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| 1 | Management of chronic hepatitis B infection: Current treatment guidelines, challenges, and new developments显示文摘Chronic hepatitis B(CHB)virus infection is a global public health problem,affecting more than 400 million people worldwide.The clinical spectrum is wide,ranging from a subclinical inactive carrier state,to progressive chronic hepatitis,cirrhosis,decompensation,and hepatocellular carcinoma.However,complications of hepatitis B virus(HBV)-related chronic liver disease may be reduced by viral suppression.Current international guidelines recommend first-line treatment of CHB infection with pegylated interferon,entecavir,or tenofovir,but the optimal treatment for an individualpatient is controversial.The indications for treatment are contentious,and increasing evidence suggests that HBV genotyping,as well as serial on-treatment measurements of hepatitis B surface antigen and HBV DNA kinetics should be used to predict antiviral treatment response.The likelihood of achieving a sustained virological response is also increased by extending treatment duration,and using combination therapy.Hence the paradigm for treatment of CHB is constantly evolving.This article summarizes the different indications for treatment,and systematically reviews the evidence for the efficacy of various antiviral agents.It further discusses the shortcomings of current guidelines,use of rescue therapy in drug-resistant strains of HBV,and highlights the promising clinical trials for emerging therapies in the pipeline.This concise overview presents an updated practical approach to guide the clinical management of CHB. | Ceen-Ming Tang Tung On Yau Jun Yu | 2014 | World Journal of Gastroenterology2014，20，20： | 41 |
| 2 | Evolution of systemic therapy of advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) commonly occurs in hepatitis B endemic areas, especially in Asian countries. HCC is highly refractory to cytotoxic chemotherapy. This resistance is partly related to its tumor biology, pharmacokinetic properties, and both intrinsic and acquired drug resistance. There is no convincing evidence thus far that systemic chemotherapy improves overall survival in advanced HCC patients. Other systemic approaches, such as hormonal therapy and immunotherapy, have also disappointing results. Recently, encouraging results have been shown in using sorafenib in the treatment of advanced HCC patients. In this review, we concisely summarize the evolution of developments in the systemic therapy of advanced HCC. | Thomas Yau Pierre Chan Richard Epstein Ronnie T Poon | 2008 | World Journal of Gastroenterology2008，14，42： | 23 |
| 3 | 通过自适应随机数据包标记实现实时IP回溯(英文)显示文摘随机数据包标记(PPM)是对拒绝服务攻击进行IP回溯的一种实用而有效的方法.提供了一种自适应的PPM算法:一个路由器按一个与路过的数据包已传输距离自适应的概率标记该数据包,从而被攻击者可以以 最短的收敛时间重构一个攻击路径.通过一个新的称为标注片段编码的IP重载方案,实现了实时的重构,从而能同时回溯数千条路径.与以前的PPM方案相比,收敛时间减少了50%,同时大大减少了重构计算量和伪证性. | 梁丰 赵新建 David Yau | 2003 | 软件学报2003，14，5： | 22 |
| 4 | Chinese Offshore RMB Currency and Bond Markets:The Role of Hong Kong显示文摘这份报纸在中国的宏大计划讨论香港的角色作为全球储备货币建立 RMB。我们以 channeling 强调香港的经济重要性到中国外国直接投资进中国,以后,其中一些将在 RMB 被给取名。我们讨论中国的 RMB 货币的发展在香港交换并且扔市场。这些近海市场使 RMB 能自由地做贸易,为 RMB 作准备成为充分可改变、允许的市场强迫在定价起一个作用 RMB 的价值,和在给 RMB 取名的债券的发展的帮助(或暗淡的和债券) 在香港的市场。最后,我们在香港的暗淡的和契约市场的非凡的生长的现在的证据,它能进一步提高并且加强 RMB 外面的中国的使用。 | Hung-Gay Fung Jot Yau | 2012 | China & World Economy2012，20，3： | 14 |
