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| 1 | Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non-Small-Cell Lung Cancer(摘要)显示文摘 | Hu, ZB Chen, X Zhao, Y Tian, T Jin, GF Shu, YQ Chen, YJ Xu, L Zen, K Zhang, CY Shen, HB | 2010 | 南京医科大学学报(自然科学版)2010，30，7： | 141 |
| 2 | Recent developments and future prospects of Vitreoscilla hemoglobin application in metabolic engineering显示文摘 | Zhang, L Li, YJ Wang, ZN Xia, Y Chen, WS Tang, KX | 2007 | 中国生物学文摘2007，21，10： | 25 |
| 3 | 前瞻随机对照比较射频消融联合/不联合经导管肝动脉栓塞化疗术治疗肝细胞癌的临床研究显示文摘背景和目的射频消融术(RFA)是近年发展比较快的肝癌治疗手段,具有微创、操作简单、可反复治疗的特点,多项研究证明其对于小肝癌的疗效与手术切除相似,被认为是不能手术小肝癌的主要替代手段,甚至可作为小肝癌的一线治疗手段。经导管肝动脉栓塞化疗术(TACE)是中晚期肝癌的主要治疗手段。TACE联合射频消融,TACE可发现和治疗一些以前没有发现的微小病灶,控制肝肿瘤周围可能存在的微卫星灶,并有利于日后射频治疗的施行;此外,射频消融术前行TACE治疗,可以减少肝肿瘤的血流,从而减少射频消融过程中的热流失,从而增加消融范围;射频消融过程中产生的热量可以协同发挥TACE过程中注入化疗药物的疗效。因此TACE联合射频消融可提高肝细胞癌的疗效。本研究是第一项研究RFA联合TACE的前瞻随机对照研究,目的在于比较RFA联合或不联合TACE治疗肝细胞癌(HCC)的效果。方法此项单中心随机对照临床试验在中山大学肿瘤医院完成。自2006年10月至2009年6月,189例直径小于7 cm的肝细胞癌患者符合入选标准完成对照试验。入选标准:1年龄18~75岁;2HCC单个病灶≤7 cm,或3个或以下病灶,每个≤3 cm;3无影像学证据显示大血管侵犯且无肝外转移;4B超下可见病灶且病灶和腹壁之间有安全距离;5ECOG体力状态评分0;6之前未接受过HCC治疗;7患者Child-Pugh肝功能A或B级。患者随机接受TACE联合RFA治疗(TACE-RFA,n=94)或单纯RFA治疗(n=95)。该研究的主要终点为总体生存率,次要终点为无复发生存率,第三终点为不良事件。结果随访7至62月期间,TACE-RFA组死亡34例,复发33例;RFA组死亡48例,复发52例。TACE-RFA组与RFA组患者1年、3年及4年总体生存率分别为92.6%、66.6%、61.8%以及85.3%、59%和45.0%。两组对应的无复发生存率分别为79.4%、60.6%、54.8%以及66.7%、44.2%和38.9%。TACE-RFA组患者的总体生存率(RR=0.525,95%CI:0.335~0.822;P=0.002)以及无复发生存率(RR=0.575,95%CI:0.374~0.897;P=0.009)均优于RFA组患者。研究中未出现治疗相关死亡病例。Logistic回归分析显示,治疗分组、肿瘤大小以及肿瘤数量为患者总体生存率的显著预后因素,同时,治疗分组与肿瘤数量为患者无复发生存率的显著预后因素。结论对于直径小于7 cm的HCC患者,接受TACERFA较单纯RFA治疗生存获益更显著。 | Peng ZW Zhang YJ Chen MS 张信华 | 2013 | 消化肿瘤杂志(电子版)2013，5，3： | 23 |
| 4 | Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms.显示文摘 | Zhang YJ Xu YF Liu YIH Yin J Li HL Wang Q Wang JZ. | 2006 | 中国生物学文摘2006，20，9： | 10 |
| 5 | 醛固酮可通过NLRP3炎症小体诱导小鼠肝星状细胞活化和肝纤维化显示文摘【据《J Gastroenterol Hepatol》2020年6月报道】题:醛固酮通过NLRP3炎症小体诱导小鼠肝星状细胞活化和肝纤维化(作者Li Y等)已有证据表明,醛固酮和NLRP3炎症小体是诱导肝星状细胞活化以及肝纤维化的重要因素。然而,醛固酮与NLRP3炎症小体在肝星状细胞激活以及肝纤维化过程中是否存在相互作用,目前尚不清楚。该研究旨在探讨醛固酮与NLRP3炎症小体在调控肝星状细胞活化以及肝纤维化形成过程中的相互作用关系。 | LI Y ZHANG YJ CHEN TT 李洋 李旭 | 2020 | 临床肝胆病杂志2020，36，8： | 7 |
| 6 | Induction of mucosal and systemic immune response by single-dose oral immunization with biodegradable microparticles containing DNA encoding HBsAg显示文摘 | He XW Wang F Jiang L Li J Liu SK Xiao ZY Jin XQ Zhang YN He Y Li K Guo YJ Sun SH | 2005 | 第二军医大学学报2005，26，10： | 5 |
| 7 | Expression of matrix metallo-proteinase-28 in human normal cytotrophoblast cells and a choriocarcinoma cell line,JEG-3显示文摘There are striking similiarities present between the behavior of invasive placentaL cells and that of invasive cancer cells. Matrix metalloproteinases (MMPs) are one of the most important mediators. MMP-28, the new member of MMPs, was sequenced and identified recently. Expression of MMP-28 mRNA and protein in the cytotrophoblast cells and a choriocarcinoma cell line, JEG-3 cell, was conducted by zymography, RT-PCR and Northern blot. There is MMP-28 mRNA expression in both the cytotrophoblast cells and JEG-3 cells by RT-PCR. The activity of MMP-28 in cytotrophoblast cells was significantly weaker than that in JEG-3 (P < 0.01) by zymography. Furthermore, mRNA expression of MMP-28 was significantly stronger (P < 0.001) in JEG-3 than in human cytotrophoblast cells in a time-dependent way by Northern Blot. Our results suggest that MMP-28 may play a role in some of the tissue-remodeling events associated with normal pregnancy and tumor progression. | Zhang, J Cao, YJ Liu, WM Zhao, BS Zeng, GQ Duan, EK | 2002 | Chinese Science Bulletin2002，47，9： | 4 |
