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| 1 | Sedum alfredii H:A new Zn hyperaccumulating plant first found in China显示文摘Field survey and greenhouse experiments were carried out to identify and characterize zinc (Zn) uptake and accumulation by a new Zn hyperaccumulating plant species (Sedum alfredii Hance) native to China. Zinc concentration in the shoots of Sedum alfredii Hance grown on an ancient mined area ranged from 4134 to 5000 mg/kg, with a mean of 4515 mg/kg. It suggests that Sedum alfredii could not only grow on heavily Pb/Zn contaminated soils, but also could accumulate extraordinarily high concentration of Zn. Under nutrient solution culture conditions, Sedum alfredii Hance grew healthy at Zn supplying levels from 0.006 to 240 mg · L-1. Zinc concentration in the shoots increased with external Zn levels increasing. The Zn concentration and accumulation in the shoots reached the highest at Zn supply level of SO mg/L, with 19.67 g/kg and 19.83 nig/plant, respectively. All the results showed that Sedum alfredii Hance is a new Zn hyperaccumulating plant. This provides a new plant material to explore mechanism of | YANG Xiao’e LONG Xinxian NI Wuzhong FU Chenxin | 2002 | Chinese Science Bulletin2002，47，19： | 50 |
| 2 | Host cellular signaling induced by influenza virus显示文摘A wide range of host cellular signal transduction pathways can be stimulated by influenza virus infection. Some of these signal transduction pathways induce the host cell's innate immune response against influenza virus, while others are essential for efficient influenza virus replication. This review examines the cellular signaling induced by influenza virus infection in host cells, including host pattern recognition receptor (PRR)-related signaling, protein kinase C (PKC), Raf/MEK/ERK and phosphatidylinositol-3-kinase (PI3K)/Akt signaling, and the corresponding effects on the host cell and/or virus, such as recognition of virus by the host cell, viral absorption and entry, viral ribonucleoprotein (vRNP) export, translation control of cellular and viral proteins, and virus-induced cell apoptosis. Research into influenza virus-induced cell signaling promotes a clearer understanding of influenza virus-host interactions and assists in the identification of novel antiviral targets and antiviral strategies. | DAI XinXian ZHANG LiShu HONG Tao | 2011 | Science China(Life Sciences)2011，54，1： | 12 |
| 3 | Catalytic synthesis of acetals and ketals with H3PW12O40/PAn显示文摘A new environmental friendly catalyst H3PW12O40/PAn was prepared and identified by means of FT-IR,XRD,and TG/DTA.The optimum conditions have been found;that is,the mass ratio of PAn to H3PW12O40 is 1:1.5,the volume of methanol is 20 mL,and the reflux reaction time is 3 h.The structural identity of Keggin units is preserved after the incorporation into polyaniline matrix.Catalytic activities of H3PW12O40/PAn in synthesizing 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane,2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane,cyclohexanone ethylene ketal,cyclohexanone 1,2-propanediol ketal,butanone ethylene ketal,butanone 1,2-propanediol ketal,2-phenyl-1,3-dioxolane,4-methyl-2-phenyl-1,3-dioxolane,2-propyl-1,3-dioxolane,and 4-methyl-2-propyl-1,3-dioxolane were reported.It has been demon-strated that H3PW12O40/PAn is an excellent catalyst.Various factors concerned in these reactions were investigated.The optimum conditions are as follows:the molar ratio of aldehyde/ketone to glycol(r) is 1:1.5,the mass ratio of the catalyst used to the reactants is 0.6%,and the reaction time is 1.0 h.Under these conditions,the yield is as follows:2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane,69.0%;2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane,79.5%;cyclohexanone ethylene ketal,78.9%;cyclohexanone 1,2-propanediol ketal,85.3%;butanone ethylene ketal,56.9%;butanone 1,2-propanediol ketal,78.1%;2-phenyl-1,3-dioxolane,76.3%;4-methyl-2-phenyl-1,3-dioxolane,94.2%;2-propyl-1,3-dioxolane,70.7%;and 4-methyl-2-propyl-1,3-dioxolane,79.2%. | YANG Shuijin ZHANG Yijun DU Xinxian Philippe G. Merle | 2008 | Rare Metals2008，27，1： | 11 |
