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| 1 | Effects of essential oils on performance,egg quality, nutrient digestibility and yolk fatty acid profile in laying hens显示文摘The study was conducted to investigate the effect of essential oils on performance, egg quality, nutrient digestibility and yolk fatty acid profile in laying hens. A total of 960 Lohmann laying hens aged 53 weeks were enrolled, under 4 different treatment diets supplemented with 0, 50.100 and 150 mg/kg essential oils(Enviva EO, Dupont Nutrition Biosciences ApS, Denmark), respectively. Each treatment was replicated8 times with 30 birds each. Birds were fed dietary treatment diets for 12 weeks(54 to 65 weeks). For data recording and analysis, a 12-week period was divided into 3 periods of 4 weeks' duration each: period 1(54 to 57 weeks), period 2(58 to 61 weeks), and period 3(62 to 65 weeks). For the diet supplemented with Enviva EO, hen-day egg production and the feed conversion ratio(FCR) were significantly improved(P < 0.05) at weeks 58 to 61, and the eggshell thickness was significantly increased(P < 0.05) at week 65.However, egg production, egg weight, feed intake, FCR and other egg quality parameters(albumen height, Haugh unit, egg yolk color and eggshell strength) were not affected by the dietary treatment. In addition, compared with the control diet, protein digestibility in the 100 mg/kg Enviva EO treatment group was significantly increased(P < 0.05), and fat digestibility in the 100 and 150 mg/kg Enviva EO treatment groups was significantly decreased(P < 0.05), but Enviva EO had no effect on energy apparent digestibility. Saturated fatty acid(SFA) and monounsaturated fatty acid(MUFA) gradually decreased and polyunsaturated fatty acid(PUFA) increased with Enviva EO supplementation, but the difference was not significant. The data suggested that the supplementation of essential oils(Enviva EO) in laying hen diet did not show a significant positive effect on performance and yolk fatty acid composition but it tended to increase eggshell thickness and protein digestibility, especially at the dose of 50 mg/kg. | Xuemei Ding Yang Yu Zhuowei Su Keying Zhang | 2017 | Animal Nutrition2017，，2： | 10 |
| 2 | Significance and challenges of stereoselectivity assessing methods in drug metabolism显示文摘Stereoselectivity in drug metabolism can not only influence the pharmacological activities, tolerability,safety, and bioavailability of drugs directly, but also cause different kinds of drug–drug interactions. Thus,assessing stereoselectivity in drug metabolism is of great significance for pharmaceutical research and development(R&D) and rational use in clinic. Although there are various methods available for assessing stereoselectivity in drug metabolism, many of them have shortcomings. The indirect method of chromatographic methods can only be applicable to specific samples with functional groups to be derivatized or form complex with a chiral selector, while the direct method achieved by chiral stationary phases(CSPs) is expensive. As a detector of chromatographic methods, mass spectrometry(MS) is highly sensitive and specific, whereas the matrix interference is still a challenge to overcome. In addition, the use of nuclear magnetic resonance(NMR) and immunoassay in chiral analysis are worth noting. This review presents several typical examples of drug stereoselective metabolism and provides a literature-based evaluation on current chiral analytical techniques to show the significance and challenges of stereoselectivity assessing methods in drug metabolism. | Zhuowei Shen Chuang Lv Su Zeng | 2016 | Journal of Pharmaceutical Analysis2016，6，1： | 3 |
