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| 1 | The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism显示文摘在动物农业和药的抗菌素的 overuse 引起了一系列潜在的威胁到公共健康。Macleaya cordata 是从 Papaveraceae 家庭的药用的植物种,提供为抗菌剂的制造的一个安全资源为家畜喂添加剂。从 M. 的活跃成分 ? cordata 被知道包括 benzylisoquinoline 碱(偏爱) 象 sanguinarine (圣) 和 chelerythrine (CHE ) 那样的 ?,而是他们的新陈代谢的小径还得在这非模型植物被学习。在 M. 的圣和 CHE 的活跃生合成 ? cordata 被喂 13标记 C 的酷氨酸。为了增加,推进卓见,我们 de novo 定序 M 的整个染色体。cordata,第一从 Papaveraceae 家庭被定序。M.? 盖住 378 Mb 的 cordata 染色体与 43.5%being 编码 22,328 预言的编码蛋白质的基因 transposable 元素。作为基础 eudicot 的一个成员, M.? cordata 染色体缺乏 ? 发生在几乎所有 eudicots 的 paleohexaploidy 事件。从 genomics 数据, 16 的一个完全的集合 ? 新陈代谢 ? 为圣和 CHE 生合成的基因被检索,并且 14 项他们的生物化学的活动被验证。这些 genomics 和新陈代谢的数据在 M. 显示出保存 BIA 新陈代谢的小径 ? cordata 并且由庄稼改进或微生物引起的小径重建为圣和 CHE 的未来生产提供知识基础。 | Xiubin Liu Yisong Liu Peng Huang Yongshuo Ma Zhixing Qing Qi Tang Huifen Cao Pi Cheng Yajie Zheng Zejun Yuan Yuan Zhou Jinfeng Liu Zhaoshan Tang Yixiu Zhuo Yancong Zhang Linlan Yu Jialu Huang Peng Yang Qiong Peng dinbo Zhang Wenkai Jiang Zhonghua Zhang Kui Lin Dae-Kyun Ro Xiaoya Chen Xingyao Xiong Yi Shang Sanwen Huang Jianguo Zeng | 2017 | Molecular Plant2017，10，7： | 19 |
| 2 | Superior mesenteric venous thrombosis after laparoscopic radical resection of rectal cancer: a report of a rare case and literature review显示文摘Mesenteric venous thrombosis(MVT) is rare, but life-threatening. MVT is often characterized by occult and nonspecific signs and symptoms. Diagnosis requires a high index of clinical suspicion, and emergency surgery is necessary to optimize patient survival, especially in people aged more than 70 years. MVT is a rare but fatal complication after laparoscopic radical surgery for rectal cancer. This study reports a case of extensive intestinal ischemic infarction caused by acute MVT after laparoscopic radical surgery for rectal cancer in a 70-year-old male. | Xinliang Jin Weijie Xue Yixiu Wang Qinkai Xue Zhiqi Gong Yongke Liu Zhaojian Niu Chengzhan Zhu | 2018 | Oncology and Translational Medicine2018，4，6： | 9 |
| 3 | Toll-Like Receptor 4 Deficiency Causes Reduced Exploratory Behavior in Mice Under Approach-Avoidance Conflict显示文摘Abnormal approach-avoidance behavior has been linked to deficits in the mesolimbic dopamine(DA)system of the brain. Recently, increasing evidence has indicated that toll-like receptor 4(TLR4), an important pattern-recognition receptor in the innate immune system,can be directly activated by substances of abuse, resulting in an increase of the extracellular DA level in the nucleus accumbens. We thus hypothesized that TLR4-dependent signaling might regulate approach-avoidance behavior. To test this hypothesis, we compared the novelty-seeking and social interaction behaviors of TLR4-deficient(TLR4^(-/-))and wild-type(WT) mice in an approach-avoidance conflict situation in which the positive motivation to explore a novel object or interact with an unfamiliar mouse was counteracted by the negative motivation to hide in exposed,large spaces. We found that TLR4^(-/-)mice exhibitedreduced novelty-seeking and social interaction in the large open spaces. In less stressful test apparatuses similar in size to the mouse cage, however, TLR4^(-/-)mice performed normally in both novelty-seeking and social interaction tests. The reduced exploratory behaviors under approachavoidance conflict were not due to a high anxiety level or an enhanced fear response in the TLR4^(-/-)mice, as these mice showed normal anxiety and fear responses in the open field and passive avoidance tests, respectively. Importantly,the novelty-seeking behavior in the large open field induced a higher level of c-Fos activation in the nucleus accumbens shell(NAc Sh) in TLR4^(-/-)mice than in WT mice. Partially inactivating the NAc Sh via infusion of GABA receptor agonists restored the novelty-seeking behavior of TLR4^(-/-)mice. These data suggested that TLR4 is crucial for positive motivational behavior under approach-avoidance conflict. TLR4-dependent activation of neurons in the NAc Sh may contribute to this phenomenon. | Chunlu Li Yixiu Yan Jingjing Cheng Gang Xiao Jueqing Gu Luqi Zhang Siyu Yuan Junlu Wang Yi Shen Yu-Dong Zhou | 2016 | Neuroscience Bulletin2016，32，2： | 5 |
