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| 1 | Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks显示文摘Avian infectious bronchitis virus(IBV) is a Gammacoronavirus in the family Coronaviridae and causes highly contagious respiratory disease in chickens. Innate immunity plays significant roles in host defense against IBV. Here, we explored the interaction between IBV and the host innate immune system. Severe histopathological lesions were observed in the tracheal mucosa at 3–5days post inoculation(dpi) and in the kidney at 8 dpi, with heavy viral loads at 1–11 and 1–28 dpi,respectively. The expression of m RNAs encoding Toll-like receptor(TLR) 3 and TLR7 were upregulated at 3–8 dpi, and that of TIR-domain-containing adapter-inducing interferon(IFN) β(TRIF) was upregulated at 21 dpi in the trachea and kidney. Myeloid differentiation primary response protein 88(My D88) was upregulated in the trachea during early infection. Tumor necrosis factor receptor-associated factor(TRAF) 3 and TRAF6 were upregulated expression in both tissues.Moreover, melanoma differentiation-associated protein 5(MDA5), laboratory of genetics and physiology 2(LGP2), stimulator of IFN genes(STING), and mitochondrial antiviral signaling protein(MAVS), as well as TANK binding kinase 1(TBK1), inhibitor of kappa B kinase(IKK) ?, IKKα, IKKβ,IFN regulatory factor(IRF) 7, nuclear factor of kappa B(NF-κB), IFN-α, IFN-β, various interleukins(ILs), and macrophage inflammatory protein-1β(MIP-1β) were significantly upregulated in the trachea and downregulated in the kidney. These results suggested that the TLR and MDA5 signaling pathways and innate immune cytokine were induced after IBV infection. Additionally,consistent responses to IBV infection were observed during early infection, with differential and complicated responses in the kidney. | Yining He Zhiwen Xie Jinglong Dai Yanjie Cao Jinlian Hou Yansheng Zheng Tianchao Wei Meilan Mo Ping Wei | 2016 | Virologica Sinica2016，31，1： | 14 |
| 2 | Hypoxia-mimicking 3D bioglass-nanoclay scaffolds promote endogenous bone regeneration显示文摘Large bone defect repair requires biomaterials that promote angiogenesis and osteogenesis.In present work,a nanoclay(Laponite,XLS)-functionalized 3D bioglass(BG)scaffold with hypoxia mimicking property was prepared by foam replication coupled with UV photopolymerization methods.Our data revealed that the incorporation of XLS can significantly promote the mechanical property of the scaffold and the osteogenic differentiation of human adipose mesenchymal stem cells(ADSCs)compared to the properties of the neat BG scaffold.Desferoxamine,a hypoxia mimicking agent,encourages bone regeneration via activating hypoxia-inducible factor-1 alpha(HIF-1α)-mediated angiogenesis.GelMA-DFO immobilization onto BG-XLS scaffold achieved sustained DFO release and inhibited DFO degradation.Furthermore,in vitro data demonstrated increased HIF-1αand vascular endothelial growth factor(VEGF)expressions on human adipose mesenchymal stem cells(ADSCs).Moreover,BG-XLS/GelMA-DFO scaffolds also significantly promoted the osteogenic differentiation of ADSCs.Most importantly,our in vivo data indicated BG-XLS/GelMA-DFO scaffolds strongly increased bone healing in a critical-sized mouse cranial bone defect model.Therefore,we developed a novel BG-XLS/GelMA-DFO scaffold which can not only induce the expression of VEGF,but also promote osteogenic differentiation of ADSCs to promote endogenous bone regeneration. | Xiao Zheng Xiaorong Zhang Yingting Wang Yangxi Liu Yining Pan Yijia Li Man Ji Xueqin Zhao Shengbin Huang Qingqing Yao | 2021 | Bioactive Materials2021，6，10： | 4 |
| 3 | An experimental study on the workability of self-compacting lightweight concrete显示文摘 | Zhimin Wu Yunguo Zhang Jianjun Zheng Yining Ding | 2008 | Construction and Building Materials2008，，5： | 1 |
