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| 1 | Applications of intelligent computing in vehicular networks显示文摘Purpose–This paper aims to introduce vehicular network platform,routing and broadcasting methods and vehicular positioning enhancement technology,which are three aspects of the applications of intelligent computing in vehicular networks.From this paper,the role of intelligent algorithm in thefield of transportation and the vehicular networks can be understood.Design/methodology/approach–In this paper,the authors introduce three different methods in three layers of vehicle networking,which are data cleaning based on machine learning,routing algorithm based on epidemic model and cooperative localization algorithm based on the connect vehicles.Findings–In Section 2,a novel classification-based framework is proposed to efficiently assess the data quality and screen out the abnormal vehicles in database.In Section 3,the authors canfind when traffic conditions varied from freeflow to congestion,the number of message copies increased dramatically and the reachability also improved.The error of vehicle positioning is reduced by 35.39%based on the CV-IMM-EKF in Section 4.Finally,it can be concluded that the intelligent computing in the vehicle network system is effective,and it will improve the development of the car networking system.Originality/value–This paper reviews the research of intelligent algorithms in three related areas of vehicle networking.In thefield of vehicle networking,these research results are conducive to promoting data processing and algorithm optimization,and it may lay the foundation for the new methods. | Daxin Tian Weiqiang Gong Wenhao Liu Xuting Duan Yukai Zhu Chao Liu Xin Li | 2018 | Journal of Intelligent and Connected Vehicles2018，1，2： | 0 |
| 2 | Vaspin alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence显示文摘Background:Visceral adipose tissue-derived serine protease inhibitor(vaspin),a secretory adipokine,protects against insulin resistance.Recent studies have demonstrated that serum vaspin levels are decreased in patients with coronary artery disease and that vaspin protects against myocardial ischemia-reperfusion injury and atherosclerosis.However,it remains unclear whether vaspin exerts specific effects on pathological cardiac hypertrophy.Methods:An in vivo study was conducted using a cardiac hypertrophy model established by subcutaneous injection of isoproterenol(ISO)in C57BL/6 and vaspin-ko mice.Rapamycin was administered intraperitoneally to mice,for further study.H9c2 cells and neonatal rat ventricular myocytes(NRVMs)were treated with ISO to induce hypertrophy.Human vaspin fusion protein,the proteasome inhibitor MG132,and chloroquine diphosphate were used for further mechanistic studies.Results:Here,we provide the first evidence that vaspin knockdown results in markedly exaggerated cardiac hypertrophy,fibrosis,and cardiomyocyte senescence in mice treated with ISO.Conversely,the administration of exogenous recombinant human vaspin protected NRVMs in vitro against ISO-induced hypertrophy and senescence.Furthermore,vaspin significantly potentiated the ISO-induced decrease in autophagy.Both rapamycin and chloroquine diphosphate regulated autophagy in vivo and in vitro,respectively,and participated in vaspin-mediated cardioprotection.Moreover,the PI3K-AKT-mTOR pathway plays a critical role in vaspin-mediated autophagy in cardiac tissues and NRVMs.Our data showed that vaspin downregulated the p85 and p110 subunits of PI3K by linking p85 and p110 to NEDD4L-mediated ubiquitination degradation.Conclusion:Our results show,for the first time,that vaspin functions as a critical regulator that alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence,providing potential preventive and therapeutic targets for pathological cardiac hypertrophy. | Haiying Rui Huaxiang Yu Dan Zou Kai Chi Ping Xu Xiaoshuai Song Lulu Liu Xuting Wu Jinxin Wang Li Xue | 2024 | Emergency and Critical Care Medicine2024，4，1： | 0 |
| 3 | Blue LED promotes the chemosensitivity of human hepatoma to Sorafenib by inducing DNA damage显示文摘Background:Phototherapies based on sunlight,infrared,ultraviolet,visible,and laser-based treatments present advantages like high curative effects,small invasion,and negligible adverse reactions in cancer treatment.We aimed to explore the potential therapeutic effects of blue light emitting diode(LED)in human hepatoma cells and decipher the underlying cellular and molecular mechanisms.Methods:Wound healing and transwell assays were employed to probe the inhibition of the invasion and migration of hepatocellular carcinoma cells in the presence of blue LED.The sphere-forming test was used to evaluate the effect of LED blue light irradiation on cancer stem cell properties.Immunofluorescence and western blotting were used to detect the changes inγ-H2AX.The Cell Counting Kit-8 assay,5-ethynyl-2′-deoxyuridine staining,and colony formation assay were used to detect the combined effect of blue LED and sorafenib on cell proliferation inhibition.Results:We demonstrated that the irradiation of blue LED light in hepatoma cells could lead to cell proliferation reduction along with the increase of cell apoptosis.Simultaneously,blue LED irradiation also markedly suppressed the migration and invasion ability of human hepatoma cells.Sphere formation analysis further revealed the decreased cancer stemness of hepatoma cells upon blue LED irradiation.Mechanistically,blue LED irradiation significantly promoted the expression of the phosphorylation of the core histone protein H2AX(γ-H2AX),a sensitive molecular marker of DNA damage.In addition,we found that the combined treatment of blue LED irradiation and sorafenib increased cancer cell sensitivity to sorafenib.Conclusion:Collectively,we demonstrated that blue LED irradiation exhibited anti-tumor effects on liver cancer cells by inducing DNA damage and could enhance chemosensitivity of cancer cells,which represents a potential approach for human hepatoma treatment. | TONG WANG JINHUAN HONG JIAJIE XIE QIAN LIU JINRUI YUE XUTING HE SHIYU GE TAO LI GUOXIN LIU BENZHI CAI LINQIANG LI YE YUAN | 2023 | BIOCELL2023，47，8： | 0 |
