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| 1 | Honeysuckle-encoded atypical microRNA2911 directly Largets influenza A viruses显示文摘 | Zhen Zhou Xihan Li Jinxiong Liu Lei Dong Qun Chen Jialing Liu Huihui Kongt Qianyi Zhang Xian Qi Dongxia Hou Lin Zhang Guoquan Zhang Yuchen Liu Yujing Zhang Jing Li Jin Wang Xi Chen Hua Wang Junfeng Zhang Hualan Chen Ke Zen Chen-Yu Zhang | 2015 | Cell Research2015，25，1： | 104 |
| 2 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 3 | Mianlüe tectonic zone and Mianlüe suture zone on southern margin of Qinling-Dabie orogenic belt显示文摘The Mianle tectonic zone (Mianle zone), an ancient suture zone in addition to the Shangdan suture in the Qinling-Dabie orogenic belt, marks an important tectonic division geo-logically separating north from south and connecting east with west in China continent. To de-termine present structural geometry and kinematics in the Mianle tectonic zone and to recon-struct the formation and evolution history involving plate subduction and collision in the Qinling-Dabie orogenic belt, through a multidisciplinary study, are significant for exploring the mountain-building orogenesis of the central orogenic system and the entire process of the major Chinese continental amalgamation during the Indosinian. | ZHANG Guowei1, DONG Yunpeng1, LAI Shaocong1, GUO Anlin1, MENG Qingren2, LIU Shaofeng3, CHENG Shunyou1, YAO Anping1, ZHANG Zongqing4, PEI Xianzhi5 & LI Sanzhong6 1. Department of Geology, Northwest University, Xian 710069, China 2. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100101, China 3. Earth Science and Resource Faculty, China University of Geosciences, Beijing 100083, China 4. Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China 5. Changan University, Xian 710054, China 6. Qingdao University of Oceanography, Qingdao 266003, China | 2004 | Science China Earth Sciences2004，47，4： | 57 |
| 4 | Outcomes of primary percutaneous coronary intervention for acute ST-elevation myocardial infarction in patients aged over 75 years显示文摘背景在有圣举起心肌的梗塞(STEMI ) 的老病人的最佳的灌注策略仍然保持不清楚。这研究的目的是评估安全,在里面医院和一个年临床的为病人的结果有收到主要经皮的冠的干预(一种总线标准)的 STEMI 的 75 岁,由保守 approach.Methods 与那些相比对待有 STEMI 的 75 岁介绍了的 102 个病人 12 个小时随机仅仅被分配到主要一种总线标准( n=50 )或保守治疗( n=52 )。在一个年的基线特征,在里面医院结果和主要不利心脏的事件(向),包括的死亡,非致命的心肌的梗塞和目标容器 revascularization 临床的后续在二 groups.Results 年龄之间被比较,性分发,为冠的动脉疾病的风险因素,梗塞地点和临床的功能的地位在二个组之间是类似的,但是在主要一种总线标准组的病人在住院期间收到了更少的 low-molecularweight 肝磷脂。与保守的组相比,在主要一种总线标准的病人组织重新梗塞和死亡和弄短的医院停留的有的显著地更低的出现率。为在 30 天的后续的在里面医院幸存的合成端点在二个组之间是类似的,但是一个年向率在主要一种总线标准组是显著地更低的(21.3% 和 45.2% , P=0.029 ) 。左室的喷射部分显著地没在后续期间在两个组被改变。Multivariate 分析揭示了那个主要一种总线标准(OR=0.34, 95% CI:0.21-0.69, P =0.03 ) 为我们的结果显示了的 75 years.Conclusion 的 STEMI 病人的改进没有向的幸存率那个主要一种总线标准在与 STEMI 为老病人减少在里面医院死亡和一个年向率安全、有效。 | ZHANG Qi ZHANG Rui-yan ZHANG Jian-sheng HU Jian YANG Zhen-kun ZHENG Ai-fang ZHANG Xian SHEN Wei-feng | 2006 | Chinese Medical Journal2006，，14： | 54 |
| 5 | Prevalence of Atrial Fibrillation in China and Its Risk Factors显示文摘Objective To study the prevalence of atrial fibrillation(AF)and the relation with its risk factors in China.Methods A total of 19 363 participants(8635 males and 10 728 females) aged ≥35 years in geographically dispersed urban and rural regions of China were included in this cross-sectional survey.All participants received questionnaire,physical and blood examination.Echocardiography were performed for AF patients found in the survey.Results Of the 19 363 participants,199 were diagnosed with AF.The estimated age-standardized prevalence of AF was 0.78% in men and 0.76% in women.The prevalence of AF in participants aged <60 years was 0.41% in men and 0.43% in women,and was 1.83% in both men and women aged ≥60 years.About 19.0% of males and 30.9% of females with AF were diagnosed with valve disease.Age-and sex-adjusted multivariable logistic regression analysis revealed that myocardial infarction,left ventricular hypertrophy(LVH),obesity,and alcohol consumption were associated with a increased risk of AF(P<0.05).Conclusion The age standardized prevalence of AF is 0.77% in the participants enrolled in the present study.The number of AF cases aged ≥35 years is 5.26 million according to 2010 Chinese Census.Most risk factors for AF,identified mainly in Western countries,are also detected in China. | LI Ying WU Yang Feng CHEN Ke Ping LI Xian ZHANG Xing XIE Gao Qiang WANG Fang Zheng ZHANG Shu | 2013 | Biomedical and Environmental Sciences2013，26，9： | 48 |
| 6 | Chinese Stroke Center Alliance:a national effort to improve healthcare quality for acute stroke and transient ischaemic attack:rationale,design and preliminary findings显示文摘Background In June 2015,the Chinese Stroke Association(CSA)initiated the Chinese Stroke Center Alliance(CSCA)to establish the national hospital-based stroke care quality assessment and improvement platform.This article outlines its objectives,operational structure,patient population,quality improvement(QI)intervention tools,data elements,data collection methodology and current patient and hospital data.Methods The CSCA is a national,hospital-based,multicentre,voluntary,multifaceted intervention and continuous QI initiative.This multifaceted intervention includes stroke centre development,written care protocols,workshops and a monitoring/feedback system of evidencebased performance measures.The data coordinating centre of the CSCA resides at the China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital.results As of July 2017,1576 hospitals in China have contributed detailed clinical information to serve as a benchmark for the stroke care quality of 433264 patients with acute stroke/transient ischaemic attacks(TIA),including 352572(81.38%)acute ischaemic stroke,30362(7.01%)TIA,42080(9.71%)spontaneous intracranial haemorrhage,5505(1.27%)subarachnoid haemorrhage and 2745(0.63%)not specified stroke.Conclusion The CSCA programme is designed to establish a continuous national stroke registry and help healthcare providers develop stroke centres and treat patients in a consistent manner in accordance with accepted national guidelines and,ultimately,improve patient outcomes.It supports the CSA mission to reduce stroke burden in China. | Yongjun Wang Zixiao Li Yilong Wang Xingquan Zhao Liping Liu Xin Yang Caiyun Wang Hongqiu Gu Fuying Zhang Chunjuan Wang Ying Xian David Z Wang Qiang Dong Anding Xu Jizong Zhao Chinese Stroke Center Alliance investigators | 2018 | Stroke & Vascular Neurology2018，3，4： | 38 |
| 7 | Geochemistry and regional distribution of ophiolites and associated volcanics in Mianlüe suture, Qinling-Dabie Mountains显示文摘Systematic studies of the ophiolites and associated volcanics stretching more than 1500 km from the Derni-Nanping-Pipasi-Kangxian area in the west to the Qingshuihe area of the south Dabie Mountains in the east indicate the existence of a suture zone (the Mianl黣 suture) and a vanished paleo-ocean basin (the Mianl黣 paleo-ocean basin) in the region. From west to east, ophiolitic mlange associations distribute discontinuously along the suture. Rock assem-blages include ophiolite, island arc and oceanic island rock series. The Mianl黣 paleo-ocean basin experienced its major formation and expending episode during the Carboniferous-Permian period. The finding of the suture zone and the paleo-ocean basin is tectonically significant in timing the collision between the North China-Qinling and Yangtze blocks and determining the formation and evolution of the Qinling orogenic belt. | LAI Shaocong, ZHANG Guowei, DONG Yunpeng, PEI Xianzhi & CHEN Liang Key Laboratory of Continental Dynamics, Ministry of Education and Department of Geology, Northwest University, Xian 710069, China | 2004 | Science China Earth Sciences2004，47，4： | 25 |
