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| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | Development of systemic therapy for hepatocellular carcinoma at 2013:Updates and insights显示文摘A growing number of multi-targeted tyrosine kinase inhibitor(TKI)has undergone testing for hepatocellular carcinoma(HCC).Unfortunately,this enthusiasm has recently been discouraged by a number of negative phaseⅢstudies on several anti-angiogenic TKIs in HCC.Several postulations have been made to account for this phenomenon,namely the plateau effects of anti-angiogenesis approach,the heterogeneity of HCC in terms of background hepatitis/cirrhosis and tumor biology,as well as the way how clinical trials are designed.Regardless of the underlying reasons,these results suggested that alternative strategies are necessary to further develop systemic therapy for HCC.Several new strategies are currently evaluated:for examples,molecular agents with activities against targets other than vascular endothelial growth factor receptor are being evaluated in on-going clinical trials.In addition,different approaches of targeted agents in combination with various treatment modalities,such as concurrently with another molecular agent,cytotoxic chemotherapy or transarterial chemoembolization,are being developed.This review aims to give a summary on the results of recently released clinical trials on TKIs,followed by discussion on some of the potential novel agents and combinational approaches.Future directions for testing innovative systemic agents for HCC will also be discussed. | Stephen L Chan Winnie Yeo | 2014 | World Journal of Gastroenterology2014，20，12： | 2 |
| 3 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 4 | Video visualization for compact presentation and fast browsing of pictorial content显示文摘 | Yeung M M Yeo B L | 1997 | IEEE Transactions on Circuits and Systems for Video Technology1997，7，5： | 1 |
| 5 | Positive Management of Differences for Risk Reduction in BOT Projects显示文摘 | ROBERT L K | 2000 | International Journal of Project Management2000，18，4： | 1 |
| 6 | Positive Management of differences for risk reduction in BOT projects显示文摘 | Yeo K T Tiong R L K | 2001 | International Journal of Project Management2001，18，4： | 1 |
| 7 | Dual-polarized slotcoupled planar antenna with wide bandwidth显示文摘 | GAO S LI L LEONG M YEO T | 2003 | IEEE Transactions on Antennas Propagat2003，51，： | 1 |
| 8 | Prenatal detection of fetal trisomy 18 through abnormal sonographic features 显示文摘 | Yeo L Guzman ER Day-Salvatore D | 2003 | J Ultrasound Meal2003，22，： | 1 |
| 9 | Fabrication of microfluidic devices using polydimethylsiloxane显示文摘 | Friend J Yeo L | 2010 | Biomicrofluidics2010，4，2： | 1 |
| 10 | Designing a symmetrical five-port waveguide junction显示文摘 | Cullen A L Yeo S P | 1988 | Microwaves Antennas and Propagation IEE Proceedings H1988，135，1： | 1 |
| 11 | Array Failure Correction with a Genetic Algorithm 显示文摘 | B K Yeo Y L Lu | 1999 | IEEE Transactions on Antennas and Propagation1999，47，5： | 1 |
| 12 | Improving results of pancreaticoduodenectomy for pancreatic cancer显示文摘 | Yeo C J Comeron J L | 1999 | World J Surg1999，23，9： | 1 |
| 13 | Health benefits of docosahexaenoic acid (DHA)显示文摘 | HORROCKS L A YEO Y K | 1999 | Pharmacol Res1999，40，： | 1 |
| 14 | Using the least-squares boundary residual method to model the symmetrical five-port waveguide junction显示文摘 | Cullen A L Yeo S P | 1987 | Microwaves Antennas and Propagation IEE Proceedings H1987，134，2： | 1 |
| 15 | 3Diet impact and toroidal bubbles显示文摘 | Zhang Y L Yeo K S Khoo B C | 2001 | Journal of Computational Physics2001，166，33： | 1 |
| 16 | Segmentation of video by clustering and graph analysis 显示文摘 | Yeung M Yeo B L Liu B | 1998 | Computer Vision and Image Understanding1998，71，1： | 1 |
| 17 | Serum TSH Level in Healthy Koreans and the Association of TSH with Serum Lipid Concentration and Metabolic Syndrome 显示文摘 | Yeo L Eun K Hyun J | 2011 | Korean J In- tern Med2011，，： | 1 |
| 18 | Synthesis and antiviral activity of Helioxanthin analogues显示文摘 | YEO H LI Y FU L | 2005 | J Med Chem2005，48，2： | 1 |
| 19 | Pre- eclampsia part 1 : current understanding of its pathophysi- ology显示文摘 | Chaiworapongsa T Chaemsaithong P Yeo L | 2014 | Nat Rev Nephrol2014，10，8： | 1 |
| 20 | Piezoelectric ultrasonic microm- illi scale actuators 显示文摘 | WATSON B FRIEND J YEO L | 2009 | Sensors and Actuators A: Physical2009，152，5： | 1 |
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