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| 1 | Preparation and visible-light photocatalytic property of nanostructured Fe-doped TiO_2 from titanium containing electric furnace molten slag显示文摘Nanostructured Fe-doped titanium dioxide was synthesized from titanium containing electric furnace molten slag(TCEFMS)by using an alkali fusion,followed by a hydrolyzation-acidolysis-calcination route.The efects of alkali/slag mass ratio,calcinating temperature,calcinating time,and water/slag mass ratio on the extraction efciency and purity of products were systematically studied in this paper.It is indicated that the best extraction efciency of nanostructured Fedoped titanium dioxide is 99.35%,when the molten slag is calcinated at 700 C for 1 h with the mass ratio of alkali/molten slag of 1.5:1.The influence of alkali/slag mass ratio on the photocatalytic activity of final products was evaluated by the photodegradation of methyl blue under visible light irradiation.A maximum photodegradation efciency of 88.12%over30 min was achieved under the optimum conditions. | Yang Li Yi Yue Zai-qing Que Mei Zhang Min Guo | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，10： | 10 |
| 2 | LAG-3 expression on tumor-infiltrating T cells in soft tissue sarcoma correlates with poor survival显示文摘Objective: To elucidate the role and prognostic significance of lymphocyte activation-gene-3(LAG-3) in soft tissue sarcoma(STS).Methods: The expression of LAG-3 in patient and matched normal blood samples was analyzed by flow cytometry. The localization and prognostic values of LAG-3^+ cells in 163 STS patients were analyzed by immunohistochemistry. In addition, the expression of tumor-infiltrating CD3^+ T, CD4^+ T, and CD8^+ T cells and their role in the prognosis of STS were evaluated by immunohistochemistry. The effect of LAG-3 blockade was evaluated in an immunocompetent MCA205 fibrosarcoma mouse model.Results: Peripheral CD8^+ and CD4^+ T cells from STS patients expressed higher levels of LAG-3 than those from healthy donors.LAG-3 expression in STS was significantly associated with a poor clinical outcome(P = 0.038) and was correlated with high pathological grade(P < 0.001), advanced tumor stage(P = 0.016). Additionally, LAG-3 expression was highly correlated with CD8^+ T-cell infiltration(r = 0.7034, P < 0.001). LAG-3 was expressed in murine tumor-infiltrating lymphocytes, and its blockade decreased tumor growth and enhanced secretion of interferon-gamma by CD8^+ and CD4^+ T cells.Conclusions: LAG-3 blockade may be a promising strategy to improve the effects of targeted therapy in STS. | Yi Que Zhixin Fang Yuanxiang Guan Wei Xiao Bushu Xu Jingjing Zhao Huoying Chen Xinke Zhang Musheng Zeng Yao Liang Xing Zhang | 2019 | Cancer Biology & Medicine2019，16，2： | 9 |
| 3 | Feiji Recipe inhibits the growth of lung cancer by modulating T-cell immunity through indoleamine-2,3-dioxygenase pathway in an orthotopic implantation model显示文摘Objective: Escape from the body's immune response is a basic characteristic of lung cancer, and indoleamine-2,3-dioxygenase(IDO) plays a key role in mediating immune escape of non-small-cell lung cancer, which leads to recurrence and metastasis. Feiji Recipe, a compound Chinese herbal medicine, has the effect of stabilizing lesions and prolonging survival in patients with lung cancer. The purpose of this study was to investigate the mechanisms underlying the anticancer properties of Feiji Recipe.Methods: An orthotopic transplant model of mouse Lewis lung cancer, with stable expression of IDO gene, was established in C57 BL/6 mice. Optical imaging was used to observe the effects of Feiji Recipe in the treatment of lung cancer in vivo. The effects of Feiji Recipe on the proliferation of mouse Lewis lung cancer cell line 2 LL, 2 LL-enhanced green fluorescent protein(2 LL-EGFP) and 2 LL-EGFP-IDO were investigated, and the apoptosis of T-cells was examined by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2 H-tetra zolium bromide using flow cytometry. Chemical composition of Feiji Recipe was validated by highperformance liquid