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| 1 | The Sunway TaihuLight supercomputer: system and applications显示文摘The Sunway Taihu Light supercomputer is the world's first system with a peak performance greater than 100 PFlops. In this paper, we provide a detailed introduction to the Taihu Light system. In contrast with other existing heterogeneous supercomputers, which include both CPU processors and PCIe-connected many-core accelerators(NVIDIA GPU or Intel Xeon Phi), the computing power of Taihu Light is provided by a homegrown many-core SW26010 CPU that includes both the management processing elements(MPEs)and computing processing elements(CPEs) in one chip. With 260 processing elements in one CPU, a single SW26010 provides a peak performance of over three TFlops. To alleviate the memory bandwidth bottleneck in most applications, each CPE comes with a scratch pad memory, which serves as a user-controlled cache. To support the parallelization of programs on the new many-core architecture, in addition to the basic C/C++and Fortran compilers, the system provides a customized Sunway Open ACC tool that supports the Open ACC2.0 syntax. This paper also reports our preliminary efforts on developing and optimizing applications on the Taihu Light system, focusing on key application domains, such as earth system modeling, ocean surface wave modeling, atomistic simulation, and phase-field simulation. | Haohuan FU Junfeng LIAO Jinzhe YANG Lanning WANG Zhenya SONG Xiaomeng HUANG Chao YANG Wei XUE Fangfang LIU Fangli QIAO Wei ZHAO Xunqiang YIN Chaofeng HOU Chenglong ZHANG Wei GE Jian ZHANG Yangang WANG Chunbo ZHOU Guangwen YANG | 2016 | Science China(Information Sciences)2016，59，7： | 45 |
| 2 | SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2显示文摘 | Huize Pan Di Guan Xiaomeng Liu Jingyi Li Lixia Wang Jun Wu Junzhi Zhou Weizhou Zhang Ruotong Ren Weiqi Zhang Ying Li Jiping Yang Ying Hao Tingting Yuan Guohong Yuan Hu Wang Zhenyu Ju Zhiyong Mao Jian Li Jing Qu FuchouTang Guang-Hui Liu | 2016 | Cell Research2016，26，2： | 32 |
| 3 | TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy显示文摘 | Chengyan Wang Xuming Tang Xiaomeng Sun Zhenchuan Miao Yaxin Lv Yanlei Yang Huidan Zhang Pengbo Zhang Yang Liu LiyingDu Yang Gao Ming Yin Mingxiao Ding Hongkui Deng | 2012 | Cell Research2012，22，1： | 17 |
| 4 | Effect of Protein Kinase C on Proliferation and Apoptosis of T Lymphocytes in Idiopathic Thrombocytopenic Purpura Children显示文摘It is well-documented that T lymphocyte proliferation and apoptosis are abnormal in idiopathic thrombocytopenic purpura (ITP) children. However, the underlying regulation mechanisms especially in terms of signal transduction remain unknown. In this paper, we reported the changes of protein kinase C (PKC) activity in peripheral blood T lymphocytes and the effect of PKC on T lymphocyte proliferation and apoptosis. We demonstrated that in ITP children, the activator (PMA) and inhibitor (H-7) of PKC affected on T lymphocyte proliferation and apoptosis dramatically, but they altered little in healthy children. PKC activity was significantly enhanced in ITP children together with an increased expression of FasL on CD3+ T, CD4+ T and CD8+T cells, resulting in a positive correlation between PKC activity and the expression of FasL on T cells. While the PKC activity and the platelet count were negatively correlated. Taken together, our findings suggest that the PKC activation may enhance T lymphocytes activity, suppress T cell apoptosis and be involve in thrombocytes damage as a mechanism related to immune pathogenesis of ITP. | Changlin Wu~(1,2) Fang Liu~1 Xuemin Zhou~1 Zhengwei Cheng~1 Xiaomeng Yang~1 Hong Xiao~1 Qun Chen~1 Kangrong Cai~1 ~1Department of Microbiology and Immunology,Guangdong Medical College,Zhanjiang,Guangdong,524023,China ~2Corresponding to:Dr.Changlin Wu,Department of Microbiology and Immunology,Guangdong Medical College,2 Wen-Ming East Road,Zhanjiang,Guangdong,524023,China. | 2005 | Cellular & Molecular Immunology2005，2，3： | 12 |
| 5 | Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding显示文摘 | Jiping Yang Jingyi Li Keiichiro Suzuki Xiaomeng Liu Jun Wu Weiqi Zhang Ruotong Ren Weizhou Zhang Piu Chan Juan Carlos Izpisua Belmonte Jing Qu Fuchou Tang Guang-Hui Liu | 2017 | Cell Research2017，27，9： | 12 |