| 3 | SB216763, a selective small molecule inhibitor of glycogen synthase kinase-3, improves bleomycin-induced pulmonary fibrosis via activating autophagy显示文摘An excessive accumulation of extracellular matrix composed by insoluble collagen is the core pathogenic change of fibroproliferative diseases including pulmonary fibrosis.We recently found that autophagy,a self-catabolic process that maintains intracellular homeostasis,participates critically in the regulation of collagen degradation in the fibrotic tissues.Here we report that treatment of mice with SB216763,a potent and selective inhibitor of glycogen synthase kinase-3(GSK3),significantly decreased the bleomycin(BLM)-induced acute inflammation,attenuated pulmonary fibrosis,improved the lung function and increased animal survival through activating autophagy.Indeed,we found that treatment of mice or cultured cells with SB216763 restored the autophagy in vivo and in vitro through increasing the expression of autophagy related proteins and decreasing the physical interaction of Bcl-2 and Beclin-1.Additionally,SB216763 stimulated the binding of Bcl-2 and GSK3,which reduces the interaction of Bcl2 and Beclin-1.We conclude that the GSK3 inhibitor SB216763 improves the BLM-induced pulmonary fibrosis through stimulating autophagy core complex to restore the activity of autophagy in fibrotic lung tissue.Our work suggests that using a moderate autophagic agonist,such as SB216763,is a promising therapeutic strategy for the treatment of devastating fibroproliferative diseases such as idiopathic pulmonary fibrosis. | Hong Liu Su Mi Zhe Li Xiaoxi Lv Ke Li Fang Hua Zhuowei Hu | 2013 | Acta Pharmaceutica Sinica B2013，3，4： | 1 |
| 4 | Effects of a multi-enzyme complex on growth performance,nutrient utilization and bone mineralization of meat duck显示文摘Background:Previous studies with broiler have shown dietary supplementation with multi-enzyme complex containing non-starch polysaccharides(NSP) degrading enzymes and phytase is efficient in releasing phosphorus(P),calcium(Ca),energy and amino acids from corn-soybean meal diets or corn-sorghum diets,hence compensating considerable levels of nutrients in formulation.Notwithstanding,such potentials have not been well defined in duck nutrition.Giving China being the largest duck producing country,we conducted this study to establish adequate specifications of major nutrients along with multi-enzyme complex to meat duck from day-old to slaughter,focusing on performance,utilization of nutrients and bone mineralization.Five dietary treatments were:Positive control(PC,T1):the nutrients concentration of diet for 1 to 14 d of age were apparent metabolizable energy(AME) 2,800 kcal/kg,crude protein(CP)19.39%,Ca 0.85%,available phosphorus(avP) 0.42%;for 15 to 35 d of age these parameters were AME2,900 kcal/kg,CP 16.47%,Ca 0.76%,avP 0.38%;Negative control 1(NC1,T2),the AME and digestible amino acids(DAA)were reduced by 70 kcal/kg and 2.0%,avP and Ca by 1.0 g/kg from PC diet;Negative control 2(NC2T4),the downspec from PC diet was AME 100 kcal/kg,DAA 2.5%,avP 1.5 g/kg and Ca 1.2 g/kg;The enzyme complex was added at the same dosage(200 ml7 1,000 kg) on NCI(T3) and NC2(T5) diets.Results:Comparing with the ducks fed on T1,T3 and T5 diets,the birds fed on NC2 diet showed the lowest(P < 0.05)body weight(d 14 and 35),feed intake(d 35),tibia ash,Ca and P contents(d 14 and 35),and the utilization of nutrients(P< 0.05).The supplementation with the enzyme complex to the NC diets restored growth rate,utilization of nutrients and bone mineralization to the level of the PC diet,and increased AME by 60 kcal/kg and117 kcal/kg,respectively for the NCI and NC2 diets.Conclusion:These results suggest that down-spec AME by 100 kcal/kg,DAA by 2.5%,avP by 1.5 g/kg and Ca by1.2 g/kg caused detrimental effects on duck performance compared with those fed on the PC diet,and these performance losses can be compensated by the addition of the multiple-enzyme complex. | Qiufeng Zeng Xueqin Huang Yuheng Luo Xuemei Ding Shiping Bai Jianping Wang Yue Xuan Zhuowei Su Yonggang Liu Keying Zhang | 2015 | Journal of Animal Science and Biotechnology2015，6，4： | 1 |
| 5 | NEU-P11, a novel melatonin agonist, inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats显示文摘 | Meihua She Xiaojian Deng Zhenyu Guo Moshe Laudon Zhuowei Hu Duanfang Liao Xiaobo Hu Yi Luo Qingyun Shen Zehong Su Weidong Yin | 2009 | Pharmacological Research2009，，4： | 1 |
