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| 1 | Effects of dietary supplementation of probiotic,Clostridium butyricum,on growth performance,immune response,intestinal barrier function,and digestive enzyme activity in broiler chickens challenged with Escherichia coli K88显示文摘Background:Colibacillosis caused by enterotoxigenic Escherichia coli(E.coli) results in economic losses in the poultry industry.Antibiotics are usually used to control colibacillosis,however,E.coli has varying degrees of resistance to different antibiotics.Therefore the use of probiotics is becoming accepted as an alternative to antibiotics.In this study,we evaluated the effects of Clostridium butyricum(C.butyricum) on growth performance,immune response,intestinal barrier function,and digestive enzyme activity in broiler chickens challenged with Escherichia coli(E.coif) K88.Methods:The chickens were randomly divided into four treatment groups for 28 days.Negative control treatment(NC) consisted of birds fed a basal diet without E.coli K88 challenge and positive control treatment(PC) consisted of birds fed a basal diet and challenged with E.coli K88.C.butyricum probiotic treatment(CB) consisted of birds fed a diet containing 2×10~7 cfu C butyricum/kg of diet and challenged with E.coli K88.Colistin sulfate antibiotic treatment(CS)consisted of birds fed a diet containing 20 mg colistin sulfate/kg of diet and challenged with E.coli K88.Results:The body weight(BW) and average day gain(ADG) in the broilers of CB group were higher(P< 0.05) than the broilers in the PC group overall except the ADG in the 14-21 d post-challenge.The birds in CB treatment had higher(P < 0.05) concentration of tumor necrosis factor-α(TNF-α) at 3 and 7 d post-challenge,and higher(P < 0.05)concentration of interleukin-4(IL-4) at 14 d post-challenge than those in the PC treatment group.The concentration of serum endotoxin in CB birds was lower(P<0.05) at 21 d post-challenge,and the concentrations of serum diamine oxidase in CB birds were lower(P < 0.05) at 14 and 21 d post-challenge than in PC birds.Birds in CB treatment group had higher(P< 0.05) jejunum villi height than those in PC,NC,or CS treatment at 7,14,and 21 d post-challenge.In comparison to PC birds,the CB birds had lower(P < 0.05) jejunum crypt depth during the whole experiment.The birds in CB or CS treatment group had higher(P < 0.05) activities of amylase and protease at 3,7,and 14 d post-challenge,and higher(P< 0.05) activity of lipase at 3,7 d post-challenge than PC birds.Conclusions:In all,these results indicate that dietary supplementation with C.butyricum promotes immune response,improves intestinal barrier function,and digestive enzyme activities in broiler chickens challenged with E.coli K88.There is no significant difference between the C.butyricum probiotic treatment and the colistin sulfate antibiotic treatment.Therefore,the C.butyricum probiotic may be an alternative to antibiotic for broiler chickens. | Ling Zhang Lingling Zhang Xiu'an Zhan Xinfu Zeng Lin Zhou Guangtian Cao An'guo Chen Caimei Yang | 2016 | Journal of Animal Science and Biotechnology2016，7，1： | 43 |
| 2 | Survey of convex optimization for aerospace applications显示文摘Convex optimization is a class of mathematical programming problems with polynomial complexity for which state-of-the-art, highly efficient numerical algorithms with predeterminable computational bounds exist. Computational efficiency and tractability in aerospace engineering, especially in guidance, navigation, and control (GN&C), are of paramount importance. With theoretical guarantees on solutions and computational efficiency, convex optimization lends itself as a very appealing tool. Coinciding the strong drive toward autonomous operations of aerospace vehicles, convex optimization has seen rapidly increasing utility in solving aerospace GN&C problems with the potential for onboard real-time applications. This paper attempts to provide an overview on the problems to date in aerospace guidance, path planning, and control where convex optimization has been applied. Various convexification techniques are reviewed that have been used to convexify the originally nonconvex aerospace problems. Discussions on how to ensure the validity of the convexification process are provided. Some related implementation issues will be introduced as well. | Xinfu Liu Ping Lu Binfeng Pan | 2017 | Astrodynamics2017，1，1： | 32 |
