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| 1 | Small bowel ulcerative lesions are common in elderly NSAIDs users with peptic ulcer bleeding显示文摘AIM: To determine the frequency of small bowel ulcerative lesions in patients with peptic ulcer and define the significance of those lesions. METHODS: In our prospective study, 60 consecutive elderly patients with upper gastrointestinal bleeding from a peptic ulceration(cases) and 60 matched patients with a non-bleeding peptic ulcer(controls) underwent small bowel capsule endoscopy, after a negative colonoscopy(compulsory in our institution). Controls were evaluated for non-bleeding indications. Known or suspected chronic inflammatory conditions and medication that could harm the gut were excluded. During capsule endoscopy, small bowel ulcerative lesions were counted thoroughly and classified according to Graham classification. Other small bowellesions were also recorded. Peptic ulcer bleeding was controlled endoscopically, when adequate, proton pump inhibitors were started in both cases and controls, and Helicobacter pylori eradicated whenever present. Both cases and controls were followed up for a year. In case of bleeding recurrence upper gastrointestinal endoscopy was repeated and whenever it remained unexplained it was followed by repeat colonoscopy and capsule endoscopy.RESULTS: Forty(67%) cases and 18(30%) controls presented small bowel erosions(P = 0.0001), while 22(37%) cases and 4(8%) controls presented small bowel ulcers(P < 0.0001). Among non-steroidal antiinflammatory drug(NSAID) consumers, 39(95%) cases and 17(33%) controls presented small bowel erosions(P < 0.0001), while 22(55%) cases and 4(10%) controls presented small bowel ulcers(P < 0.0001). Small bowel ulcerative lesions were infrequent among patients not consuming NSAIDs. Mean entry hemoglobin was 9.3(SD = 1.4) g/d L in cases with small bowel ulcerative lesions and 10.5(SD = 1.3) g/dL in those without(P = 0.002). Cases with small bowel ulcers necessitate more units of packed red blood cells. During their hospitalization, 6(27%) cases with small bowel ulcers presented bleeding recurrence most possibly attributed to small bowel ulcers, nevertheless 30-d mortality was zero. Presence of chronic obstructive lung disease and diabetes was related with unexplained recurrence of hemorrhage in logistic regression analysis, while absence of small bowel ulcers was protective(relative risk 0.13, P = 0.05).CONCLUSION: Among NSAID consumers, more bleeders than non-bleeders with peptic ulcers present small bowel ulcers; lesions related to more severe bleeding and unexplained episodes of bleeding recurrence. | Panagiotis Tsibouris Chissostomos Kalantzis Periklis Apostolopoulos Antonios Zalonis Peter Edward Thomas Isaacs Mark Hendrickse Georgios Alexandrakis | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，12： | 6 |
| 2 | Gastric cancer in the elderly: An overview显示文摘 | M.W. Saif N. Makrilia A. Zalonis M. Merikas K. Syrigos | 2010 | European Journal of Surgical Oncology2010，，8： | 2 |
| 3 | Targeted therapy for oesophageal cancer:an overview显示文摘 | Syrigos KN Zalonis A Kotteas E | | 0，，02： | 1 |
| 4 | Gastric cancer in the elderly: an overview显示文摘 | Saif MW Makrilia N Zalonis A | 2010 | Eur J Surg Oncol2010，36，8： | 1 |
| 5 | Gastric cancer in the elderly: an overview显示文摘 | Saif MW Makrilia N Zalonis N | 2010 | Eur J Surg Oncol2010，36，8： | 1 |
| 6 | Cognition in epilepsy amultichannel event-related study显示文摘 | JRIANTAFYLLON NJ ZALONIS KOKTIS P | 1992 | Acta Neurol Scand1992，86，5： | 1 |
| 7 | Selective Reminding Test:demographic predictors of performance and normative data for the Greek population显示文摘 | Zalonis I Kararizou E Christidi F | 2009 | Psychol Rep2009，104，2： | 1 |
| 8 | Gastric cancer in the elderly:an overview显示文摘 | Saif MW Makrilia N Zalonis A | | 0，，： | 1 |
| 9 | Targeted therapy for oesophageal cancer: an overview 显示文摘 | Yrigos KN Zalonis A Kotteas E | 2008 | Cancer Metastasis Rev2008，27，2： | 1 |
| 10 | Unusual cases of multiple symmetrical lipomatosis with neurological disorders 显示文摘 | Triantafyllou NI Zalonis I Kararizos G | 2009 | Clin Med Res2009，7，： | 1 |
| 11 | Gastric cancer in the elderly:an overview显示文摘 | Saif MW Makrilia N Zalonis A | 2010 | Eur J Surg Oncol2010，36，8： | 1 |
| 12 | Targeted therapyfor oesophageal cancer:an overview显示文摘 | Syrigos KN Zalonis A Kotteas E | 2008 | Cancer Metasta-sis Rev2008，27，2： | 1 |
| 13 | Cognition in homozygous beta-thalassemia disease:a multichannel auditory event-related potential (P300) study显示文摘 | Triantafyllou NI Anthracopoulos M Zalonis I | 1992 | Electromyogr Clin Neurophysiol1992，32，1011： | 1 |
| 14 | Cognition in Epilepsy amultichannel event-related stady显示文摘 | Jriantafyllon NI Zalonis Koktis P | 1992 | Acta Neurol Scand1992，86，5： | 1 |
| 15 | Gastric emptying after semi–solid food in multiple system atrophy and Parkinson disease显示文摘 | T. Thomaides T. Karapanayiotides Y. Zoukos C. Haeropoulos E. Kerezoudi N. Demacopoulos G. Floodas E. Papageorgiou F. Armakola Y. Thomopoulos I. Zaloni | 2005 | Journal of Neurology2005，，9： | 1 |
| 16 | Targeted therapy for oesoph- ageal cancer: an overview 显示文摘 | Syrigos KN Zalonis A Kotteas E | 2008 | Cancer Metastasis Rev2008，27，2： | 1 |
| 17 | Unusual cases of multiple symmetrical lipomatosis with neurological disorders显示文摘 | Triantafyllou NL Zalonis I Kararizos G | 2009 | Clin Meal Res2009，7，4： | 1 |
| 18 | Cognition in epilepsy amultichannel event-related study显示文摘 | Jriantafyllon N J Zalonis Koktis P | 1992 | Aeta Neurol Seand1992，86，5： | 1 |
| 19 | Gastric cancer in the elderly:An overview显示文摘 | Saif MW Makrilia N Zalonis A | | 0，，08： | 1 |
| 20 | Targeted therapy for oesophageal cancer: an overview显示文摘 | Syrigos KN Zalonis A Kotteas E | 2008 | Cancer Metastasis Rev2008，27，2： | 1 |
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