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| 1 | MicroRNA and mRNA profiling of cerebral cortex in a transgenic mouse model of Alzheimer’s disease by RNA sequencing显示文摘In a previous study,we found that long non-coding genes in Alzheimer’s disease(AD)are a result of endogenous gene disorders caused by the recruitment of microRNA(miRNA)and mRNA,and that miR-200a-3p and other representative miRNAs can mediate cognitive impairment and thus serve as new biomarkers for AD.In this study,we investigated the abnormal expression of miRNA and mRNA and the pathogenesis of AD at the epigenetic level.To this aim,we performed RNA sequencing and an integrative analysis of the cerebral cortex of the widely used amyloid precursor protein and presenilin-1 double transgenic mouse model of AD.Overall,129 mRNAs and 68 miRNAs were aberrantly expressed.Among these,eight down-regulated miRNAs and seven up-regulated miRNAs appeared as promising noninvasive biomarkers and therapeutic targets.The main enriched signaling pathways involved mitogen-activated kinase protein,phosphatidylinositol 3-kinase-protein kinase B,mechanistic target of rapamycin kinase,forkhead box O,and autophagy.An miRNA-mRNA network between dysregulated miRNAs and corresponding target genes connected with AD progression was also constructed.These miRNAs and mRNAs are potential biomarkers and therapeutic targets for new treatment strategies,early diagnosis,and prevention of AD.The present results provide a novel perspective on the role of miRNAs and mRNAs in AD.This study was approved by the Experimental Animal Care and Use Committee of Institute of Medicinal Biotechnology of Beijing,China(approval No.IMB-201909-D6)on September 6,2019. | Li Zeng Hai-Lun Jiang Ghulam Md Ashraf Zhuo-Rong Li Rui Liu | 2021 | Neural Regeneration Research2021，16，10： | 6 |
| 2 | Epstein-Barr virus-encoded latent membrane protein 1 modulates cyclin D1 by c-Jun/Jun B heterodimers显示文摘In our recent studies, we found that LMP1 encoded by Epstein-Barr virus could accelerate the formation of active c-Jun/Jun B heterodimer. We studied the regulation of cyclinD1 by c-Jun/Jun B heterodimers by laser scanning confocal influorescence microscopy, Western blot, luciferase activity assay, super-EMSA and flow cytometry in the Tet-on-LMP1 HNE2 cell line, in which LMP1 expression was regulated by Tet-on system. c-Jun/Jun B heterodimers induced by LMP1 could up regulate cyclin D1 promoter activity and expression. Overexpression of cy-clinD1 accelerated the progression of cell cycle. | SONG Xin1, TAO Yongguang1, ZENG Liang1, YANG Jing1, TANG Faqing1, Leo M. Lee2, GONG Jianping3, WU Qiao4 & CAO Ya1 1. Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha 410078, China 2. Laboratory of Molecular Technology SAIC-Frederick, National Cancer Institute P.O. Box B, Frederick, MD 21702, USA 3. Molecular Medical Center, Tongji Hospital, Tongji Medical University, Wuhan 430030, China 4. Key Laboratory of the Ministry of Education for Cell Biology, and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, China | 2005 | Science China(Life Sciences)2005，48，4： | 4 |
| 3 | Prediction of significant fibrosis in HBeAg-positive patients with chronic hepatitis B by a noninvasive model显示文摘 | Zeng MD Lu LG Mao YM | 2005 | Hepatology2005，42，6： | 1 |
| 4 | Prediction of significant fibrosis in HBeAg-positive patients with chronic hepatitis B by a noninvasive model显示文摘 | Zeng MD Lu LG Mao YM | | 0，，： | 1 |
| 5 | Characterization of the 3a protein of SARS-assoeiated coronavirus in infected vero E6 cells and SARS patients显示文摘 | Zeng R Yang RF Shi MD | 2004 | J Mol Biol2004，341，1： | 1 |
| 6 | beta-Catenin is critical for early postnatal liver growth 显示文摘 | Apte U Zeng G Thompson MD | 2007 | Am J Physiol Gastrointest Liver Physiol2007，292，6： | 1 |
| 7 | Prediction of significant fibrosis in HBeAg-positive patients with chronic hepatitis B by a noninva- sire model显示文摘 | Zeng MD Lu LG Mao YM | 2005 | Hepatology2005，42，6： | 1 |
| 8 | Prediction of significant fibrosis in HBeAg-positive patients with chronic hepatitis B by a noninvasive medel显示文摘 | Zeng MD Lu LG Mao YM | 2005 | Hepatology2005，42，6： | 1 |
| 9 | Prediction of significant fibrosis in HBeAg-positive patients with chronic hepatitis B by a noninvasive model显示文摘 | Zeng MD Lu LG Mao YM | 2005 | Hepatology2005，42，6： | 1 |
| 10 | Prediction of significant fibrosis in HBeAg -positive patients with chronic hepatitis B by a noninvasive model显示文摘 | ZENG MD LU LG MAO YM | 2005 | Hepatology2005，42，6： | 1 |
| 11 | Cuidelines for the diagnosis andtreat mentof nonalcoholic fatty liver discases显示文摘 | Zeng MD Fan JG Lu LG et a1 | 2008 | J Dig Dis2008，9，2： | 1 |
| 12 | Five years of treatment with adefovir dipivoxil in Chinese patients with HBeAg-positive chronic hepatitis B 显示文摘 | Zeng MD Mao YM Yao GB | 2012 | Liver Int2012，32，1： | 1 |
| 13 | Guidelines for the diagnosis and treat- ment of nonalcoholic fattyliver diseases显示文摘 | Zeng MD Fan JG Lu LG | | J Dig Dis0，9，： | 1 |
| 14 | Regulation of cell death and epileptogenesis by the mammalian target of rapamyein (mTOR) : A double- edged sword显示文摘 | Zeng LH Sharon MD Nicholas RR | 2010 | Cell Cycle2010，9，12： | 1 |
| 15 | Prediction of significant fibro- sis in HBeAg- positive patients with chronic hepatitis B by a non- invasive model 显示文摘 | Zeng MD Lu LG Mao YM | 2005 | Hepatology2005，42，6： | 1 |
| 16 | A double-blind randomized trial of adefovir dipivoxil in Chinese subjects with HBeAg-positive chronic hepatitis B显示文摘 | Zeng MD Mao YM Yao GB | 2006 | Hepatology2006，44，： | 1 |
| 17 | Characterization of the 3a protein of SARS-associated coronavirus in infected vero E6 cells and SARS patients显示文摘 | Zeng R Yang RF Shi MD | 2004 | J Mol Biol2004，341，1： | 1 |
| 18 | Guidelines for the diagnosis and treatment of nonalcoholic fatty liver disease 显示文摘 | Zeng MD Fan JG Lu LG | 2008 | J Dig Dis2008，9，2： | 1 |
| 19 | Prediction of significant fibrosis in HBeAg-positive patients with chronic hepatitis B by a noninvasive model显示文摘 | ZENG MD LU LG MAO YM | 2005 | Hepatology2005，42，： | 1 |
| 20 | Guidelines for the diagnosisand treatment of nonalcoholic fatty liver diseases 显示文摘 | Zeng MD Fan JG Lu LG | 2008 | J DigDis2008，9，2： | 1 |
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