chromatography.Results: Compared to the control group, the survival of animals treated with Feiji Recipe was significantly prolonged(P = 0.0074), and the IDO protein level decreased(P = 0.0072); moreover, the percentages of CD4+CD25+T-cells and Foxp3+T-cells were significantly decreased(P < 0.05). The molecular mechanism of Feiji Recipe against lung cancer may relate to the regulation of immune cells, such as T-cells and regulatory T-cells.Conclusion: The molecular mechanism of Feiji Recipe in treatment of lung cancer is to restore the function of T-cells in the cancer microenvironment through interfering with the IDO pathway. | Bin Luo Zu-jun Que Zhi-yi Zhou Qing Wang Chang-sheng Dong Yi Jiang Bing Hu Hui Shi Yu Jin Jian-wen Liu He-gen Li Lin Wang Jian-hui Tian | 2018 | Journal of Integrative Medicine2018，16，4： | 5 |
| 4 | Using Materialise’s interactive medical image control system to reconstruct a model of a patient with rectal cancer and situs inversus totalis: A case report显示文摘BACKGROUND Situs inversus totalis(SIT)is a rare congenital anomaly that refers to a completely reversed location of abdominal and thoracic organs.An extremely small number of patients with this condition,especially those with rectal neoplasms,have been reported.Surgery in these patients is technically challenging.Therefore,we reconstructed a three-dimensional(3D)digital model with the Materialise’s interactive medical image control system(Mimics)as a guide for laparoscopic resection.CASE SUMMARY We report the case of a 68-year-old woman with rectal neoplasms and SIT diagnosed by electronic colonoscopy biopsy and enhanced computed tomography(CT),which showed that there was a soft tissue mass protruding into the lumen in the lower rectal segment,a lesion that involved the serosal layer,multiple enlarged peripheral lymph nodes,and visceral situs abnormalities.Based on the CT images,we reconstructed a 3D model with Mimics to assist with our surgical planning.Then,we performed laparoscopyassisted radical resection of the rectal neoplasms and total excision of the lesion.Adjuvant chemotherapy with the XELOX regimen(oxaliplatin 150 mg,D1+Xeloda 1.0 g,Bid,D1-14)was initiated 1 mo after the operation.The patient recovered well after surgery,and her physical condition remained stable.CONCLUSION Preoperative 3D reconstruction of the imaging results could help reduce the unknown risks during surgery caused by anatomical abnormalities and improvethe perioperative safety for patients. | Tao Chen Yu-Tao Que Yi-Hao Zhang Fei-Yu Long Yi Li Xin Huang Ya-Nan Wang Yan-Feng Hu Jiang Yu Guo-Xin Li | 2020 | World Journal of Clinical Cases2020，8，4： | 5 |
| 5 | Extraction and separation of nickel and cobalt from saprolite laterite ore by microwave-assisted hydrothermal leaching and chemical deposition显示文摘Extraction and separation of nickel and cobalt from saprolite laterite ore were studied by using a method of microwave-assisted hydrothermal leaching and chemical deposition. The effects of leaching temperature and time on the extraction efficiencies of Ni2+ and Co2+ were investigated in detail under microwave conditions. It is shown that the extraction efficiencies of Ni2+ and Co2+ from the ore pre-roasted at 300 C for 5 h were 89.19% and 61.89% when the leaching temperature and time were about 70 C and 60 min, respectively. For the separation process of Ni and Co, the separation of main chemical components was performed by adjusting the pH values of sulfuric leaching solutions using a NaOH solution based on the different pH values of precipitation for metal hydroxides. The final separation efficiencies of Ni and Co were 77.29% and 65.87%, respectively. Furthermore, the separation efficiencies of Fe of 95.36% and Mg of 92.2% were also achieved at the same time. | Yan Zhao Jian-ming Gao Yi Yue Ben Peng Zai-qing Que Min Guo Mei Zhang | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，7： | 4 |
