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| 1 | Clinical Research on Alzheimer's Disease: Progress and Perspectives显示文摘Alzheimer's disease(AD), the most common type of dementia, is becoming a major challenge for global health and social care. However, the current understanding of AD pathogenesis is limited, and no early diagnosis and disease-modifying therapy are currently available. During the past year, significant progress has been made in clinical research on the diagnosis, prevention, and treatment of AD.In this review, we summarize the latest achievements,including diagnostic biomarkers, polygenic hazard score,amyloid and tau PET imaging, clinical trials targeting amyloid-beta(Ab), tau, and neurotransmitters, early intervention, and primary prevention and systemic intervention approaches, and provide novel perspectives for further efforts to understand and cure the disease. | Bin-Lu Sun Wei-Wei Li Chi Zhu Wang-Sheng Jin Fan Zeng Yu-Hui Liu Xian-Le Bu Jie Zhu Xiu-Qing Yao Yan-Jiang Wang | 2018 | Neuroscience Bulletin2018，34，6： | 29 |
| 2 | Flame retardant polyamide 6 by in situ polymerization of ε-caprolactam in the presence of melamine derivatives显示文摘An improved method for preparing melamine cyanurate (MCA) based flame retardant polyamide 6 (FRPA6) materials has been proposed. This processing method, i.e., improved in situ polymerization, was used to synthesize flame retardant PA6. In situ formed MCA nanoparticles were supposed to be linked to PA6 chains in the e-caprolactam hydrolytic polymerization system to obtain star- type polymers for the first time. Through TEM photographs, it can be found that the in situ formed MCA nanoparticles with diametric size of less than 50 nm, are nanoscaled, highly uniformly dispersed in the PA6 matrix. Synthesized ?ame retardant PA6 have good fire performance which can achieve UL-94 V-0 rating at 1.6 mm thickness with the presence of 7.34 wt.% MCA in the matrix. | Zhi Yong Wu Wei Xu Jin Kui Xia Yao Chi Liu Qian Xin Wu Wei Jian Xu | 2008 | Chinese Chemical Letters2008，19，2： | 15 |
| 3 | A new variational inequality formulation for unconfined seepage flow through fracture networks显示文摘Darcy's law only applying to the flow domain is extended to the entire fracture network domain including the dry domain.The partial differential equation(PDE) formulation for unconfined seepage flow problems for discrete fracture network is established,in which a boundary condition of Signorini's type is prescribed over the potential seepage surfaces.In order to reduce the difficulty in selecting trial functions,a new variational inequality formulation is presented and mathematically proved to be equivalent to the PDE formulation.The numerical procedure based on the VI formulation is proposed and the corresponding algorithm has been developed.Since a continuous penalized Heaviside function is introduced to replace a jump function in finite element analysis,oscillation of numerical integration for facture elements cut by the free surface is eliminated and stability of numerical solution is assured.The numerical results from two typical examples demonstrate,on the one hand the effectiveness and robustness of the proposed method,and on the other hand the capability of predicting main seepage pathways in fractured rocks and flow rates out of the drainage system,which is very important for performance assessments and design optimization of complex drainage system. | JIANG QingHui YE ZuYang YAO Chi ZHOU ChuangBing | 2012 | Science China(Technological Sciences)2012，55，11： | 11 |
| 4 | Bacteriophage therapy against Enterobacteriaceae显示文摘The Enterobacteriaceae are a class of gram-negative facultative anaerobic rods, which can cause a variety of diseases, such as bacteremia, septic arthritis, endocarditis, osteomyelitis, lower respiratory tract infections, skin and soft-tissue infections, urinary tract infections, intra-abdominal infections and ophthalmic infections, in humans, poultry, animals and fish. Disease caused by Enterobacteriaceae cause the deaths of millions of people every year, resulting in enormous economic loss. Drug treatment is a useful and efficient way to control Enterobacteriaceae infections. However, with the abuse of antibiotics, drug resistance has been found in growing number of Enterobacteriaceae infections and, as such, there is an urgent need to find new methods of control. Bacteriophage therapy is an efficient alternative to antibiotics as it employs a different antibacterial mechanism. This paper summarizes the history of bacteriophage therapy, its bacteriallytic mechanisms, and the studies that have focused on Enterobacteriaceae and bacteriophage therapy. | Youqiang Xu Yong Liu Yang Liu Jiangsen Pei Su Yao Chi Cheng | 2015 | Virologica Sinica2015，30，1： | 10 |
