|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection,histological types and staging显示文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer(GC)and other gastric mucosallesions and their relations to Helicobacter pylori(H.pylori)infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or14C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia(IM)and/or dysplasia(Dys).In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis(CAG)than those withnegative H.pylori(CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP<0.05),Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori(Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P<0.05).Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group(Ellipser:53±14,40±12μm,Area1:748±572,302±202 μm2,Area2:3050±1661,1681±1990 μm2,all P<0.05;Ellipseb:79±23,58±15 μm,Ratio1:22%±5%,13%±4%,Ratio2:79%±17%,53%±20%,all P<0.01).There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis(Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP<0.05).CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role in the early genesis/ progression of gastric carcinoma and are associated with H. pylori infection. p53 gene is relatively late event in gastric tumorigenesis and mainly relates to its progression. There is more cellular-biological behavior of malignant tumor in gastric mucosal lesions with H. pylori infection. Aberrant Bcl-2 protein expression appears to be preferentially associated with the intestinal type cancer. COX-2 seems to be related to tumor staging and lymph node metastasis. | Heng Jun Gao Lian Zhen Yu Jian Feng Bai Yan Shen Peng Gu Sun Han Lin Zhao Kun Miu Xiu Zhen Lü Xiao Yong Zhang Zhi Quan Zhao | 2000 | World Journal of Gastroenterology2000，6，6： | 52 |
| 2 | 社会政策与中国社会工作的本土化显示文摘在中国社会政策的情境下,如何进行社会工作的本土化?首先定义一下什么叫做indigenization(“本土化”),笔者之前发表的一篇文章中就用本土化(bentuhua)的拼音(Yan&Tsang,2008),因为英文的indigenization并不能够很好地表示中文“本土化”的意思,但大多数人都用这个词,特别是英语世界的朋友,所以还是用英文的indigenization。 | Miu Chung Yan | 2017 | 社会工作2017，，2： | 3 |
| 3 | Characterization of mi R ‐210 in 3 T 3‐ L 1 adipogenesis显示文摘 | Wei‐Cheng Liang Yan Wang David Chi‐Cheong Wan Venus Sai‐Ying Yeung Mary Miu‐Yee Waye | 2013 | J Cell Biochem2013，，12： | 1 |
| 4 | Social Work as a Moral and Political Practice 显示文摘 | CHU WILLIAM C K TSUI MING -SUM YAN MIU -CHUNG | 2009 | International Social Work2009，52，3： | 1 |
| 5 | Thermal depolymerization mechanisms of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)显示文摘Thermal degradation processes and decomposition mechanisms of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) were investigated by using thermal gravity analysis(TGA), Gel permeation chromatography(GPC), elemental analyzer, pyrolysis-gas chromatography-mass spectrometry(Py GC-MS) and ~1H nuclear magnetic resonance(~1H NMR). The degradation activation energy was calculated via the dependence of residual mass on isothermal temperature.~1H NMR and Py GC-MS were used to investigate the chemical structure and component proportion of volatile gases and degradation residues which were produced by thermal decomposition, and to infer the process of macromolecular chain scission. Besides, the influence of the factors, such as outfield atmosphere, residual metal ions, on the degradation behaviors of PHBV was also studied. Finally, the PHBV thermal decomposition mechanisms were speculated on the basis of the degradation behaviors of molecular and chemical structure. | Hengxue Xiang Xiaoshuang Wen Xiaohui Miu Yan Li Zhe Zhou Meifang Zhu | 2016 | Progress in Natural Science:Materials International2016，26，1： | 0 |
| 6 | A novel mitofusin 2 gene mutation causing Charcot-Marie-Tooth type 2A disease in a Chinese family显示文摘 | CHING Chor Kwan LAU Kwok Kwong YU Kwok Wai CHAN Yan Wo Albert MAK Miu Chloe | 2010 | Chinese Medical Journal2010，，11： | 0 |
| 7 | Molecular movements of trehalose inside a single network enabling a rapidly-recoverable tough hydrogel显示文摘It remains a challenge to achieve rapidly recoverable hydrogels by molecular hydrogen-bonding interaction because of its slow inter-action kinetics.This work for the first time reports a trehalose(Tre)-based molecular movement mechanism inside a single network of polyacrylamide(PAM)that accelerates the kinetics of hydrogenbonding interaction,and thereby endows the hydrogel with high toughness and rapid shape and mechanical recoverability.The resultant PAM@Tre hydrogel is capable of full shape recovery after 10,000 loading/unloading cycles at a strain of 500%.Even after being stretched at a strain of 2500%,it can recover to its original shape within 10 seconds.Moreover,the molecular movement of trehalose also endows the PAM@Tre hydrogel with fracture energy and toughness as high as~9000 J m^(-2) and~1600 kJ m^(-3),respec-tively,leading to strong resistance to both static and dynamic piercing.The PAM@Tre hydrogel is thus believed to have enormous potentials in protection devices,bionic skin,soft actuator,and stretchable electronics. | Xiaowen Huang Jimin Fu Huiyan Tan Yan Miu Mengda Xu Qiuhua Zhao Yujie Xie Shengtong Sun Haimin Yao Lidong Zhang | 2022 | International Journal of Smart and Nano Materials2022，13，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员