| 4 | The mechanistic target of rapamycin complex 1 pathway involved in hepatic gluconeogenesis through peroxisome-proliferator-activated receptorγcoactivator-1a显示文摘Cattle can efficiently perform de novo generation of glucose through hepatic gluconeogenesis to meet post-weaning glucose demand.Substantial evidence points to cattle and non-ruminant animals being characterized by phylogenetic features in terms of their differing capacity for hepatic gluconeogenesis,a process that is highly efficient in cattle yet the underlying mechanism remains unclear.Here we used a variety of transcriptome data,as well as tissue and cell-based methods to uncover the mechanisms of high-efficiency hepatic gluconeogenesis in cattle.We showed that cattle can efficiently convert propionate into pyruvate,at least partly,via high expression of acyl-CoA synthetase short-chain family member 1(ACSS1),propionyl-CoA carboxylase alpha chain(PCCA),methylmalonyl-CoA epimerase(MCEE),methylmalonyl-CoA mutase(MMUT),and succinate-CoA ligase(SUCLG2)genes in the liver(P<0.01).Moreover,higher expression of the rate-limiting enzymes of gluconeogenesis,such as phosphoenolpyruvate carboxykinase(PCK)and fructose 1,6-bisphosphatase(FBP),ensures the efficient operation of hepatic gluconeogenesis in cattle(P<0.01).Mechanistically,we found that cattle liver exhibits highly active mechanistic target of rapamycin complex 1(mTORC1),and the expressions of PCCA,MMUT,SUCLG2,PCK,and FBP genes are regulated by the activation of mTORC1(P<0.001).Finally,our results showed that mTORC1 promotes hepatic gluconeogenesis in a peroxisome proliferator-activated receptor γ coactivator 1a(PGC-1a)dependent manner.Collectively,our results not only revealed an important mechanism responsible for the quantitative differences in the efficiency of hepatic gluconeogenesis in cattle versus non-ruminant animals,but also established that mTORC1 is indeed involved in the regulation of hepatic gluconeogenesis through PGC-1a.These results provide a novel potential insight into promoting hepatic gluconeogenesis through activated mTORC1 in both ruminants and mammals. | Guoyan Wang Jun Zhang Shengru Wu Senlin Qin Yining Zheng Chao Xia Huijun Geng Junhu Yao Lu Deng | 2022 | Animal Nutrition2022，，4： | 1 |
| 5 | Denoising of quartered ultrasound Doppler signal from bi- directional flow based on matching pursuit显示文摘 | Zheng Yining | 2009 | Ultrasonic2009，49，1： | 1 |
| 6 | Thermostable Nitrogen-Doped HTiNbO5 Nanosheets with a High Visible-Light Photocatalytic Activity显示文摘做氮的 HTiNbO5 nanosheets 被第一 exfoliating 成功地综合了在 tetrabutylammonium 氢氧化物(TBAOH ) 到的分层的 HTiNbO5 获得 HTiNbO5 nanosheets 然后与脲加热 nanosheets。产生样品被 X 光检查描绘衍射(XRD ) ,传播电子显微镜学(TEM ) ,扫描电子显微镜学(SEM ) ,精力散的 X 光检查(EDX ) , X 光检查光电子光谱学(XPS ) ,紫外力的光谱学和 N2 吸附解吸附作用大小。在分层的结构,内在的 bandgap 变窄和可见轻回答的高得多的 thermostability 结果,被发现那做 N。做的氮原子主要位于 TiNbO5 lamellae 的空隙的地点并且化学上跳了到氢离子。与做 N 的 HTiNbO5 相比,做 N 的 HTiNbO5 nanosheets 由于 titanoniobate nanosheets 的相当松开、不规则的安排有一个大得多的特定的表面区域和更富有的 mesoporosity。做 N 的分层的 HTiNbO5 和 HTiNbO5 nanosheets 为玫瑰精 B (RhB ) 的降级显示出一项很高可见光的 photocatalytic 活动水的答案。而且由于更加更大的表面区域,更富有的 mesoporosity 和更强壮的酸味,做 N 的 HTiNbO5 nanosheets 比做 N 的 HTiNbO5 举办了一项甚至更高的活动,尽管后者在可见区域有更强壮的吸收。染料分子主要被降级到脂肪族的有机化合物并且部分使矿物化到 CO2 或公司,而非简单地被将脱色。photosensitization 的效果是不足道的, RhB 主要经由典型 photocatalytic 反应线路被降级。为在在做 N 的 HTiNbO5 nanosheets 上的可见轻照耀下面的 RhB 的 photodegradation 的二条不同反应线路被建议了。现在的方法能被扩大到有置闰和脱落的特征的很多分层的金属氧化物,因此为高度有效、潜在地实际的可见光的光催化剂的制造提供新机会。 | Zheng Zhai Yucheng Huang Lin Xu Xiaoyan Yang Chenhui Hu Lihong Zhang Yining Fan Wenhua Hou | 2011 | Nano Research2011，4，7： | 1 |
| 7 | Study on the Reduction Behavior of Zirconia Supported Iron Oxide Catalysts by Temperature-programmed Reduction Combined with in Situ Moessbauer Spectroscopy显示文摘 | CHEN Kaidong FAN Yining HU Zheng | 1996 | Journal of Solid State Chemistry (S0022-4596)1996，121，1： | 1 |
| 8 | Denoising of quadrature ultrasound Doppler signal from bi-directional flow based on matching pursuit显示文摘 | Zheng Yining | 2009 | Ultrasonics2009，49，1： | 1 |
