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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | NKX6.3 protects against gastric mucosal atrophy by downregulatingβ-amyloid production显示文摘BACKGROUND Atrophic gastritis is characterized by loss of appropriate glands and reduction in gastric secretory function due to chronic inflammatory processes in gastric mucosa. Moreover, atrophic gastritis is considered as a precancerous condition of gastric cancer. However, little is known about the molecular mechanism underlying gastric mucosal atrophy and its contribution to gastric carcinogenesis.Thus, we hypothesized that transcription factor NKX6.3 might be involved in maintaining gastric epithelial homeostasis by regulating amyloid β(Aβ)production.AIM To determine whether NKX6.3 might protect against gastric mucosal atrophy by regulating Aβ production.METHODS We identified NKX6.3 depletion induced cell death by cell count and Western blot assay. Production and mechanism of Aβ oligomer were analyzed by enzymelinked immunosorbent assay, Western blot, immunoprecipitation, real-timequantitative polymerase chain reaction and immunofluorescence analysis. We further validated the correlation between expression of NKX6.3, Helicobacter pylori CagA, Aβ oligomer, apolipoprotein E(ApoE), and β-secretase 1(Bace1) in 55 gastric mucosae.RESULTS NKX6.3 depletion increased both adherent and floating cell populations in HFE-145 cells. Expression levels of cleaved caspase-3,-9, and poly ADP ribose polymerase were elevated in floating HFE-145^(shNKX6.3) cells. NKX6.3 depletion produced Aβ peptide oligomers, and increased expression of ApoE, amyloid precursor protein, Aβ, Bace1, low-density lipoprotein receptor, nicastrin, high mobility group box1, and receptor for advanced glycosylation end product proteins. In immunoprecipitation assay, γ-secretase complex was stably formed only in HFE-145^(shNKX6.3) cells. In gastric mucosae with atrophy, expression of Aβpeptide oligomer, ApoE, and Bace1 was detected and inversely correlated with NKX6.3 expression. Treatment with recombinant Aβ 1-42 produced Aβoligomeric forms and decreased cell viability in HFE-145^(shNKX6.3) cells. Additionally,NKX6.3 depletion increased expression of inflammatory cytokines and cyclooxygenase-2.CONCLUSION NKX6.3 inhibits gastric mucosal atrophy by regulating Aβ accumulation and inflammatory reaction in gastric epithelial cells. | Jung Hwan Yoon Yeon Soo Lee Olga Kim Hassan Ashktorab Duane T Smoot Suk Woo Nam Won Sang Park | 2019 | World Journal of Gastroenterology2019，25，3： | 6 |
| 3 | Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial显示文摘 | William T Cefalu Lawrence A Leiter Kun-Ho Yoon Pablo Arias Leo Niskanen John Xie Dainius A Balis William Canovatchel Gary Meininger | 2013 | The Lancet2013，，： | 3 |
| 4 | Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation 显示文摘 | Yoon J C Chickering T W Rosen E D | 2000 | Mol Cell Biol2000，20，14： | 2 |
| 5 | Preparation and characterization of M/TiO2 (M=Ag, Au, Pt) nanocomposite thin films显示文摘 | YOON J W SASAKI T KOSHIZAKI N | 2001 | Scripta Mater2001，44，89： | 2 |
| 6 | Live births after vitrification of oocytes in a stimulated in vitro fertilization-embryo transfer program显示文摘 | Kim T J Park S E | 2003 | Fertil Steril2003，79，： | 1 |
| 7 | Evaluation of traumatic brain injured patients in correlation with functional status by localized 1 H-MR spectroscopy 显示文摘 | Yoon S J Lee J H Kim S T | 2005 | Clin Rehabi2005，19，2： | 1 |
| 8 | Biological treatment of wastewater containing dimethyl sulphoxide from the semi- conductor industry 显示文摘 | Park S Yoon T Bae J | 2001 | Process Biochem2001，36，6： | 1 |
| 9 | Magnetic fluid grinding of ceramic balls显示文摘 | CHILDS T H C MAHMOOD S YOON H J | | 0，，06： | 1 |
| 10 | Comparison of molecular and biological characteristics of a modified live porcine reproductive and respiratory syndrome virus(PRRSV)vaccine(ingelvac PRRS MLV),the parent strain of the vaccine (ATCC VR2332),ATCC VR2385,and two recent field isolates of PRRS显示文摘 | Opriessnig T Halbur P G Yoon K J | | 0，，23： | 1 |
| 11 | Laparoendoscopic single-slte (LESS) myomectomy : characteristics of the appropriate myoma显示文摘 | Yoon A Kim T J Lee YY | 2014 | Eur J Ob- stet Gynecol Reprod Biol2014，175，： | 1 |
| 12 | Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation显示文摘 | Yu K N Yoon T J Minai-Tehrani A | 2013 | Toxicol in Vitro2013，27，： | 1 |
| 13 | Numerical study of unsteady flow field around high speed trains passing by each other 显示文摘 | Hwang J Yoon T S Lee D H | 2001 | JSME International Journal2001，44，3： | 1 |
| 14 | Polymer matrix degradation and color or formation in melt processed nylon6 /clay nanocomposites显示文摘 | Fornes T D Yoon P J Paul D R | 2003 | Polymer2003，44，24： | 1 |
| 15 | Effects of chemical and physical properties of influent on copper sorption onto activated carbon fixed - bed columns 显示文摘 | CHEN J P YOON J T YIACOUMI S | 2003 | Carbon2003，41，8： | 1 |
| 16 | Magnetic, dielectric, and microwave absorbing properties of iron particles dispersed in rubber matrix in gigahertz frequencies 显示文摘 | Kim S S Kim S T Yoon Y C | 2005 | J Appl Phys2005，97，10： | 1 |
| 17 | Transfer of the gene for neomycin resistance into goldfish (Carassius auratus)显示文摘 | Hallerman E M Gross M L | 1990 | Aquaculture1990，85，： | 1 |
| 18 | Unex Dected severe calcifi-cation after transplantation of bone marrow cells in acute myocardialinfarction显示文摘 | Yoon Y S Park J S Tkebuchava T et a1 | 2004 | Circulation2004，109，25： | 1 |
| 19 | Cadmium zinc telluride and its use as a nuclear radiation detector material 显示文摘 | T E Schlesinger J E Toney H Yoon | 2001 | Materials Science and Engineering R-Reports2001，32，45： | 1 |
| 20 | Stability characteristics of Pt1Ni1/C as cathode catalysts in membrane electrode assembly of polymer electrolyte membrane fuel cell显示文摘 | CHO Y H JEON T Y YOO S J LEE K S AHN M KIM O H CHO Y H LIM J W JUNG N YOON W S CHOE H SUNG Y E | 2012 | Electrochim Acta2012，59，： | 1 |
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