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| 1 | Early changes to the extracellular space in the hippocampus under simulated microgravity conditions显示文摘The smooth transportation of substances through the brain extracellular space(ECS)is crucial to maintaining brain function;however,the way this occurs under simulated microgravity remains unclear.In this study,tracer-based magnetic resonance imaging(MRI)and DECS-mapping techniques were used to image the drainage of brain interstitial fluid(ISF)from the ECS of the hippocampus in a tail-suspended hindlimb-unloading rat model at day 3(HU-3)and 7(HU-7).The results indicated that drainage of the ISF was accelerated in the HU-3 group but slowed markedly in the HU-7 group.The tortuosity of the ECS decreased in the HU-3 group but increased in the HU-7 group,while the volume fraction of the ECS increased in both groups.The diffusion rate within the ECS increased in the HU-3 group and decreased in the HU-7 group.The alterations to ISF drainage and diffusion in the ECS were recoverable in the HU-3 group,but neither parameter was restored in the HU-7 group.Our findings suggest that early changes to the hippocampal ECS and ISF drainage under simulated microgravity can be detected by tracer-based MRI,providing a new perspective for studying microgravity-induced nano-scale structure abnormities and developing neuroprotective approaches involving the brain ECS. | Yajuan Gao Hongbin Han Jichen Du Qingyuan He Yanxing Jia Junhao Yan Hui Dai Bin Cui Jing Yang Xunbin Wei Liu Yang Rui Wang Ren Long Qiushi Ren Xing Yang Jiabin Lu | 2022 | Science China(Life Sciences)2022，65，3： | 2 |
| 2 | Structural optimization and evaluation of butenolides as potent antifouling agents: modification of the side chain affects the biological activities of compounds显示文摘 | Yongxin Li Fengying Zhang Ying Xu Kiyotaka Matsumura Zhuang Han Lingli Liu Wenhan Lin Yanxing Jia Pei-Yuan Qian | 2012 | Biofouling2012，，8： | 1 |
| 3 | Preparation and self-assembly of chitosan/carbon microsphere composite显示文摘 | Yongzhen Yang Yanxing Han Xuguang Liu Bingshe Xu | 2012 | Journal of Wuhan University of Technology-Mater Sci Ed2012，，3： | 1 |
| 4 | Design and synthesis of oxymatrine analogues overcoming drug resistance in hepatitis B virus through targeting host heat stress cognate 70显示文摘 | Gao Limei Han Yanxing Wang Yuping | 2011 | J Med Chem2011，54，3： | 1 |
| 5 | 查看详情显示文摘 | YanX B Han Z J Yang Y | | 0，，123： | 1 |
| 6 | Establishment of drug-resistant HBV small-animal models by hydrodynamic injection显示文摘In antiviral therapy of hepatitis B virus(HBV)infection,drug resistance remains a huge obstacle to the long-term effectiveness of nucleoside/tide analogs(NAs).Primary resistance mutation(rtM204V)contributes to lamivudine(LAM)-resistance,and compensatory mutations(rtL180M and rtV173L)restore viral fitness and increase replication efficiency.The evaluation of new anti-viral agents against drug-resistant HBV is limited by the lack of available small-animal models.We established LAM-resistance HBV replication mice models based on clinical LAM-resistant HBV mutants.Double(rtM204VþrtL180M)or triple(rtM204VþrtL180MþrtV173L)lamivudine-resistant mutations were introduced into HBV expression vector,followed by hydrodynamic injection into tail vein of NOD/SCID mice.Viremia was detected on days 5,9,13 and 17 and liver HBV DNA was detected on day 17 after injection.The serum and liver HBV DNA levels in LAM-resistant model carrying triple mutations are the highest among the models.Two NAs,LAM and entecavir(ETV),were used to test the availability of the models.LAM and ETV inhibited viral replication on wild-type model.LAM was no longer effective on LAM-resistant models,but ETV retains a strong activity.Therefore,these models can be used to evaluate anti-viral agents against lamivudine-resistance,affording new opportunities to establish other drug-resistant HBV small-animal models. | Junjun Cheng Yanxing Han Jian-Dong Jiang | 2014 | Acta Pharmaceutica Sinica B2014，4，4： | 0 |