| 3 | Seismotectonics of the 26 November 2005 Jiujiang-Ruichang,Jiangxi,Ms 5.7 Earthquake显示文摘The 26 November 2005 Jiujiang-Ruichang,Jiangxi,Ms 5.7 earthquake occurred in a seismotectonic setting of moderate earthquake.The northwest-trending Xiangfan-Guangji fault(XFG) does not enter into the epicenter vicinity,but the northeast-trending Ruichang-Wuning fault(RWF) as a regional fault extends to the epicenter nearby,appearing as the Ruichang basin and its marginal faults.Tilting of the Ruichang Basin(RCB) in the Quaternary was controlled by the RCB southeast-marginal,buried fault(RSMBF).Shallow geophysical survey reveals that the RSMBF caused an offset of the reflection layers.Drill hole columnar section demonstrates that there are about 10-12 m displacement in the lower section of the middle-Pleistocene Series along the RSMBF,but no disruption is found in the upper section of the middle-Pleistocene Series.The RSMBF not only has activity in the Quaternary,but also coincides with the nodal plane I from the focal mechanism of the Jiujiang-Ruichang Ms 5.7 earthquake.This evidence,including aftershock distribution and isoseismic lines,strongly suggests that the RSMBF might be the seismogenic tectonics.The RWF is discontinuous at the surface,and consists of three en echelon Quaternary basins,which are the Ruichang,Fanzhen and Wuning basins.Three moderate earthquakes,the Fanzhen ML 4.9 earthquake,the Yejiapu ML 4.1 earthquake and the Jiujiang-Ruichang Ms 5.7 earthquake,have happened in the basins since 1995.The seismogenic tectonics of the Jiujiang-Ruichang Ms 5.7 earthquake is not isolated,but may be controlled by the RWF at depth,the slip of which causes the accumulation of energy for earthquake occurrence. | HAN Zhujun LUFushui JI Fengju ZENG Xinfu An Yanfen | 2012 | Acta Geologica Sinica(English Edition)2012，86，2： | 6 |
| 4 | Differential gene expression analysis of ‘Chili’ (Pyrus bretschneideri) fruit pericarp with two types of bagging treatments显示文摘Preharvest bagging is a simple,grower-friendly and safe physical protection technique commonly applied to many fruits,and the application of different fruit bags can have various effects.To explore the molecular mechanisms underlying the fruit quality effects of different bagging treatments,digital gene expression(DGE)profiling of bagged and unbagged‘Chili’(Pyrus bretschneideri Rehd.)pear pericarp during development was performed.Relative to unbagged fruit,a total of 3022 and 769 differentially expressed genes(DEGs)were detected in the polyethylene(PE)-bagged and non-woven fabric-bagged fruit,respectively.DEGs annotated as photosynthesis-antenna proteins and photosynthesis metabolism pathway were upregulated in non-woven fabric-bagged fruit but downregulated in the PE-bagged fruit.Non-woven fabric bagging inhibited lignin synthesis in‘Chili’pear pericarp by downregulating DEGs involved in phenylpropanoid biosynthesis;consequently,the fruit lenticels in non-woven fabric-bagged fruit were smaller than those in the other treatments.The results indicate that the non-woven fabric bagging method has a positive effect on the appearance of‘Chili’pear fruit but neither of the two bagging treatments is conducive to the accumulation of soluble sugar. | Yuling Wang Xinfu Zhang Ran Wang Yingxin Bai Chenglian Liu Yongbing Yuan Yingjie Yang Shaolan Yang | 2017 | Horticulture Research2017，4，1： | 6 |
| 5 | b-DAZL:A novel gene in bovine spermatogenesis显示文摘DAZL 基因在 gametogenesis 起一个重要作用。这基因的 Microdeletion 和变化经常在脊椎动物和无脊椎动物与绝育被联系了。这里,包含 DAZL 基因的完全的开的读物框架的 cDNA,它编码通常认为的 RRM RNA 有约束力的蛋白质,被 RT-PCR 从牛的纸巾孤立。孤立的基因被叫作 b-DAZL。基于计算机的地点分析证明 b-DAZL 在染色体 1 的结束附近被定位。b-DAZL 基因和它的脊椎动物相当或相同事物分享了高核苷酸类似(90 94%) 在编码区域并且在 genomic 组织,每由 10 前 ons 和 9 introns 组成。他们的蛋白质产品包含了一个高度保存的 RNA 有约束力的主题,一次唯一的 DAZ 重复,和 PUM2 和 PABP 交往领域。RT-PCR 试金表明 b-DAZL 在睾丸和卵巢被表示。然而,没有信号在无菌的雄的牛牦牛的睾丸被检测。不育的男性的睾丸的微观结构显示出很少的 spermatocytes 但是主要体的房间。这些观察与有有缺点的 DAZL 表示的睾丸的典型显型一致。随后的基因察觉研究显示那抄写拘捕可能在牛牦牛的睾丸导致一个 b-DAZL 抄本缺点。我们的结果建议 b-DAZL 可以涉及精子发生,并且基因的那抄写拘捕在牛牦牛与男绝育被联系。 | Qingbo Zhang Qifa Li Jiahuang Li Xinfu Li Zhenshan Liu Dawei Song Zhuang Xie | 2008 | Progress in Natural Science:Materials International2008，18，10： | 6 |