| 8 | Effects of carcinogen-induced transcription factors on the activation of hepatitis B virus expression in human hepatoblastoma HepG2cells and its implication on hepatocellulor carcinomas 显示文摘 | Banerjee R Caruccio L Zhang YJ | 2000 | Hepatology2000，32，： | 2 |
| 9 | Step Sintering of Microwave Heating and MicrowavePlasma Heating for Alumina Ceramics显示文摘The invention of microwave induced plasma during microwave heating makes it possible to confine plasma inside a crucible, in the pressure range of 1.33 Pa to 0.5 MPa, and above 900℃.In this study, the step sintering of microwave heating and microwave plasma heating (SSMP)was proposed. In this process, microwave heating and plasma heating was ingeniously combined in one chamber, and vacuum was unnecessary for microwave induced plasma. In the first step, the microwave energy directly heated alumina ceramics to a given temperature. above which microwave will mainly ionize the gas and sustain a plasma. Then the plasma further heated alumina ceramics to the final temperature to finish sintering. Maintaining the advantages of microwave heating and plasma heating, this step sintering approach will overcome the limitation of both processes for processing ceramics. and it will be suitable for sintering all kinds of ceramics in | Zhang, JS Cao, L Yang, YJ Diao, YX Shen, XX | 1999 | Journal of Materials Science & Technology1999，15，5： | 2 |
| 10 | Immunohistochemical detection of alatoxin B1 -DNA adducts and hepatitis B virus antigens in hepatocellular carcinoma and nontumorous liver tissue 显示文摘 | Santella RM Zhang YJ Chen CJ | 1993 | Environ Health Perspect1993，99，： | 1 |
| 11 | Embryonic stem cell transplantation for the treatment of myocardial infarction: Immune privilege or rejection 显示文摘 | Yuan X Zhang H Wei YJ | 2007 | Transpl Immunol2007，18，2： | 1 |
| 12 | The effect of atmospheric pressure helium plasma treatment on the surface and mechanical properties of ultrahighmodulus polyethylene fibers 显示文摘 | Y Qiu C Zhang YJ Hwang BL Bures M McCord | 2002 | Journal of Adhesion Science and Technology2002，16，1： | 1 |
| 13 | Auticancer effects of chinese red yeast rice versus monacolin K alone on colon cancer cells 显示文摘 | Mee YH Navindra PS Zhang YJ | 2008 | Journal of Nutritional Biochemis- try2008，，19： | 1 |
| 14 | MicroRNA-1 down regulation by propranol- ol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotection 显示文摘 | Lu YJ Zhang Y Shah HL | 2009 | Cardiovasc Res2009，84，3： | 1 |
| 15 | X chromosome polymorphism in Koreans on DXS7132 and DXS6800显示文摘 | Lee SD Ahn JS Zhang YJ | 2002 | Forensic Sci Int2002，126，： | 1 |
| 16 | Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling显示文摘 | Tang DZ Hou W Zhou Q Zhang M Holz J Sheu TJ Li TF Cheng SD Shi Q Harris SE Chen D Wang YJ | 2010 | J Bone Miner Res2010，25，6： | 1 |
| 17 | Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease显示文摘 | Li J Wang YJ Zhang M | 2011 | Neurology2011，76，： | 1 |
| 18 | Aggravated cognitive and brain functional impairment in mild cognitive impairment patients with type 2 diabetes: a resting-state functional MRI study 显示文摘 | Zhou XQ Zhang JY Chen YJ | 2014 | Journal of Alzheimer'' s Disease2014，41，3： | 1 |
| 19 | Molecular cloning and functional characterization of porcine toll - like receptor 7 involved in recognition of single - stranded RNA virus/ssRNA 显示文摘 | Zhang YL Guo YJ Sun SH | 2008 | Mol lnununol2008，45，4： | 1 |
| 20 | Targeting roTOR network in colorectal cancer therapy 显示文摘 | Wang XW Zhang YJ | 2014 | World J Gastroenterol2014，20，15： | 1 |
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