| 8 | Antidepressant-like effect of essential oil of Perilla frutescens in a chronic, unpredictable, mild stress-induced depression model mice显示文摘Perilla frutescens(Perilla leaf), a garnishing vegetable in East Asian countries, as well as a plant-based medicine, has been used for centuries to treat various conditions, including depression. Several studies have demonstrated that the essential oil of P. frutescens(EOPF) attenuated the depressive-like behavior in mice. The present study was designed to test the anti-depressant effects of EOPF and the possible mechanisms in an chronic, unpredictable, mild stress(CUMS)-induced mouse model. With the exposure to stressor once daily for five consecutive weeks, EOPF(3, 6, and 9 mg·kg-1) and a positive control drug fluoxetine(20 mg·kg-1) were administered through gastric intubation to mice once daily for three consecutive weeks from the 3rd week. Open-field test, sucrose consumption test, tail suspension test(TST), and forced swimming test(FST) were used to evaluate the behavioral activity. The contents of 5-hydroxytryptamine(5-HT) and its metabolite, 5-hydroxyindoleacetic acid(5-HIAA), in mouse hippocampus were determined by HPLC–ECD. Serum interleukin(IL)-1, IL-6, and tumor necrosis factor(TNF)-α levels were evaluated by enzyme-linked immunosorbent assay(ELISA). The results showed that CUMS significantly decreased the levels of 5-HT and 5-HIAA in the hippocampus, with an increase in plasma IL-6, IL-1β, and TNF-α levels. CUMS also reduced open-field activity, sucrose consumption, as well as increased immobility duration in FST and TST. EOPF administration could effectively reverse the alterations in the concentrations of 5-HT and 5-HIAA; reduce the IL-6, IL-1β, and TNF-α levels. Moreover, EOPF could effectively reverse alterations in immobility duration, sucrose consumption, and open-field activity. However, the effect was not dose-dependent. In conclusion, EOPF administration exhibited significant antidepressant-like effects in mice with CUMS-induced depression. The antidepressant activity of EOPF might be related to the relation between alteration of serotonergic responses and anti-inflammatory effects. | JI Wei-Wei LI Rui-Peng LI Meng WANG Shu-Yuan ZHANG Xian NIU Xing-Xing LI Wei YAN Lu WANG Yang FU Qiang MA Shi-Ping | 2014 | Chinese Journal of Natural Medicines2014，12，10： | 26 |
| 9 | Latest Progress of the Chinese Meteorological Satellite Program and Core Data Processing Technologies显示文摘In this paper,the latest progress,major achievements and future plans of Chinese meteorological satellites and the core data processing techniques are discussed.First,the latest three FengYun(FY)meteorological satellites(FY-2H,FY-3D,and FY-4A)and their primary objectives are introduced Second,the core image navigation techniques and accuracies of the FY meteorological satellites are elaborated,including the latest geostationary(FY-2/4)and polar-orbit(FY-3)satellites.Third,the radiometric calibration techniques and accuracies of reflective solar bands,thermal infrared bands,and passive microwave bands for FY