| 6 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders:executive summary and 2019 update of the management of high-risk population显示文摘Aim Cerebrovascular disease is the leading cause of death and disability in China,causing a huge burden among patients and their families.Hence,stroke prevention is critical,especially in the high-risk population.Here,we present the evidence-based guideline suitable for the Chinese population.Methods Literature search of PubMed and Cochrane library(from January 1964 to June 2019)was done.After thorough discussion among the writing group members,recommendations were listed and summarised.This guideline was reviewed and discussed by the fellow writing committees of the Chinese Stroke Association’s Stroke.Results This evidence-based guideline was written in three parts:controlling the risk factors of stroke,utilisation of antiplatelet agents and assessing the risks of first-ever stroke.All recommendations were listed along with the recommending classes and levels of evidence.Conclusions This guideline provides recommendations for primary prevention of cerebrovascular disease among high-risk population in China.Controlling related risk factors,appropriately using antiplatelet agents,assessing the risk of developing first-ever stroke should help reduce the rate of cerebrovascular disease in China. | Yilong Wang Shangrong Han Haiqiang Qin Huaguang Zheng Bin Jiang Yong Cao Yuan Gao Ling Guan Qian Jia Yong Jiang Yuming Jiao Shuya Li Yapeng Li Zixiao Li Wei Liu Xiaojuan Ru Dongling Sun Haixin Sun Penglian Wang Tingting Wang Lixia Zong Lei Guo Xuewei Xie Yuming Xu Yuyuan Xu Xiaomeng Yang Yingying Yang Mengyuan Zhou Wenzhi Wang Chinese Stroke Association Stroke Council Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 11 |
| 7 | Altered Local Field Potential Relationship Between the Parafascicular Thalamic Nucleus and Dorsal Striatum in Hemiparkinsonian Rats显示文摘The thalamostriatal pathway is implicated in Parkinson's disease(PD); however, PD-related changes in the relationship between oscillatory activity in the centromedian-parafascicular complex(CM/Pf, or the Pf in rodents) and the dorsal striatum(DS) remain unclear.Therefore, we simultaneously recorded local field potentials(LFPs) in both the Pf and DS of hemiparkinsonian and control rats during epochs of rest or treadmill walking. The dopamine-lesioned rats showed increased LFP power in the beta band(12 Hz–35 Hz) in the Pf and DS during both epochs, but decreased LFP power in the delta(0.5 Hz–3 Hz) band in the Pf during rest epochs and in the DS during both epochs, compared to control rats. In addition,exaggerated low gamma(35 Hz–70 Hz) oscillations after dopamine loss were restricted to the Pf regardless of the behavioral state. Furthermore, enhanced synchronization of LFP oscillations was found between the Pf and DS after the dopamine lesion. Significant increases occurred in the mean coherence in both theta(3 Hz–7 Hz) and beta bands,and a significant increase was also noted in the phase coherence in the beta band between the Pf and DS during rest epochs. During the treadmill walking epochs, significant increases were found in both the alpha(7 Hz–12 Hz)and beta bands for two coherence measures. Collectively,dramatic changes in the relative LFP power and coherence in the thalamostriatal pathway may underlie the dysfunction of the basal ganglia-thalamocortical network circuits in PD, contributing to some of the motor and non-motor symptoms of the disease. | Haiyan Zhang Jing Yang Xuenan Wang Xiaomeng Yao Hongyu Han Yunfeng Gao Hongli Chang Tianyu Xiang Shuang Sun Yanan Wang Xiusong Wang Min Wang | 2019 | Neuroscience Bulletin2019，35，2： | 5 |
| 8 | Polarization and Apoptosis of T Cell Subsets in Idiopathic Thrombocytopenic Purpura显示文摘It is well-known that idiopathic thrombocytopenic purpura (ITP) is an acquired organ-specific autoimmune hemorrhagic disease and dysfunctional cellular immunity is considered important in the pathophysiology of ITP. However, polarization patterns and apoptosis profiles of T lymphocytes remain unclear. In this study, we investigated the polarization of T cell subsets, the expressions of apoptotic proteins Fas/FasL on the subsets and the level of anti-apoptotic gene bcl-2 and bax mRNA. It was demonstrated that the ratios of Th1/Th2 and Tc1/Tc2 in ITP children were increased obviously and that the average percentages were increased clearly for Th1 and Th2,but not for Tc1 and Tc2. In ITP children, the enhancing expressions were detected for FasL on Th1 and Tc1 and for Fas