| 6 | Prediction of Flowing Bottomhole Pressures for Two-Phase Coalbed Methane Wells显示文摘A method is proposed to predict the flowing bottomhole pressures(FBHPs)for two-phase coalbed methane(CBM)wells.The mathematical models for both gas column pressure and two-phase fluid column pressure were developed based on the well liquid flow equation.FBHPs during the production were predicted by considering the effect of entrained liquid on gravitational gradients.Comparison of calculated BHPs by Cullender-Smith and proposed method was also studied.The results show that the proposed algorithm gives the desired accuracy of calculating BHPs in the lowproductivity and low-pressure CBM wells.FBHP is resulted from the combined action of wellhead pressure,gas column pressure and fluid column pressure.Variation of kinetic energy term,compressibility and friction factors with depth increments and liquid holdup with velocity should be considered to simulate the real BHPs adequately.BHP is a function of depth of each column segment.The small errors of less than 1.5%between the calculated and measured values are obtained with each segment within 25 m.Adjusting BHPs can effectively increase production pressure drop,which is beneficial to CBM desorption and enhances reservoir productivity.The increment of pressure drop from 5.37 MPa2 to 8.66 MPa2 leads to an increase of CBM production from 3270 m3/d to 6700 m3/d and is attributed to a decrease in BHP from 2.25 MPa to 1.33 MPa. | LIU Xinfu | 2013 | Acta Geologica Sinica(English Edition)2013，87，5： | 5 |
| 7 | Rayleigh wave phase velocities of South China block and its adjacent areas显示文摘Using records of continuous seismic waveforms from 609 broadband seismic stations in the South China Block and its adjacent areas in 2010–2012, empirical Green's functions of surface waves were obtained from cross-correlation functions of ambient noise data between these stations. High quality phase velocity dispersion curves of Rayleigh waves were obtained using time-frequency analysis. These interstation dispersion curves were then inverted to build Rayleigh wave phase velocity maps at periods of 6–50 s. The results of phase velocity maps indicate that phase velocities at 6–10 s periods are correlated with the geological features in the upper crust. Major basins and small-scale grabens and basins display slow velocity anomalies; while most of the orogenic belts and the fold belts display high velocity anomalies. With the gravity gradient zone along Taihang Mountain to Wuling Mountain as the boundary for the phase velocity maps at period of 20–30 s, the western area mainly displays low velocity anomalies, while the eastern side shows high velocity anomalies. Phase velocities in the eastern South China Block south to the Qinling-Dabie orogenic belt is higher than that in the eastern North China Block to the north, which is possibly due to the differences of tectonic mechanisms between the North China Craton and the South China Block. The phase velocities at periods of40–50 s are possibly related to the lateral variations of the velocity structure in the lower crust and upper mantle: The low-velocity anomalies in the eastern part of the Tibetan Plateau are caused by the thick crust; while the Sichuan Basin and the southern part of the Ordos Basin display distinct high-velocity anomalies, reflecting the stable features of the lithosphere in these blocks. The lateral variation pattern of phase velocities in the southern part of the South China Block is not consistent with the surface trace of the block boundary in the eastern Yunnan Province and its vicinities. The phase velocities in the Sichuan Basin are overall slow at short periods and gradually increase with period from the central part to the edge of the basin, indicating the features of shallower basement in the center and overall stable lithospheric mantle of the basin. The middle and upper crust of the southern Ordos Basin in the North China Block is heterogeneous, while in lower crust and the uppermost mantle the phase velocities mainly exhibit high anomalies. High-velocity anomalies are widespread at the middle of the Qinling-Dabie orogenic belt, as well as the areas in southeastern Guangxi with Caledonian granite explosion, but its detailed mechanism is still unclear. | L Jian XIE ZuJun ZHENG Yong ZHA XiaoHui HU Rui ZENG XinFu | 2016 | Science China Earth Sciences2016，59，11： | 5 |
