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| 1 | HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation显示文摘N6-methyladenosine(m6A),and its reader protein YTHDF1,play a pivotal role in human tumorigenesis by affecting nearly everystage of RNA metabolism.Autophagy activation is one of the ways by which cancer cells survive hypoxia.However,the possibleinvolvement of m6A modification of mRNA in hypoxia-induced autophagy was unexplored in human hepatocellular carcinoma(HCO).In this study,specific variations in YTHDF1 expression were detected in YTHDF1-overexpressing,knockout,and-knockdownHCC cells,HCC organoids,and HCC patient-derived xenograft(PDX)murine models.YTHDF1 expression and hypoxia inducedautophagy were significantly correlated in vitro;signifhcant overexpression of YTHDF1 in HCC tissues was associated with poorprognosis,Multivariate cox regression analysis identihed YTHDF1 expression as an independent prognostic factor in patients withHCC.Multiple HC models conhrmed that YTHDF1 deficiency inhibited HCC autophagy,growth,and metastasis.Luciferase reporterassays and chromatin immunoprecipitation demonstrated that HlIF-1a regulated YTHDF1 transcription by directly binding to itspromoter region under hypoxia.The results of methylated RNA immunoprecipitation sequencing,proteomics,and polysomeprofling indicated that YTHDF1 contibuted to the translation of autophagy-related genes ATG2A and ATG14 by binding to m6A-modifhed ATG2A and ATG14 mRNA,thus facilitating autophagy and autophagy-related malignancy of HCC.Taken together,HlE-1d-induced YTHDF1 expression was associated with hypoxia-induced autophagy and autophagy-related HCC progression via promoting translation of autophagy-related genes ATG2A and ATG14 in a m6A-dependent manner.Our fndings suggest thatYTHDF1 is a potential prognostic biomarker and therapeutic target for patients with HCC. | Qing Li Yong Ni Liren Zhang Runqiu Jiang Jing Xu Hong Yang Yuanchang Hu Jiannan Qiu Liyong Pu Jinhai Tang Xuehao Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 24 |
| 2 | Developing individual tree-based models for estimating aboveground biomass of five key coniferous species in China显示文摘Estimating individual tree biomass is critical to forest carbon accounting and ecosystem service modeling.In this study,we developed one-(tree diameter only) and two-variable(tree diameter and height) biomass equations,biomass conversion factor(BCF) models,and an integrated simultaneous equation system(ISES) to estimate the aboveground biomass for five conifer species in China,i.e.,Cunninghamia lanceolata(Lamb.) Hook.,Pinus massoniana Lamb.,P.yunnanensis Faranch,P.tabulaeformis Carr.and P.elliottii Engelm.,based on the field measurement data of aboveground biomass and stem volumes from 1055 destructive sample trees across the country.We found that all three methods,including the one-and two-variable equations,could adequately estimate aboveground biomass with a mean prediction error less than 5%,except for Pinus yunnanensis which yielded an error of about 6%.The BCF method was slightly poorer than the biomass equation and the ISES methods.The average coefficients of determination(R^2) were 0.944,0.938 and 0.943 and the mean prediction errors were 4.26,4.49 and 4.29% for the biomass equation method,the BCF method and the ISES method,respectively.The ISES method was the best approach for estimating aboveground biomass,which not only had high accuracy but also could estimate stocking volumes simultaneously that was compatible with aboveground biomass.In addition,we found that it is possible to develop a species-invariant one-variable allometric model for estimating aboveground biomass of all the five coniferous species.The model had an exponent parameter of 7/3 and the intercept parameter a_0 could be estimated indirectly from stem basic density(a_0= 0.294 q). | Weisheng Zeng Liyong Fu Ming Xu Xuejun Wang Zhenxiong Chen Shunbin Yao | 2018 | Journal of Forestry Research2018，29，5： | 5 |
| 3 | Estimates of heritability and correlation for growth traits of Turbot(Scophthalmus maximus L.) under low temperature conditions显示文摘The objectives of this present research were to assess the heritability of growth traits under low temperature conditions in turbot(Scophthalmus maximus L.), and to analyze the correlation between body weight(BW) and body length(BL). There were 536 individuals from 25 full- and half-sib families involved in this study. During the entire 90-day period, which was initiated at 233 dph(day old) and ended at 323 dph, the individuals' BW and BL were weighed consecutively six times every 18 days. The heritability of BW and BL and the correlation between these two traits were estimated based on an