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| 1 | African Swine Fever Virus MGF360-12L Inhibits Type Ⅰ Interferon Production by Blocking the Interaction of Importin α and NF-κB Signaling Pathway显示文摘African swine fever(ASF)is an infectious transboundary disease of domestic pigs and wild boar and spreading throughout Eurasia.There is no vaccine and treatment available.Complex immune escape strategies of African swine fever virus(ASFV)are crucial factors affecting immune prevention and vaccine development.MGF360 genes have been implicated in the modulation of the IFN-Ⅰresponse.The molecular mechanisms contributing to innate immunity are poorly understood.In this study,we demonstrated that ASFV MGF360-12 L(MGF360 families 12 L protein)significantly inhibited the mRNA transcription and promoter activity of IFN-βand NF-κB,accompanied by decreases of IRF3,STING,TBK1,ISG54,ISG56 and AP-1 m RNA transcription.Also,MGF360-12 L might suppress the nuclear localization of p50 and p65 mediated by classical nuclear localization signal(NLS).Additionally,MGF360-12 L could interact with KPNA2,KPNA3,and KPNA4,which interrupted the interaction between p65 and KPNA2,KPNA3,KPNA4.We further found that MGF360-12 L could interfere with the NF-κB nuclear translocation by competitively inhibiting the interaction between NF-κB and nuclear transport proteins.These findings suggested that MGF360-12 L could inhibit the IFN-Ⅰproduction by blocking the interaction of importinαand NF-κB signaling pathway,which might reveal a novel strategy for ASFV to escape the host innate immune response. | Yisha Zhuo Zeheng Guo Tongtong Ba Cheng Zhang Lihua He Cuiping Zeng Hanchuan Dai | 2021 | Virologica Sinica2021，36，2： | 21 |
| 2 | Digitized Outcrop Geomodeling of Ramp Shoals and its Reservoirs: as an Example of Lower Triassic Feixianguan Formation of Eastern Sichuan Basin显示文摘Numerous hydrocarbon accumulations are found in ramp crest shoals worldwide and therefore this depositional setting has a high potential of being the hydrocarbon reservoir.In this paper,we combined digital outcrop geology and traditional geological mapping to build an outcrop-based geocellular model of the ramp-crest shoal complex of the Lower Triassic Feixianguan Formation in the Eastern Sichuan Basin.The outcrop model serves as an analogue for the subsurface reservoir of the Feixianguan Formation and illustrates the complexity of the lithofacies types,stratigraphic architecture,and reservoir heterogeneities at a scale below conventional subsurface data resolution.The studied ramp-crest shoal complex consists of thirteen types of lithofacies that can be grouped into three facies-groups corresponding to subtidal intraclastic shoal,sub-to inter-tidal oolitic shoal,and tidal flat depositional environments respectively.The stratigraphic architecture of the shoal complex shows mostly a strong progradation of the high energy facies associated with an overall decrease of accommodation space associated with relative sea level still stand.Two reservoir facies associations have been recognized.The first one consists of supratidal dolomudstone and upper intertidal partially dolomitized oolitic packstone with anhydrite or nodules.These facies were deposited above the high energy oolitic grainstones and occurs as thin-bedded and laterally continuous layers,characterized by high porosity and low permeability.The second reservoir facies association is composed of intertidal crystalline dolomite and subtidal intraclastic bindstone that occurs stratigraphically below the oolitic grainstones.These deposits consist of massive laterally discontinuously beds,and are characterized by high porosity and high permeability.Both types of reservoir facies tend to be stacked vertically and migrated laterally with the progradation of the shoal complex.The construction of the outcrop-based 3D geological model provide a description and quantification of the facies distribution within a robust stratigraphic framework and the style and amount of reservoir heterogeneities associated with a ramp-crest shoal complex reservoir such as the one found in Lower Triassic Feixianguan Formation and Cambrian Longwangmiao Formation in Sichuan Basin or other ramp-crest reservoir worldwide. | QIAO Zhanfeng SHEN Anjiang ZHENG Jianfeng Xavier JANSON CHANG Shaoying WANG Xiaofang CHEN Yana LIAO Yisha | 2017 | Acta Geologica Sinica(English Edition)2017，91，4： | 8 |