| 4 | Information acquisition system of multipoint soil surface height variation for profiling mechanism of seeding unit of precision corn planter显示文摘The emergence rate and vitality of maize are directly affected by the sowing depth,and the uniformity of this depth is an important performance indicator of a planter,while the effective soil surface height information acquisition is the prerequisite for ensuring the accuracy of sowing depth control.The soil surface height variation acquisition system of a precision corn planter often produces profiling errors when performing active profiling due to interference from ground debris.In this study,a multipoint soil surface height variation information acquisition system was investigated,which consists of a ranging sensor group and a microcontroller unit(MCU)using a data comparison and screening method.The structure and specifications of the ranging sensors were determined according to the soil surface height variation and debris size,and a nonessential profiling control program was developed.Performed tests on the information acquisition system indicated that the measurement accuracy of the system was 3 mm,and when advancing at a speed of 8 km/h,the accuracy of the profiling decision and the system stability were 97.1%and 94.1%,respectively,indicating that the system was capable of nonessential profile control.The designed ranging system could provide a reference for the design of a ground information acquisition system of precision planters with an active profiling mechanism. | Bo Zhang Wei Zhang Liqiang Qi Haiba Fu Lijuan Yu Rui Li Yue Zhao Xinxian Ma | 2018 | International Journal of Agricultural and Biological Engineering2018，11，6： | 4 |
| 5 | Dissolution of different zinc salts and Zn uptake by Sedum alfredii and maize in mono-and co-cropping under hydroponic culture显示文摘Previous soil pot and field experiments demonstrated that co-cropping the hyperaccumulator Sedum alfredii with maize increased Zn phytoextraction by S. alfredii and decreased Zn uptake by maize shoots. This hydroponic experiment was conducted to investigate whether the facilitation of Zn phytoextraction by S. alfredii resulted from improved dissolution in this co-cropping system and its relation to root exudates. S. alfredii and maize were mono-and co-cropped (without a root barrier) in nutrient solution spiked with four Zn compounds, ZnS, ZnO, Zn3(PO4)2 and 5ZnO·2CO3·4H2O (represented as ZnCO3 ) at 1000 mg/L Zn for 15 days without renewal of nutrient solution after pre-culture. The root exudates were collected under incomplete sterilization and analyzed. The results indicated that the difference in Zn salts had a greater influence on the Zn concentration in maize than for S. alfredii, varying from 210-2603 mg/kg for maize shoots and 6445-12476 mg/kg for S. alfredii in the same order: ZnCO3 > ZnO >Zn3(PO4)2 > ZnS. For the four kinds of Zn sources in this experiment, co-cropping with maize did not improve Zn phytoextraction by S. alfredii. In most cases, compared to co-cropped and mono-cropped maize, mono-cropped S. alfredii resulted in the highest Zn2+ concentration in the remaining nutrient solution, and also had a higher total concentration of low molecular weight organic acids (LMWOA) and lower pH of root exudation. Root exudates did partly influence Zn hyperaccumulation in S. alfredii. | Cheng'ai Jiang Qitang Wu Shucai Zeng Xian Chen Zebin Wei Xinxian Long | 2013 | Journal of Environmental Sciences2013，25，9： | 3 |
| 6 | 3D fully-enclosed triboelectric nanogenerator with bionic fish-like structure for harvesting hydrokinetic energy显示文摘The hydrokinetic energy of river current,as one of the essential and widespread renewable energies,is difficult to be harvested in low flow velocity and shallow water areas.In this work,a three-dimensional(3D)fully-enclosed triboelectric nanogenerator(FETENG)with bionic fish-like structure for harvesting hydrokinetic energy is reported,which is comprised of the triboelectric powergeneration unit,bionic fish-like structure and connection unit.Through the bionic structure,the FE-TENG realizes zero head power generation in shallow water with low flow velocity.What’s more,the effect of external excitations and bionic structures on the electrical performance are systematically studied in this work.The FE-TENG can generate peak power density of 7 and 0.36 W/m^(3)respectively under the simulated swing state with frequency of 1.25 Hz and simulated river current with flow velocity of 0.81 m/s.In practical applications,due to the 3D fully-enclosed design,the FE-TENG immersed in water for 35 days demonstrates excellent immersion durability with undiminished electrical performance.Therefore,the work proposes an efficient method realizing zero head power generation,and provides a good candidate for long-term service in the river current. | Zhaoxu Jing Jiacheng Zhang Jianlong Wang Mingkang Zhu Xinxian Wang Tinghai Cheng Jianyang Zhu Zhong Lin Wang | 2022 | Nano Research2022，15，6： | 3 |