| 5 | Preliminary experience with drug-coated balloon angioplasty in primary percutaneous coronary intervention显示文摘We evaluated the clinical feasibility of using drugcoated balloon(DCB) angioplasty in patients undergoingprimary percutaneous coronary intervention(PPCI). Between January 2010 to September 2014,89 STelevation myocardial infarction patients(83% male,mean age 59 ± 14 years) with a total of 89 coronary lesions were treated with DCB during PPCI. Clinical outcomes are reported at 30 d follow-up. Left anterior descending artery was the most common target vessel for PCI(37%). Twenty-eight percent of the patients had underlying diabetes mellitus. Mean left ventricular ejection fraction was 44% ± 11%. DCB-only PCI was the predominant approach(96%) with the remaining 4% of patients receiving bail-out stenting. Thrombolysis in Myocardial Infarction(TIMI) 3 flow was successfully restored in 98% of patients. An average of 1.2 ± 0.5 DCB were used per patient,with mean DCB diameter of 2.6 ± 0.5 mm and average length of 23.2 ± 10.2 mm. At 30-d follow-up,there were 4 deaths(4.5%). No patients experienced abrupt closure of the infarctrelated artery and there was no reported target-lesion failure. Our preliminary experience showed that DCB angioplasty in PPCI was feasible and associated with a high rate of TIMI 3 flow and low 30-d ischaemic event. | Hee Hwa Ho Julian Tan Yau Wei Ooi Kwok Kong Loh Than Htike Aung Nwe Tun Yin Dasdo Antonius Sinaga Fahim Haider Jafary Paul Jau Lueng Ong | 2015 | World Journal of Cardiology2015，7，6： | 14 |
| 6 | Energy-efficient Virtual Machine Allocation Technique Using Flower Pollination Algorithm in Cloud Datacenter:A Panacea to Green Computing显示文摘Cloud computing has attracted significant interest due to the increasing service demands from organizations offloading computationally intensive tasks to datacenters.Meanwhile,datacenter infrastructure comprises hardware resources that consume high amount of energy and give out carbon emissions at hazardous levels.In cloud datacenter,Virtual Machines(VMs)need to be allocated on various Physical Machines(PMs)in order to minimize resource wastage and increase energy efficiency.Resource allocation problem is NP-hard.Hence finding an exact solution is complicated especially for large-scale datacenters.In this con text,this paper proposes an Energy-oriented Flower Pollination Algorithm(E-FPA)for VM allocation in cloud datacenter environments.A system framework for the scheme was developed to enable energy-oriented allocation of various VMs on a PM.The allocation uses a strategy called Dynamic Switching Probability(DSP).The framework finds a near optimal solution quickly and balances the exploration of the global search and exploitation of the local search.It considers a processor,storage,and memory constraints of a PM while prioritizing energy-oriented allocation for a set of VMs.Simulations performed on MultiRecCloudSim utilizing planet workload show that the E-FPA outperforms the Genetic Algorithm for Power-Aware(GAPA)by 21.8%,Order of Exchange Migration(OEM)ant colony system by 21.5%,and First Fit Decreasing(FFD)by 24.9%.Therefore,E-FPA significantly improves datacenter performance and thus,enhances environmental sustainability. | Mohammed Joda Usman Abdul Samad Ismail Hassan Chizari Gaddafi Abdul-Salaam Ali Muhammad Usman Abdulsalam Yau Gital Omprakash Kaiwartya Ahmed Aliyu | 2019 | Journal of Bionic Engineering2019，16，2： | 13 |
| 7 | “原位开窗”技术重建主动脉弓上分支血管的Meta分析显示文摘目的系统评价应用'原位开窗'技术治疗胸主动脉(夹层)动脉瘤重建主动脉弓上分支血管的安全性及有效性。方法收集截止2018年8月前发表的关于应用'原位开窗'技术腔内修复主动脉弓部病变(夹层/动脉瘤),同时保留弓上血管血供的文献,回顾性分析技术成功率、内漏发生率、并发症发生率及病死率等近中期临床结果。结果共纳入11篇文献的262例胸主动脉(夹层)动脉瘤患者,技术成功率为94%,平均随访时间为16.85个月,共13例患者出现术后支架内漏(Ⅰ型内漏10例,Ⅱ型内漏3例),术后内漏总发生率为8%,30天病死率和随访期手术相关病死率分别为3.44%和0。结论应用'原位开窗'技术重建弓上分支血管技术成功率较高,并发症发生率及病死率较低。 | 周楚 Tung On Yau 乔彤 | 2018 | 中国血管外科杂志(电子版)2018，10，3： | 11 |
| 8 | Epigenetic dysregulation in Epstein-Barr virus-associated gastric carcinoma: Disease and treatments显示文摘Epstein-Barr virus(EBV)-associated gastric carcinoma(EBVaGC)comprises nearly 10%of gastric carcinoma cases worldwide.Recently,it was recognised to have unique clinicopathologic characteristics,including male predominance,lower rates of lymph node involvement,and better prognosis.EBVaGC is further characterised by abnormal hypermethylation of tumour suppressor gene promoter regions,causing down-regulation of their expression.In the present review,we critically discuss the role of EBV in gastric carcinogenesis,summarising the role of viral proteins and microRNAs with respect to aberrant methylation in EBVaGC.Given the role of epigenetic dysregulation in tumourigenesis,epigenetic modifiers may represent a novel therapeutic strategy. | Tung On Yau Ceen-Ming Tang Jun Yu | 2014 | World Journal of Gastroenterology2014，20，21： | 11 |