| 4 | CuAlCl4 doped MIL-101 as a high capacity CO adsorbent with selectivity over N2显示文摘 | Yixiu WANG Chao LI Fanchao MENG Shuling LV Jintao GUO Xiaoqin LIU Chongqing WANG Zhengfei MA | 2014 | Frontiers of Chemical Science and Engineering2014，8，3： | 3 |
| 5 | A Missing Power Data Filling Method Based on Improved Random Forest Algorithm显示文摘Missing data filling is a key step in power big data preprocessing,which helps to improve the quality and the utilization of electric power data.Due to the limitations of the traditional methods of filling missing data,an improved random forest filling algorithm is proposed.As a result of the horizontal and vertical directions of the electric power data are based on the characteristics of time series.Therefore,the method of improved random forest filling missing data combines the methods of linear interpolation,matrix combination and matrix transposition to solve the problem of filling large amount of electric power missing data.The filling results show that the improved random forest filling algorithm is applicable to filling electric power data in various missing forms.What’s more,the accuracy of the filling results is high and the stability of the model is strong,which is beneficial in improving the quality of electric power data. | Wei Deng Yixiu Guo Jie Liu Yong Li Dingguo Liu Liang Zhu | 2019 | Chinese Journal of Electrical Engineering2019，5，4： | 3 |
| 6 | Vacancy manipulating of molybdenum carbide MXenes to enhance Faraday reaction for high performance lithium-ion batteries显示文摘“Intrinsic”strategies for manipulating the local electronic structure and coordination environment of defect-regulated materials can optimize electrochemical storage performance.Nevertheless,the structure–activity relationship between defects and charge storage is ambiguous,which may be revealed by constructing highly ordered vacancy structures.Herein,we demonstrate molybdenum carbide MXene nanosheets with customized in-plane chemical ordered vacancies(Mo_(1.33)CT_(x)),by utilizing selective etching strategies.Synchrotron-based X-ray characterizations reveal that Mo atoms in Mo1.33CTx show increased average valence of+4.44 compared with the control Mo_(2)CT_(x).Benefited from the introduced atomic active sites and high valence of Mo,Mo_(1.33)CT_(x)achieves an outstanding capacity of 603 mAh·g^(−1)at 0.2 A·g^(−1),superior to most original MXenes.Li+storage kinetics analysis and density functional theory(DFT)simulations show that this optimized performance ensues from the more charge compensation during charge–discharge process,which enhances Faraday reaction compared with pure Mo_(2)CT_(x).This vacancy manipulation provides an efficient way to realize MXene’s potential as promising electrodes. | Xin Guo Changda Wang Wenjie Wang Quan Zhou Wenjie Xu Pengjun Zhang Shiqiang Wei Yuyang Cao Kefu Zhu Zhanfeng Liu Xiya Yang Yixiu Wang Xiaojun Wu Li Song Shuangming Chen Xiaosong Liu | 2022 | Nano Research Energy2022，1，3： | 2 |
| 7 | Thermally induced structural transitions from fluids to hydrogels with pH - switchable anionic wormlike micelles 显示文摘 | ZHANG YONGMIN HAN YIXIU CHU ZONGLIN | 2013 | Journal of Colloid and Interface Science2013，394，： | 1 |
| 8 | A simple inorganic-solvent-thermal route to nanocrystalline niobium diboride显示文摘 | Jianhua Ma Yihong Du Meining Wu Guoxing Li Zhiqing Feng Ming Guo Yixiu Sun Weihua Song Mingjin Lin Xule Guo | 2008 | Journal of Alloys and Compounds2008，，： | 1 |
| 9 | “Green”anionic wormlike micelles induced by choline显示文摘 | Han Yixiu Chu Zonglin Sun Huangquan | 2012 | RSC Advances2012，2，： | 1 |
| 10 | Construction of redox-active multilayer film for electrochemically con- trolled release 显示文摘 | SUN Yixin REN Kefeng ZHAO Yixiu | 2013 | Langmuir2013，29，11： | 1 |
| 11 | An experimental investigation of the in-situ combustion behavior of Karamay crude oil显示文摘 | Zhao Renbao Chen Yixiu Huan Rongping | 2015 | Journal of Petroleum Science and Engineering2015，21，3： | 1 |
| 12 | Wormlike micelles formed by sodium erucate in the presence of a tetraalkylammonium hydrotrope显示文摘 | Feng Yujun Han Yixiu Sun Huanquan | 2011 | J Phys Chem B2011，115，： | 1 |
| 13 | Novel bio-antifelting a- gent based on waterborne polyurethane and cellulose nano- crystals显示文摘 | Qun Zhao Gang Sun Yixiu Chen | 2013 | Carbohydrate Polymers2013，，91： | 1 |
| 14 | Hanyudiyi,di’eryuyanbiyinyinjieweishuchuyanjiu汉语第一、第二语言鼻音音节尾输出研究[-ProductionofMandarinChinesenasalcodabyL1andL2speakersofMandarinChinese]显示文摘 | Yixiu(赖怡秀) | 2008 | 汉语语言教学2008，5，： | 1 |