| 3 | Reconstruction of nerve root sheaths for sacral extradural spinal meningeal cysts with spinal nerve root fibers显示文摘This study analyzed the clinical characteristics and outcomes of sacral extradural spinal meningeal cysts with spinal nerve root fibers treated by reconstruction of the nerve root sheaths.The relationships between the cysts and spinal nerve root fibers were examined microscopically,the cysts were partially excised,and the defects were oversewn to reconstruct the nerve root sheaths.The Improved Japanese Orthopedic Association(IJOA)scoring system was used to evaluate preoperative and postoperative neurological function.Thirty-eight patients were included in this study,with a mean age of 41.4±15.57 years.The mean IJOA score was 18.8±1.32 preoperatively and 19.6±0.65 postoperatively,which was a significant difference(t=–3.77,P=0.001).These results indicate a significant improvement in neurological function after surgery.The most significant improvement in neurological function was sensation(z=–2.86,P=0.004),followed by bowel/bladder function(z=–2.31,P=0.02). | SUN JianJun WANG ZhenYu LI ZhenDong WU HaiBo YEN RuYu ZHENG Mei CHANG Qing LIU Isabelle Yisha | 2013 | Science China(Life Sciences)2013，56，11： | 8 |
| 4 | Six kilowatt record all-fiberized and narrow-linewidth fiber amplifier with near-diffraction-limited beam quality显示文摘In this work,an all-fiberized and narrow-linewidth fiber amplifier with record output power and near-diffraction-limited beam quality is presented.Up to 6.12 kW fiber laser with the conversion efficiency of approximately 78.8%is achieved through the fiber amplifier based on a conventional step-index active fiber.At the maximum output power,the 3 dB spectral linewidth is approximately 0.86 nm and the beam quality factor is M_(x)^(2)=1.43,M_(y)^(2)=1.36.We have also measured and compared the output properties of the fiber amplifier employing different pumping schemes.Notably,the practical power limit of the fiber amplifier could be estimated through the maximum output powers of the fiber amplifier employing unidirectional pumping schemes.Overall,this work could provide a good reference for the optimal design and potential exploration of high-power narrow-linewidth fiber laser systems. | Guangjian Wang Jiaxin Song Yisha Chen Shuai Ren Pengfei Ma Wei Liu Tianfu Yao Pu Zhou | 2022 | High Power Laser Science and Engineering2022，10，4： | 5 |
| 5 | 根袖重建术治疗包含有神经根的骶管囊肿显示文摘分析了包含有神经根的骶管囊肿的临床特性,评估了根袖重建术的治疗效果.根据术中显微镜下所见,判明神经根和骶管囊肿的关系(确定神经根在囊肿内),切除多余的囊肿壁,重叠缝合重建神经根袖.用改良的IJOA评分来评价患者手术前后的神经功能状况.38例患者入组本研究,平均年龄(41.4±15.57)岁,术前IJOA评分为18.8±1.32,术后IJOA评分为19.6±0.65,手术前后IJOA分值差异显著(t=3.77,P=0.001),有统计学意义,术后神经功能状况得以显著改善.感觉功能改善最明显(z=2.86,P=0.004),其次是二便功能(z=2.31,P=0.02). | 孙建军 王振宇 李振东 邬海博 颜如玉 郑梅 常青 LIU Isabelle Yisha | 2013 | 中国科学:生命科学2013，43，11： | 3 |
| 6 | Near-infrared small molecular fluorescent dyes for photothermal therapy显示文摘Near-infrared(NIR)fluorescent dyes based on small organic molecules are characterized with low cytotoxicity,good biocompatibility and minimum interference from auto-fluorescence background,which are widely used in tumor diagnosis.Intensive research on molecular properties and photothermal properties of fluorescent dyes have been explored for non-invasive photothermal treatment of cancer.In this review,we focus on the development of imaging-induced photothermal therapy of small molecules and classification according to the structures of organic molecules including cyanines,phthalocyanines,rhodamine analogues and BODIPYs. | Yisha Chen Li Li Weijie Chen Haiyan Chen Jun Yin | 2019 | Chinese Chemical Letters2019，30，7： | 3 |