meteorological satellites are discussed.It also illustrates the latest progress of real-time calibration with the onboard calibration system and validation with different methods,including the vicarious China radiance calibration site calibration,pseudo invariant calibration site calibration,deep convective clouds calibration,and lunar calibration.Fourth,recent progress of meteorological satellite data assimilation applications and quantitative science produce are summarized at length.The main progress is in meteorological satellite data assimilation by using microwave and hyper-spectral infrared sensors in global and regional numerical weather prediction models.Lastly,the latest progress in radiative transfer,absorption and scattering calculations for satellite remote sensing is summarized,and some important research using a new radiative transfer model are illustrated. | Peng ZHANG Qifeng LU Xiuqing HU Songyan GU Lei YANG Min MIN Lin CHEN Na XU Ling Sun Wenguang BAI Gang MA Di XIAN | 2019 | Advances in Atmospheric Sciences2019，36，9： | 26 |
| 10 | One-year clinical outcomes of Chinese sirolimus-eluting stent in the treatment of unselected patients with coronary artery disease显示文摘 | ZHANG Qi ZHANG Rui-yan ZHANG Jian-sheng HU Jian YANG Zhen-kun NI Jun FANG Yue-hua ZHANG Xian SHEN Wei-feng | 2006 | Chinese Medical Journal2006，，2： | 23 |
| 11 | Impact of admission creatinine level on clinical outcomes of patients with acute ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention with drug-eluting stent implantation显示文摘收到了主要经皮的冠的干预(一种总线标准)的有尖锐圣举起心肌的梗塞( STEMI )和肾的机能障碍( RD )的病人的背景预后充分没在 era.This 学习试图在病人在短期的结果上评估承认浆液 creatinine 水平的影响的 drug-eluting stent ( DES )被调查与经历 基于DES 的主要 PCI.Methods 的尖锐 STEMI ,有 DES 培植的主要一种总线标准在 12 个小时以内在 619 个连续 STEMI | ZHANG Qi ZHANG Rui-yan SHEN Jie ZHANG Jian-sheng HU Jian YANG Zheng-kun ZHANG Xian ZHENG Ai-fang SHEN Wei-feng | 2008 | Chinese Medical Journal2008，，23： | 22 |
| 12 | Report on Childhood Obesity in China (9): Sugar-sweetened Beverages Consumption and Obesity显示文摘Objective To explore the associations between sugar-sweetened beverage (SSB) consumption and obesity as well as obesity-related cardiometabolic disorders among children in China. Methods A total of 6974 (boys 3558, girls 3412) children aged 6-13 years participated in the study. Each participant's height, weight, waist circumference, fasting glucose, triglycerides, total cholesterol, high- density lipoprotein cholesterol, and low-density lipoprotein cholesterol were measured. The type of beverage consumption was determined using a self-administered questionnaire. Results SSBs were consumed regularly by 46.1% of the children. The prevalence [adjusted odds ratio (95% confidence internal (CI)] of obesity was 7.6% [as the reference group (ref.)], 10.1% [1.36(1.07, 1.74)], and 11.6% [1.46(1.21, 1.75)], among children who regularly drank milk, other beverages and SSBs, respectively. Regularly drinking SSBs elevated the likelihood of abdominal obesity [adjusted odds ratio (95% CI): 1.36 (1.17, 1.59)]. The prevalence [adjusted odds ratio (95% CI)] of obesity among children who regularly drank sports/caloric beverages, carbonated beverages, sweet tea, and plant protein beverages was 16.8% [2.00(1.31, 3.07)], 12.7% [1.52(1.23, 1.88)], 11.5% [1.52(1.18, 1.95)], and 10.4% [1.41(1.03, 1.94)], respectively, which was higher than that of regular milk drinkers [7.6 % (ref.)]. The prevalence [adjusted odds ratio (95% CI)] of abdominal obesity among children who regularly drank sweet tea, fruit/vegetable juices, and carbonated beverages was 17.7% [1.55(1.26, 1.90)], 16.2% [1.36(1.09, 1.70)], and 15.3% [1.24(1.03, 1.50)], respectively, which was much higher than that of regular milk drinkers [12.8% (ref.)]. Conclusions Regular SSB consumption was positively related to obesity and abdominal obesity. This relationship should be investigated further using a longitudinal study design. | SHANG Xian Wen LIU Ai Ling ZHANG Qian HU Xiao Qi DU Song Ming MA Jun XU Gui Fa LI Ying GUO Hong Wei DU Lin LI Ting Yu MA Guan Sheng | 2012 | Biomedical and Environmental Sciences2012，25，2： | 23 |