| 5 | KNaY-zeolite catalyzed dehydration of methyl lactate显示文摘A promising catalyst,KNaY was prepared by an ion exchange method with aqueous potassium chloride solution.Comparedwith NaY,KNaY was an effective catalyst for the dehydration of methyl lactate to methyl acrylate.Under the optimized conditions,an improved yield of 37.9 mol%was achieved. | Hai Feng Shi Yao Chi Hu Yang Wang He Huang | 2007 | Chinese Chemical Letters2007，18，4： | 8 |
| 6 | Relationship between settlements and topographical factors:An example from Sichuan Province,China显示文摘Terrain can influence the spatial distribution of settlements. Studies on the terrain characteristics of settlements can help to understand the effects of the environment on human activities. This paper provides a quantitative analysis of the relationship between settlements and topographical factors. A statistically significant sample of residential locations and ASTER GDEM V2 were used to investigate terrain traits and settlements distributions. We selected eight topographical factors and introduced a practical concept, distributive entropy, into assessing the aggregation extent of the settlements' spatial distribution. The study showed that topography varies within the study area, and distributive entropy indicates that settlements have distinctive distribution tendency in statistic approach. According to the results of this study, mountain inhabitants prefer to settle in valleys. Additionally, with distributive entropy, residential suitability was divided to three levels: suitable, normal, and unsuited. The results showed that suitable area is small in Sichuan Province, accounting for 8.2%~29.9%; however, unsuited area is large, accounting for 33%~63.3%. | XI Chang-bai QIAN Tian-lu CHI Yao CHEN Jie WANG Jie-chen | 2018 | Journal of Mountain Science2018，15，9： | 8 |
| 7 | MicroRNA-29a attenuates angiotensin-Ⅱ induced-left ventricular remodeling by inhibiting collagen,TGF-β and SMAD2/3 expression显示文摘Background Left ventricular(LV)remodeling is the most common target organ damage in hypertension.Previously,our study found that plasma microRNA-29a(miR-29a)level was associated with the LV remodeling in hypertensive patients.However,the causal relationship between miR-29a and LV remodeling remains unknown.Thus,the aim of this study was to investigate the regulation mechanism of miR-29a in LV remodeling.Methods&Results Overexpression and knockdown miR-29a mice were generated by tail-intravenous injection of miR-29a-mimic and inhibitor lentivirus for one week respectively.Then the mice were subjected to angiotensin-II(AngII)induced LV remodeling by subcutaneous AngII capsule osmotic pumping into AngII for four weeks.AngII-induced LV remodeling mice as the model group(n=9).Age-matched male SPF C57/BL6J mice(6–8 weeks old)were treated with the pumping of saline as a vehicle(n=6).In vivo,overexpression miR-29a ameliorated AngII-induced LV remodeling,while knockdown miR-29a deteriorated LV remodeling.Simultaneously,we observed that overexpression miR-29a mice inhibited but knockdown miR-29a mice increased cardiac cross-sectional area,indicating that miR-29a has an antagonistic effect on cardiac hypertrophy.Further studies found that overexpression miR-29a inhibited the content of the LV collagen including collagen I and III.Moreover,the expression of transforming growth factor-β(TGF-β)and phosphorylated SMAD2/3 decreased with the down-regulation of collagen I and III in overexpression miR-29a mice.Conclusions Our finding indicates that overexpression miR-29a attenuates LV remodeling by inhibiting collagen deposition,TGF-β,and phosphorylated SMAD2/3 expression.Thus,intervention miR-29a may be a therapeutic target for attenuating LV remodeling. | Si-Jin ZHANG Cui-Juan YUN Jie LIU Si-Yu YAO Yao LI Miao WANG Chi WANG Yong-Yi BAI Hao XUE | 2020 | Journal of Geriatric Cardiology2020，17，2： | 7 |