on Th2 and Tc2. With increasing level of bcl-2 mRNA and decreasing expression of bax mRNA in ITP children, the ratio of bcl-2/bax mRNA was improved obviously, which was positive correlated with the ratio of Th1/Th2. Taken together, our findings indicate that ITP is a Th1 predominant disease. This polarization pattern of T cell subsets might be related to the high ratio of bcl-2/bax mRNA and the abnormal expressions of Fas and FasL on T cell subsets. Cellular & Molecular Immunology. | Fang Liu~(1,2) Changlin WU~1 Xiaomeng Yang~1 Hong Xiao~1 Xuemin Zhuo~1 Zhengwei Cheng~1 Qun Chen~1 ~1Department of Microbiology and Immunology,Guangdong Medical College,Zhanjiang,Guangdong 524023,China ~2Department of Microbiology and Immunology,Guangdong Medical College,No.2 Wen-ming East Road,Zhanjiang,Guangdong 524023,China. | 2005 | Cellular & Molecular Immunology2005，2，5： | 5 |
| 9 | Expert consensus on perioperative management of liver transplantation in adults with acute-on-chronic liver failure显示文摘Acute-on-chronic liver failure(ACLF)is a syndrome in which acute liver failure with extrahepatic organ failure occurs on chronic liver disease.Recently,liver transplantation is the only effective treatment for ACLF.There is still room for discussion on the optimal surgery timing for ACLF,perioperative infection prevention and control,and maintenance of nutrition and organ function.The Transplantation Immu-nology Committee of Branch of Organ Transplantation Physician of Chinese Medical Doctor Association and Enhanced Recovery of Liver Transplantation Group of Enhanced Recovery after Surgery Committee of Chinese Research Hospital Association invited relevant experts to discuss the perioperative management of ACLF liver transplantation in areas including surgery timing,organ protection,nutritional support,infection prevention and control,rehabilitation exercises,regulation of the internal environment,etc.An expert consensus was developed as reference for clinicians. | Transplantation Immunology Committee of Branch of Organ Transplantation Physician of Chinese Medical Doctor Association Enhanced Recovery of Liver Transplantation Group of Enhanced Recovery after Surgery Committee of Chinese Research Hospital Society Guihua Chen Yang Yang Huimin Yi Jianrong Liu Pinglan Lu Lijuan Li Mingming Fan Xiaomeng Yi Haijin Lv Xuxia Wei | 2021 | Liver Research2021，5，2： | 3 |
| 10 | Study on extraction of thiophene from model gasoline with brønsted acidic ionic liquids显示文摘Brønsted acidic ionic liquids(ILs),N-methylimidazole hydrogen sulfate([HMIm]HSO_(4))and N-methylpyrrolidone hydrogen sulfate([HNMP]HSO_(4)),are synthesized and employed as extractants to extract thiophene from model gasoline(thiophene dissolved in noctane).The effect of extraction temperature,extraction time and volume ratio of ILs to model gasoline on desulfurization rates is investigated.Then,the optimal desulfurization conditions are obtained:the ratio of ILs to model gasoline is 1∶1,extraction temperature is 50℃ for[HMIm]HSO_(4)and 60℃ for[HNMP]HSO_(4),extraction time is 60 min.Meanwhile,the desulfurization rate of[HNMP]HSO_(4)for model gasoline is 62.8%,which is higher than that of[HMIm]HSO_(4)(55.5%)under optimal conditions.The reason is discussed on the basis of the interaction energy between thiophene and ILs at the B3LYP/6-311++G(d,p)level.Furthermore,the total desulfurization rate of[HNMP]HSO_(4)and[HMIm]HSO_(4)reaches 96.4%and 94.4%,respectively,by multistage extraction.Finally,the used ILs can be reused by vacuum drying,and their desulfurization rates are not significantly decreased after recycling 7 times in single-stage desulfurization. | Xiaomeng WANG Mingjuan HAN Hui WAN Cao YANG Guofeng GUAN | 2011 | Frontiers of Chemical Science and Engineering2011，5，1： | 3 |