| 8 | Approach to the Design Calculation of Sucker Rod Pumping Systems in Coalbed Methane Wells显示文摘The existing design of the pumping systems mainly focuses on the approximate computational formulae and procedures,which are developed based on the analytic approaches of conventional oil/gas fields.The calculation of polished rod loads usually just concerns about the static and inertial loads.And the computation of gearbox torque generally uses empirical formulae and correction factors.The above modeling procedures,if applied to the coalbed methane(CBM) wells,can not give the desired accuracy of the system design and its pertinent analysis.In this paper,based on the kinematic and dynamic analysis of the pumping system,the kinematic relation of polished rod is analyzed,and the variation of the total loads of polished rod is developed with the limits of CBM well conditions along the string.The gearbox torque calculation model is established by combining the counterbalance effect with the calculated dynamometer cards and torque factors.The application characteristics of this model are demonstrated by the example of ZH002-4 well in Qinshui basin.The interpretations of results show that the cranks of beam units should rotate in a counter clockwise direction viewed with the wellhead to the right.Compared with oil?gas fields,the dynamic and friction to polished rod load ratios are relatively high and the computation of polished rod loads should involve the static and inertial loads,as well as vibration and friction loads.And the dynamic load ratio decreases rapidly during the production.Besides,the total deformation of the string is small in CBM wells.As for balanced operation,the gearbox torque load usually has two approximately equal peaks and the magnitudes of instantaneous torque are just within 50% of unbalanced gearbox loadings.The proposed research improves efficiency of the pumping system,loads the pumping unit more uniformly,and provides the reasonable basis for selecting the units. | WANG Fudong LIU Xinfu Guan Zhichuan LIU Chunhua | 2011 | Chinese Journal of Mechanical Engineering2011，24，6： | 4 |
| 9 | Application Value of Topical Aneasthesia in Children Strabismus Surgery显示文摘Purpose:Comparison of topical vs general aneasthesia for strabismus surgery. Methods: Preoperative patients (aged 6~12 years) were divided into two study groups: the topical aneasthesia group (n=22), and the general aneasthesia group (n=21). The study groups were compared on the following measures:.analgesic effect, surgical correction effect, eye-heart reflex, preoperative preparation time. and operation time, using t-tests or X2 tests where appropriate. Results:.Compared with the general aneasthesia group, the topical aneasthesia group gained better surgical correction results(P<0.05), had a lower rate of eye-heart reflex (P<0.05), and had a shorter preoperative preparation time (P<0.001). No significant difference was observed between the groups in terms of the analgesic effect or operation time (P>0.05). Conclusion:Topical aneasthesia represents a safe and effective alternative to general aneasthesia for strabismus surgery in children. | Xiaoping He Lina Chen Xinfu Pan Huiyong Hu Zhimin Shi | 2012 | Eye Science2012，27，3： | 3 |
| 10 | Effects of osmotic stress on the expression profiling of aquaporin genes in the roughskin sculpin(Trachidermus fasciatus)显示文摘Aquaporins(AQPs)are a family of integral membrane proteins that have been shown to be important for osmoregulation in many vertebrates.To identify potential stress resistance-related aqp genes in salinity adaptation of the roughskin sculpin Trachidermus fasciatus,we investigated the time-course expression dynamics of seven aquaporin genes(aqp1,4,7,8,10,11 and 12)in three osmoregulatory tissues(kidney,gill and intestine)and one metabolic tissue(liver).The fish were subjected to two different acute osmotic treatments(seawater-tofreshwater transfer respectively achieved