| 7 | Expression, purification of a synthetic fuse-protein-TSF from PF4 and TSP1 fragments and its effect on angio-genesis and tumor growth显示文摘Sequences encoding PF4 (58-70) and TSP1 (429-459) were linked to yield a single gene TSF which encodes the fuse-protein of TSF. The gene was cloned into a pGEX-2T expression vector to generate a protein GST-TSF, which was strongly expressed in E. coli. The purified GST-TSF was degraded with thrombin to generate the protein TSF. With the methods of MTT and wound repair assay, the effects of TSF on the proliferation and migration of EC were detected, respectively. The results showed that TSF significantly suppressed BAEC proliferation and migration in a dose-dependent manner. The fuse protein GST-TSF, and the peptides PF4 (58-70) and TSP1 (429-459) also inhibited BAEC proliferation and migration, respectively, but their inhibition rates were not as high as TSF. Using the CAM assay, it was shown that TSF, GST-TSF, PF4 (58-70) and TSP1 (429-459) inhibited angiogenesis in chick CAM potentially, the effect of TSF was the highest. In vivo, the growth of Lewis lung carcinoma was potently inhibited by TSF | SHEN Xianrong JI Dongmei HU Youqing JIA Fuxing DENG Xinxian WANG Ling CHU Zhiyong JIANG Dingwen LEI Chengxiang HUANG Jiansheng HU Xinran REN Darning | 2001 | Chinese Science Bulletin2001，46，24： | 2 |
| 8 | 流感病毒引起的宿主细胞信号通路研究进展显示文摘流感每年造成全球数千人死亡.造成巨大的经济损失,是一个非常重要的公共卫生问题。流感病毒易发生变异。快速变异的病毒株能够逃逸宿主免疫系统的攻击。每年都投入大量的疫苗用于预防季节性流感.但是疫苗并不能预防所有的流感病毒株感染。 | DAI XinXian 吴华伟(译) 樊晓旭(校) | 2011 | 河南畜牧兽医(市场版)2011，32，12： | 2 |
| 9 | Control of fibrosis and hypertrophic scar formation via glycolysis regulation with IR780显示文摘Background:Hypertrophic scars(HS)represent one of the most common clinical challenges due to unsatisfactory therapeutic results.HS formation is associated with the abnormal activation of fibroblasts and their excessive fibrotic behavior.Glycolysis dysregulation has been shown to participate in the incidence and progression of various fibrotic diseases and shows potential as a means of controlling HS formation.This work aimed to discuss the impact of augmented glycolysis on HS and to propose a method for controlling HS formation through glycolysis regulation.Methods:Here,augmented glycolysis was confirmed together with enhanced fibrotic activity in both HS fibroblasts(HFs)and HS tissues,and the suppression of glycolysis also attenuated fibroblast activation.We also introduced IR780,a heptamethine cyanine dye,to regulate glycolysis for the control of HS formation.Results:In vitro,cell studies indicated that IR780 significantly down-regulated glycolysis and suppressed the fibrotic activity of HFs.In vivo,the intralesional injection of IR780 into rabbit HS models led to the downregulation of glycolysis and the control of HS formation.Furthermore,IR780 accumulated preferentially in activated fibroblasts in both in vitro and in vivo studies,and thus specifically downregulated glycolysis and efficiently controlled fibrosis by targeting activated fibroblasts.Conclusions:This work identified a strategy for controlling fibrosis and HS formation from the perspective of glycolysis regulation with IR780 targeting of activated fibroblasts. | Xinxian Meng Zhixi Yu Wanyu Xu Jun Chai Shuo Fang Peiru Min Yunsheng Chen Yixin Zhang Zheng Zhang | 2022 | Burns & Trauma2022，10，1： | 2 |
| 10 | Self-anti-angiogenesis nanoparticles enhance anti-metastatic-tumor efficacy of chemotherapeutics显示文摘Beyond traditional endothelium-dependent vessel(EDV),vascular mimicry(VM)is another critical tumor angiogenesis that further forms in many malignant metastatic tumors.However,the existing anti-angiogenesis combined chemotherapeutics strategies are only efficient for the treatment of EDV-based subcutaneous tumors,but remain a great challenge for the treatment of in situ malignant metastatic tumor associated with EDV and VM.Here,we demonstrate a self-assembled nanoparticle(VE-DDP-Pro)featuring self-anti-EDV and-VM capacity enables to significantly enhance the treatment efficacy of cisplatin(DDP)against the growth and metastasis of ovarian cancer.The VE-DDP-Pro is constructed by patching DDP loaded cRGD-folate-heparin nanoparticles(VE)onto the surface of protamine(Pro)nanoparticle.We demonstrated the self-anti-angiogenesis capacity of VE-DDP-Pro was attributed to VE,which could significantly inhibit the formation of EDV and VM by regulating signaling pathway of MMP-2/VEGF,AKT/mTOR/MMP-2/Laminin and AKT/mTOR/EMT,facilitating chemotherapeutics to effectively suppress the development and metastasis of ovarian cancer.Thus,combing with the chemotherapeutics effectiveness of DDP,the VE-DDP-Pro can significantly enhance treatment efficacy and prolong median survival of mice with metastatic ovarian cancer.We believe our self-assembled nanoparticles integrating the anti-EDV and anti-VM capacity provide a new preclinical sight to enhance the efficacy of chemotherapeutics for the treatment malignant metastasis tumor. | Jiamao Luo Xinxian Zhong Yingming Peng Chenyuan Hao Xiaomei Liang Yulu Yang Xiubo Shi Xuncai Chen Xiao Yi iaoxuan Li Jianhua Wu Jinheng Li Qian Xiao Chentian Wu b Ruojing Lu b Yao Pan Xuejiao Wang Jun-Bing Fan Yifeng Wang Ying Wang | 2022 | Bioactive Materials2022，7，7： | 1 |