| 4 | The quality control and hypoglycemic effect of Cinnamomi Cortex aqueous extract显示文摘Cinnamomi Cortex was a material as medicinal and edible resources and it has been demonstrated that Cinnamomi Cortex aqueous extract(CCAE)possess hypoglycemic effect,but there were no active compounds identified as quality standard of CCAE to be used in the investigate of hypoglycemic activity.Hence,in this study,the quality standard and the hypoglycemic effect of CCAE were investigated.Cinnamaldehyde and coumarin as the quality control in CCAE were analyzed by high performance liquid chromatography(HPLC)method.The results showed that the average yield of extraction was 10.06%.The concentration of coumarin was linear with peak area ranging from 0.02–1.00μg/mL(r=0.9996,n=6)and that of cinnamaldehyde also demonstrated a good linear relationship with peak area in the range of 1.05–52.50μg/mL(r=0.9997,n=6).The average recovery rate of coumarin and cinnamaldehyde was 99.42%and 100.11%,respectively.The investigation of hypoglycemic effect revealed that CCAE could improve weight loss,lower liver and pancreas indices,improve organ damage caused by diabetes,and lower fasting blood glucose,glycosylated serum protein(GSP)and total cholesterol(TC)levels.The results showed that CCAE can reduce fasting blood glucose and blood lipid levels in diabetic mice. | Xuting Hao Ziheng Jin Ruiyu Gao Shiming Li Changqin Li Lijun Liu Jinmei Wang | 2024 | Journal of Future Foods2024，4，2： | 0 |
| 5 | Phosphorus-doped iron-nitrogen-carbon catalyst with pentacoordinated single atom sites for efficient oxygen reduction显示文摘Single-atomic Fe-N4 is the well-acknowledged active site in iron-nitrogen-carbon(Fe-N-C)material for oxygen reduction reaction(ORR).The adjusting of the electronic distribution of Fe-N4 is promising for further enhancing the performance of the Fe-N-C catalyst.Herein,a phosphorus(P)-doped Fe-N-C catalyst with penta-coordinated single atom sites(FeNPC)is reported for efficient oxygen reduction.Fe K-edge X-ray absorption spectroscopy(XAS)verifies the coordination environment of single Fe atom,while density functional theory(DFT)calculations reveal that the penta-coordination and neighboring doped P atoms can simultaneously change the electronic distribution of Fe-N_(4)and its adsorption strength of key intermediates,reducing the reactionfree energy of the potential-limiting step.Electrochemical tests validate the remarkable intrinsic ORR activity of FeNPC in alkaline media(a half-wave potential(E_(1/2))of 0.904 V vs.reversible hydrogen electrode(RHE)and limited current density(JL)of 6.23 mA·cm^(−2))and an enhanced ORR performance in neutral(E_(1/2)=0.751 V,J_(L)=5.27 mA·cm^(−2))and acidic media(E_(1/2)=0.735 V,JL=5.82 mA·cm^(−2))with excellent stability,highlighting the benefits of optimizing the local environment of singleatomic Fe-N4. | Lili Fan Xiaofei Wei Xuting Li Zhanning Liu Mengfei Li Shuo Liu Zixi Kang Fangna Dai Xiaoqing Lu Daofeng Sun | 2023 | Nano Research2023，16，2： | 0 |
| 6 | High-resolution spatio-temporal analysis of snowmelt over Antarctic Peninsula ice shelves from 2015 to 2021 using SAR images显示文摘Ice shelves play an essential role in the dynamics of the Antarctic ice sheet.The surface meltwater is important,as it can irreversibly weaken ice shelves by exerting additional hydrostatic pressure.Therefore,high-resolution snowmelt products are urgently needed to accurately analyze melting patterns of ice shelves and further estimate mass loss.In this study,a new high-resolution(40 m)snowmelt dataset over all of the Antarctic Peninsula ice shelves larger than 100 km^(2) was developed based on the modified snowmelt detection framework by using a co-orbit normalization method.The dataset provides detailed snowmelt information on each ice shelf,including the image coverage,melting area and melting ratio every 5 days.The melting patterns of three typical ice shelves(George VI,Wilkins and Larsen C Ice Shelves)and the spatio-temporal melting distribution of the Antarctic Peninsula(AP)were further analyzed.The snowmelt information indicates that both the extent and duration of snowmelt have been increasing in the Antarctic Peninsula from 2015 to 2021,and we found that the snowmelt on the Antarctic Peninsula showed a spatial pattern of significantly intense snowmelt on the western side.We believe this study will provide essential data for ice shelf investigation to support otherfields of polar research. | Qi Zhu Huadong Guo Lu Zhang Dong Liang Xuting Liu Heng Zhou Yiting Gou | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
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