in 1 h and 24 h,namely,E-acute and acute group).The expression profiling of the seven aqp genes were performed using quantitative real-time PCR(qRT-PCR).At the time of all sampling time points(0 h,12 h,24 h and 48 h),no expression of aqp4 was found in the gill,liver and intestine;no expression of aqp7 was found in the gill and liver.Significant differences of aqp expression were determined in the four target tissues,and the mRNA levels were largely variable among gene members and tissues.Similar patterns of the time-course expression were detected in most of the aqp genes in T.fasciatus between the two acute groups,except that only one gene(aqp12)in the kidney and three genes(aqp7,aqp8 and aqp10)in the intestine revealed different expression patterns.These results suggest that the expression response of aqp genes was similar under osmotic changes with different rates. | Qian Ma Xinfu Liu Ang Li Shufang Liu Zhimeng Zhuang | 2020 | Acta Oceanologica Sinica2020，39，6： | 3 |
| 11 | Use of Double Differential-mode Current Injection Method Equivalent to High Level Illumination for Susceptibility Testing显示文摘To achieve the electric field strength and the induced currents in equivalence in susceptibility tests with the high-level field radiation above 400 MHz,a double differential-mode(DM) current injection method based on directional couplers is proposed.Two cascaded symmetrical directional couplers compose a coupling device to inject the DM currents.When the coupling device is used,two devices are necessary to achieve the equivalence between radiation and injection,i.e.the equivalence between the injected voltages and the field strength,which is linear,regardless of the characteristics of the equipment under test(EUT).The results are verified by experiments using typical coaxial cables and nonlinear devices,where the equivalence between the nonlinear EUT responses induced by radiation and injection at both ends is achieved by using two coupling devices.At a frequency up to 1.75 GHz,the maximal experimental error is only 3.39%.The experimental results confirm the accuracy of the proposed method even both the EUTs work in the nonlinear region.The proposed method is applicable for radiated susceptibility(RS) testing of interconnected systems in the microwave frequency band. | LU Xinfu WEI Guanghui PAN Xiaodong | 2013 | 高电压技术2013，39，10： | 3 |
| 12 | Dynamic behavior of coalbed methane flow along the annulus of single-phase production显示文摘Dynamic behavior of coalbed methane (CBM) flow will provide the theoretical basis to optimize production performance for a given well.A mathematical model is developed to simulate flowing pressures and pressure drops of CBM column from well head to bottom hole.The measured parameters and independent variables of flow rates,flowing pressures and temperatures are involved in CBM producing process along the annulus.The developed relationships are validated against full-scale measured data in single-phase CBM wellbores.The proposed methodology can analyze the dynamic behavior in CBM reservoir and process of CBM flow with an overall accuracy of 2%.The calculating process of flowing pressures involves friction factor with variable Reynolds number and CBM temperature and compressibility factor with gravitational gradients.The results showed that the effect of flowing pressure on CBM column was more obvious than that on CBM and water column accompanied by an increase of dynamic water level.The ratios of flowing pressure on increment of CBM column to the whole column increased with the declined flow rates of water column.Bottom-hole pressure declined with the decreased flowing pressure of CBM column along the annulus.It will lead to the results of the increased pressure drop of CBM column and CBM flow rate in single-phase CBM wellbores. | Xinfu Liu Chunhua Liu Guoqiang Liu | 2019 | International Journal of Coal Science & Technology2019，6，4： | 3 |