| 6 | Herbal formula of Bushen Jianpi(补肾健脾方)combined with sorafenib inhibits hepatocellular carcinoma growth by promoting cell apoptosis and blocking the cell cycle显示文摘OBJECTIVE:To investigate the efficacy of an herbal formula of Bushen Jianpi(补肾健脾方,BSJP)combined with sorafenib on hepatocellular carcinoma(HCC)in vitro and in vivo,and to study the underlying mechanisms of action.METHODS:BSJP,a mixture of 12 raw herbs,was extracted in 70%alcohol/30%water and freeze-dried into a powder.The in vitro effects of BSJP alone,sorafenib alone,and their combination on cell survival,apoptosis,and cell cycle distribution were evaluated in HCC cell lines HCCLM3,HepG2,and SMMC-7721.The expression of B-cell lymphoma-2(Bcl-2),caspase-3,and caspase-9 in HCCLM3 cells was measured using Western blots after drug administration.The in vivo effects of BSJP and sorafenib were evaluated in a tumor surgical resection model using 4-week old male athymic BALB/c nude mice injected with HCCLM3 cells.Immunohistochemical analysis of tumor tissues was performed to evaluate the effects of BSJP alone,sorafenib alone,and their combination on the expression of caspase-3,caspase-9,and Bcl-2.RESULTS:BSJP decreased the survival rate of HCC cell lines,and the combination of BSJP and sorafenib further decreased the survival rate.BSJP significantly promoted cell apoptosis and blocked cell-cycle progression in HCCLM3,HepG2,and SMMC-7721 cells in a dose-dependent manner.Furthermore,the administration of BSJP and sorafenib inhibited the growth of HCCLM3 cell xenografts in nude mice,with no reduction in body weight.In vivo and in vitro experiments showed that BSJP combined with sorafenib could significantly decrease the expression of Bcl-2.CONCLUSION:Our findings suggest that the herbal formula of BSJP is a potential HCC antitumor agent. | ZHOU Zhangjie LIU Xinhua WU Tingting QUE Zujue WU Zhonghua WU Weizhong FU Shujuan ZHANG Shiqiang YANG Yun JIANG Haiyan XIA Xiaoting LV Junqiang DU Boqian LI Yun LU Tao ZHANG Zhihui ZHONG Yi | 2021 | Journal of Traditional Chinese Medicine2021，41，2： | 3 |
| 7 | ABT-263 induces G1/G0-phase arrest, apoptosis and autophagy in human esophageal cancer cells in vitro显示文摘 | Qing-huan LIN Fu-chang QUE Chun-ping GU De-sheng ZHONG Dan ZHOU Yi KONG Le YU Shu-wen LIU | 2017 | Acta Pharmacologica Sinica2017，38，12： | 2 |
| 8 | Pim-3 protects against cardiomyocyte apoptosis in anoxia/reoxygenation injury via p38-mediated signal pathway显示文摘 | Dan Liu Ming He Bo Yi Wu-hua Guo Ai-ling Que Ji-xiang Zhang | 2009 | International Journal of Biochemistry and Cell Biology2009，，11： | 1 |
| 9 | Sulfur-doped graphene nanoribbons with a sequence of distinct band gaps显示文摘不同于 graphene 表, graphene nanoribbons (GNR ) 能展出能被控制杂质做和 GNR 宽度和边结构调节的半导体的乐队差距特征。然而,完成如此的控制是在 GNR 的制造的主要挑战。V 形臂章类型 GNR 最近经由太古或代替 N 的 oligophenylene 单体的帮助表面的聚合被综合。原则上, GNR 异质接面能被混合二不同单体制作。在这份报纸,我们用代替硫的 oligophenylene 单体报导 V 形臂章类型 GNR 的制造和描述第一次生产 GNR 和相关 heterostructures。第一原则的计算证明 GNR 差距能被经由 debromination 和 intramolecular cyclodehydrogenation 从 cyclodehydrogenated 异构体使用不同的硫配置定制。这个特征应该由设计他们的硫配置为多重 GNR 异质接面的创造启用一条新途径。这些预言经由扫描通道显微镜学并且扫描通道光谱学被证实了。例如,我们发现了包含 S GNR 与不同乐队差距包含片断,即,导致量的一个序列的多重异质接面的一个序列点。这个不平常的 intraribbon 异质接面序列可能在使用量点的 nanoscale optoelectronic 应用是有用的。 | Yan-Fang Zhang Yi Zhang Geng Li Jianchen Lu Yande Que Hui Chen Reinhard Berger Xinliang Feng Klaus Müllen Xiao Lin Yu-Yang Zhang Shixuan Du Sokrates T. Pantelides Hong-Jun Gao | 2017 | Nano Research2017，10，10： | 1 |
| 10 | Safety and clinical efficacy of sintilimab (anti-PD-1) in pediatric patients with advanced or recurrent malignancies in a phase I study显示文摘The aim of this phase I study is to evaluate,for the first time,the safety and efficacy of sintilimab in pediatric patients diagnosed with advanced or recurrent malignancies.During the dose escalation phase,patients received a single intravenous infusion of sintilimab at varying doses of 1,3,and 10 mg/kg.The primary endpoints included the identification of dose-limiting toxicities(DLTs)as well as the evaluation of safety and tolerance.Secondary endpoints focused on assessing objective response rate(ORR),progression-free survival(PFS),and overall survival(OS).A total of 29 patients were enrolled,including 10 individuals diagnosed with Hodgkin lymphoma(HL)and 19 patients with various