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| 1 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 2 | The spatio-temporal variations of frost-free period in China from 1951 to 2012显示文摘The frost-free period(FFP)first frost date(FFD) and last frost date(LFD) have been regard as the important climate variables for agricultural production. Understanding the spatio-temporal variations of the FFPFFD and LFD is beneficial to reduce the harmful impacts of climate change on agricultural production and enhance the agricultural adaptation. This study examined daily minimum temperatures for 823 national-level meteorological stationscalculated the values of FFDLFD and FFP for station-specific and region-specific from 1951 to 2012estimated the gradients of linear regression for station-specific moving averages of FFDLFD and FFPand assessed station-specific time series of FFP and detected the abrupt change. The results as follows: at both the station level and the regional levelthe FFP across China decreases with the increase of latitude from south to northand with the increase of altitude from east to west generally. At the station levelthe inter-annual fluctuations of FFDLFD and FFP in south and west agricultural regions are greater than those in north and east. At the regional levelexcluding the QT regiontemporal changes of FFP are relatively small in both the low-latitude and the high-latitude regionsbut for the mid-latitude regions. According to the linear trend gradients of the moving average values of station-specific FFDLFD and FFPFFD was delayedLFD advancedand FFP extended gradually over the 80% of China. Furthermorethe change magnitudes for FFDLFD and FFP in the north and east agricultural regions are higher than that in the southern and western. Among the 659 station-specific time series of FFP examined by the Mann-Kendall test341 stationslocated mainly in the north regionhave one identifiable and significant abrupt change. And at the 341 stations with identified abrupt changesmost(57%) abrupt changes occurred during 1991–2012followed by the periods of 1981–1990(28%)1971–1980(12%)and 1951–1970(3%). The spatio-temporal variations of FFDLFD and FFP would provide important guidance to agricultural practices. | NING Xiaoju LIU Gangjun ZHANG Lijun QIN Xiaoyang ZHOU Shenghui QIN Yaochen | 2017 | Journal of Geographical Sciences2017，27，1： | 2 |
| 3 | A novel Web page filtering system by combining texts and images显示文摘 | Zhou yaochen Wu Ming liangzhu | 2006 | IEEE Computer Society2006，，： | 1 |
| 4 | A novel Web page filtering system by combining texts and images显示文摘 | Zhou yaochen Ou Wu Ming liangzhu | 2006 | IEEE Computer Society2006，，： | 1 |
| 5 | Charge transport and quantum confinement in MoS2 dual-gated transistors显示文摘Semiconductive two dimensional(2D)materials have attracted significant research attention due to their rich band structures and promising potential for next-generation electrical devices.In this work,we investigate the MoS2 field-effect transistors(FETs)with a dual-gated(DG)architecture,which consists of symmetrical thickness for back gate(BG)and top gate(TG)dielectric.The thickness-dependent charge transport in our DG-MoS2 device is revealed by a four-terminal electrical measurement which excludes the contact influence,and the TCAD simulation is also applied to explain the experimental data.Our results indicate that the impact of quantum confinement effect plays an important role in the charge transport in the MoS2 channel,as it confines charge carriers in the center of the channel,which reduces the scattering and boosts the mobility compared to the single gating case.Furthermore,temperature-dependent transfer curves reveal that multi-layer MoS2 DG-FET is in the phonon-limited transport regime,while single layer MoS2 shows typical Coulomb impurity limited regime. | Fuyou Liao Hongjuan Wang Xiaojiao Guo Zhongxun Guo Ling Tong Antoine Riaud Yaochen Sheng Lin Chen Qingqing Sun Peng Zhou David Wei Zhang Yang Chai Xiangwei Jiang Yan Liu Wenzhong Bao | 2020 | Journal of Semiconductors2020，41，7： | 0 |
| 6 | Opportunities and challenges of incretin-based hypoglycemic agents treating type 2 diabetes mellitus from the perspective of physiological disposition显示文摘The treatment of patients with diabetes mellitus, which is characterized by defective insulin secretion and/or the inability of tissues to respond to insulin, has been studied for decades. Many studies have focused on the use of incretin-based hypoglycemic agents in treating type 2 diabetes mellitus(T2DM). These drugs are classified as GLP-1 receptor agonists, which mimic the function of GLP-1,and DPP-4 inhibitors, which avoid GLP-1 degradation. Many incretin-based hypoglycemic agents have been approved and are widely used, and their physiological disposition and structural characteristics are crucial in the discovery of more effective drugs and provide guidance for clinical treatment of T2DM.Here, we summarize the functional mechanisms and other information of the drugs that are currently approved or under research for T2DM treatment. In addition, their physiological disposition, including metabolism, excretion, and potential drug drug interactions, is thoroughly reviewed. We also discuss similarities and differences in metabolism and excretion between GLP-1 receptor agonists and DPP-4 inhibitors. This review may facilitate clinical decision making based on patients' physical conditions and the avoidance of drug drug interactions. Moreover, the identification and development of novel drugs with appropriate physiological dispositions might be inspired. | Yaochen Xie Qian Zhou Qiaojun He Xiaoyi Wang Jincheng Wang | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 0 |
| 7 | Top gate engineering of field-effect transistors based on wafer-scale two-dimensional semiconductors显示文摘The investigation of two-dimensional(2D)materials has advanced into practical device applications,such as cascaded logic stages.However,incompatible electrical properties and inappropriate logic levels remain enormous challenges.In this work,a doping-free strategy is investigated by top gated(TG)MoS_(2) field-effect transistors(FETs)using various metal gates(Au,Cu,Ag,and Al).These metals with different work functions provide a convenient tuning knob for controlling threshold voltage(V_(th))for MoS_(2) FETs.For instance,the Al electrode can create an extra electron doping(n-doping)behavior in the MoS_(2) TG-FETs due to a dipole effect at the gate-dielectric interface.In this work,by achieving matched electrical properties for the load transistor and the driver transistor in an inverter circuit,we successfully demonstrate wafer-scale MoS_(2) inverter arrays with an optimized inverter switching threshold voltage(V_(M))of 1.5 V and a DC voltage gain of 27 at a supply voltage(V_(DD))of 3 V.This work offers a novel scheme for the fabrication of fully integrated multistage logic circuits based on wafer-scale MoS_(2) film. | Jingyi Ma Xinyu Chen Yaochen Sheng Ling Tong Xiaojiao Guo Minxing Zhang Chen Luo Lingyi Zong Yin Xia Chuming Sheng Yin Wang Saifei Gou Xinyu Wang Xing Wu Peng Zhou David Wei Zhang Chenjian Wu Wenzhong Bao | 2022 | Journal of Materials Science & Technology2022，，11： | 0 |
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