| 13 | Chemical compositions of sulfides in the porphyry Cu ores,Yangla Cu deposit,Yunnan,China:implication for ore genesis显示文摘The Yangla Cu deposit is the largest ore deposit in the Jinshajiang polymetallic metallogenic belt,northwest Yunnan,China.There is no consensus on the genesis of the ore deposit owing to the limited studies on the chemical compositions of sulfides.This study used an electron probe micro-analyzer to constrain the chemical compositions of pyrite,chalcopyrite,molybdenite,and sphalerite in the porphyry Cu ore of the Yangla Cu deposit and compared them with the chemical compositions of sulfides in the skarn Cu ore.The trace element contents and their occurrences were used to estimate the metallogenic temperature and infer the genesis of the Yangla deposit.The results show that the sulfides in the porphyry Cu ores have variations of ore element concentrations relative to their theoretical values.Pyrite is depleted in S but elevated in Fe;chalcopyrite is depleted in Cu,Fe,and S;and molybdenite and sphalerite are enriched in S whilst depleted in Mo and Zn.The concentrations of the main metallogenic elements Cu,Fe,Mo,Zn,and S in the porphyry are generally lower than those in skarn,suggesting that the porphyry ore was formed in a moderate to moderate-high temperature metallogenic environment.The formation time may also be slightly later than that of the skarn Cu ore.Elements such as As,Co,Cu.Pb,Zn,Mo,Cd,and Ni mainly exist as isomorphic replacements and mineral inclusions in the sulfides of both porphyry and skarn Cu ores.The trace element features of sulfides in the two ore bodies show that the Yangla Cu deposit may be a composite super imposed ore deposit,and让s formation has undergone the process of exhalative-sedimentary to skarnporphyry mineralization. | Xinfu Wang Bo Li Zuopeng Xiang Yan Yue Guo Tang | 2020 | Acta Geochimica2020，39，6： | 3 |
| 14 | Crystal-KMC: Parallel Software for Lattice Dynamics Monte Carlo Simulation of Metal Materials显示文摘Kinetic Monte Carlo(KMC) is a widely used method for studying the evolution of materials at the microcosmic level. At present, while there are many simulation software programs based on this algorithm, most focus on the verification of a certain phenomenon and have no analog-scale requirement, so many are serial in nature. The dynamic Monte Carlo algorithm is implemented using a parallel framework called SPPARKS, but it does not support the Embedded Atom Method(EAM) potential, which is commonly used in the dynamic simulation of metal materials. Metal material — the preferred material for most containers and components — plays an important role in many fields, including construction engineering and transportation. In this paper, we propose and describe the development of a parallel software program called Crystal-KMC, which is specifically used to simulate the lattice dynamics of metallic materials. This software uses MPI to achieve a parallel multiprocessing mode, which avoid the limitations of serial software in the analog scale. Finally, we describe the use of the parallel-KMC simulation software Crystal-KMC in simulating the diffusion of vacancies in iron, and analyze the experimental results. In addition, we tested the performance of Crystal-KMC in 'meta-Era' supercomputing clusters, and the results show the Crystal-KMC parallel software to have good parallel speedup and scalability. | Jianjiang Li Peng Wei Shaofeng Yang Jie Wu Peng Liu Xinfu He | 2018 | Tsinghua Science and Technology2018，23，4： | 2 |
| 15 | Radial Anisotropy in the Crust beneath the Northeastern Tibetan Plateau from Ambient Noise Tomography显示文摘Through analysis of Rayleigh wave and Love wave Green's functions estimated from ambient noise tomography, we obtain radial anisotropy and shear wave velocity structure beneath the northeastern Tibetan Plateau. With two hundred and twenty three broadband seismic stations deployed by China Earthquake Administration, a collaborative seismic experiment of northern Tibet(ACSENT) experiment and northeastern Tibet seismic(NETS) experiment provide the unprecedented opportunity to resolve the spatial distribution of the radial anisotropy within the crust of the northeastern Tibetan Plateau. Discrepancies between Love(sh) and Rayleigh(sv) wave velocities show complex anisotropic patterns associated with the dynamic processes of the collision between the Indian and Eurasian plates:(1) In the upper crust, V_(sv)>V_(sh) anisotropy is dominant throughout the study area which probably reflects fossil microcracks induced by