| 6 | Calcium supplementation in low nutrient density diet for meat ducksimproves breast meat tenderness associated with myocyte apoptosisand proteolytic changes显示文摘To define the relationship between dietary nutrient density, calcium (Ca), and meat quality in meatducks. A total of 288 male Cherry Valley SM3 medium ducklings were fed a common standard starter dietuntil d 14. At 15 d of age, ducks were randomly divided into 2 treatment groups and fed either a conventionaldiet or a low nutrient density (LND) diet. Compared with the conventional diet, the energy wasreduced in the LND diet by 8.6% and 16.8% in grower (15 to 35 d) and finisher (36 to 56 d) phases,respectively, while other essential nutrients were kept proportionate to energy. The LND diet decreasedthe shear force (P < 0.05) and increased the lightness values of the pectoralis muscle when compared tothe conventional diet, suggesting that LND diet exerted a beneficial role in meat quality. Subsequently,the effects of grated Ca in the LND diet on meat quality of pectoralis muscle were evaluated. A total of 576male ducklings were fed a common starter diet until d 14, followed by feeding 4 LND diets with 0.5%,0.7%, 0.9%, and 1.1% Ca. The results show that LND diets with 0.7% or more Ca decreased the shear force ofpectoralis major muscle in 42-d-old meat ducks (P < 0.05). To explore the mechanism underlying Ca andtenderness, data from birds fed either 0.5% or 1.1% Ca in the LND diet indicated that birds fed 1.1% Caexhibited lower shear force, upregulated calpains 1 expression, and higher calpains activity compared tothose fed the LND diet with 0.5% Ca (P < 0.05). Moreover, the 1.1% Ca LND diet induced a higher myocyteapoptosis (P =0.06) and upregulated mRNA expression of caspase-3 (P =0.07) in breast muscle. Our datasuggest that LND diets with 0.9% or 1.1% Ca had a positive role in the tenderness of breast meat,particularly the enhancing effect of 1.1% Ca LND diet on tenderness seems to be associated with proteolyticchanges of myofibrillar proteins and myocyte apoptosis in meat ducks. | Huaiyong Zhang Quifeng Zeng Shiping Bai Jianping Wang Xuemei Ding Yue Xuan Zhuowei Su Joris Michiels Keying Zhang | 2022 | Animal Nutrition2022，，2： | 1 |
| 7 | Effect of dietary canthaxanthin and 25-hydroxycholecalciferol supplementation on the performance of duck breeders under two different vitamin regimens显示文摘Background: Dietary canthaxanthin(CX), 25-hydroxycholecalciferol(25-OH-D3) and vitamins have been widely reported to be involved in productive and reproductive performance of broiler breeders. However, limited information is available for duck breeders. In this study, a total of 1,560 Cherry Valley SM3 duck breeder females and 312 males were used to assess if the addition of CX and 25-OH-D3 could increase the performance of duck breeders under two different dietary vitamin regimens. Four diets were used under a 2 × 2 factorial arrangement with 2 kinds of vitamin premixes(REGULAR and HIGH; HIGH premix had higher levels of all vitamins except K3 than REGULAR premix), and with or without the supplementation of the mixture of CX(6 mg/kg) and 25-OH-D3(0.069 mg/kg). The ducks were fed ad libitum with pelleted diets based on corn-soybean meal from 38 to 77 wk of age.Results: HIGH vitamin premix decreased malondialdehyde(MDA) level(P < 0.001) of egg yolk, increased hatchability of fertile eggs(P = 0.029), increased hatchability of total eggs(P = 0.029), and decreased serum protein carbonyl level(P = 0.037) of breeder males. The mixture of CX and 25-OH-D3 increased serum calcium of breeder females(P = 0.010), decreased the cracked egg rate(P = 0.001), increased the pigmentation of egg yolk(P < 0.001)and male bill(P < 0.001), and decreased MDA level of egg yolk(P < 0.001) and male serum(P = 0.034). Interactive effects were observed in cracked egg rate(P = 0.038), shell thickness(P = 0.011) and serum phosphorus(P = 0.026)of breeder females. HIGH vitamin premix together with the mixture of CX and 25-OH-D3 decreased cracked egg rate and increased shell thickness of duck breeders. Serum phosphorus was decreased in duck breeder females fed REGULAR vitamin premix without the addition of the CX and 25-OH-D3 mixture.Conclusions: Dietary HIGH vitamin premix increased antioxidant status of eggs and breeder males, and increased hatchability. The mixture of CX and 25-OH-D3 enhanced egg shell quality, and promoted pigmentation and antioxidant status of eggs and breeder males. | Zhouzheng Ren Shizhen Jiang Qiufeng Zeng Xuemei Ding Shiping Bai Jianping Wang Yuheng Luo Zhuowei Su Yue Xuan Bing Yao Fernando Cisneros Keying Zhang | 2016 | Journal of Animal Science and Biotechnology2016，7，2： | 0 |
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