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| 1 | Surveying brain tumor heterogeneity by single-cell RNA-sequencing of multi-sector biopsies显示文摘Brain tumors are among the most challenging human tumors for which the mechanisms driving progression and heterogeneity remain poorly understood.We combined single-cell RNA-seq with multi-sector biopsies to sample and analyze single-cell expression profiles of gliomas from 13 Chinese patients.After classifying individual cells;we generated a spatial and temporal landscape of glioma that revealed the patterns of invasion between the different sub-regions of gliomas.We also used single-cell inferred copy number variations and pseudotime trajectories to inform on the crucial branches that dominate tumor progression.The dynamic cell components of the multi-region biopsy analysis allowed us to spatially deconvolute with unprecedented accuracy the transcriptomic features of the core and those of the periphery of glioma at single-cell level.Through this rich and geographically detailed dataset,we were also able to characterize and construct the chemokine and chemokine receptor interactions that exist among different tumor and non-tumor cells.This study provides the first spatial-level analysis of the cellular states that characterize human gliomas.It also presents an initial molecular map of the cross-talks between glioma cells and the surrounding microenvironment with single-cell resolution. | Kai Yu Yuqiong Hu Fan Wu Qiufang Guo Zenghui Qian Waner Hu Jing Chen Kuanyu Wang Xiaoying Fan Xinglong Wu John EJ Rasko Xiaolong Fan Antonio lavarone Tao Jiang Fuchou Tang Xiao-Dong Su | 2020 | National Science Review2020，7，8： | 4 |
| 2 | Association between High Fat-low Carbohydrate Diet Score and Newly Diagnosed Type 2 Diabetes in Chinese Population显示文摘Objective To study the association between high fat-low carbohydrate diet score and newly diagnosed type 2 diabetes in Chinese population. Methods Data about 20 717 subjects aged 45-59 years from the cross-sectional 2002 China National Nutrition and Health Survey were analyzed. High fat-low carbohydrate diet was scored according to the energy of carbohydrate, fat, and protein. Results Of the 20 717 subjects, 1 332 were diagnosed with hyperglycemia and 662 were newly diagnosed with type 2 diabetes. Multivariate adjusted analysis showed that the highest score of type 2 diabetes patients was 2.75 (95% CI: 2.09-3.61). The score of type 2 diabetes patients was 1.87 (95% CI: 1.35-2.58) after further adjustment for their socioeconomic status and physical activity. No significant difference was found in the odds ratio after further adjustment for BMI, blood pressure, lipid level, and energy intake. No evidence was observed for the relation between high fat-low carbohydrate-diet score in type 2 diabetes patients due to high family income, less education, physical activity, overweight, hypertension, high TG, or low HDL level. Conclusion High fat-low carbohydrate diets, far different from traditional Chinese diets, are associated with the high incidence of type 2 diabetes in Chinese population. | HE Yu Na FESKENS EJ LI Yan Ping ZHANG Jian FU Ping MA Guan Sheng YANG Xiao Guang | 2012 | Biomedical and Environmental Sciences2012，25，4： | 4 |
| 3 | Hyperkeratinization,corneocyte cohesion,and alpha hydroxy acids显示文摘 | Van Scott Ej Yu RJ | 1984 | AM ACAD Dermatol1984，11，： | 1 |
| 4 | Surgery-first accelerated orthognathic surgery:postoperative rapid orthodontic tooth movement显示文摘 | Liou EJ Chen PH Wang YC Yu CC Huang CS Chen YR | | 0，，： | 1 |
| 5 | Ginsenoside production by hairy root cukures of Panax ginseng - influence of temperature and light quali- ty显示文摘 | Yu KW Murthy HN Hahn EJ | 2005 | BiochemEngJ2005，23，： | 1 |
| 6 | Control of Keratinization with a-Hydroxy Acids and Related Compounds 显示文摘 | Van Scott EJ Yu RJ | 1974 | Archives of Dermatology1974，110，4： | 1 |
| 7 | The membrane estrogen receptor GPR30 mediates cadmium-induced proliferation of breast cancer cells显示文摘 | Yu X Filardo EJ Shaikh ZA | 2010 | Toxicol Appl Pharmacol2010，245，1： | 1 |
| 8 | Lobar Bronchioloalveolar Carcinoma:'angiogram sign' on CT scans显示文摘 | Im JG Han MC Yu EJ | 1990 | Radiology1990，176，3： | 1 |
| 9 | Alpha-hydroxyacid and carboxyli1c acids显示文摘 | Yu RJ Van Scott EJ | 2004 | J Cosm Dermatol2004，3，2： | 1 |
| 10 | A Surgery first approach in surgical orthodontic treatment of mandibular prognathism-a case report显示文摘 | Yu CC Chen PH Liou EJ | 2010 | Chang Gung Med J2010，33，6： | 1 |
| 11 | Dietary modulation of the progression of nephropathy in aging rats : an evaluation of the importance of protein 显示文摘 | Masoro EJ Iwasaki K Gleiser CA McMahan CA Seo EJ Yu BP | 1989 | Am J Clin Nutr1989，49，6： | 1 |
| 12 | Life span study of SPF Fischer 344 male rats fed ad libitum or restricted diets: longevity, growth, lean body mass and disease显示文摘 | Yu BP Masoro EJ Murata I Bertrand HA Lynd FT | 1982 | J Gero- ntol1982，37，2： | 1 |
| 13 | Ginsenoside production by hairy root cultures of Panax ginseng : influence of temperature and light quality显示文摘 | Yu KW Murthy HN Hahn EJ | 2005 | Chemical Engineering Journal2005，23，： | 1 |
| 14 | Detection of microRNA expression in human peripheral blood microvesicles显示文摘 | Hunter MP Ismail N Zhang X Aguda BD Lee EJ Yu L | 2008 | PLoS One2008，3，11： | 1 |
| 15 | Hyperkeratinization,coeneocyte cohesion,and alpha hydroxyl acids显示文摘 | Van Scott EJ Yu RJ | 1984 | Am Acad Dermatol1984，11，： | 1 |
| 16 | Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer:a nationalmulticenter analysis显示文摘 | Yu CS Yun HR Shin EJ | 2013 | Am J Surg2013，206，4： | 1 |
| 17 | A Surgery-first approach in surgical-orthodontic treatment of mandibular prognathism-a case report显示文摘 | Yu CC Chen PH Liou EJ | 2010 | Chang Gung Med J2010，33，6： | 1 |
| 18 | Dietary vitamin E and quereetin modulate inflammatory responses of collagen- induced arthritis in mice显示文摘 | Choi EJ Bae SC Yu R | 2009 | J Med Food2009，12，： | 1 |
| 19 | Clinical and cosmeceutical uses of hydroxyacids 显示文摘 | Green BA Yu R J Van Scott EJ | 2009 | Clin Dennatol2009，27，5： | 1 |
| 20 | The membrane estrogen receptor GPR30 mediates cadmium-induced proliferation of breast cancer cells显示文摘 | Yu X Filardo EJ Shaikh ZA | 2010 | Toxicol Appl Pharmacol2010，245，1： | 1 |
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