| 11 | Research on Materi- al damage Limits of RC Components for Performance-Based Seismic Design and Assessment 显示文摘 | QI Yongle ZHOU Xinxian XIE Candong | 2013 | Applied Mechanics and Materials2013，12，477： | 1 |
| 12 | Preparation and luminescence property of Gd2 02 S : Tb X-ray nanophosphors u- sing the complex precipitation method 显示文摘 | Tian Ying Cao Wanghe Luo Xinxian | 2007 | J Alloys Com- pounds2007，433，12： | 1 |
| 13 | Research on De- formation Index Limits of RC Shear Wall Based on Material Damage 显示文摘 | QI Yongle ZHOU Xinxian XIE Candong | 2014 | Applied Mechanics and Materials2014，1，507： | 1 |
| 14 | Potential risk assessment of heavy metals in sediments during the denitriflcation process enhanced by calcium nitrate addition: effect of AVS residual 显示文摘 | WANG Lin LONG Xinxian CHONG Yunxiao | 2016 | Ecological Engineering2016，87，： | 1 |
| 15 | AID expression increased by TNF-α is associated with class switch recombination of Igα gene in cancers显示文摘 | Zhi Duan Hui Zheng Haidan Liu Ming Li Min Tang Xinxian Weng Wei Yi Ann M. Bode Ya Cao | 2016 | Cellular & Molecular Immunology2016，13，4： | 1 |
| 16 | Seedling Cultivation Techniques and Genetic Variation in Growth Traits and Their Relation- ships to Toona Ciliata Families显示文摘 | Shijun Wu Jianmin Xu Guangyou Li Chao Han Yang Hu Xinxian Hu | 2014 | 林学研究进展(中英文版)2014，2，1： | 1 |
| 17 | Deep global-attention based convolutional network with dense connections for text classification显示文摘Text classification is a classic task innatural language process(NLP).Convolutional neural networks(CNNs)have demonstrated its effectiveness in sentence and document modeling.However,most of existing CNN models are applied to the fixed-size convolution filters,thereby unable to adapt different local interdependency.To address this problem,a deep global-attention based convolutional network with dense connections(DGA-CCN)is proposed.In the framework,dense connections are applied to connect each convolution layer to each of the other layers which can accept information from all previous layers and get multiple sizes of local information.Then the local information extracted by the convolution layer is reweighted by deep global-attention to obtain a sequence representation with more valuable information of the whole sequence.A series of experiments are conducted on five text classification benchmarks,and the experimental results show that the proposed model improves upon the state of-the-art baselines on four of five datasets,which can show the effectiveness of our model for text classification. | Tang Xianlun Chen Yingjie Xu Jin Yu Xinxian | 2020 | The Journal of China Universities of Posts and Telecommunications2020，27，2： | 1 |
| 18 | Cross-talking between autophagy and viral infection in mammalian cells显示文摘Autophagy is a cellular process in degradation of long-lived proteins and organelles in the cytosol for maintaining cellular homeostasis,which has been linked to a wide range of human health and disease states,including viral infection.The viral infected cells exhibit a compli-cated cross-talking between autophagy and virus.It has been shown that autophagy interacts with both adaptive and innate immunity.For adaptive immunity,viral antigens can be processed in autophagosomes by acidic proteases before major histocompatibility complex(MHC)class II presentation.For innate immunity,autophagy may assist in the delivery of viral nucleic acids to endosomal TLRs and also functions as a part of the TLR-or-PKR-downstream responses.Autophagy was also reported to suppress the magnitude of host innate antiviral immunity in certain cases.On the other hand,viruses has evolved many strategies to combat or utilize the host autophagy for their own benefit.In this review we discussed recent advances toward clarifying the cross-talking between autophagy and viral infection in mammalian cells. | Hongya HAN Lishu ZHANG Xinxian DAI Yanpeng ZHENG | 2010 | Frontiers in Biology2010，5，6： | 1 |
| 19 | Heavy Metal Concentrations in Vegetable Garden Soils from the Suburb of Hangzhou, People’s Republic of China显示文摘 | N. Wuzhong M. Haiyan H. Jixiu L. Xinxian | 2004 | Bulletin of Environmental Contamination and Toxicology2004，，1： | 1 |
| 20 | Synthesis of acetals and ketals catalyzed by tungstosillcic acid supported on active carbon 显示文摘 | YANG SHUIJiN DU XINXIAN HE LAN | 2005 | J Zhejlang Ualv Sci2005，6，5： | 1 |
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