| 2 | Levels of synthetic musk fragrances in human milk from three cities in the Yangtze River Delta in Eastern China显示文摘Synthetic musks are used as additives in many household products.After absorption into the human body,they accumulate and their concentrations in human milk reflect both the mother and her infant's exposure level.Concentrations of four synthetic musks,musk xylene(1-tert-butyl-2,6-dimethyl-2,4,6-trinitrobenzene,MX),musk ketone(4-tert-butyl-2,6-dimethyl-3,5-dinitroacetophenone,MK),1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[γ]-2-benzopyran(HHCB) and 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4tetrahydronaphthalene(AHTN),were determined in human milk samples collected from Shanghai,Wuxi,and Shaoxing in Eastern China.The four synthetic musks were found in most samples analyzed,with HHCB the dominant component followed by MX.The median(mean) values for HHCB,AHTN,MX and MK concentrations were 63(82),5(12),17(24) and 4(9) ng/g lipid weight,respectively.These data suggested the total synthetic musk contamination was low,and the distribution percentage was HHCB > MX > AHTN ≈ MK.The relative high ratio of nitro to polycylic musk indicated that nitro musks were still widely used.The musk concentrations in these cities were not significantly different from each other(p > 0.05).Principal components score plots were obtained,which showed similar exposure sources.The amount of total synthetic musks in human milk were not associated with mother's age,although HHCB was significantly correlated with AHTN(p < 0.05).Daily ingestion of HHCB,AHTN,MX and MK for infants from human milk were estimated as(2526 ± 2926),(370 ± 524),(7391 ± 832),and(277 ± 462) ng/day,respectively.Those doses were 1-2 orders of magnitude below the provisional tolerable daily intakes. | Xiaolan Zhang Gaofeng Liang Xiangying Zeng Jing Zhou Guoying Sheng Jiamo Fu | 2011 | Journal of Environmental Sciences2011，23，6： | 8 |
| 3 | Diverse Effects of L-arginine on Cardiac Function of Rats Subjected to Myocardial Ischemia and Reperfusion in vivo显示文摘在在不同时间的 L 精氨酸的管理在心肌的局部缺血和灌注(MI/R ) 的功课期间削尖的 vivo 被显示出到差别 regulatepostischemic apoptosis。心脏的功能是过去常判定心肌的损害的度的最重要的索引之一。现在的学习试图决定在 vivo,在 MI/R 的不同阶段的 L 精氨酸的管理是否在 ischemicreperfused 心的心脏的功能上有多样的影响并且那么,调查包含的机制。雄的成年老鼠受到心肌的局部缺血由 5 h 灌注跟随了的 30 min。一丸静脉内的 L 精氨酸大丸药被给任何一个 10 min 在前和在灌注(早处理) 或 3 h 和 4 h afterreperfusion (迟了的处理) 以后的 50 min。有 L 精氨酸的早处理显著地增加了左室的收缩压力(LVSP ) 和 dP/dt_( 最大) ,并且减少心肌的 nitrotyrosinecontent。在严格的对比,有 L 精氨酸的迟了的处理在灌注,和由 nitrotyrosine 测量了的有毒的 peroxynitriteformation 的增加以后从 4 h 导致了重要减少 inLVSP 和 dP/dt_( 最大) 到 5 h。这些结果建议不同时间在 MI/R 的功课期间削尖的 L-arginineat 的管理在心脏的机能障碍上导致多样的效果。早补充减少了 nitrative 压力和改进左室的功能。然而,有 L 精氨酸的迟了的处理增加了 peroxynitrite 的形成并且加重了心脏的功能的损害。 | Xiaoliang WANG Feng LIANG Xiangying JIAO Lei LIU Xiaojie BAI Meixia LI Jianmin ZHI Huirong LIU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，3： | 7 |
| 4 | Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy显示文摘Here,we describe a combination strategy of black phosphorus(BP)-based photothermal therapy together with anti-CD47 antibody(aCD47)-based immunotherapy to synergistically enhance cancer treatment.Tumour resistance to immune checkpoint blockades in most cancers due to immune escape from host surveillance,along with the initiation of metastasis through immunosuppressive cells in the tumour microenvironment,remains a significant challenge for cancer immunotherapy.aCD47,an agent for CD47/SIRPαaxis blockade,induces modest phagocytic activity and a low response rate for monotherapy,resulting in failures in clinical trials.We showed that BP-mediated ablation of tumours through photothermal effects could serve as an effective strategy for specific immunological stimulation,improving the inherently poor immunogenicity of tumours,which is particularly useful for enhancing cancer immunotherapy.BP in combination with aCD47 blockade activates both innate and adaptive immunities and promotes local and systemic anticancer immune responses,thus offering a synergistically enhanced effect in suppression of tumour progression and in inducing abscopal effects for inhibition of metastatic cancers.Our combination strategy provides a promising platform in which photothermal agents could help to enhance the therapeutic efficacy of immunotherapy. | Zhongjian Xie Minhua Peng Ruitao Lu Xiangying Meng Weiyuan Liang Zhongjun Li Meng Qiu Bin Zhang Guohui Nie Ni Xie Han Zhang Paras N.Prasad | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 5 | Two-Dimensional Borophene:Properties,Fabrication,and Promising Applications显示文摘Monoelemental two-dimensional(2D)materials(Xenes)aroused a tremendous attention in 2D science owing to their unique properties and extensive applications.Borophene,one emerging and typical Xene,has been regarded as a promising agent for energy,sensor,and biomedical applications.However,the production of borophene is still a challenge because bulk boron has rather intricate spatial structures and multiple chemical properties.In this review,we describe its excellent properties including the optical,electronic,metallic,semiconducting,photoacoustic,and photothermal properties.The fabrication methods of borophene are also presented including the bottom-up fabrication and the top-down fabrication.In the end,the challenges of borophene in the latest applications are presented and perspectives are discussed. | Zhongjian Xie Xiangying Meng Xiangnan Li Weiyuan Liang Weichun Huang Keqiang Chen Jianming Chen Chenyang Xing Meng Qiu Bin Zhang Guohui Nie Ni Xie Xiaobing Yan Han Zhang | 2020 | Research2020，，1： | 2 |
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