| 11 | Brain-wide Mapping of Mono-synaptic Afferents to Different Cell Types in the Laterodorsal Tegmentum显示文摘The laterodorsal tegmentum(LDT) is a brain structure involved in distinct behaviors including arousal,reward, and innate fear. How environmental stimuli and top-down control from high-order sensory and limbic cortical areas converge and coordinate in this region to modulate diverse behavioral outputs remains unclear.Using a modified rabies virus, we applied monosynaptic retrograde tracing to the whole brain to examine the LDT cell type specific upstream nuclei. The LDT received very strong midbrain and hindbrain afferents and moderate cortical and hypothalamic innervation but weak connections to the thalamus. The main projection neurons from cortical areas were restricted to the limbic lobe, including the ventral orbital cortex(VO), prelimbic, and cingulate cortices. Although different cell populations received qualitatively similar inputs, primarily via afferents from the periaqueductal gray area, superior colliculus, and the LDT itself, parvalbumin-positive(PV?) GABAergic cells received preferential projections from local LDT neurons.With regard to the different subtypes of GABAergic cells, aconsiderable number of nuclei, including those of the ventral tegmental area, central amygdaloid nucleus, and VO, made significantly greater inputs to somatostatinpositive cells than to PV?cells. Diverse inputs to the LDT on a system-wide level were revealed. | Xiaomeng Wang Hongbin Yang Libiao Pan Sijia Hao Xiaotong Wu Li Zhan Yijun Liu Fan Meng Huifang Lou Ying Shen Shumin Duan Hao Wang | 2019 | Neuroscience Bulletin2019，35，5： | 3 |
| 12 | Short-term biochar effect on soil physicochemical and microbiological properties of a degraded alpine grassland显示文摘Soil remediation is an important part of the restoration process of degraded terrestrial ecosystems.Due to its unique properties,biochar is being used widely as an effective soil modifier in agricultural systems,but research is still rare on biochar application in grassland ecosystems,especially in degraded alpine grasslands.In this study,we conducted a plot experiment to investigate the effect of biochar application on soil physicochemical properties and microorganisms at the 0–20 cm soil depth of a degraded alpine grassland in Qinghai-Tibet Plateau,China.The experiment consisted of four corn straw biochar application levels(0%,0.5%,1%and 2%,with the percentage representing the ratio of biochar weight to the dry weight of soil in the surface 20 cm soil layer).When the biochar addition increased from 0%to 2%,total nitrogen,total organic carbon and available phosphorus in the 0–10 cm soil layer increased by 41%,55%and 45%,respectively,in the second year after biochar addition.Meanwhile,soil electrical conductivity decreased,and soil water content increased.Total microbial,fungal and bacterial biomasses in the 0–10 cm soil layer increased from 9.15 to 12.68,0.91 to 1.34,and 3.85 to 4.55μg g^(-1),respectively.The relative biomasses of saprophytic fungi and methanotrophic bacteria decreased,while the relative biomasses of ectomycorrhizal fungi and arbuscular mycorrhizal fungi increased.These results indicate that biochar has a great potential in improving microbial activity and soil fertility in soil remediation of the degraded alpine grassland. | Jinsheng LI Xinqing SHAO Ding HUANG Kesi LIU Jianying SHANG Qian ZHANG Tianci ZHAO Xiaomeng YANG | 2022 | Pedosphere2022，32，3： | 3 |
| 13 | Demonstration of epitaxial growth of strain-relaxed GaN films on graphene/SiC substrates for long wavelength light-emitting diodes显示文摘Strain modulation is crucial for heteroepitaxy such as GaN on foreign substrates.Here,the epitaxy of strain-relaxed GaN films on graphene/SiC substrates by metal-organic chemical vapor deposition is demonstrated.Graphene was directly prepared on SiC substrates by thermal decomposition.Its pre-treatment with nitrogen-plasma can introduce C–N dangling bonds,which provides nucleation sites for subsequent epitaxial growth.The scanning transmission electron microscopy measurements confirm that part of graphene surface was etched by nitrogen-plasma.We study the growth behavior on different areas of graphene surface after pre-treatment,and propose a growth model to explain the epitaxial growth mechanism of GaN films on graphene.Significantly,graphene is found to be effective to reduce the biaxial stress in GaN films and the strain relaxation improves indium-atom incorporation in InGaN/GaN multiple quantum wells(MQWs)active region,which results in the obvious red-shift of light-emitting wavelength of InGaN/GaN MQWs.This work opens up a new way for the fabrication of GaN-based long wavelength light-emitting diodes. | Ye Yu Tao Wang Xiufang Chen Lidong Zhang Yang Wang Yunfei Niu Jiaqi Yu Haotian Ma Xiaomeng Li Fang Liu Gaoqiang Deng Zhifeng Shi Baolin Zhang Xinqiang Wang Yuantao Zhang | 2021 | Light(Science & Applications)2021，10，7： | 2 |