other tumor categories.Notably,diverse pathological types such as thymoma,choroid plexus carcinoma,and NK/T-cell lymphoma were also included in the study cohort.By the safety data cutoff,most adverse events were grade 1 or 2,with grade 3 or higher treatment-related adverse events(TRAE)occurring in 10%of patients.Among the 27 evaluated subjects,four achieved confirmed complete response(CR)while seven patients exhibited confirmed partial response(PR).Additionally,seven patients maintained disease(SD)during the study period.Notably,sintilimab demonstrated remarkable tolerability without DLTs and exhibited promising anti-tumor effects in pediatric HL.Whole-exome sequencing(WES)was conducted in 15 patients to assess the mutational landscape and copy number variation(CNV)status.The completion of this phase I study establishes the foundation for potential combination regimens involving sintilimab in childhood cancer treatment.The trial is registered on ClinicalTrials.gov with the identifier NCT04400851. | Yi Que Juan Wang Feifei Sun Shan Wang Jia Zhu Junting Huang Zhenzhen Zhao Li Zhang Juan Liu Jiaqian Xu Zijun Zhen Xiaofei Sun Suying Lu Yizhuo Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 11 | A novel two-dimensional accordion-like titanium carbide (MXene) for adsorption of Cr(VI) from aqueous solution显示文摘Herein,we report on a novel two-dimensional(2D)material application,which shows that an accordion-like layered Ti_(3)C_(2) nanomaterial(MXene)with an excellent adsorption capacity of Cr(VI)from aqueous solution was prepared by etching Al layer from Ti3AlC2 phase in hydrofluoric acid(HF)solution.Ti_(3)C_(2) nanopowders were well characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),and the physical property of as-obtained samples was studied by UV–Vis diffuse reflectance spectra(DRS).After HF treatment,Ti3AlC2 not only has a phase transition from one crystal to another,but surprisingly,its microstructure is also undergoing an obvious change.Ti_(3)C_(2) with product of change possesses an accordion-like multilayer structure,and a relatively higher specific surface area(SSA)than untreated Ti3AlC2.Then,accordionlike Ti_(3)C_(2) with a high SSA provides abundant active sites for pollutant removal and functionalization.Accordion-like Ti_(3)C_(2) nanomaterial exhibits a stable adsorption capacity,and 1 g as-prepared accordion-like Ti_(3)C_(2) powders can remove about 80 mg potassium dichromate.Therefore,the results suggest that 2D MXenes are promising as an effective nanoadsorbent in heavy metal removal from the wastewater. | Yi Tang Chenhui Yang Wenxiu Que | 2018 | Journal of Advanced Dielectrics2018，8，5： | 0 |
| 12 | Research on the Urban Agriculture Planning Models of Metropolis:A Case Study of Chengdu显示文摘With the accelerating urbanization, ecological environment of the city has attracted increasing attention, so the resulting problems have become key research focuses in all countries. Against this background, urban agriculture has been applied as one of the effective approaches for relieving urbanization. From the perspective of industrial form of urban agriculture, planning models of urban agriculture were explored, industrial form and planning model of Chengdu urban agriculture were analyzed to forecast its development prospects. Multi-dimensional development, and sustainable development measures were given to guarantee the sustainable development of urban agriculture. | QUE Yi WANG Haoyang | 2014 | Journal of Landscape Research2014，6，5： | 0 |
| 13 | Blue light emission of porous silicon subjected to RTP treatments显示文摘多孔的硅样品在不同情形(N_2, Ar, O_2 和空气) 下面与快速的热过程(RTP ) 被对待。在处理前后,样品借助于光谱学和 Fourier 转变的光致发光(PL ) 被检查红外线的光谱学(FTIR ) 。排放山峰在多孔的硅样品的 PL 系列被发现的四盏蓝灯在 400 deg C 上面在温度使遭到了到 RTP 处理,山峰位置被发现不与 RTP 处理的情形和温度变化。它在 RTP 处理期间由于氧化被认为那,在多孔的硅的 Si 水晶的杆尺寸减少了,导致轻排放的蓝移动。与 Si 晶体大小相关不连续的假设和以前的研究人员“理论计算, PL 山峰位置没与 theRTP 温度和情形变化。 | ZHAO Yi YANG Deren LIN Lei QUE Duanlin | 2006 | Chinese Science Bulletin2006，51，22： | 0 |