| 8 | Novel synthesis of N-doped graphene as an efficient electrocatalyst towards oxygen reduction显示文摘做氮的 graphene (NG ) 被一个新奇、灵巧、可伸缩的自底向上的方法成功地综合。退火的 NG (NG -- 一) 拥有的高特定的表面区域和一块层次多孔的质地,和在在碱、酸的媒介的氧减小反应的展出显著地改进的 electrocatalytic 活动。分子的动态模拟显示了的 Ab initio 那快速的 H 转移和六成员的 N 结构的热力学的稳定性在 600 敮 x 从 pyrrolic 把包含 N 种类的转变提升了到 | Ruguanq Ma Xiaodong Ren Bao Yu Xia Yao Zhou Chi Sun Qian Liu Jianjun Liu Jiacheng Wang | 2016 | Nano Research2016，9，3： | 6 |
| 9 | MECHANISM OF SECONDARY M_(23)C_6 PRECIPITATION AROUND MC IN A COBALT-BASE SUPERALLOY显示文摘1.IntroductionCobalt-basesuperalloyshavewidelybeenusedashightemperaturestructuralcomponentsinaircraftandindustrialturbinesbecauseoftheirhighrupturestrength,goodhotcorrosionresistanceaswellashighincipientmeltfngpoint.Theyarestrengthenedprincipallybyca... | W.H. Jiang X.D. Yao H.R. Guan and Z.Q. Hu(1) Department of Superalloys, Institute of Metal Research, The Chinese Academy of Sciences, Shenyang 110015, China2) Department of Metal Materials Engineering, Shenyang Polytechnic University) Shenyang 110023, Chi | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，2： | 6 |
| 10 | Effect of short term intensive multitherapy on carotid intima-media thickness in patients with newly diagnosed type 2 diabetes mellitus显示文摘背景控制血浆葡萄糖层次,血压和类脂化合物层次被证明与类型 2 糖尿病 mellitus 在病人减少脉管的复杂并发症的风险。这推动了目标为几 macrovascular 风险 factors.Carotid intima 媒介厚度(cIMT ) 的集中的 multitherapy 是早动脉粥样硬化的一项可靠措施。我们寻求了决定一个 6 月的集中的 mutiltherapy 程序是否比平常导致了更好的目标成就在在有最新诊断的类型的病人之中的 cIMT 的开发的照顾和它的效果 2 糖尿病 mellitus。学习随机与到集中或传统的治疗的 2 糖尿病 mellitus 组织的最新诊断的类型分配了 220 个病人的方法。临床的参数例如 fasting 血浆葡萄糖,总计胆固醇, triglyceride,血压,身体重量和胰岛素在基线并且在 6 月的治疗以后被估计。获得的病人 wasalso 的 cIMT。一般水准在集中的组 fasting 血浆葡萄糖,血红素 A1c,全部的胆固醇(TC ) 和低密度的脂蛋白胆固醇(LDL-C ) 铺平的结果是比在在 6 月的治疗的结束的控制组的那些显著地低的。到 6 个月,在集中的治疗组的病人的一个更高的比例为 fasting 血浆葡萄糖( FPG )比在控制组达到了目标, TC , LDL-C 和血红素 A1c.With 集中的 multherapy 在集中的治疗组的颈动脉intima媒介厚度的水平在控制组是比那低的(( 0. | GUO Li-xin PAN Qi WANG Xiao-xia LI Hui ZHANG Li-na CHI Jia-min WANG Yao | 2008 | Chinese Medical Journal2008，，8： | 6 |
| 11 | A first attempt of inferior vena cava filter successfully guided by a mixed-reality system: a case report显示文摘Pulmonary embolism(PE)is one of the fatal heart attacks,and lower limbs deep vein thrombosis(DVT)is the most common reason for PE.Inferior vena cava filter(IVCF)implantation is a most prevention for PE.But it may carry a high risk of injury because of the radiation and contrast agent.Patients with nephrotic syndrome(NS)or some other renal diseases may prone to thrombosis due to the excretion of protein C and protein S overmuch.So,it is necessary to develop a new therapy without contrast agent.Mixed-reality(MR)is a new technology as a guidance of inferior vena cava filter implantation exposed under no X-ray and required no contrast agent. | Hang ZHU Yao LI Chi WANG Qiu-Yang LI Zheng-Yang XU Xin LI Abudureyimu Abudulitipujiang Ji-Xing PAN Er-Long FAN Jun GUO Yun-Dai CHEN | 2019 | Journal of Geriatric Cardiology2019，16，7： | 5 |
| 12 | Establishing a nonlethal and efficient mouse model of male gonadotoxicity by intraperitoneal busulfan injection显示文摘An ideal animal model of azoospermia would be a powerful tool for the evaluation of spermatogonial stem cell(SSC)transplantation.Busulfan has been commonly used to develop such a model,but 30%–87%of mice die when administered an intraperitoneal injection of 40 mg kg^?1.In the present study,hematoxylin and eosin staining,Western blot,immunofluorescence,and quantitative real-time polymerase chain reaction were used to test the effects of busulfan exposure in a mouse model that received two intraperitoneal injections of busulfan at a 3-h interval at different doses(20,30,and 40 mg kg^?1)on day 36 or a dose of 40 mg kg^?1 at different time points(0,9,18,27,36,and 63 days).The survival rate of the mice was 100%.When the mice were treated with 40 mg kg^?1 busulfan,dramatic SSC depletion occurred 18 days later and all of the germ cells were cleared by day 36.In addition,the gene expressions of glial cell line-derived neurotrophic factor(GDNF),fibroblast growth factor 2(FGF2),chemokine(C-X-C Motif)ligand 12(CXCL12),and colony-stimulating factor 1(CSF1)were moderately increased by day 36.A 63-day,long-term observation showed the rare restoration of endogenous germ cells in the testes,suggesting that the potential period for SSC transplantation was between day 36 and day 63.Our results demonstrate that the administration of two intraperitoneal injections of busulfan(40 mg kg^?1 in total)at a 3-h interval to mice provided a nonlethal and efficient method for recipient preparation in SSC transplantation and could improve treatments for infertility and the understanding of chemotherapy-induced gonadotoxicity. | Yun Xie Cun-Can Deng Bin Ouyang Lin-Yan Lv Jia-Hui Yao Chi Zhang Hai-Cheng Chen Xiao-Yan Liang Xiang-Zhou Sun Chun-Hua Deng Gui-Hua Liu | 2020 | Asian Journal of Andrology2020，22，2： | 5 |