| 9 | 利用路由器自适应限流防御分布拒绝服务攻击(英文)显示文摘提出一种自适应路由器限流算法防御分布拒绝服务攻击的机制.该算法的关键是由被攻击者要求经挑选的相距k跳(hop)的上游路由器对目的为被攻击者的数据流进行限流,从而将被攻击者的服务支援在各数据流之间达到一种类最大-最小公平的流量分配.还在一个实际的因特网拓扑上针对攻击数据流和合法数据流的不同分布和流量模型考察了算法的效果.结果表明这种以服务器为中心的路由器限流是对抗分布拒绝服务攻击的一种很有前途的方法. | 梁丰 David Yau | 2002 | 软件学报2002，13，7： | 10 |
| 10 | A Geometric Understanding of Deep Learning显示文摘This work introduces an optimal transportation(OT)view of generative adversarial networks(GANs).Natural datasets have intrinsic patterns,which can be summarized as the manifold distribution principle:the distribution of a class of data is close to a low-dimensional manifold.GANs mainly accomplish two tasks:manifold learning and probability distribution transformation.The latter can be carried out using the classical OT method.From the OT perspective,the generator computes the OT map,while the discriminator computes the Wasserstein distance between the generated data distribution and the real data distribution;both can be reduced to a convex geometric optimization process.Furthermore,OT theory discovers the intrinsic collaborative-instead of competitive-relation between the generator and the discriminator,and the fundamental reason for mode collapse.We also propose a novel generative model,which uses an autoencoder(AE)for manifold learning and OT map for probability distribution transformation.This AE–OT model improves the theoretical rigor and transparency,as well as the computational stability and efficiency;in particular,it eliminates the mode collapse.The experimental results validate our hypothesis,and demonstrate the advantages of our proposed model. | Na Lei Dongsheng An Yang Guo Kehua Su Shixia Liu Zhongxuan Luo Shing-Tung Yau Xianfeng Gu | 2020 | Engineering2020，6，3： | 10 |
| 11 | SARS-CoV-2 infects human neural progenitor cells and brain organoids显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)1 has resulted in over 13 million confirmed cases and more than 580,045 deaths across 218 countries and geographical regions as of July 16,2020.This novel coronavirus primarily causes respiratory illness with clinical manifestations largely resembling those of SARS.However,neurological symptoms including headache,anosmia,ageusia,confusion,seizure,and encephalopathy have also been frequently reported in COVID-19 patients. | Bao-Zhong Zhang Hin Chu Shuo Han Huiping Shuai Jian Deng Ye-fan Hu Hua-rui Gong Andrew Chak-Yiu Lee Zijiao Zou Thomas Yau Wutian Wu Ivan Fan-Ngai Hung Jasper Fuk-Woo Chan Kwok-Yung Yuen Jian-Dong Huang | 2020 | Cell Research2020，30，10： | 8 |
| 12 | Geometric aspects of the moduli space of Riemann surfaces显示文摘We describe some recent progress in the study of moduli space of Riemann surfaces in this survey paper. New complete Kahler metrics were introduced on the moduli space and Teichmuller space. Their curvature properties and asymptotic behavior were studied in details. These natural metrics served as bridges to connect all the known canonical metrics, especially the Kahler-Einstein metric. We showed that all the known complete metrics on the moduli space are equivalent and have Poincare type growth. Furthermore,the Kahler-Einstein metric has strongly bounded geometry. This also implied that the logarithm cotangent bundle of the moduli space is stable in the sense of Mumford. | Shing-Tung Yau | 2005 | Science China Mathematics2005，48，z1： | 8 |
