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| 1 | Guanidinium-based ionic liquids for sulfur dioxide sorption显示文摘 | Ying Shang Hongping Li Suojiang Zhang Hui Xu Zanxia Wang Li Zhang Jianmin Zhang | 2011 | Chemical Engineering Journal2011，，： | 2 |
| 2 | Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of Neuroligin显示文摘 | Li Xiang Zhang Jiahai Cao Zanxia | 2006 | Protein Science2006，15，9： | 1 |
| 3 | Remtoe sensingimage fusion based on local deviation of wavelet transform 显示文摘 | Qiang Zanxia Peng Jiaxiong Wang Hongqun | 2003 | Journal of Huazhong University of Science and Technology2003，31，6： | 1 |
| 4 | Structural and thermodynamics characters of isolated α-syn12 peptide: long-time temperature replica-exchange molecular dynamics in aqueous solution显示文摘结构并且 -syn12 的热力学字符(残余 112 人的 -synuclein 蛋白质) 在水的答案的肽通过有 GROMOS 43A1 力量的分子的动力学(T-REMD ) 模拟回答的温度复制品交换被调查。二独立 T-REMD 模拟被完成分别地从一个起始的 conformational 螺旋和不规则的结构开始。每件复制品被竞选 300 ns。结构并且热力学人物基于象脊梁的分布那样的参数被学习二面的角度,免费精力表面,合拢的发卡结构的稳定性,和喜爱的符合构造。结果证明水里的孤立的 -syn12 肽采用了四个不同 conformational 状态:第一个状态是有 Turn96 和四张氢契约的一个发卡整体,第二个状态是有二拐弯(Turn96 和 Turn52 ) 的一个发卡整体,三氢结合,第三个状态是混乱结构与 Turn85 和 Turn52,和最后说是一个螺旋整体。同时,我们从展开的状态学习了 -syn12 肽的免费精力变化到发卡状态,它为一些另外的肽在对实验和分子的动力学模拟的好同意。我们也分析了肽转变的驱动力。结果显示驱动力在第二等的结构是恐水病的 Leu8 和恐水病的残余的高溶剂暴露。到我们的知识,这是第一份报告由 T-REMD 在水里学习孤立的 -syn12 肽。 | Zanxia Cao Lei Liu Ping Wu Jihua Wang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，3： | 0 |
| 5 | Mechanical stretching boosts expansion and regeneration of intestinal organoids through fueling stem cell self-renewal显示文摘Intestinal organoids,derived from intestinal stem cell self-organization,recapitulate the tissue structures and behav-iors of the intestinal epithelium,which hold great potential for the study of developmental biology,disease modeling,and regenerative medicine.The intestinal epithelium is exposed to dynamic mechanical forces which exert profound effects on gut development.However,the conventional intestinal organoid culture system neglects the key role of mechanical microenvironments but relies solely on biological factors.Here,we show that adding cyclic stretch to intestinal organoid cultures remarkably up-regulates the signature gene expression and proliferation of intestinal stem cells.Furthermore,mechanical stretching stimulates the expansion of SOX9+progenitors by activating the Wnt/β-Catenin signaling.These data demonstrate that the incorporation of mechanical stretch boosts the stemness of intestinal stem cells,thus benefiting organoid growth.Our findings have provided a way to optimize an organoid generation system through understanding cross-talk between biological and mechanical factors,paving the way for the application of mechanical forces in organoid-based models. | Fanlu Meng Congcong Shen Li Yang Chao Ni Jianyong Huang Kaijun Lin Zanxia Cao Shicai Xu Wanling Cui Xiaoxin Wang Bailing Zhou Chunyang Xiong Jihua Wang Bing Zhao | 2022 | Cell Regeneration2022，11，1： | 0 |
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