| 13 | Exposure Effects of Terahertz Waves on Primary Neurons and Neuron-like Cells Under Nonthermal Conditions显示文摘Objective This study aimed to explore the potential effects of terahertz(THz) waves on primary cultured neurons from 4 rat brain regions(hippocampus, cerebral cortex, cerebellum, and brainstem)and 3 kinds of neuron-like cells(MN9 D, PC12, and HT22 cells) under nonthermal conditions.Methods THz waves with an output power of 50(0.16 THz) and 10(0.17 THz) m W with exposure times of 6 and 60 min were used in this study. Analysis of temperature change, neurite growth, cell membrane roughness, micromorphology, neurotransmitters and synaptic-related proteins(SYN and PSD95) was used to evaluate the potential effects.Results Temperature increase caused by the THz wave was negligible. THz waves induced significant neurotransmitter changes in primary hippocampal, cerebellar, and brainstem neurons and in MN9 D and PC12 cells. THz wave downregulated SYN expression in primary hippocampal neurons and downregulated PSD95 expression in primary cortical neurons.Conclusion Different types of cells responded differently after THz wave exposure, and primary hippocampal and cortical neurons and MN9 D cells were relatively sensitive to the THz waves. The biological effects were positively correlated with the exposure time of the THz waves. | TAN Sheng Zhi TAN Peng Cheng LUO Lan Qing CHI Yun Liang YANG Zi Long ZHAO Xue Long ZHAO Li DONG Ji ZHANG Jing YAO Bin Wei XU Xin Ping TIAN Guang CHEN Jian Kui WANG Hui PENG Rui Yun | 2019 | Biomedical and Environmental Sciences2019，32，10： | 5 |
| 14 | Loading-free supramolecular organic framework drug delivery systems(sof-DDSs) for doxorubicin:normal plasm and multidrug resistant cancer cell-adaptive delivery and release显示文摘Four water-soluble porous supramolecular organic framework drug delivery systems(sof-DDSs) have been used to adsorb doxorubicin(DOX) in water at physiological pH of 7.4,which is driven exclusively by hydrophobicity.The resulting complexes DOX@SOFs are formed instantaneously upon dissolving the components in water.The drug-adsorbed sof-DDSs can undergo plasm circulation with important maintenance of the drug and overcome the multidrug resistance of human breast MCF-7/Adr cancer cells.DOX is released readily in the cancer cells due to the protonation of its amino group in the acidic medium of cancer cells.In vitro and in vivo experiments reveal that the delivery of SOF-a-d remarkably improve the cytotoxicity of DOX for the MCF-7/Adr cells and tumors,leading to 13-19-fold reduction of the 1C_(50)values as compared with that of DOX.This new sof-DDSs strategy omits the indispensable loading process required by most of reported nano-scaled carriers for neutral hydrophobic chemotherapeutic agents,and thus should be highly valuable for future development of low-cost delivery systems. | Chi Yao Jia Tian Hui Wang Dan-Wei Zhang Yi Liu Fan Zhang Zhan-Ting Li | 2017 | Chinese Chemical Letters2017，28，4： | 5 |
| 15 | Enhancing prime editing by Csy4-mediated processing of pegRNA显示文摘Dear Editor,The most advanced prime editor 3(PE3)system comprises the editor,a fusion protein of Cas9 H840A nickase and mutant reverse transcriptase(RTase)(hereafter termed NMRT),a prime editing guide RNA(pegRNA)and an alternative single-guide RNA(sgRNA).1 The pegRNA contains a primer binding site(PBS)and a reverse transcription(RT)template for introducing new genetic information1(Fig.1a;Supplementary information,Fig.S1a).We noted that the PBS,which is generally 10–16 nt at the 3′end of pegRNA,is complementary to part of the spacer at the 5′end of pegRNA,and their annealing is expected to cause pegRNA circularization,which can potentially hamper editing(Fig.1a;Supplementary information,Fig.S1b,c). | Yao Liu Guang Yang Shuhong Huang Xiangyang Li Xin Wang Guanglei Li Tian Chi Yulin Chen Xingxu Huang Xiaolong Wang | 2021 | Cell Research2021，31，10： | 5 |