| 14 | Optimizing write operation on replica in data grid显示文摘Replication technique can improve access performance and data availability of data grid systems. So far,most related work on data replication in data grid systems focuses on read-only dataset.Though write operations have been widely used in practice,its optimization problem has not been suciently studied.In this paper,we show that write requests from users can be processed by a nearest site,regardless of the location of latest written replicas.The policy of write nearby instead of write to the latest replica can improve the performance of write operations,while inconsistency is caused between multiple replicas.Therefore,we propose two metadata management algorithms to make sure that users can retrieve up-to-date datasets at any time.We extend OptorSim to support the implementation and evaluation of our scheme.The results of simulation show that our scheme achieves performance gains up to 3.3 compared with WriteMaster scheme. | XU PengZhi WU YongWei HUANG XiaoMeng YANG GuangWen ZHENG WeiMin | 2011 | Science China(Information Sciences)2011，54，1： | 2 |
| 15 | The Arabidopsis pentatricopeptide repeat protein PDM1 is associated with the intergenic sequence of S11-rpoA for rpoA monocistronic RNA cleavage显示文摘The PDM1 gene encodes a pentatricopeptide repeat protein of the PLS subfamily.It is essential for rpoA polycistronic processing in Arabidopsis.In this study,we performed functional analysis of PDM1 in rpoA monocistronic cleavage and chloroplast development.The pdm1 mutants display an albino lethal phenotype with severe chloroplast development defects.When the construct of PDM1 fused with the GFP gene was introduced into Arabidopsis protoplasts,the GFP signal was exclusively observed in chloroplasts.This shows that PDM1 is localized to chloroplast.In the wild type,the rpoA transcript of about 990 nt is processed.In pdm1,this transcript is absent.However,Western blot showed that the RpoA protein in pdm1 is accumulated at a level approximately 1/3 of the wild type.This suggests that certain other transcripts processed from L23-L2-S19-L22-S3-L16-L14S8-L36-S11-rpoA polycistronic precursor may be used as templates for protein translation.To determine whether PDM1 can bind to the rpoA pre-mRNA,we generated a transgenic Arabidopsis line with PDM1 fused to FLAG tag that was capable of complementing the pdm1-1 mutant phenotype.RNA immunoprecipitation analysis showed that PDM1 is associated with S11-rpoA intergenic sequence.This indicates that PDM1 may bind to the S11-rpoA intergenic region to perform rpoA processing. | YIN QianQian CUI YongLan ZHANG GuoRui ZHANG HongDao WANG XiaoMeng YANG ZhongNan | 2012 | Chinese Science Bulletin2012，57，26： | 2 |
| 16 | Suppression of FHL2 Expression Induces Cell Differentiation and Inhibits Gastric and Colon Carcinogenesis显示文摘 | Jide Wang Yi Yang Harry H.X. Xia Qing Gu Marie C.M. Lin Bo Jiang Ying Peng Guoqing Li Xiaomeng An Yali Zhang Zehao Zhuang Zhenshu Zhang Hsiang Fu Kung Benjamin C.Y. Wong | 2007 | Gastroenterology2007，，3： | 1 |
| 17 | Artificial nanomotors: Fabrication, locomotion characterization, motion manipulation, and biomedical applications显示文摘Artificial nanomotors are nanoscale machines capable of converting surrounding other energy into mechanical motion and thus entering the tissues and cells of organisms.They hold great potential to revolutionize the diagnosis and treatment of diseases by actively targeting the lesion location,though there are many new challenges that arise with decreasing the size to nanoscale.This review sum-marizes and comments on the state-of-the-art artificial nanomotors with ad-vantages and limitations.It starts with the fabrication methods,including common physical vapor deposition and colloidal chemistry methods,followed by the locomotion characterization and motion manipulation.Then,the in vitro and in vivo biomedical applications are introduced in detail.The challenges and future prospects are discussed at the end. | Liangmeng Wang Xiaomeng Hao Zhixue Gao Zili Yang Yi Long Ming Luo Jianguo Guan | 2022 | Interdisciplinary Materials2022，1，2： | 1 |
| 18 | Origin of ground fissures in the Shanxi Graben System,Northern China显示文摘 | Youli Li Jingchun Yang Xiaomeng Hu | 2000 | Engineering Geology2000，，55： | 1 |