| 15 | An adaptive data replication algorithm 显示文摘 | Jajodia S Huang Yixiu | 1997 | ACM Transactions on Database Systems (TODS)1997，22，2： | 1 |
| 16 | Chitosan biopolymer-derived self-powered triboelectric sensor with optimized performance through molecular surface engineering and data-driven learning显示文摘The state-of-the-art triboelectric nanogenerators(TENGs)are constructed with synthetic polymers,curtailing their application prospects and relevance in sustainable technologies.The economically viable transformation and engineering of naturally abundant materials into efficient TENGs for mechanical energy harvesting is meaningful not only for fundamental scientific exploration,but also for addressing societal needs.Being an abundant natural biopolymer,chitosan enables exciting opportunity for low-cost,biodegradable TENG applications.However,the electrical outputs of chitosan-based TENGs are low compared with the devices built with synthetic polymers.Here,we explore the facile molecular surface engineering in chitosan to significantly boost the performance of chitosan-based TENG for enabling the practical applications,for example,self-powered car speed sensor.The molecular surface engineering offers a potentially promising scheme for designing and implementing high-performance biopolymer-based TENGs for selfpowered nanosystems in sustainable technologies.We further explore for the first time the feasibility of data mining approaches to analyze and learn the acquired triboelectric signals from the car speed sensors and predict the relationship between the triboelectric signals and car speed values. | Chenxiang Ma Shengjie Gao Xinqi Gao Min Wu Ruoxing Wang Yixiu Wang Zhiyuan Tang Fengru Fan Wenxuan Wu Hong Wan Wenzhuo Wu | 2019 | InfoMat2019，1，1： | 1 |
| 17 | 'Green'anionic wormlike micelles induced by choline显示文摘 | Han Yixiu Chu Zonglin Sun Huanquan | 2012 | RSC Advances2012，2，： | 1 |
| 18 | Numerical study of vortex breaker optimization in a first stage oxygen tank显示文摘One of the crucial factors affecting the carrying capacity of the cryogenic liquid launch vehicle is the effective volume of the tank.Theoretical and experimental investigations on vortex breaker mechanisms have proposed promising schemes applied in the oxygen tank of the liquid-propellant launch vehicle to ensure the normal operation of the engine.In this paper,the liquid surface profile functions of the laminar core when the vortex generates were derived based on the Rankine vortex model.The dimensionless residual volume V/d3 and the Froude number were applied to compare the theoretical prediction of critical height with the actual simulation data of liquid oxygen.This comparison method can improve the model’s accuracy.The efficiency of different basic shapes of vortex breakers was tested by conducting CFD modelling on a non-vertical outflow tank under a specific operating condition.Simulation results suggest negligible effects of heat transfer and surface tension.A circular plate is considered the optimal vortex breaker shape in traditional vertical outflow tanks,while a higher optimize efficiency was discovered in the half baffle basic shape in a non-vertical outflow tank by comparing the dimensionless residual volume and flow coefficient.A 34.26%reduction in flow resistance of half baffle breaker can be reached when applying a twenty-degree outlet pipe chamfering setting compared to a zero-degree chamfer.Considering practical operating limitations,it is concluded that a vortex breaker mechanism in a half baffle basic shape with a radius of 2.5d and a height of 4/d is the optimal scheme,which is suitable for all types of tanks.Its optimization efficiency of the residual volume reduction is about 56.68%compared to a nobreaker installation case.Lastly,a general equation based on CFD simulation for predicting the residual volume under a certain outflow velocity was proposed:V=d3yaFr0:3,which trend is consistent with that of mathematical prediction V=d3yaFr1=3.This consistency proves the accuracy and applicability of optimization strategy in this paper. | Yixiu Shen Yimeng Li Zhenggang Du | 2023 | Propulsion and Power Research2023，12，3： | 0 |
