|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Whole-genome resequencing of Osmanthus fragrans provides insights into flower color evolution显示文摘Osmanthus fragrans is a well-known ornamental plant that has been domesticated in China for 2500 years.More than 160 cultivars have been found during this long period of domestication,and they have subsequently been divided into four cultivar groups,including the Yingui,Jingui,Dangui,and Sijigui groups.These groups provide a set of materials to study genetic evolution and variability.Here,we constructed a reference genome of O.fragrans‘Liuyejingui’in the Jingui group and investigated its floral color traits and domestication history by resequencing a total of 122 samples,including 119 O.fragrans accessions and three other Osmanthus species,at an average sequencing depth of 15×.The population structure analysis showed that these 119 accessions formed an apparent regional cluster.The results of linkage disequilibrium(LD)decay analysis suggested that varieties with orange/red flower color in the Dangui group had undergone more artificial directional selection;these varieties had the highest LD values among the four groups,followed by the Sijigui,Jingui,and Yingui groups.Through a genome-wide association study,we further identified significant quantitative trait loci and genomic regions containing several genes,such as ethylene-responsive transcription factor 2 and Arabidopsis pseudoresponse regulator 2,that are positively associated with petal color.Moreover,we found a frameshift mutation with a 34-bp deletion in the first coding region of the carotenoid cleavage dioxygenase 4 gene.This frameshift mutation existed in at least one site on both alleles in all varieties of the Dangui group.The results from this study shed light on the genetic basis of domestication in woody plants,such as O.fragrans. | Hongguo Chen Xiangling Zeng Jie Yang Xuan Cai Yumin Shi Riru Zheng Zhenqi Wang Junyi Liu Xinxin Yi Siwei Xiao Qiang Fu Jingjing Zou Caiyun Wang | 2021 | Horticulture Research2021，8，1： | 5 |
| 2 | Tuning exsolution of nanoparticles in defect engineered layered perovskite oxides for efficient CO_(2) electrolysis显示文摘Solid oxide electrolysis cell(SOEC) could be a potential technology to afford chemical storage of renewable electricity by converting water and carbon dioxide.In this work,we present the Ni-doped layered perovskite oxides,(La_(4)Sr_(n-4))_(0.9)Ti_(0.9n)Ni_(0.1n)O_(3n+2) with n=5,8,and 12(LSTNn) for application as catalysts of CO_(2) electrolysis with the exsolution of Ni nanoparticles through a simple in-situ growth method.It is found that the density,size,and distribution of exsolved Ni nanoparticles are determined by the number of n in LSTNn due to the different stack structures of TiO_6 octahedra along the c axis.The Ni doping in LSTNn significantly improved the electrochemical activity by increasing oxygen vacancies,and the Ni metallic nanoparticles afford much more active sites.The results show that LSTNn cathodes can successfully be manipulated the activity by controlling both the n number and Ni exsolution.Among these LSTNn(n=5,8,and 12),LSTN8 renders a higher activity for electrolysis of CO_(2) with a current density of 1.50A cm^(-2)@2.0 V at 800℃ It is clear from these results that the number of n in(La_(4)Sr_(n-4))_(0.9)Ti_(0.9n)Ni_(0.1n)O_(3n+2)with Ni-doping is a key factor in controlling the electrochemical performance and catalytic activity in SOEC. | Zhengrong Liu Jun Zhou Yueyue Sun Xiangling Yue Jiaming Yang Lei Fu Qinyuan Deng Hongfei Zhao Chaofan Yin Kai Wu | 2023 | Journal of Energy Chemistry2023，，9： | 1 |
| 3 | Enhanced antibacterial activity of silica nanorattles with ZnO combination nanoparticles against methicillin-resistant Staphylococcus aureus显示文摘Silica nanorattles(SNs) with zinc oxide(ZnO) combination nanoparticles are reported to inhibit methicillin-resistant Staphylococcus aureus(MRSA) for the first time. SNs loaded with ZnO nanoparticles,which can produce free radicals, can cause severe damage to bacteria. ZnO nanoparticles not only provide free radicals in the combined nanostructures, which can inhibit the growth of bacteria, but also form nanorough surfaces with an irregular distribution of spikes on the SNs, which can enhance their adhesion to bacteria. Nanorough silica shell surfaces maintain the high activity and stability of small-sized ZnO nanoparticles and gather ZnO nanoparticles together to enhance production, which improves the efficiency of free radicals against the cytomembranes of bacterial