| 16 | Nosocomial Infection Surveillance in a Tuberculosis Specialized Hospital in China显示文摘Nosocomial infections(NIs) are a critical issue affecting the quality of healthcare. In this study, we performed a retrospective study to explore the incidence rates, mortality rates, and microbial spectrum of NIs in Beijing Chest Hospital, a tuberculosis(TB) specialized hospital in China. Our data demonstrate that the overall incidence rate of inpatients with NIs slightly decreased from 2012 to 2016, which may be associated with the implementation of hand hygiene measures, while the mortality rates associated with NI did not significantly change. In addition, the species distribution of NIs was quite different from that presented in previous reports, and Klebsiella pneumoniae was the most frequently isolated microorganism. | XIE Zhong Yao HUANG Guo Fang GAO Hui CHI Yu Qing WANG Yan Xia PANG Yu WANG Jing Ping | 2017 | Biomedical and Environmental Sciences2017，30，9： | 5 |
| 17 | The variational inequality formulation for unconfined seepage through three-dimensional dense fracture networks显示文摘The space block search technology is used to determine a connected three-dimensional fracture network in polygonal shapes,i.e.,seepage paths.After triangulation on these polygons,a finite element mesh for 3D fracture network seepage is obtained.Through introduction of the generalized Darcy's law,conservative equations for both fracture surface and fracture interactions are established.Combined with the boundary condition of Signorini's type,a partial differential equation(PDE) formulation is presented for the whole domain concerned.To solve this problem efficiently,an equivalent variational inequality(VI) formulation is given.With the penalized Heaviside function,a finite element procedure for unconfined seepage problem in 3D fracture network is developed.Through an example in a homogeneous rectangular dam,validity of the algorithm is verified.The analysis of an unconfined seepage problem in a complex fracture network shows that the proposed algorithm is very applicable to complex three-dimensional problems,and is effective in describing some interesting phenomenon usually encountered in practice,such as 'preferential flow'. | YAO Chi JIANG QingHui WEI Wei ZHOU ChuangBing | 2013 | Science China(Technological Sciences)2013，56，5： | 5 |
| 18 | In situ-prepared homogeneous supramolecular organic framework drug delivery systems(sof-DDSs):Overcoming cancer multidrug resistance and controlled release显示文摘Water-soluble three-dimensional porous supramolecular organic frameworks(SOFs) have been demonstrated as a new generation of homogeneous polycationic platforms for anti-cancer drug delivery.The new SOF drug delivery systems(sof-DDSs) can adsorb dianionic pemetrexed(PMX),a clinically used chemotherapeutic agent instantaneously upon dissolving in water,which is driven by both electrostatic attraction and hydrophobicity.The in situ-prepared PMX@SOFs are highly stable and can avoid important release of the drug during plasm circulation and overcome the multidrug resistance of human breast MCF-7/Adr cancer cells to enter the cancer cells.Acidic microenvironment of cancer cells promotes the release of the drug in cancer cells.Both in vitro and in vivo studies have revealed that sofDDSs considerably improve the treatment efficacy of PMX,leading to 6-12-fold reduction of the IC50 values,as compared with that of PMX alone.The new drug delivery strategy omits the loading process required by most of reported nanoparticle-based delivery systems and thus holds promise for future development of low-cost drug delivery | Jia Tian Chi Yao Wen-Lin Yang Lei Zhang Dan-Wei Zhang Hui Wang Fan Zhang Yi Liu Zhan-Ting Li | 2017 | Chinese Chemical Letters2017，28，4： | 4 |