| 7 | Micro RNAs Regulating Signaling Pathways:Potential Biomarkers in Systemic Sclerosis显示文摘Systemic sclerosis(SSc) is a multisystem fibrotic and autoimmune disease. Both genetic and epigenetic elements mediate SSc pathophysiology. This review summarizes the role of one epigenetic element, known as micro RNAs(mi RNAs), involved in different signaling pathways of SSc pathogenesis. The expression of key components in transforming growth factor-b(TGF-b)signaling pathway has been found to be regulated by mi RNAs both upstream and downstream of TGF-b. We are specifically interested in the pathway components upstream of TGF-b, while mi RNAs in other signaling pathways have not been extensively studied. The emerging role of mi RNAs in vasculopathy of SSc suggests a promising new direction for future investigation. Elucidation of the regulatory role of mi RNAs in the expression of signaling factors may facilitate the discovery of novel biomarkers in SSc and improve the understanding and treatment of this disease. | Yisha Li Jing Huang Muyao Guo Xiaoxia Zuo | 2015 | Genomics, Proteomics & Bioinformatics2015，13，4： | 3 |
| 8 | Distributed Sparse Signal Estimation in Sensor Networks Using H_∞-Consensus Filtering显示文摘This paper is concerned with the sparse signal recovery problem in sensor networks, and the main purpose is to design a filter for each sensor node to estimate a sparse signal sequence using the measurements distributed over the whole network. A so-called 1-regularized H_∞filter is established at first by introducing a pseudo-measurement equation, and the necessary and sufficient condition for existence of this filter is derived by means of Krein space Kalman filtering.By embedding a high-pass consensus filter into 1-regularized H∞filter in information form, a distributed filtering algorithm is developed, which ensures that all node filters can reach a consensus on the estimates of sparse signals asymptotically and satisfy the prescribed H∞performance constraint. Finally, a numerical example is provided to demonstrate effectiveness and applicability of the proposed method. | Haiyang Yu Yisha Liu Wei Wang | 2014 | IEEE/CAA Journal of Automatica Sinica2014，1，2： | 2 |
| 9 | Photodynamic therapy based on organic small molecular fluorescent dyes显示文摘Photodynamic therapy(PDT) has shown promise as an effective treatment modality for cancer and other localized diseases due to its noninvasive properties and spatiotemporal selectivity. Near-infrared(NIR)fluorescent dyes based on organic small molecules are characterized with low cytotoxicity, good biocompatibility and excellent phototoxicity, which are widely used in PDT. In this review, we attempt to summarize the development of imaging-induced PDT based on organic small molecules and classify it according to the structures of dyes including cyanines, 4,4-difluoro-4-bora-3 a,4 a-diaza-s-indacene(BODIPY) analogues, phthalocyanine and other agents such as rhodamine analogues. | Li Li Yisha Chen Weijie Chen Ying Tan Haiyan Chen Jun Yin | 2019 | Chinese Chemical Letters2019，30，10： | 2 |
| 10 | Effective suppression of the photodarkening effect in high-power Yb-doped fiber amplifiers by H2 loading显示文摘The radical suppression of the photodarkening effect and laser performance deterioration via H2 loading were demonstrated in high-power Yb-doped fiber(YDF)amplifiers.The photodarkening loss at equilibrium was114.4 d B/m at 702 nm in the pristine fiber,while it vanished in the H2-loaded fiber.To obtain a deeper understanding of the impact of photodarkening on laser properties,the evolution of the mode instability threshold and output power in fiber amplifiers was investigated.After pumping for 300 min,the mode instability threshold of the pristine fiber dropped from 770 to 612 W,and the periodic fluctuation of the output power became intense,finally reaching 100 W.To address the detrimental effects originating from photodarkening,H2 loading was applied in contrast experiments.The output power remained stable,and no sign of mode instability was observed in the H2-loaded fiber.Moreover,the transmittance at 638 nm confirmed the absence of the photodarkening effect.The results pave the way for the further development of high-power fiber lasers. | RUITING CAO GUI CHEN YISHA CHEN ZHILUN ZHANG XIANFENG LIN BIN DAI LUYUN YANG JINYAN LI | 2020 | Photonics Research2020，8，3： | 2 |
| 11 | MicroRNA-21 in Scleroderma Fibrosis and its Function in TGF-β- Regulated Fibrosis-Related Genes Expression显示文摘 | Honglin Zhu Hui Luo Yisha Li Yaou Zhou Ying Jiang Jin Chai Xianzhong Xiao Yunhui You Xiaoxia Zuo | 2013 | Journal of Clinical Immunology2013，，6： | 1 |