individual animal model with the derivative-free restricted maximum likelihood(DFREML) method. These results showed that the specific growth rates(SGR) of 25 families was from 0.75±0.11 to 1.05±0.14 under water temperature of 10.5–12°C. In addition, the heritability of BW and BL estimated under low-temperature were 0.32±0.04 and 0.47±0.06, respectively. The BW had a medium heritability(0.2–0.4), and the BL had a high heritability(>0.45), which suggested that selection for increased weight and length was feasible. Moreover, there was potential for mass selection on growth. The genetic and phenotypic correlations between BW and BL were 0.95±0.01 and 0.91±0.01(P < 0.01), respectively. A significant correlation between BW and BL showed that BL could be instead of BW for indirect selection, which could be effectively implemented in the breeding program. | XU Liyong WANG Weiji KONG Jie LUAN Sheng HU Yulong MA Yu | 2015 | Acta Oceanologica Sinica2015，34，2： | 4 |
| 4 | Overview of research on agricultural robots in China显示文摘As the representation of new concept agricultural machinery,agricultural robots possess great advantages of improving agricultural productivity,enhancing production environment and solving the problem of labor shortage.Therefore,the strategy for application of agricultural robots and precision agriculture to improve the intelligence and information level of agriculture is the inevitable trend for China’s agriculture in the twentieth century.Based on the developmental status of agricultural robots in China,the agricultural robots are categorized and the performances,structures and characteristics of various agricultural robots such as vegetable grafting robots,transplanting robots,spraying robots,mowing robots,harvesting robots,grading and detecting robots are amply introduced.It can be seen that vegetable grafting robots,spraying robots,harvesting robots,grading and detecting robots have already been put into production while others are still at experimental stage.At present,there are several problems such as low popularization,great limitations,high cost and low intelligence,which greatly restrict the development of agricultural robots in China.Thus,open agricultural robot system with good expansibility,generality and flexibility should be developed and adopted to decrease its cost and shorten developing cycle.The mechanical structure of robots should also be designed as simply as possible.Finally,multi-robot system would become another important development direction of agricultural robots in the future. | Zhang Libin Yang Qinghua Bao Guanjun Wang Yan Qi Liyong Gao Feng Xu Fang | 2008 | International Journal of Agricultural and Biological Engineering2008，1，1： | 4 |
| 5 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 6 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 7 | A proposed direct measurement of cross section at Gamow window for key reaction 19F(p,α) 16O in Asymptotic Giant Branch stars with a planned accelerator in CJPL显示文摘In 2014, the National Natural Science Foundation of China(NSFC) approved the Jinping Underground Nuclear Astrophysics laboratory(JUNA) project, which aims at direct cross-section measurements of four key stellar nuclear reactions right down to the Gamow windows. In order to solve the observed fluorine overabundances in Asymptotic Giant Branch(AGB) stars, measuring the key ^(19)F( p,α)^(16)O reaction at effective burning energies(i.e., at Gamow window) is established as one of the scientific research sub-projects. The present paper describes this sub-project in details, including motivation, status, experimental setup, yield and background estimation, aboveground test, as well as other relevant reactions. | JianJun He ShiWei Xu ShaoBo Ma Jun Hu LiYong Zhang ChangBo Fu NingTao Zhang Gang Lian Jun Su YunJu Li ShengQuan Yan YangPing Shen SuQing Hou BaoLu Jia Tao Zhang XiaoPeng Zhang Bing Guo Shigeru Kubono WeiPing Liu | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，5： | 3 |
| 8 | Phosphonate-Decorated Covalent Organic Frameworks for Actinide Extraction: A Breakthrough Under Highly Acidic Conditions显示文摘Although solid-phase extraction is a useful approach for metal ion separation from aqueous solutions,existing sorbents suffer from low extraction effici-encies and/or instability when in contact with strong acidic media.We report here the first study on rational design and fabrication of phosphonate-decorated covalent organic frameworks,COF-IHEP1 and COF-IHEP2,for efficient and selective extraction of of uranium(VI)[U(VI)]and plutonium(IV)[Pu(IV)]from highly acidic solutions. | Jipan Yu Liyong Yuan Shuai Wang Jianhui Lan Lirong Zheng Chao Xu Jing Chen Lin Wang Zhiwei Huang Wuqing Tao Zhirong Liu Zhifang Chai John K.Gibson Weiqun Shi | 2019 | CCS Chemistry2019，1，3： | 3 |
