| 4 | Lin28a is Essential for Synaptic Plasticity in Dentate Granule Cells and Spatial Memory显示文摘Dear Editor,The dentate gyrus(DG),a subregion of the hippocampus,is involved in multiple physiological functions such as cognition and mood regulation.Dentate granule cells(DGCs),the primary neurons in the DG,are essential for coding spatial and contextual memories in the hippocampal neural circuits.The entorhinal cortex provides a majority of cortical projections to the DG via the perforant path,and forms synaptic connections with DGCs within the outer two-thirds of the molecular layer of the DG[1].The plasticity of the perforant path-to-DGC synapses strengthens the connections of ensembles encoding spatial,contextual,or temporal information,and promotes the recall of related memories when certain perforant path inputs are reactivated[2]. | Zhechun Hu Jiao Ma Yan Gu | 2021 | Neuroscience Bulletin2021，37，2： | 0 |
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