| 12 | Genetic variants at 4q21, 4q23 and 12q24 are associated with esophageal squamous cell carcinoma risk in a Chinese population显示文摘 | Yong Gao Yisha He Jing Xu Lin Xu Jiangbo Du Chen Zhu Haiyong Gu Hongxia Ma Zhibin Hu Guangfu Jin Xiaofei Chen Hongbing Shen | 2013 | Human Genetics2013，，6： | 1 |
| 13 | Reliable H∞filtering for discrete time-delay systems with randomly occurred nonlinearities via delay-partitioning method显示文摘 | Liu Yisha Wang Zidong Wang Wei | 2011 | Signal Processing2011，91，： | 1 |
| 14 | Characteristics and Mechanism of Upper Permian Reef Reservoirs in the Eastern Longgang Area, Northeastern Sichuan Basin, China显示文摘As a typical kind of lithologic reservoirs,reef reservoirs are generally featured by their large single-well reservoir thickness,good reservoir physical properties,and high gas well productivity.The Upper Permian Changxing Formation is an important natural gas exploration target in the Sichuan Basin,which hosts a large reef gas reservoir and is mainly distributed along the Kaijiang-Liangping Trough.Comprehensive analyses are implemented to investigate reservoir characteristics and identify controlling factors of reef reservoirs in Changxing Formation in the Eastern Longgang Area,Northeastern Sichuan Basin,including core,logging,and seismic data analyses.Changxing Formation reservoirs in the study area mainly occur in the reef-shoal complex,which are featured by wide distribution,large thickness and generally good physical properties.Reservoir rocks are dominantly composed of bioclastic dolomite and silty-fine dolomite(with grain phantom structure),while the main reservoir space consists of residual intergranular pores,intergranular dissolution pores,and karst vugs.In the seismic profiles,typical mound-shaped chaotic reflections can be clearly seen.It is suggested by the main reservoir development controlling factor analysis that the distributions of reef reservoirs are typically controlled by sedimentary facies belts,while the scale of the reef-shoal complex is determined by the pene-sedimentary micro-paleo-geomorphology.Dolomitization can not only significantly preserve the primary pores but also enhance the permeability of rocks.Moreover,karstification is the key to high-quality reef-shoal reservoirs. | Lei Tan Hong Liu Yuzhe Tang Bing Luo Ya Zhang Yuran Yang Yisha Liao Weifeng Du Xiran Yang | 2020 | Petroleum2020，6，2： | 1 |
| 15 | Study on Application of Conflict Analysis in Chinese Stock Market显示文摘 | Yisha Na Congdong Li | 2004 | China-USA Business Review2004，3，5： | 0 |
| 16 | ERPApplication in China.显示文摘 | Yisha Na Congdong Li | 2004 | China-USA Business Review2004，3，1： | 0 |
| 17 | Research on the implementation of West Africa-North Africa grid interconnection using new electricity-water composite transmission technology显示文摘Combining the characteristics of the reverse distribution of solar resources and water resources in North Africa,West Africa and the Sahara,this paper proposes the West Africa-North Africa grid interconnection project to realize the optimal configuration of desert solar resources and surrounding water resources,and introduce the water resources of West Africa's Niger River and North Africa's desalinated seawater to improve the living environment and development conditions in the hinterland of the Sahara Desert;build photovoltaic bases along the route to send clean electricity to North Africa and West Africa.This paper studies the transmission channel path,electricity-water composite transmission technology and project scheme,and analyzes the economics of the project and the water supply and demand conditions of the Niger River.The research results show that it is feasible in hydrological characteristics to lead the Niger River water along the power transmission channel that crosses the Sahara Desert,and the new electricity-water composite transmission technology has obvious economic advantages. | Yu Zhang Jinyu Xiao Zhou Zhou Yun Zhao Haibin Wan Yisha Lin | 2021 | Global Energy Interconnection2021，4，5： | 0 |
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