| 13 | Effect of Rhubarb on Gastrointestinal Dysfunction in Critically III Patients: A Retrospective Study Based on Propensity Score Matching显示文摘 | Xian Zhang Lyu Wang De-Chang Chen | 2018 | Chinese Medical Journal2018，，10： | 22 |
| 14 | Multiple imaging techniques in the diagnosis of ampullary carcinoma显示文摘BACKGROUND:Ampullary carcinoma is a neoplasia with a good prognosis compared to pancreatic cancer. But it is difficult to early diagnose because it lacks clear clinical symptoms.This study aimed to evaluate the efficacy of abdominal ultrasonography(US),enhanced computed tomography(CT),magnetic resonance cholangiopancreatography(MRCP)and endoscopic retrograde cholangiopancreatography(ERCP)in detecting ampullary carcinoma. METHODS:Forty-one patients with ampullary carcinoma who had been confirmed pathologically among the inpatients at the First Affiliated Hospital of Zhejiang University School of Medicine from February 2003 to March 2007 were analyzed retrospectively.The accuracy of US,CT,MRCP and ERCP were compared in the diagnosis of ampullary carcinoma. RESULTS:The accurate rate for detection of ampullary carcinoma with US was 26.83%.The accuracy of CT and ERCP in detection of ampullary tumors was 84.62%and 100%,respectively,which were significantly higher than that of US(P<0.05).The accuracy of MRCP in detection of ampullary tumors was similar to that of US in spite of visualization of obstruction and dilatation of the pancreaticobiliary duct with MRCP. CONCLUSIONS:Because of the obscure and late onset of symptoms,ampullary carcinoma is difficult to diagnose early.Multiple imaging techniques should be carried out appropriately in order to early diagnose the disease and improve the prognosis. | Chen, Wei-Xing Xie, Qi-Gui Zhang, Wei-Fang Zhang, Xian Hu, Tian-Tian Xu, Ping Gu, Zhu-Ying | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，6： | 20 |
| 15 | Inhibitory effects of tanshinone Ⅱ-A on invasion and metastasis of human colon carcinoma cells显示文摘 | Yun-feng SHAN Xian SHEN Yuan-kang XIE Ji-cai CHEN Hong-qi SHI Zheng-ping YU Qi-tong SONG Men-tao ZHOU Qi-yu ZHANG | 2009 | Acta Pharmacologica Sinica2009，30，11： | 18 |
| 16 | Effect of icarisid II on diabetic rats with erectile dysfunction and its potential mechanism via assessment of AGEs, autophagy, roTOR and the NO-cGMP pathway显示文摘可勃起的机能障碍(编辑) 是糖尿病 mellitus 的主要复杂并发症。Icariin 被显示了通过它的 bioactive 形式提高可勃起的功能, icarisid II。这研究经由对先进 glycosylation 结束的评价与编辑和它的潜在的机制在糖尿病的老鼠上调查 icarisid II 的效果产品(年龄) , autophagy, mTOR 和 NO-cGMP 小径。Icarisid II 被一个酶的方法从 icariin 提取。在控制和糖尿病的编辑组,老鼠被管理正常盐;在 icarisid II 组,老鼠 intragastrically 是管理 icarisid II。可勃起的功能被测量 intracavernosal 压力 / 平均数评估动脉的压力(ICP/MAP ) 。年龄集中,氮的氧化物 synthase (NOS ) 活动和 cGMP 集中被酶免疫分析估计。房间增长被分析使用甲基 thiazolyl tetrazolium 试金和流动 cytometry。Autophagosomes 被传播电子显微镜学, monodansylcadaverine 染色和 GFP-LC3 本地化观察。在 autophagy 的 NOS isoforms 和关键蛋白质的表示被西方的污点检验。我们的结果证明了 Icarisid II 增加了 ICP/MAP 价值,光滑的肌肉房间(SMC ) 生长曲线, S 阶段和 SMC/collagen 纤丝(SMC/CF ) 比例和减少的 Beclin 1 (P< 0.05 ) 。Icarisid II 显著地增加了 proliferative 索引和 p-p70S6K (Thr389 ) 层次并且减少 autophagosomes 的数字和 LC3-II 的层次(P< 0.01 ) 。Icarisid II 减少了年龄集中和增加的 cGMP 集中, NOS 活动(P< 0.05 ) 并且 cNOS 层次(P< 0.01 ) 在糖尿病的编辑组。因此, Icarisid II 组成有希望的混合物因为糖尿病的编辑和力量涉及 SMC 增长和 NO-cGMP 小径和年龄, autophagy 和 mTOR 小径的 downregulation 的 upregulation。 | Jian Zhang Ai-Min Li Bao-Xing Liu Fei Han Feng Liu Shao-Peng Sun Xin Li Shu-Jin Cui Shao-Zhong Xian Guang-Qi Kong Zhong-Cheng Xin Zhi-Li Ji | 2013 | Asian Journal of Andrology2013，15，1： | 17 |
