom-band显示文摘Heralded single-photon source(HSPS)intrinsically suffers from the trade-off between the heralded single-photon rate and the single-photon purity.To break through this trade-off,one can apply multiplexing technology in different degrees of freedom that significantly improves the performance of the HSPS.Here,we propose a 1.5μm chip-scale HSPS on lithium niobate on insulator by employing spectral multiplexing and active feedforward spectral manipulating,and we demonstrate a proof-of-principle experiment with discrete fiber-based components.With continuous-wave laser pumping and three spectral modes multiplexed,our experimental results show that the spectral multiplexing improves the heralded single-photon rate by near threefold while keeping the g^((2))(0)as low as 0.0006±0.0001 at a measured single-photon rate of 3.1 kHz.By measuring the joint spectral intensity,we show that the spectral multiplexing and feed-forward control effectively erase the frequency correlation of photon pairs.Moreover,we implement the Hong-Ou-Mandel interference between the spectrally multiplexed single photons and photons from an independent weak coherence source,which indicates that the multiplexed single photons are highly indistinguishable after the spectral manipulation.Our results pave a way for on-chip scalable and high-performance HSPS with spectral multiplexing toward deterministic single-photon emission. | HAO YU CHENZHI YUAN RUIMING ZHANG ZICHANG ZHANG HAO LI YOU WANG GUANGWEI DENG LIXING YOU HAIZHI SONG ZHIMING WANG GUANG-CAN GUO QIANG ZHOU | 2022 | Photonics Research2022，10，6： | 0 |
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