| 14 | Efficient and cost-effective method to synthesize highly purified Ti_(4)AlN_(3) and Ti_(2)AlN显示文摘Nitrides MAX have attracted ever-growing interest owing to its unique metallic and ceramic characteristics and properties.Here,we report on the synthesis of highly purified Ti_(2)AlN and Ti_(4)AlN_(3) powders from Ti,Al and TiN powders by a facile atmosphere sintering method.The obtained nitrides show highly pure phase and excellent layered structure.Except for the composition difference of raw materials,both the nitrides can be sintered and obtained by same sintering temperature and holding time,which thus makes less processing time and less usage of synthesis parameters as compared to previously synthesis methods.To our knowledge,present work is one of the few reports on synthesis of Ti_(4)AlN_(3) and Ti_(2)AlN using atmosphere sintering method.Furthermore,the lattice changes of the layered structure of Ti_(2)AlX(X/C=N)were studied by changing the composition of X position from the synthesis of Ti_(2)AlCN and Ti_(2)AlC,and the optimal formulation and synthesis mechanism of Ti_(4)AlN_(3) were also studied. | Muhammad Faraz Ud Din Chenhui Yang Yi Tang* Yapeng Tian Yangyang Luo Yutao Wu Wenxiu Que | 2019 | Journal of Advanced Dielectrics2019，9，1： | 0 |
| 15 | CAS and CEA in the Treatment of Severe Internal Carotid Artery Stenosis显示文摘Objective:To explore the clinical value of carotid artery stent implantation(CAS)and carotid endarterectomy(CEA)in the treatment of patients with severe internal carotid artery stenosis.Methods:88 patients with severe carotid artery stenosis who underwent CAS and CEA in the First People's Hospital of Changde City(hereafter referred as 'our hospital')from January 2018 to December 2020 were selected as the research objects and divided into CAS group(n=43)and CEA group(n=45).To understand the clinical application value and feasibility of the two surgical schemes by comparing the general situation,cerebral blood flow,MMSE scale,MOCA scale score and serum miR-145,IGF1R levels of the two surgical schemes.Conclusions:CAS and CEA in the treatment of patients with severe internal carotid artery stenosis,have good curative effect,can effectively improve the patient's cerebral blood flow,regulate serum miR-145,IGF 1R levels,promote the recovery of cognitive function,but relatively speaking,the incidence of stroke and hypotension after CAS is higher,and the incidence of hypertension after CEA is higher. | Ling Yao Jing Yi Lixin Xu Jun Wen Siwei Que | 2021 | Journal of Clinical and Nursing Research2021，5，4： | 0 |
| 16 | Temperature inversion enables superior stability for low-temperature Zn-ion batteries显示文摘It is challenging for aqueous Zn-ion batteries(ZIBs)to achieve comparable low-temperature(low-T)performance due to the easy-frozen electrolyte and severe Zn dendrites.Herein,an aqueous electrolyte with a low freezing point and high ionic conductivity is proposed.Combined with molecular dynamics simulation and multi-scale interface analysis(time of flight secondary ion mass spectrometry threedimensional mapping and in-situ electrochemical impedance spectroscopy method),the temperature independence of the V_(2)O_(5)cathode and Zn anode is observed to be opposite.Surprisingly,dominated by the solvent structure of the designed electrolyte at low temperatures,vanadium dissolution/shuttle is significantly inhibited,and the zinc dendrites caused by this electrochemical crosstalk are greatly relieved,thus showing an abnormal temperature inversion effect.Through the disclosure and improvement of the above phenomena,the designed Zn||V_(2)O_(5)full cell delivers superior low-T performance,maintaining almost 99%capacity retention after 9500 cycles(working more than 2500 h)at-20°C.This work proposes a kind of electrolyte suitable for low-T ZIBs and reveals the inverse temperature dependence of the Zn anode,which might offer a novel perspective for the investigation of low-T aqueous battery systems. | Fu-Da Yu Zhe-Jian Yi Rui-Yang Li Wei-Hao Lin Jie Chen Xiao-Yue Chen Yi-Ming Xie Ji-Huai Wu Zhang Lan Lan-Fang Que Bao-Sheng Liu Hao Luo Zhen-Bo Wang | 2024 | Journal of Energy Chemistry2024，91，4： | 0 |
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