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| 1 | Safety and efficacy of ciprofol vs.propofol for sedation in intensive care unit patients with mechanical ventilation:a multi-center,open label,randomized,phase 2 trial显示文摘Background:Ciprofol(HSK3486;Haisco Pharmaceutical Group Co.,Ltd.,Chengdu,China),developed as a novel 2,6-disubstituted phenol derivative showed similar tolerability and efficacy characteristics as propofol when applicated as continuous intravenous infusion for 12 h maintenance sedation in a previous phase 1 trial.The phase 2 trial was designed to investigate the safety,efficacy,and pharmacokinetic characteristics of ciprofol for sedation of patients undergoing mechanical ventilation.Methods:In this multicenter,open label,randomized,propofol positive-controlled,phase 2 trial,39 Chinese intensive care unit patients receiving mechanical ventilation were enrolled and randomly assigned to a ciprofol or propofol group in a 2:1 ratio.The ciprofol infusion was started with a loading infusion of 0.1-0.2 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 0.30 mg·kg^(-1)·h^(-1),which could be adjusted to an infusion rate of 0.06 to 0.80 mg·kg^(-1)·h^(-1),whereas for propofol the loading infusion dose was 0.5-1.0 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 1.50 mg·kg^(-1)·h^(-1),which could be adjusted to 0.30-4.00 mg·kg^(-1)·h^(-1)to achieve-2 to+1 Richmond Agitation-Sedation Scale sedation within 6-24 h of drug administration.Results:Of the 39 enrolled patients,36 completed the trial.The median(min,max)of the average time to sedation compliance values for ciprofol and propofol were 60.0(52.6,60.0)min and 60.0(55.2,60.0)min,with median difference of 0.00(95%confidence interval:0.00,0.00).In total,29(74.4%)patients comprising 18(69.2%)in the ciprofol and 11(84.6%)in the propofol group experienced 86 treatment emergent adverse events(TEAEs),the majority being of severity grade 1 or 2.Drug-and sedation-related TEAEs were hypotension(7.7%vs.23.1%,P=0.310)and sinus bradycardia(3.8%vs.7.7%,P=1.000)in the ciprofol and propofol groups,respectively.The plasma concentration-time curves for ciprofol and propofol were similar.Conclusions:ciprofol is comparable to propofol with good tolerance and efficacy for sedation of Chinese intensive care unit patients undergoing mechanical ventilation in the present study setting.Trial registration:ClinicalTrials.gov,NCT04147416. | Yongjun Liu Xiangyou Yu Duming Zhu Jun Zeng Qinhan Lin Bin Zang Chuanxi Chen Ning Liu Xiao Liu Wei Gao Xiangdong Guan | 2022 | Chinese Medical Journal2022，，9： | 19 |
| 2 | Research Progress on Heat Stress of Rice at Flowering Stage显示文摘Global warming has caused frequent occurrence of heat stress at the flowering stage of single-season rice in the Yangtze River region of China, which results in declines of spikelet fertility and yield in rice. Rice flowering stage is the most sensitive period to high temperatures, and therefore, the key for heat stress happening is the flowering stage coinciding with high temperature, which causes spikelet fertility decreasing in heat-sensitive varieties, and is the major factor for heat injury differences among various rice planting regions. With the development of rice breeding, temperature indexes for heat stress has been converted from daily maximum temperature of 35 oC to 38 oC with the stress duration of more than 3 d. During the flowering stage, anther dehiscence inhibition and low pollen shedding onto the stigma are two main reasons for spikelet fertility reduction under high temperatures. At panicle initiation stage, high temperatures aggravate spikelet degeneration, and destroy floral organ development. Various types of rice varieties coexist in production, and indica-japonica hybrid rice demonstrates the highest heat resistance in general, followed by indica and japonica rice varieties. In production, avoiding high temperature is the main strategy of preventing heat stress, and planting suitable cultivars and adjustment of sowing date are the most effective measures. Irrigation is an effective real-time cultivation measure to decline the canopy temperature during the rice flowering stage. We suggested that further study should be focused on exploring heat injury differences among different rice variety types, and innovating rice-planting methods according to planting system changes in rice planting regions with extreme heat stress. Meanwhile, high temperature monitor and warning systems should be improved to achieve optimal heat stress management efficiencies. | WANG Yaliang WANG Lei ZHOU Jianxia HU Shengbo CHEN Huizhe XIANG Jing ZHANG Yikai ZENG Yongjun SHI Qinghua ZHU Defeng ZHANG Yuping | 2019 | Rice science2019，26，1： | 13 |
| 3 | Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid‐induced apoptosis through down‐regulation of EZH 2 expression by miR ‐101显示文摘 | Yongjun Wang Wei Xiang Miao Wang Tao Huang Xingyuan Xiao Liang Wang Dan Tao Liyun Dong Fuqing Zeng Guosong Jiang | 2014 | Br J Pharmacol2014，，3： | 2 |
| 4 | A study of Ni-based WC composite coatings by laser induction hybrid rapid cladding with elliptical spot 显示文摘 | ZHOU SHENGFENG HUANG YONGJUN ZENG XIAOYAN | 2008 | Applied Surface Science2008，，31： | 1 |