the uplift, folding and erosion geodynamic processes;(2) in the middle crust, V_(sh)>V_(sv) observed beneath the Songpan-Ganzi terrane and the northwestern Qilian orogen correlates well with a mid-crustal low velocity zone(LVZ);(3) at depths deeper than 40 km, V_(sh)>V_(sv) is still found in the Songpan-Ganzi terrane. This anisotropy could be caused by the sub-horizontal alignment of anisotropic minerals that has followed the collision between India and Eurasia. However, the northwestern Qilian orogen is associated with V_(sv)>V_(sh) anisotropy which may be related to the vertically aligned seismic anisotropic minerals caused by the crustal thickening. | Jing Tan Hongyi Li Xinfu Li Ming Zhou Longbin Ouyang Sanjian Sun Dan Zheng | 2015 | Journal of Earth Science2015，26，6： | 2 |
| 16 | Ratiometric sensing lysosomal pH in inflammatory macrophages by a BODIPY-rhodamine dyad with restrained FRET显示文摘Inflammation,as the pathophysiological response of body to harmful stimuli,leads to changes in cellular microenvironment.To research pH changes in lysosomes of macrophages during inflammation,we designed a FRET(F(o|')rster resonance energy transfer)based probe,BDP-RhB.The probe showed good lysosome targeting ability,wide response range of pH from 8.0 to 4.0 with significant ratio(I582/I518)change from 0.6 to 3.4,and good reversibility and sustainability.By applying BDP-RhB,we found a decrease of lysosomal pH of macrophages during inflammation. | Yu Yan Xiaodong Zhang Xinfu Zhang Ning Li Huizi Man Lingcheng Chen Yi Xiao | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
| 17 | Expression profiles of sex-related genes in gonads of genetic male Takifugu rubripes after 17β-estradiol immersion显示文摘Estradiol treatment during early life stages of tiger puffer Takifugu rubripes induces feminization in genetic males.However,the ovaries in genetic males may revert to testes once estradiol treatment is halted.Therefore studies should investigate molecular mechanisms underlying ovary-to-testis recovery in genetic males after treatment.In the present study,tiger puffer were exposed to 10,and 100μg/L 17β-estradiol(E 2)from 15 to 100 days post-hatching(dph),then gonad phenotypes and expression profi les of six sex-related genes(cyp19a,foxl2,dmrt1,amh,sox9a,and sox9b)were characterized after the exposure.Results showed that both 10 and 100μg/L E2 induced ovarian development in genetic males at 100 dph.However,all ovaries induced by 10μg/L E2 first developed into intersexual gonads and subsequently reverted to testes after the exposure.As for treatment of 100μg/L E2,while the rest of the ovaries maintained morphological stability,percentages of intersexual gonads reached 38%-57%,and none were reverted to testes.Increased mRNA levels of cyp19a,foxl2 and sox9b and decreased mRNA levels of dmrt1,amh,and sox9a were observed during the ovarian development in genetic males.While contrary gene expression profiles were detected during ovary-to-testis transformation.The mRNA levels of all the six genes were increased during the development of intersexual gonads.These results indicated that up-regulation of dmrt1,amh and sox9a is associated with initial ovary-to-intersexual transformation,and suppression of foxl2,cyp19a and sox9b is essential for complete ovary-to-testis recovery in genetic males.This research will help to trace the molecular processes underlying gonadal transformation in teleosts. | HU Peng LIU Bin MA Qian LIU Shufang LIU Xinfu ZHUANG Zhimeng | 2019 | Journal of Oceanology and Limnology2019，37，3： | 2 |
| 18 | A strongly coupled predator-prey system with non-monotonic functional response显示文摘 | Chen Xinfu Qi Yuanwei Wang Mingxin | 2007 | Nonlinear Analysis2007，67，： | 1 |
| 19 | Integrated Coal Pyrolysis with Methane Aromatization over Mo/HZSM-5 for Improving Tar Yield显示文摘 | Jin Lijun Zhou Xun He Xinfu | 2013 | Fuel2013，114，12： | 1 |
| 20 | Central GLP-2 Enhances Hepatic Insulin Sensitivity via Activating PI3K Signaling in POMC Neurons显示文摘 | Xuemei Shi Fuguo Zhou Xiaojie Li Benny Chang Depei Li Yi Wang Qingchun Tong Yong Xu Makoto Fukuda Jean J. Zhao Defa Li Douglas G. Burrin Lawrence Chan Xinfu Guan | 2013 | Cell Metabolism2013，，1： | 1 |
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