| 17 | Genome-wide identification and characterization of odorant-binding protein (OBP) genes in the malaria vector Anopheles sinensis (Diptera: Culicidae)显示文摘疟蚊属 sinensis 是主要疟疾向量。昆虫有气味的东西绑定蛋白质(OBP ) 可以在嗅觉的系统在有气味的东西的接收工作。分类和描述一。sinensis OBP 基因系统地没被学习。在这研究, 64 通常认为的 OBP 基因在整个染色体的水平被识别一。sinensis 基于在 OBP 之间的比较保存了主题, PBP_GOBP,和种系发生的分析与一。gambiae OBP。描述一。包括主题保存,基因结构, genomic 组织和分类, sinensis OBP 被调查。新基因, AsOBP73,属于 Plus-C 亚科,与抄本和保守主题的支持被识别。这些一。sinensis OBP 基因在亚科经典著作与 37, 15 和 12 基因被分类进三个亚科,不正常并且 Plus-C 分别地。genomic 组织一。sinensis OBP 越过九不同脚手架建议聚类的分布。八基因(OBP23-28, OBP63-64 ) 可能至少在疟蚊属,一种蚊虫和豹脚蚊的分叉前通过一系列历史性的复制事件从单个基因发源。microsynteny 分析显示很高的 synteny 在之间一。sinensis 并且一。gambiae OBP。更早在 Plus-C 下面分类在的 OBP70 和 OBP71 一。gambiae 作为属于经典亚科的组 Obp59a 被认出,并且更早在 Plus-C 下面分类的 OBP69 在这研究被移动了到不正常的亚科。学习在昆虫以及在为 OBP 基因的进一步的学习建立了一个基本信息框架一。sinensis。 | Xiu He Zheng-Bo He Yu-Juan Zhang Yong Zhou Peng-Jie Xian Liang Qiao Bin Chen | 2016 | Insect Science2016，23，3： | 16 |
| 18 | Potentially predictive microRNAs of gastric cancer with metastasis to lymph node显示文摘AIM:To detect the expression of 60 microRNAs(miRNAs)in gastric cancer tissues and find new predictive biomarkers of gastric cancer with metastasis.METHODS:The expressions of 60 candidate miRNAs in 30 gastric cancer tissues and paired normal tissues were detected by stem-loop real-time reverse transcription-polymerase chain reaction.After primary screening of miRNAs expression,5 selected miRNAs were further testified in another 22 paired gastric tissues.Based on the expression level of miRNAs and the status of metastasis to lymph node(LN),receiver-operating-characteristic(ROC)curve were used to evaluate their ability in predicting the status of metastasis to LN.RESULTS:Thirty-eight miRNAs expressions in gastric cancer tissues were significantly different from those in paired normal tissues(P<0.01).Among them,31miRNAs were found to be up-expressed in cancer tissues and 1 miRNAs were down-expressed≥1.5 fold vs paired normal gastric tissue.Five microRNAs(miR-125a-3p,miR-133b,miR-143,miR-195 and miR-212)were differently expressed between different metastatic groups in 30 gastric cancer biopsies(P<0.05).Partial correlation analysis showed that hsa-mir-212 and hsa-mir-195 were correlated with the status of metastasis to LN in spite of age,gender,tumor location,tumor size,depth of invasion and cell differentiation.ROC analysis indicated that miR-212 and miR-195 have better sensi-tivities(84.6%and 69.2%,respectively)and specifici-ties(both 100%)in distinguishing biopsies with metastasis to LN from biopsies without metastasis to LN.CONCLUSION:miR-212 and miR-195 could be independent biomarkers in predicting the gastric cancer with metastasis to LN. | Wen-Yi Wu Xiang-Yang Xue Zhe-Jing Chen Shao-Liang Han Ying-Peng Huang Li-Fang Zhang Guan-Bao Zhu Xian Shen | 2011 | World Journal of Gastroenterology2011，17，31： | 15 |