cells. The enhanced adhesion of ZnO@SN nanoparticles to MRSA cells shortens the effective touching distance between free radicals and MRSA, which also improves antibacterial activity. As we expected, the ZnO@SN nanoparticles exhibit a better antibacterial effect than free ZnO nanoparticles against MRSA in vitro and in vivo. We also demonstrate that SNs loaded with ZnO nanoparticles can accelerate wound healing in MRSA skin inflammation models. This method of multilevel functionalization will be potentially applicable to the antibacterial field. | Qianqian Chai Qiong wu Tianlong Liu Longfei Tan Changhui Fu Xiangling Ren Yue Yang Xianwei Meng | 2017 | Science Bulletin2017，62，17： | 1 |
| 4 | Weighted composition operators on some weighted spaces in the unit ball 显示文摘 | FU Xiaohong ZHU Xiangling | 2008 | Abstr Appl Anal2008，，2： | 1 |
| 5 | Weighted composition operators on some weighted spaces in the unit ball 显示文摘 | FU Xiaohong ZHU Xiangling | 2008 | Abstract and Applied Analysis2008，605，3： | 1 |
| 6 | Luminescent silver nanoclusters for efficient detection of adenosine triphosphate in a wide range of pH values显示文摘In this work,polymethacrylic acid(PMAA)-templated silver nanoclusters(Ag NCs)were developed as the fluorescent probe for the efficient and sensitive detection of adenosine triphosphate(ATP)in a wide range of pH values.The fluorescence intensity of the Ag NCs could keep stable with pH values ranging from2.5 to 9.3.The detection of ATP was based on the quenching of the fluorescent Ag NCs in the presence of ATP.The fluorescence quenching of the Ag NCs with increasing ATP concentration was studied at pH 2.5,4.5,7.0 and 8.5 which involved a wide pH environment in body fluids.The limit of detection(LOD)for ATP was as low as 0.1 mmol/L in an acidic environment with pH of 2.5 and all the linear correlation coefficients were satisfactory under wide-span pH values from 2.5 to 8.5.In addition,the sensitive determination of ATP was also achieved by adding copper ions(Cu^2+).The high selectivity and rapid detection process proved that the fluorescent probe had great potential to detect ATP in biological samples under different pH conditions. | Meijia Liu Xiangling Ren Xin Liu Longfei Tan Hui Li Jing Wei Changhui Fu Qiong Wu Jun Ren Hongbo Li Xianwei Meng | 2020 | Chinese Chemical Letters2020，31，12： | 1 |
| 7 | Nanoscale metal organic frameworks inhibition of pyruvate kinase of M2显示文摘Tumor cells usually show abnormally high glycolysis rate to maintain the dynamic balance of energy.The growth of tumor cells can be affected by inhibiting the activity of pyruvate kinase(especially M2-type isozyme,PKM2),the rate limiting enzyme of glycolysis.This is helpful to the treatment of tumor.Herein,metal organic frameworks(MOFs) were found to inhibit the activity of PKM2.Nanoscale ZIF-8 was synthesized by standing and ultrasonic method,respectively.The ZIF-8 has the performance of inhibiting PKM2.Further research showed that the inhibition ability was attributed to zinc ion in ZIF-8.Interestingly,the IC_(50) of ZIF-8 on PKM2 was one percent of that of zinc ion.This novel enzyme inhibitor is expected to be used in cancer therapy. | Xiangling Ren Xinyuan Huang Qiong Wu Longfei Tan Changhui Fu Yi Chen Xianwei Meng | 2021 | Chinese Chemical Letters2021，32，10： | 0 |
| 8 | Zirconium metal-organic framework nanocrystal as microwave sensitizer for enhancement of tumor therapy显示文摘Although surgical resection and chemotherapy were widely applied in tumor therapy, the dysfunction of normal cells resulted in the side effects (such as anorexia, nausea). MW thermal therapy is a non-invasive anticancer strategy under the help of MW sensitizer, with the safety and higher efficacy. Zirconium metal-organic framework nanocubes (ZrMOF NCs) modified with polyethylene glycol, were prepared via one pot method and carbodiimide technique, resulting in their large specific surface area and porosity.Our results showed that non-ion-loaded ZrMOF NCs in 0.9% NaCl solution exhibited better heating effect,higher than that in pure water, due to the robust collision among the ions under MW irradiation. The in vivo experiments confirmed that ZrMOF-PEG NCs + MW group exhibited the higher temperature in the tumor region than that of only MW treatment, suggesting a better MW thermal therapeutic anticancer efficacy. This work provides a new preparation strategy of biosafety nanomaterial as MW sensitizer for enhancing MW thermal anticancer therapy. | Yuanwen Zou Wei Zhang Hongqiao Zhou Changhui Fu Longfei Tan Zhongbing Huang Xiangling Ren Jun Ren Xudong Chen Xianwei Meng | 2019 | Chinese Chemical Letters2019，30，2： | 0 |