| 9 | An experimental study on the workability of self-compacting lightweight concrete显示文摘 | Zhimin Wu Yunguo Zhang Jianjun Zheng Yining Ding | 2008 | Construction and Building Materials2008，，5： | 1 |
| 10 | Advances on the modification and biomedical applications of acellular dermal matrices显示文摘Acellular dermal matrix(ADM)is derived from natural skin by removing the entire epidermis and the cell components of dermis,but retaining the collagen components of dermis.It can be used as a therapeutic alternative to“gold standard”tissue grafts and has been widely used in many surgical fields,since it possesses affluent predominant physicochemical and biological characteristics that have attracted the attention of researchers.Herein,the basic science of biologics with a focus on ADMs is comprehensively described,the modification principles and technologies of ADM are discussed,and the characteristics of ADMs and the evidence behind their use for a variety of reconstructive and prosthetic purposes are reviewed.In addition,the advances in biomedical applications of ADMs and the common indications for use in reconstructing and repairing wounds,maintaining homeostasis in the filling of a tissue defect,guiding tissue regeneration,and delivering cells via grafts in surgical applications are thoroughly analyzed.This review expectedly promotes and inspires the emergence of natural raw collagen-based materials as an advanced substitute biomaterial to autologous tissue transplantation. | Yining Chen Xinhua Liu Xin Zheng Xuantao Huang Weihua Dan Zhengjun Li Nianhua Dan Yunbing Wang | 2022 | Journal of Leather Science and Engineering2022，4，1： | 0 |
| 11 | Heat Shock Factor A1s are required for phytochrome-interacting factor 4-mediated thermomorphogenesis in Arabidopsis显示文摘Thermomorphogenesis and the heat shock(HS)response are distinct thermal responses in plants that are regulated by PHYTOCHROME-INTERACTING FACTOR 4(PIF4)and HEAT SHOCK FACTOR A1s(HSFA1s),respectively.Little is known about whether these responses are interconnected and whether they are activated by similar mechanisms.An analysis of transcriptome dynamics in response to warm temperature(28℃)treatment revealed that 30 min of exposure activated the expression of a subset of HSFA1 target genes in Arabidopsis thaliana.Meanwhile,a loss-of-function HSFA1 quadruple mutant(hsfa1-cq)was insensitive to warm temperature-induced hypocotyl growth.In hsfa1-cq plants grown at 28℃,the protein and transcript levels of PIF4 were greatly reduced,and the circadian rhythm of many thermomorphogenesis-related genes(including PIF4)was disturbed.Additionally,the nuclear localization of HSFA1s and the binding of HSFA1d to the PIF4 promoter increased following warm temperature exposure,whereas PIF4 overexpression in hsfa1-cq partially rescued the altered warm temperature-induced hypocotyl growth of the mutant.Taken together,these results suggest that HSFA1s are required for PIF4 accumulation at a warm temperature,and they establish a central role for HSFA1s in regulating both thermomorphogenesis and HS responses in Arabidopsis. | Bingjie Li Shimeng Jiang Liang Gao Wenhui Wang Haozheng Luo Yining Dong Zhihua Gao Shuzhi Zheng Xinye Liu Wenqiang Tang | 2024 | Journal of Integrative Plant Biology2024，66，1： | 0 |
| 12 | Identification of stress-related characteristics of the WRKY gene family: A case study of Dendrobium catenatum显示文摘As one of the largest families of transcription factors(TFs)in plants,the WRKY TF family plays a key role in regulating plant responses to various biotic and abiotic stresses.However,there is no confirmed method to quickly identify stress-responsive members from the WRKY gene family.In this study,all reported functional WRKY genes were first analyzed,and the amino acid patterns in response to stress were identified in group II-c(T-R/K-S/T-E/Q/D-V/I/L-E/D-I/V/H/N-L/M-D/E-D-G/E-F/Y-K/R-WRKYG-Q/K-K-A/T-VKN-S/N-P),group