| 13 | Fat cell-secreted adiponectin mediates physical exercise-induced hippocampal neurogenesis: an alternative anti-depressive treatment?显示文摘Psychological depression is drawing accumulating attention nowadays, due to the skyrocketing incidence worldwide and the enormous burdens it incurs. Physical exercise has been long recognized for its therapeutic effects on depressive disorders, although knowledge of the underlying mechanisms remains limited. Suppressed hippocampal neurogenesis in adult brains has been regarded, at least partly, contributive to depression, whereas physical exercise that restores neurogenesis accordingly exerts the anti-depressive action. Several recent publications have suggested the potential role of adiponectin, a protein hormone secreted by peripheral mature adipocytes, in mediating physical exercise-triggered enhancement of hippocampal neurogenesis and alleviation of depression. Here, we briefly review these novel findings and discuss the possibility of counteracting depression by modulating adiponectin signaling in the hippocampus with interventions including physical exercise and administration of pharmacological agents. | Suk Yu Yau Ang Li Aimin Xu Kwok-fai So | 2015 | Neural Regeneration Research2015，10，1： | 7 |
| 14 | An antifungal peptide from Phaseolus vulgaris cv. brown kidney bean显示文摘A 5.4-kDa 抗真菌的肽与对对 Mycosphaerella arachidicola (IC50= 3 M ) 的 defensins 和禁止的活动高度相应的一个 N 终端序列, Setospaeria turcica 和 Bipolaris maydis,从 Phaseolus vulgaris cv 的种子被孤立。棕色的菜豆。肽被采用必要的一个协议净化 Affi 胶化蓝胶化和单音的 S 上并且最后的吸附 Superdex 75 上的胶化过滤。对 M 的肽的抗真菌的活动。arachidicola 在 pH 范围是稳定的 312 并且在温度范围 0 桴 ?? 整浲湩污搠浯楡獮漠 ? | Yau Sang Chan Jack Ho Wong Evandro Fei Fang Wen Liang Pan Tzi Bun Ng | 2012 | Acta Biochimica et Biophysica Sinica2012，44，4： | 6 |
| 15 | 首乌在保护高血压患者肾脏方面的研究显示文摘总结首乌治疗有肾脏损害的原发性高血压患者30例的临床疗效。应用首乌15g/d,口服治疗3个月。治疗后发现患者血肌酐、血尿素氮明显下降,尿微量白蛋白、免疫球蛋白G、视黄醇蛋白排量明显减少。结果提示,首乌对原发性高血压患者有明显的保护肾脏作用。 | Raymond Yau(邱国定) 唐树德 陆旭辉 钱岳晟 | 1997 | 上海医药1997，，9： | 6 |
| 16 | Financing Alternatives for Chinese Small and Medium Enterprises: The Case for a Small and Medium Enterprise Stock Market显示文摘在中国为小、中等的企业资助选择在现在的学习被讨论。特别地,我们分析重要变化,在中国 s 的开发第二上证券市场。地区性的财产和公平的广泛的网络交换的中国 s,它被设置便于私人公平转移,和非执行的贷款交易似乎部分为小、中等的企业充满虚空,它不能容易为在股票交易所列出获得赞同。外国投资者能通过这些地区性的财产和公平交换在非列出的国内国有、私人的企业识别投资机会。同时,外国证券市场现在正在吸引年轻中国企业在他们的交换上列出他们的股票。 | Hung-gay Fung Qingfeng Liu Jot Yau | 2007 | China & World Economy2007，15，1： | 6 |
| 17 | 结构非线性设计与建筑创新显示文摘结构非线性设计是大多数建筑师感觉非常陌生的领域,然而它与现代建筑的关系将越来越紧密。本文从技术角度讨论了结构非线性设计的概念与技术内涵以及对建筑创新的影响。 | 方立新 陈绍礼 CY Yau | 2005 | 建筑学报2005，，1： | 6 |
| 18 | 托珠单抗治疗住院新型冠状病毒肺炎的临床研究显示文摘炎症风暴在重症和危重症新型冠状病毒肺炎(以下简称新冠肺炎)发病机制中发挥着重要作用。研究证实白介素-6(IL-6)可作为预警新冠肺炎患者炎症风暴的生物标记物,且IL-6水平升高与新冠肺炎不良预后相关。IL-6受体拮抗剂托珠单抗(tocilizumab)已应用于类风湿关节炎等多种自身炎症性疾病的治疗。为了评估托珠单抗(tocilizumab)治疗新冠肺炎的疗效和安全性,美国西奈山医院等多家医院联合进行了一项全球性多中心3期临床试验。入组标准是:住院治疗的新冠肺炎确诊病例且年龄≥18岁;已接受无创正压通气或有创机械通气的患者被排除。该研究随机分配(以2∶1的比例)未接受机械通气的新冠肺炎住院患者接受一或两剂托珠单抗(剂量:8 mg/kg)或安慰剂治疗,临床结局包括28 d内机械通气和死亡情况。 | 谷丽(编译) 尹玉东(编译) Salama C Han J Yau L | 2021 | 中华医学杂志2021，101，10： | 5 |
| 19 | Mining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients显示文摘Dear Editor,The ongoing coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus-2(SARSCoV-2)is a serious threat to global public health,and is imposing severe burdens on human society.Several candidate vaccines against SARS-CoV-2 are now undergoing clinical trials.The Spike(S)protein of SARS-CoV-2 is widely considered as a promising antigen.However. | Bao-zhong Zhang Ye-fan Hu Lin-lei Chen Thomas Yau Yi-gang Tong Jing-chu Hu Jian-piao Cai Kwok-Hung Chan Ying Dou Jian Deng Xiao-lei Wang Ivan Fan-Ngai Hung Kelvin Kai-Wang To Kwok Yung Yuen Jian-Dong Huang | 2020 | Cell Research2020，30，8： | 5 |
| 20 | Development of Hong Kong Liver Cancer Staging System with Treatment Stratification for Patients with Hepatocellular Carcinoma显示文摘 | Thomas Yau Vikki Y.F. Tang Tzy-Jyun Yao Sheung-Tat Fan Chung-Mau Lo Ronnie T.P. Poon | 2014 | Gastroenterology2014，，： | 5 |
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