| 5 | A study of Ni- based WC composite coatings by laser induction hybrid rapid cladding with elliptical spot显示文摘 | Zhou Shengfeng Huang Yongjun Zeng Xiaoyan | 2008 | Applied Surface Science2008，254，10： | 1 |
| 6 | A study of Ni-based WC composite coatings by laser induction hybrid rapid cladding with elliptical spot 显示文摘 | ZHOU SHENGFENG HUANG YONGJUN ZENG XI- AOYAN | 2008 | Applied Surface Science2008，，254： | 1 |
| 7 | A study of Ni-based WC composite coatings by laser induction hybrid rapid cladding with elliptical spot显示文摘 | ZHOU SHENGFENG HUANG YONGJUN ZENG XIAOYAN | 2008 | App Sur Sci2008，，254： | 1 |
| 8 | Microstructure characteristics of Ni-based WC composite coatings by laser induction hybrid rapid cladding显示文摘 | ZHOU SHENGFENG HUANG YONGJUN ZENG XIAOYAN | 2008 | Mat Sci Eng2008，，480： | 1 |
| 9 | Microstructure characteristics of Ni-based WC composite coatings by laser induction hybrid rapid cladding显示文摘 | Zhou Shengfeng Huang Yongjun Zeng Xiaoyan | 2008 | Mater Sci Eng A2008，480，： | 1 |
| 10 | A study of Ni-based WC composite coatings by laser induction hybrid rapid cladding with elliptical spot 显示文摘 | Zhou Shengfeng Huang Yongjun Zeng Xiaoyan | 2008 | Applied Surface Science2008，254，10： | 1 |
| 11 | Microstructure characteristics of Ni-based WC composite coatings by laser induction hybrid rapid cladding 显示文摘 | Zhou Shengfeng Huang Yongjun Zeng Xiaoyan | 2008 | Materials Science and Engineering2008，480，12： | 1 |
| 12 | A study of Ni-based WC composite coatings by laser induction hybrid rapid cladding with elliptical spot 显示文摘 | Zhou Shengfeng Huang Yongjun Zeng Xiaoyan | 2008 | Applied Surface Science2008，254，10： | 1 |
| 13 | PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE)-a population-based prospective cohort study: rationale, design and baseline participant characteristics显示文摘Background and purpose Cardiovascular diseases and dementia are two major diseases in the elderly.Atherosclerosis is associated with future vascular events and cognitive impairment.The PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events(PRECISE)study is a population-based prospective cohort study with comprehensive evaluation of multiterritorial artery stenosis and plaque using advanced vascular imaging techniques and prospective collection of vascular events and cognitive assessments.Methods Between May 2017 and September 2019,the PRECISE study enrolled 3067 community-dwelling adults with ages between 50 and 75 years cluster sampled from six villages and four communities of Lishui city in China.Data are collected in face-to face interviews at baseline,2-year and 4-year follow-up visits.Brain MRI including high-resolution sequences for intracranial and carotidal arteries and CT angiography for thoracoabdominal arteries were performed at baseline and will be rescanned after 4 years.Cardiovascular/cerebrovascular events and cognitive assessment will be prospectively collected after the enrollment.Blood and urine samples were collected and biomarkers were tested at baseline.Results A total of 3067 subjects were enrolled,among which 53.5%were female with an average age of 61.2±6.7 years.Among them,2.8%,8.1%,43.1%and 21.6%had a history of stroke,coronary heart diseases,hypertension and diabetes mellitus,respectively.Conclusions The PRECISE study is a population-based prospective cohort study with comprehensive evaluation of atherosclerotic stenosis and plaque using advanced vascular imaging techniques.Data from this cohort provide us an opportunity to precisely evaluate polyvascular atherosclerosis and its association with future vascular events and cognitive impairment. | Yuesong Pan Jing Jing Xueli Cai Yilong Wang Suying Wang Xia Meng Chunlai Zeng Jiong Shi Jiansong Ji Jinxi Lin Lingchun Lyu Zhe Zhang Lerong Mei Shiping Li Shan Li Wanlin Zhu Hao Li Tiemin Wei Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，1： | 1 |
| 14 | Analysis of crack behavior for Ni-based WC composite coatings by laser cladding and crack-free realization显示文摘 | Shengfeng Zhou Xiaoyan Zeng Qianwu Hu Yongjun Huang | 2008 | Applied Surface Science2008，，5： | 1 |
| 15 | Microstructure and interface interaction in laser induction hybrid cladding of Ni-based coating显示文摘 | Yongjun Huang Xiaoyan Zeng Qianwu Hu Shengfeng Zhou | 2008 | Applied Surface Science2008，，7： | 1 |
| 16 | A study of Ni-based WC composite coatings by laser induction hybrid rapid cladding with elliptical spot显示文摘 | Shengfeng Zhou Yongjun Huang Xiaoyan Zeng | 2007 | Applied Surface Science2007，，10： | 1 |
| 17 | Study on modes of energy action in laser-induction hybrid cladding显示文摘 | Yongjun Huang Xiaoyan Zeng | | 0，，： | 1 |
| 18 | Microstructure and interface interaction in laser induction hybrid cladding of Ni-based coating 显示文摘 | HUANG Yongjun ZENG Xiaoyan | 2009 | Applied Surface Science2009，255，： | 1 |
| 19 | Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid‐induced apoptosis through down‐regulation of EZH 2 expression by miR ‐101显示文摘 | Yongjun Wang Wei Xiang Miao Wang Tao Huang Xingyuan Xiao Liang Wang Dan Tao Liyun Dong Fuqing Zeng Guosong Jiang | | Br J Pharmacol0，，3： | 1 |
| 20 | Micro-structure and interface interaction in laser induction hybridcladding of Ni-based coating显示文摘 | HUANG Yongjun ZENG Xiaoyan HU Qianwu | 2009 | Applied Surface Science2009，255，7： | 1 |
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