II-d(VPA-I/V-S-X-K-M/L/V/I-ADIP-P/A/V-D-D/EY/F-S-WRKYGQKPIKGSP-H/Y-PRGYYKCS-S/T-V/M-RGCPARKVER),and group II-e(PSD-S/A/L-WAWRKYGQKPIKGSPYPR-G/S-YYRCSSSKGC).WRKY genes in Dendrobium catenatum were used to validate the accuracy of these patterns.A total of 63 DcaWRKY genes were identified,their gene structures,conserved motifs,and gene expression patterns were analyzed,and a phylogenetic tree was constructed.Gene expression patterns were then analyzed under drought stress,and seven DcaWRKY genes(Dca002550,Dca002715,Dca005648,Dca007842,Dca010430,Dca016437,and Dca006787)were randomly selected to determine their expression levels and verify their expression patterns by quantitative real-time polymerase chain reaction analysis.The identified amino acid patterns were validated by drought-responsive WRKY genes in D.catenatum,confirming the accuracy of these amino acid patterns and providing valuable insights into further research of the WRKY family in D.catenatum. | Yining Zhao Yifei Zheng Luyuan Jiang Yunxia Niu Yanfang Yang Duanfen Chen Shance Niu | 2022 | Ornamental Plant Research2022，2，1： | 0 |
| 13 | Text information aggregation with centrality attention显示文摘A lot of natural language processing problems need to encode the text sequence as a fix-length vector, which usually involves an aggregation process of combining the representations of all the words, such as pooling or self-attention. However, these widely used aggregation approaches do not take higher-order relationships among the words into consideration. Hence we propose a new way of obtaining aggregation weights, called eigen-centrality self-attention. More specifically, we build a fully-connected graph for all the words in a sentence, then compute the eigen-centrality as the attention score of each word. The explicit modeling of relationships as a graph is able to capture some higher-order dependency among words, which helps us achieve better results in 5 text classification tasks and one SNLI task than baseline models such as pooling, self-attention, and dynamic routing. Besides, in order to compute the dominant eigenvector of the graph, we adopt a power method algorithm to get the eigen-centrality measure. Moreover, we also derive an iterative approach to get the gradient for the power method process to reduce both memory consumption and computation requirement. | Jingjing GONG Hang YAN Yining ZHENG Qipeng GUO Xipeng QIU Xuanjing HUANG | 2021 | Science China(Information Sciences)2021，64，12： | 0 |
| 14 | Characteristics and health risks of population exposure to phthalates via the use of face towels显示文摘The production of face towels is growing at an annual rate of about 4%in China,reaching 1.13 million tons by 2021.Phthalates(PAEs)are widely used in textiles,and face towels,as an important household textile,may expose people to PAEs via the skin,further leading to health risks.We collected new face towels and analyzed the distribution characterization of PAEs in them.The changes of PAEs were explored in a face towel use experiment and a simulated laundry experiment.Based on the use of face towels by 24 volunteers,we calculated the estimated daily intake(EDI)and comprehensively assessed the hazard quotient(HQ),hazard index(HI),and dermal cancer risk(DCR)of PAEs exposure in the population.PAEs were present in new face towels at total concentrations of | Wenhui Zhang Na Zheng Sujing Wang Siyu Sun Qirui An Xiaoqian Li Zimeng Li Yining Ji Yunyang Li Jiamin Pan | 2023 | Journal of Environmental Sciences2023，，8： | 0 |
