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| 1 | An interpolating boundary element-free method (IBEFM) for elasticity problems显示文摘The paper begins by discussing the interpolating moving least-squares (IMLS) method. Then the formulae of the IMLS method obtained by Lancaster are revised. On the basis of the boundary element-free method (BEFM), combining the boundary integral equation method with the IMLS method improved in this paper, the interpolating boundary element-free method (IBEFM) for two-dimensional elasticity problems is presented, and the corresponding formulae of the IBEFM for two-dimensional elasticity problems are obtained. In the IMLS method in this paper, the shape function satisfies the property of Kronecker δ function, and then in the IBEFM the boundary conditions can be applied directly and easily. The IBEFM is a direct meshless boundary integral equation method in which the basic unknown quantity is the real solution to the nodal variables. Thus it gives a greater computational precision. Numerical examples are presented to demonstrate the method. | REN HongPing 1 , CHENG YuMin 2 & ZHANG Wu 1 1 School of Computer Engineering and Science, Shanghai University, Shanghai 200072, China 2 Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, Shanghai 200072, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，4： | 5 |
| 2 | 显示文摘 | Jingwen Mao Yumin Qiu Richard J. Goldfarb Zhaochong Zhang Steve Garwin Ren Fengshou | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
| 3 | 显示文摘 | Jingwen Mao Yumin Qiu Richard J. Goldfarb Zhaochong Zhang Steve Garwin Ren Fengshou | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
| 4 | 显示文摘 | Jingwen Mao Yumin Qiu Richard J. Goldfarb Zhaochong Zhang Steve Garwin Ren Fengshou | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
| 5 | Cyclooxygenase-2 ?765 G/C polymorphisms and susceptibility to hepatitis B-related liver cancer in Han Chinese population显示文摘 | Jianhong He Quanbao Zhang Zhijian Ren Yumin Li Xun Li Wence Zhou Hui Zhang Wenbo Meng Jun Yan Wenting He | 2012 | Molecular Biology Reports2012，，4： | 1 |
| 6 | SOX2-dependent expression of dihydroorotate dehydrogenase regulates oral squamous cell carcinoma cell proliferation显示文摘Oral squamous cell carcinoma(OSCC)become a heavy burden of public health,with approximately 300000 newly diagnosed cases and 145000 deaths worldwide per year.Nucleotide metabolism fuel DNA replication and RNA synthesis,which is indispensable for cell proliferation.But how tumor cells orchestrate nucleotide metabolic enzymes to support their rapid growth is largely unknown.Here we show that expression of pyrimidine metabolic enzyme dihydroorotate dehydrogenase(DHODH)is upregulated in OSCC tissues,compared to non-cancerous adjacent tissues.Enhanced expression of DHODH is correlated with a shortened patient survival time.Inhibition of DHODH by either shRNA or selective inhibitors impairs proliferation of OSCC cells and growth of tumor xenograft.Further,loss of functional DHODH imped de novo pyrimidine synthesis,and disrupt mitochondrial respiration probably through destabilizing the MICOS complex.Mechanistic study shows that transcriptional factor SOX2 plays an important role in the upregulation of DHODH in OSCC.Our findings add to the knowledge of how cancer cells co-opt nucleotide metabolism to support their rapid growth,and thereby highlight DHODH as a potential prognostic and therapeutic target for OSCC treatment. | Xuemei Qiu Sheng Jiang Yanxuan Xiao Yumin He Tao Ren Lu Jiang Rui Liu Qianming Chen | 2021 | International Journal of Oral Science2021，13，1： | 1 |
| 7 | 显示文摘 | Jingwen Mao Yumin Qiu Richard J. Goldfarb Zhaochong Zhang Steve Garwin Ren Fengshou | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
| 8 | 显示文摘 | Jingwen Mao Yumin Qiu Richard J. Goldfarb Zhaochong Zhang Steve Garwin Ren Fengshou | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
| 9 | 显示文摘 | Jingwen Mao Yumin Qiu Richard J. Goldfarb Zhaochong Zhang Steve Garwin Ren Fengshou | 2002 | Mineralium Deposita (-)2002，，3： | 1 |
