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| 1 | Emerging blood-based biomarkers for detection of gastric cancer显示文摘Early detection and efficient monitoring of tumor dynamics are prerequisites for reducing disease burden and mortality, and for improving the management of patients with gastric cancer(GC). Blood-based biomarker assays for the detection of early-stage GC could be of great relevance both for population-wide or risk groupbased screening programs, while circulating biomarkers that reflect the genetic make-up and dynamics of the tumor would allow monitoring of treatment efficacy, predict recurrences and assess the genetic heterogeneity of the tumor. Recent research to identify blood-based biomarkers of GC has resulted in the identification of a wide variety of cancer-associated molecules, including various proteins, autoantibodies against tumor associated antigens, cell-free DNA fragments, m RNAs and various non-coding RNAs, circulating tumor cells and cancer-derived extracellular vesicles. Each type of these biomarkers provides different information on the disease status, has different advantages and disadvantages, and distinct clinical usefulness. In the current review, we summarize the recent developments in blood-based GC biomarker discovery, discuss the origin of various types of biomarkers and their clinical usefulness and the technological challenges in the development of biomarker assays for clinical use. | Zane Kalnina Irēna Meistere Ilze Kikuste Ivars Tolmanis Pawel Zayakin Aija Linē | 2015 | World Journal of Gastroenterology2015，21，41： | 7 |
| 2 | Sperm-associated antigens as targets for cancer immunotherapy:expression pattern and hu- moral immune response in cancer patients 显示文摘 | Silina K Zayakin P Kalnina Z | 2011 | J Immunother2011，34，1： | 1 |
| 3 | Alterations of pre mRNA splicing in cancer显示文摘 | KALNIN Z ZAYAKIN P SILIN K | 2005 | Genes Chromosome Canc2005，42，4： | 1 |
| 4 | Ranking-based kernels in applied piomedical diagnostics using support vector machine显示文摘 | Jumutc V Zayakin P Borisov A | 2011 | International Journal of Neural Systems2011，21，6： | 1 |
| 5 | Ranking-based kernels in applied biomedical diagnostics using support vector machine显示文摘 | Jumutc V Zayakin P Borisov A | 2011 | International Journal of Neural Systems2011，21，6： | 1 |
| 6 | Theoretical and experimental investigations of the effect of diffractive muhifocal focusing of radiation显示文摘 | Letfullin R R Zayakin O A George T F | 2001 | Appl Opt2001，40，13： | 1 |
| 7 | Ranking-based Kernels in Applied Biomedical Diagnostics Using Support Vector Machine显示文摘 | Jumutc V Zayakin P Borisov A | | 0，，06： | 1 |
| 8 | Sperm-associated antigens as targets for cancer immunotherapy: expression pattern and humoral immune response in cancer patients显示文摘 | Silina K Zayakin P Kalnina Z | 2011 | J Immunother2011，34，1： | 1 |
| 9 | Tumor-associated autoantibody signature for the early detection of gastric cancer显示文摘 | Zayakin P Ancans G Silina K | | 0，，1： | 1 |
| 10 | Alterations of pre-mRNA splicing in cancer显示文摘 | Kalnina Z Zayakin P Silina K | 2005 | Genes Chromosomes Cancer2005，42，4： | 1 |
| 11 | Derivatives of Thiohydrazides as Effective Antibacterial Remedies for Chlamydial Infection Treatment at Chronic Stages of Infections显示文摘 | Vladimir Nikolaevich Yarovenko Egor Sergeevich Zayakin Michail Mikhailovich Krayushkin Victoria Vladlmlrovna Zorma Lydia Nikolaevna Kapotina Nayha Akhatovna Zlganglrova | 2010 | Journal of Chemistry and Chemical Engineering2010，4，4： | 0 |
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