| 15 | Atomically precise gold nanoclusters for healthcare applications显示文摘The potential application of gold nanoparticles(GNPs)in biomedicine has been extensively reported.However,there is still too much puzzle about their real face and potential health risks in comparison with the commercial drug molecules.The emergence of atomically precise gold nanoclusters(APGNCs)provides the opportunity to address the puzzle due to their ultrasmall size,defined molecular formula,editable surface engineering,available structures and unique physicochemical properties including excellent biocompatibility,strong luminescence,enzyme-like activity and efficient renal clearance,et al.Recently,these advantages of APGNCs also endow them promising performances in healthcare such as bioimaging,drug delivery,antibacterial and cancer therapy.Especially,their clear composition and structures like the commercial drug molecules facilitate the study of their functions and the structure-activity relationship in healthcare,which is essential for the guided design of APGNC nanomedicine.Therefore,this review will focus the advantages and recent progress of APGNCs in health care and envision their prospects for the future. | Tiansheng Wei Congcong Mi Yan Sun Yining Chen Xiaoyang Hu Zibao Gan Xiuwen Zheng | 2023 | Biomedical Engineering Communications2023，2，4： | 0 |
| 16 | Deeply‐Recursive Attention Network for video steganography显示文摘Video steganography plays an important role in secret communication that conceals a secret video in a cover video by perturbing the value of pixels in the cover frames.Imperceptibility is the first and foremost requirement of any steganographic approach.Inspired by the fact that human eyes perceive pixel perturbation differently in different video areas,a novel effective and efficient Deeply‐Recursive Attention Network(DRANet)for video steganography to find suitable areas for information hiding via modelling spatio‐temporal attention is proposed.The DRANet mainly contains two important components,a Non‐Local Self‐Attention(NLSA)block and a Non‐Local Co‐Attention(NLCA)block.Specifically,the NLSA block can select the cover frame areas which are suitable for hiding by computing the correlations among inter‐and intra‐cover frames.The NLCA block aims to effectively produce the enhanced representations of the secret frames to enhance the robustness of the model and alleviate the influence of different areas in the secret video.Furthermore,the DRANet reduces the model parameters by performing similar operations on the different frames within an input video recursively.Experimental results show the proposed DRANet achieves better performance with fewer parameters than the state‐of‐the‐art competitors. | Jiabao Cui Liangli Zheng Yunlong Yu Yining Lin Huajian Ni Xin Xu Zhongfei Zhang | 2023 | CAAI Transactions on Intelligence Technology2023，8，4： | 0 |
| 17 | Computational design of catalysts for ammonia synthesis显示文摘Ammonia plays a crucial role in agriculture and chemical engineering,and acts as a promising carbon-free transportation fuel.Catalysts design is deemed as a key to solve the restriction of energy-intensive Haber-Bosch process of ammonia production.With the development of computational modeling,computation-aided catalyst design serves as one important driving force for material innovation,saving a lot of experimental efforts based on trial and error.Computational modeling not only provides fundamental mechanistic insights into the reaction with great details regarding adsorbate geometries,electronic structures,and elementary-step energies,but also expedites the material discovery with descriptor-based catalyst design,core of which is the establishment of thermo/kinetic scaling relations.In this review,we present firstly the mechanistic understanding of ammonia synthesis and transition state scaling relations developed on pure transition-metal catalysts.We then summarize catalysts design strategies guided by alloy,size,and magnetic effects with the goal of breaking the limitations set by scaling relations to achieve better catalytic performance.Finally,future opportunities and challenges associated with computation design of optimal catalysts for ammonia synthesis are outlined. | Yining Zhang Sha Li Wei Zheng Xi Wang | 2023 | Nano Research Energy2023，2，3： | 0 |
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