| 9 | Chemical chaperone delivered nanoscale metal–organic frameworks as inhibitor of endoplasmic reticulum for enhanced sensitization of thermo-chemo therapy显示文摘Thermotherapy and chemotherapy have received extensive attention to tumor treatment. However, thermal tolerance and drug resistance severely limit clinical effect of tumor therapy owing to endoplasmic reticulum(ER) stress. Reducing thermal tolerance and drug resistance of tumors is an urgent challenge to be solved. In this work, we design a nanoplatform of PBA-Dtxl@MIL-101 as an ER inhibitor. Amino functionalized Fe-metal organic framework(MIL-101) nanoparticles are synthesized as p H and microwave(MW) dual stimuli-responsive drug delivery system. Then, the chemical chaperones of 4-phenylbutyric acid(PBA) and antineoplastic drug Docetaxel(Dtxl) were successfully loaded into MIL-101 nanoparticles to form PBA-Dtxl@MIL-101 nanoparticles. Furthermore, PBA-Dtxl@MIL-101 nanoparticles exhibit inhibitor effect of ER stress through upregulating caspase 9 proteins and reduce thermal tolerance by downregulating HSP 90. It was demonstrated that the therapy sensitized by PBA-Dtxl@MIL-101 nanoparticles obviously destroyed tumor cells, showing simultaneously enhanced thermo-chemo therapy. | Xiaoyan Ma Qiong Wu Longfei Tan Changhui Fu Xiangling Ren Qijun Du Lufeng Chen Xianwei Meng | 2022 | Chinese Chemical Letters2022，33，3： | 0 |
| 10 | A survey of automated International Classification of Diseases coding:development,challenges,and applications显示文摘The International Classification of Diseases(ICD)is an international standard and tool for epidemiological in-vestigation,health management,and clinical diagnosis with a fundamental role in intelligent medical care.The assignment of ICD codes to health-related documents has become a focus of academic research,and numerous studies have developed the process of ICD coding from manual to automated work.In this survey,we review the developmental history of this task in recent decades in depth,from the rules-based stage,through the traditional machine learning stage,to the neural-network-based stage.Various methods have been introduced to solve this problem by using different techniques,and we report a performance comparison of different methods on the pub-licly available Medical Information Mart for Intensive Care dataset.Next,we summarize four major challenges of this task:(1)the large label space,(2)the unbalanced label distribution,(3)the long text of documents,and(4)the interpretability of coding.Various solutions that have been proposed to solve these problems are analyzed.Further,we discuss the applications of ICD coding,from mortality statistics to payments based on disease-related groups and hospital performance management.In addition,we discuss different ways of considering and evaluat-ing this task,and how it has been transformed into a learnable problem.We also provide details of the commonly used datasets.Overall,this survey aims to provide a reference and possible prospective directions for follow-up research work. | Chenwei Yan Xiangling Fu Xien Liu Yuanqiu Zhang Yue Gao Ji Wu Qiang Li | 2022 | Intelligent Medicine2022，2，3： | 0 |
| 11 | Toxicity and bio-distribution of carbon dots after single inhalation exposure in vivo显示文摘Because of the advantages of excellent light stability, carbon dots(CDs) are considered to be a promising agent in the bio-marker application. Nevertheless, there are many unresolved issues with the toxicity of CDs in vitro and in vivo. In the study, CDs were synthesized by citric acid and ethylenediamine into deionized water, then the inhalation toxicity and bio-distribution of CDs in vivo were systematically assessed. The results showed that CDs caused animals death at higher dosages and induced injury in the lung and liver including inflammation and necrosis after single inhalation exposure at 5, 2 and 1 mg/kg dosages of the CDs. We also found that the injury increase with a dose-dependent and time-dependent manner. Fluorescent examination and TEM results showed that CDs mainly located at the lung and liver.And the fluorescent intensity increase with a time-dependent manner. This study provides a theoretical basis of the respiratory toxicity of CDs, and provides a basis for the use of CDs as a bio-marker. | Yue Yang Xiangling Ren Zhenning Sun Changhui Fu Tianlong Liu Xianwei Meng Zili Wang | 2018 | Chinese Chemical Letters2018，29，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员