| 19 | The effect of Fe-Mn minerals and seawater interface and enrich-ment mechanism of ore-forming elements of polymetallic crusts and nodules from the South China Sea显示文摘Ferromanganese crusts and nodules are important submarine mineral resources that contain various metal elements with significant economic value. In this study, polymetallic crusts and nodules obtained from the South China Sea(SCS) were determined by using X-ray power diffraction(XRD), Raman spectroscopy(RS), Fourier transform infrared spectroscopy(FTIR), and X-ray photoelectron spectroscopy(XPS) to systematically investigate and analyze the mineralogical and spectral characteristics of the Fe-Mn minerals. XRD measurements revealed that the SCS polymetallic crusts and nodules were composed of vernadite, quartz, and plagioclase. The nodules also contained todorokite. The Fe-phase minerals of the SCS crusts and nodules were composed of amorphous Fe oxide/hydroxide, and the Mn-and Fe-phases minerals exhibited relatively poor degrees of crystallization. FTIR results showed that the Fe-Mn minerals in the crusts and nodules included a large number of surface hydroxyl groups. These surface hydroxyl groups contained protons that could provide reactive sites for complexation of ore-forming elements in seawater. XPS results indicated that the surfaces of the Fe-Mn minerals mainly contained Fe, Mn, and O. Fe was present in the trivalent oxidation state, while Mn, which may contain several bivalent oxidation state, was present in the tetravalent and trivalent oxidation states. The SCS polymetallic crusts and nodules were compared with Pacific seamount crusts, and results showed that the surface hydroxyl(-OH) groups of the SCS crusts and nodules numbered more than the lattice oxygen(O^(2-)). But the lattice oxygen of Pacific seamount crusts numbered more than the surface hydroxyl groups. This characteristic indicated that the degree of crystallization of Fe-Mn minerals from the Pacific Ocean was higher than that of minerals from the South China Sea. Comprehensive studies showed that ore-forming elements in the interface between seawater and the Fe-Mn minerals in the submarine ferromanganese crusts and nodules employed the following enrichment mechanisms:(1) the metal ion complexed with the surface hydroxyl of Fe-Mn minerals to form hydroxyl complexes, which were connected by coordination bonds or stable inner-sphere complexes that exchanged protons on the mineral surfaces;(2) the charged surfaces of the minerals and metal cations formed outer-sphere complexes, which made up the electrostatic double layer, through electrostatic adsorption; and(3) the metal cations isomorphously exchanged the Mn and Fe ions of the mineral lattice structure. | GUAN Yao SUN Xiaoming IANG Xiaodong SA Rina ZHOU Li HUANG Yi LIU Yating LI Xiaojie LU Rongfei WANG Chi | 2017 | Acta Oceanologica Sinica2017，36，6： | 4 |
| 20 | Reactive power optimization of a distribution network with high-penetration of wind and solar renewable energy and electric vehicles显示文摘As high amounts of new energy and electric vehicle(EV)charging stations are connected to the distribution network,the voltage deviations are likely to occur,which will further affect the power quality.It is challenging to manage high quality voltage control of a distribution network only relying on the traditional reactive power control mode.If the reactive power regulation potentials of new energy and EVs can be tapped,it will greatly reduce the reactive power optimization pressure on the network.Keeping this in mind,our reasearch first adds EVs to the traditional distribution network model with new forms of energy,and then a multi-objective optimization model,with achieving the lowest line loss,voltage deviation,and the highest static voltage stability margin as its objectives,is constructed.Meanwihile,the corresponding model parameters are set under different climate and equipment conditions.Ultimately,the optimization model under specific scenarios is obtained.Furthermore,considering the supply and demand relation-ship of the network,an improved technique for order preference by similarity to an ideal solution decision method is proposed,which aims to judge the adaptability of different algorithms to the optimized model,so as to select a most suitable algorithm for the problem.Finally,a comparison is made between the constructed model and a model without new energy.The results reveal that the constructed model can provide a high quality reactive power regula-tion strategy. | Biao Xu Guiyuan Zhang Ke Li Bing Li Hongyuan Chi Yao Yao Zhun Fan | 2022 | Protection and Control of Modern Power Systems2022，7，1： | 4 |
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