| 10 | Long-Chain Gemini Surfactant-Assisted Blade Coating Enables Large-Area Carbon-Based Perovskite Solar Modules with Record Performance显示文摘Carbon-based perovskite solar cells show great potential owing to their low-cost production and superior stability in ambient air.However,scaling up to high-efficiency carbon-based solar modules hinges on reliable deposition of uniform defect-free perovskite films over large areas,which is an unsettled but urgent issue.In this work,a long-chain gemini surfactant is introduced into perovskite precursor ink to enforce self-assembly into a network structure,considerably enhancing the coverage and smoothness of the perovskite films.The long gemini surfactant plays a distinctively synergistic role in perovskite film construction,crystallization kinetics modulation and defect passivation,leading to a certified record power conversion efficiency of 15.46%with Voc of 1.13 V and Jsc of 22.92 mA cm^(-2)for this type of modules.Importantly,all of the functional layers of the module are printed through a simple and high-speed(300 cm min^(-1))blade coating strategy in ambient atmosphere.These results mark a significant step toward the commercialization of all-printable carbon-based perovskite solar modules. | Yumin Ren Kai Zhang Zedong Lin Xiaozhen Wei Man Xu Xianzhen Huang Haining Chen Shihe Yang | 2023 | Nano-Micro Letters2023，15，10： | 0 |
| 11 | Anti-apoptotic protein BCL-XL as a therapeutic vulnerability in gastric cancer显示文摘Background: New therapeutic targets are needed to improve the outcomes for gastric cancer(GC) patients with advanced disease. Evasion of programmed cell death(apoptosis) is a hallmark of cancer cells and direct induction of apoptosis by targeting the pro-survival BCL2 family proteins represents a promising therapeutic strategy for cancer treatment. Therefore, understanding the molecular mechanisms underpinning cancer cell survival could provide a molecular basis for potential therapeutic interventions. Method: Here we explored the role of BCL2L1 and the encoded anti-apoptotic BCL-XL in GC. Using Droplet Digital PCR(ddPCR) technology to investigate the DNA amplification of BCL2L1 in GC samples and GC cell lines, the sensitivity of GC cell lines to selective BCL-XL inhibitors A1155463 and A1331852, pan-inhibitor ABT-263, and VHL-based PROTAC-BCL-XL was analyzed using(CellTiter-Glo) CTG assay in vitro. Western Blot(WB) was used to detect the protein expression of BCL2 family members in GC cell lines and the manner in which PROTAC-BCL-XL kills GC cells. Coimmunoprecipitation(Co-IP) was used to investigate the mechanism of A1331852 and ABT-263 kills GC cell lines. DDPCR, WB, and real-time PCR(RTPCR) were used to investigate the correlation between DNA, RNA, protein levels, and drug activity. Results: The functional assay showed that a subset of GC cell lines relies on BCL-XL for survival. In gastric cancer cell lines, BCL-XL inhibitors A1155463 and A1331852 are more sensitive than the pan BCL2 family inhibitor ABT-263, indicating that ABT-263 is not an optimal inhibitor of BCL-XL. VHL-based PROTAC-BCL-XL DT2216 appears to be active in GC cells. DT2216 induces apoptosis of gastric cancer cells in a time-and dose-dependent manner through the proteasome pathway. Statistical analysis showed that the BCL-XL protein level predicts the response of GC cells to BCL-XL targeting therapy and BCL2L1 gene CNVs do not reliably predict BCL-XL expression.Conclusion: We identified BCL-XL as a promising therapeutic target in a subset of GC cases with high levels of BCL-XL protein expression. Functionally, we demonstrated that both selective BCL-XL inhibitors and VHL-based PROTAC BCL-XL can potently kill GC cells that are reliant on BCL-XL for survival. However, we found that BCL2L1 copy number variations(CNVs) cannot reliably predict BCL-XL expression, but the BCL-XL protein level serves as a useful biomarker for predicting the sensitivity of GC cells to BCL-XL-targeting compounds. Taken together, our study pinpointed BCL-XL as potential druggable target for specific subsets of GC. | Yumin Wei Liping Zhang Chao Wang Zefeng Li Mingjie Luo Guomin Xie Xingjiu Yang Mengyuan Li Shuyue Ren Dongbing Zhao Ran Gao Jia-Nan Gong | 2023 | Animal Models and Experimental Medicine2023，6，3： | 0 |
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