| 19 | Power-to-Hydrogen by Electrolysis in Carbon Neutrality: Technology Overview and Future Development显示文摘Power-to-hydrogen by electrolysis(PtHE)is a promising technology in the carbon-neutral evolution of energy.PtHE not only contributes to renewable energy integration but also accelerates decarbonization in industrial sectors through green hydrogen production.This paper presents a comprehensive review of PtHE technology.First,technical solutions in PtHE technology are introduced to clarify pros and cons of one another.Besides,the multiphysics coupling and the multi-energy flow are investigated to reveal the insight mechanism during operation of compactly assembled industrial PtHE plants.Then,the development trends of core components in PtHE plants,including electrocatalysts,electrode plates and operation strategy,are reviewed,respectively.Research thrusts needed for PtHE in carbon-neutral transition are also summarized.Finally,three configurations of the PtHE plant in energy system integration are introduced,which can achieve renewable energy integration and efficient energy utilization.Index Terms-Carbon neutrality,power-to-hydrogen nby electrolysis(PtHE),multiphysics coupling,multidisciplinary. | Zhiyao Zhong Jiakun Fang Kewei Hu Danji Huang Xiaomeng Ai Xiaobo Yang Jinyu Wen Yuan Pan Shijie Cheng | 2023 | CSEE Journal of Power and Energy Systems2023，9，4： | 1 |
| 20 | Central sensibility of human cases with different body mass during oral glucose tolerance test using functional magnetic resonance imaging显示文摘BACKGROUND: Because of the limitation of technique, there are few researches on regulating function o central hypothalamus by metabolism, especially the researches on real-time function. OBJECTIVE: To evaluate the response of hypothalamus to oral glucose tolerance test (OGTT) in differen body-weighted subjects by using functional magnetic resonance imaging (fMRI) so as to investigate th relationship between the sensitivity of hypothalamus in glycoregulation and disturbance of carbohydrat metabolism. DESIGN: Paired design. SETTING: Department of Radiology and Beijing Geriatrics Institute, Beijing Hospital, National Publi Health Bureau. PARTICIPANTS: A total of twenty healthy volunteers were selected from Beijing Geriatrics Institute National Public Health Bureau, including 10 subjects with obesity (5 males and 5 females; body mass > 28.0 kg/m2) and 10 subjects with normal body mass (5 males and 5 females; body mass from 18.5 to 23.9 kg/m2). All subjects gave written informed consent before participating in the study. METHODS: fMRI study was performed on GE 1.5 T Signa Twinspeed Infinity with Excite. Each voluntee was ingested of glucose during the fMRI scan. T2* images were acquired using a single-shot gradient echo (EPI) technique. The parameters of EPI included: TR 3 000 ms, TE 40 ms, Flip angle 90°, field of view (FOV) 24 cm × 24 cm, thickness 5 mm, gap 0 mm, matrix 64 × 64, number of excitation 1. All 10 subjects with normal body mass underwent a repeat fMRI scan after consuming an equivalent amount o water without glucose on a separate day. The procedure for the fMRI scan with water intake was the same a for glucose ingestion. fMRI data were processed with Intensity Averaging Method. MAIN OUTCOME MEASURES: The central response of hypothalamus and feedback orientation during OGTT in different body-weighted subjects. RESULTS: An acute transient decrease of fMRI intensity in posterior inferior and anterior inferior o hypothalamus was observed in all subjects within 2 minutes after oral glucose intake. This decrease wa followed by a recovery to the baseline. However, obese subjects had a delayed intensity decrease [(1.96± 1.06) minutes vs. (1.04±0.71) minutes, t =2.14, P < 0.05] and longer recovery time [(26.62±7.35 minutes vs. (16.29±6.42) minutes, t =3.67, P < 0.01] as compared with normal body-weight subjects Furthermore, decreased fMRI intensity was significant different from baseline intensity [(5.7±2.5)% vs (14.3±5.5)%, t =2.56, P < 0.05] in obese subjects, but not in normal body-weight subjects. The area o hypothalamus in normal body-weight volunteers demonstrated no significant signal change before and afte oral water ingestion (P > 0.05). CONCLUSION: Hypothalamus response to glucose loading is different in normal body-weighted and obes subjects. This suggests that fMRI is a useful tool to evaluate the central regulation of glucose metabolism. | Min Chen Yunting Zhang Tiemei Zhang Cheng Zhou Xiaomeng Wu Kui Cai Zhenghan Yang Wenchao Wang Weifeng Zhao Saying Li Zhi Wang Guozhen Li | 2007 | Neural Regeneration Research2007，2，9： | 1 |
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