| 7 | A Preliminary Research on the Application of GPS to Regional Crustal Movement and Judgement of Seismic Risk Region显示文摘We analyzed the present state of crustal horizontal movement in part of the North China region using existing GPS re-observation data (1992-1995) and drew the following conclusions: (1) The monitored region appears to be in tensile movement, with the trend of the principal tensile strain in the WNW-ESE direction; (2) There are two zones of higher maximum shear strain in the monitored region, namely, the Beijing zone and two sides of the Tancheng-Lujiang fault near Linyi; (3) There exists a striped compressive zone which stretches in the NNE-SSW direction; the zone of maximum planar compression is located in the Beijing zone; (4) The displacement field has an obvious zoned distribution. | Yang Guohua, Li Yanxing, Bo Wanju, and Han YuepingThe First Crustal Deformation Monitoring Center, China Seismological Bureau, Tianjin 300180, China | 1998 | Earthquake Research in China1998，12，3： | 0 |
| 8 | Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection显示文摘Zika virus(ZIKV)is an emerging pathogen associated with neurological complications,such as Guillain–Barrésyndrome in adults and microcephaly in fetuses and newborns.This mosquito-borne flavivirus causes important social and sanitary problems owing to its rapid dissemination.However,the development of antivirals against ZIKV is lagging.Although various strategies have been used to study anti-ZIKV agents,approved drugs or vaccines for the treatment(or prevention)of ZIKV infections are currently unavailable.Repurposing clinically approved drugs could be an effective approach to quickly respond to an emergency outbreak of ZIKV infections.The well-established safety profiles and optimal dosage of these clinically approved drugs could provide an economical,safe,and efficacious approach to address ZIKV infections.This review focuses on the recent research and development of agents against ZIKV infection by repurposing clinical drugs.Their characteristics,targets,and potential use in anti-ZIKV therapy are presented.This review provides an update and some successful strategies in the search for anti-ZIKV agents are given. | Weibao Song Hongjuan Zhang Yu Zhang Rui Li Yanxing Han Yuan Lin Jiandong Jiang | 2021 | Frontiers of Medicine2021，15，3： | 0 |
| 9 | Identification of anti-Mycobacterium tuberculosis agents targeting the interaction of bacterial division proteins FtsZ and SepFe显示文摘Tuberculosis(TB)is one of the deadly diseases caused by Mycobacterium tuberculosis(Mtb),which presents a significant public health challenge.Treatment of TB relies on the combination of several anti-TB drugs to create shorter and safer regimens.Therefore,new anti-TB agents working by different mechanisms are urgently needed.FtsZ,a tubulin-like protein with GTPase activity,forms a dynamic Z-ring in cell division.Most of FtsZ inhibitors are designed to inhibit GTPase activity.In Mtb,the function of Z-ring is modulated by SepF,a FtsZ binding protein.The FtsZ/SepF interaction is essential for FtsZ bundling and localization at the site of division.Here,we established a yeast twohybrid based screening system to identify inhibitors of FtsZ/SepF interaction in M.tuberculosis.Using this system,we found compound T0349 showing strong anti-Mtb activity but with low toxicity to other bacteria strains and mice.Moreover,we have demonstrated that T0349 binds specifically to SepF to block FtsZ/SepF interaction by GST pull-down,fluorescence polarization(FP),surface plasmon resonance(SPR)and CRISPRi knockdown assays.Furthermore,T0349 can inhibit bacterial cell division by inducing filamentation and abnormal septum.Our data demonstrated that FtsZ/SepF interaction is a promising anti-TB drug target for identifying agents with novel mechanisms. | Hongjuan Zhang Ying Chen Yu Zhang Luyao Qiao Xiangyin Chi Yanxing Han Yuan Lin Shuyi Si Jiandong Jiang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 0 |
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