| 19 | Parallel Nanoimprint Forming of One-Dimensional Chiral Semiconductor for Strain-Engineered Optical Properties显示文摘The low-dimensional,highly anisotropic geometries,and superior mechanical properties of one-dimensional(1D) nanomaterials allow the exquisite strain engineering with a broad tunability inaccessible to bulk or thin-film materials.Such capability enables unprecedented possibilities for probing intriguing physics and materials science in the 1-D limit.Among the techniques for introducing controlled strains in 1D materials,nanoimprinting with embossed substrates attracts increased attention due to its capability to parallelly form nanomaterials into wrinkled structures with controlled periodicities,amplitudes,orientations at large scale with nanoscale resolutions.Here,we systematically investigated the strain-engineered anisotropic optical properties in Te nanowires through introducing a controlled strain field using a resist-free thermally assisted nanoimprinting process.The magnitude of induced strains can be tuned by adjusting the imprinting pressure,the nanowire diameter,and the patterns on the substrates.The observed Raman spectra from the chiral-chain lattice of 1D Te reveal the strong lattice vibration response under the strain.Our results suggest the potential of 1D Te as a promising candidate for flexible electronics,deformable optoelectronics,and wearable sensors.The experimental platform can also enable the exquisite mechanical control in other nanomaterials using substrate-induced,on-demand,and controlled strains. | Yixiu Wang Shengyu Jin Qingxiao Wang Min Wu Shukai Yao Peilin Liao Moon JKim Gary JCheng Wenzhuo Wu | 2020 | Nano-Micro Letters2020，12，11： | 0 |
| 20 | Multitranscriptome analyses of keloid fibroblasts reveal the role of the HIF-1α/HOXC6/ERK axis in keloid development显示文摘Background:A keloid is a disease of excessive fibrosis that is characterized by the aberrant prolifer-ation of fibroblasts.However,the molecular mechanisms of fibroblasts during the development of keloids remain unclear.This study aims to identify new molecular targets that promote the proliferation and migration of keloid fibroblasts,providing new ideas for the prevention and treatment of keloids.Methods:We utilized bioinformatics tools to analyze data from keloid fibroblasts(KFs)available in the Gene Expression Omnibus(GEO)database to identify the key genes involved in keloid development.Homeobox C6(HOXC6)emerged as a hub gene in KFs from the GEO database was verified in keloid tissue samples and KFs using reverse transcription-quantitative polymerase chain reaction,western blot(WB)and immunohistochemistry.Subsequently,the effects of down-regulated HOXC6 expression on the cellular behaviors of KFs were examined by performing Cell Counting Kit-8,flow cytometry,transwell migration and WB assays.Meanwhile,we performed transcriptome sequencing and gene set enrichment analysis(GSEA)to further explore HOXC6-related mechanisms and validated the signaling pathways by performing a series of experiments.Results:HOXC6 was the top-ranking hub gene of KFs in microarray datasets from GEO and was upregulated in keloid tissue samples and KFs.Downregulation of HOXC6 inhibited proliferation,migration and extracellular matrix(ECM)accumulation and promoted KF apoptosis.GSEA pre-dicted that the hypoxia signaling pathway was associated with HOXC6 in KFs.Transcriptome sequencing suggested that the extracellular regulated protein kinase(ERK)pathway was one of the downstream pathways of HOXC6 in KFs.Our experiments confirmed that hypoxia-inducible factor-1α(HIF-1α)upregulates HOXC6,contributing to KFs proliferation,migration,apoptosis inhibition and collagen accumulation through the ERK signaling pathway.Conclusions:Our findings first revealed that HOXC6 acts as an oncogenic driver in the molec-ular mechanisms of fibroblasts in keloids.The HIF-1α/HOXC6/ERK axis promotes proliferation,migration and ECM production by KFs,contributing to the progression of keloids.Taken together,HOXC6 may serve as a promising novel therapeutic target and new focus for research designed to understand the pathogenesis of keloids. | Qi Wang Yixiu Zhong Zhijia Li Dingheng Zhu Hongyan Lu Pingjiao Chen Changxing Li Xuebiao Peng Qian Li Kang Zeng | 2022 | Burns & Trauma2022，10，1： | 0 |
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