| 19 | Bone morphogenetic protein-7 represses hepatic stellate cell activation and liver fibrosis via regulation of TGF-β/Smad signaling pathway显示文摘BACKGROUND Liver fibrosis is a refractory disease whose persistence can eventually induce cirrhosis or even liver cancer.Early liver fibrosis is reversible by intervention.As a member of the transforming growth factor-beta(TGF-β)superfamily,bone morphogenetic protein 7(BMP7)has anti-liver fibrosis functions.However,little is known about BMP7 expression changes and its potential regulatory mechanism as well as the relationship between BMP7 and TGF-βduring liver fibrosis.In addition,the mechanism underlying the anti-liver fibrosis function of BMP7 needs to be further explored.AIM To investigate changes in the dynamic expression of BMP7 during liver fibrosis,interactions between BMP7 and TGF-β1,and possible mechanisms underlying the anti-liver fibrosis function of BMP7.METHODS Changes in BMP7 expression during liver fibrosis and the interaction between BMP7 and TGF-β1 in mice were observed.Exogenous BMP7 was used to treat mouse primary hepatic stellate cells(HSCs)to observe its effect on activation,migration,and proliferation of HSCs and explore the possible mechanism underlying the anti-liver fibrosis function of BMP7.Mice with liver fibrosis received exogenous BMP7 intervention to observe improvement of liver fibrosis by using Masson’s trichrome staining and detecting the expression of the HSC activation indicator alpha-smooth muscle actin(α-SMA)and the collagen formation associated protein type I collagen(Col I).Changes in the dynamic expression of BMP7 during liver fibrosis in the human body were further observed.RESULTS In the process of liver fibrosis induced by carbon tetrachloride(CCl4)in mice,BMP7 protein expression first increased,followed by a decrease;there was a similar trend in the human body.This process was accompanied by a sustained increase in TGF-β1 protein expression.In vitro experiment results showed that TGF-β1 inhibited BMP7 expression in a time-and dose-dependent manner.In contrast,high doses of exogenous BMP7 inhibited TGF-β1-induced activation,migration,and proliferation of HSCs;this inhibitory effect was associated with upregulation of pSmad1/5/8 and downregulation of phosphorylation of Smad3 and p38 by BMP7.In vivo experiment results showed that exogenous BMP7 improved liver fibrosis in mice.CONCLUSION During liver fibrosis,BMP7 protein expression first increases and then decreases.This changing trend is associated with inhibition of BMP7 expression by sustained upregulation of TGF-β1 in a time-and dose-dependent manner.Exogenous BMP7 could selectively regulate TGF-β/Smad pathway-associated factors to inhibit activation,migration,and proliferation of HSCs and exert antiliver fibrosis functions.Exogenous BMP7 has the potential to be used as an antiliver fibrosis drug. | Gao-Liang Zou Shi Zuo Shuang Lu Rui-Han Hu Yin-Ying Lu Jing Yang Kai-Sheng Deng Ye-Ting Wu Mao Mu Juan-Juan Zhu Jing-Zhang Zeng Bao-Fang Zhang Xian Wu Xue-Ke Zhao Hai-Yang Li | 2019 | World Journal of Gastroenterology2019，25，30： | 15 |
| 20 | Reference values of brachial-ankle pulse wave velocity for Northern Chinese显示文摘背景臂脚关节的脉搏波浪速度(baPWV ) 是为测量动脉的弹性的一个可靠方法,但是为 baPWV 的引用价值的缺席限制了它的宽使用。我们在北方中国进行了传染病的研究调查 baPWV 的参考价值因为中国人民和它 974 全部的有影响的 factors.Methods A 鉴别健康对象在这研究被招募。baPWV 的价值为健康人口与自动 device.Results noninvasively 被评估, baPWV 的吝啬的价值为男性是更高的(P < 0.001 ) 。多重回归分析证明年龄和收缩血压断然为男性和女性与 baPWV 被联系(P < 0.001 ) 。BaPWV 价值比在在更年轻的组的女性在男性是更高的(< 50 年) 然而并非在更老的组(P0.001 ) 。 baPWV 的上面的限制是为在 .Conclusions 老化是的 10 年间隔(年龄范围 20-70 年)的健康男性/女性的 1394/1264 cm/s , 1435/1361 cm/s , 1552/1433 cm/s , 1597/1609 cm/s 和 1798/1915 cm/s 动脉的僵硬的最重要的原因,但是 baPWV 扩大上的年龄的效果比他们的男对应物为健康女性是更大的。由性别和年龄的 baPWV 的参考价值为临床、预防的药是很有用的。 | WANG Xian XIE Jiang ZHANG Li-jing HU Da-yi LUO Ya-li WANG Jin-wen | 2009 | Chinese Medical Journal2009，，18： | 15 |
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