| 9 | 2-14 Investigation of the Thermonuclear 18Ne(α, p)21Na Reaction Rate via Resonant Elastic Scattering of 21Na + p显示文摘A nuclear astrophysics experiment was performed at CRIB (CNS low-energy Radioactive-Ion Beam separator)on Mar. 2011. The goal of this experiment is to study the reaction rate of 18Ne(,p)21Na reaction, which mightbe a key breakout reaction from the hot CNO cycle to rp-process in X-ray burst and nova. Yet its reaction rate ispoorly known.Explosive hydrogen burning is thought to be the main source of energy generation and a source of nucleosynthesisin X-ray burst and nova[1;2]. For example, XRBs are characterized by a sudden increase of X-ray emission withinonly a few seconds to a total energy output of about 1040 ergs, which is observed to repeat with some regularity.The recurrence time for single bursts can range from hours to days at the typical temperature of 0.4~2 GK. Thebursts have been interpreted as being generated by thermonuclear runaway on the surface of a neutron star thataccretes H- and He-rich material from a less evolved companion star in a close binary system. As shown in Fig. 1,under its typical temperature, the hydrogen burning in X-ray burst occurs from the hot CNO cycle: | Zhang Liyong He Jianjun Xu Shiwei H.Yamaguchi S. Kubono Y.Wakabayashi Chen Size Hu Jun Ma Peng Y. Togano T. Hashimoto D. Kahl T. Teranishi Chen Ruofu Wang Hongwei Tian Wendong Guo Bing S. Hayakawa N. Iwasa T. Yamada T. Komatsubara | 2014 | IMP & HIRFL Annual Report2014，，1： | 2 |
| 10 | Interfacial engineering of printable bottom back metal electrodes for full-solution processed flexible organic solar cells显示文摘Printing of metal bottom back electrodes of flexible organic solar cells(FOSCs) at low temperature is of great significance to realize the full-solution fabrication technology. However, this has been difficult to achieve because often the interfacial properties of those printed electrodes, including conductivity, roughness, work function,optical and mechanical flexibility, cannot meet the device requirement at the same time. In this work, we fabricate printed Ag and Cu bottom back cathodes by a low-temperature solution technique named polymer-assisted metal deposition(PAMD) on flexible PET substrates. Branched polyethylenimine(PEI) and ZnO thin films are used as the interface modification layers(IMLs) of these cathodes. Detailed experimental studies on the electrical, mechanical, and morphological properties, and simulation study on the optical properties of these IMLs are carried out to understand and optimize the interface of printed cathodes. We demonstrate that the highest power conversion efficiency over 3.0% can be achieved from a full-solution processed OFSC with the device structure being PAMDAg/PEI/P3 HT:PC_(61)BM/PH1000. This device also acquires remarkable stability upon repeating bending tests. | Hongyu Zhen Kan Li Yaokang Zhang Lina Chen Liyong Niu Xiaoling Wei Xu Fang Peng You Zhike Liu Dongrui Wang Feng Yan Zijian Zheng | 2018 | Journal of Semiconductors2018，39，1： | 2 |
| 11 | Statistical method for mapping QTLs for complex traits based on two backcross populations显示文摘Most important agronomic and quality traits of crops are quantitative in nature.The genetic variations in such traits are usually controlled by sets of genes called quantitative trait loci (QTLs),and the interactions between QTLs and the environment.It is crucial to understand the genetic architecture of complex traits to design efficient strategies for plant breeding.In the present study,a new experimental design and the corresponding statistical method are presented for QTL mapping.The proposed mapping population is composed of double backcross populations derived from backcrossing both homozygous parents to DH (double haploid) or RI (recombinant inbreeding) lines separately.Such an immortal mapping population allows for across-environment replications,and can be used to estimate dominance effects,epistatic effects,and QTL-environment interactions,remedying the drawbacks of a single backcross population.In this method,the mixed linear model approach is used to estimate the positions of QTLs and their various effects including the QTL additive,dominance,and epistatic effects,and QTL-environment interaction effects (QE).Monte Carlo simulations were conducted to investigate the performance of the proposed method and to assess the accuracy and efficiency of its estimations.The results showed that the proposed method could estimate the positions and the genetic effects of QTLs with high efficiency. | ZHU ZhiHong HAYART Yousaf YANG Jian CAO LiYong LOU XiangYang XU HaiMing | 2012 | Chinese Science Bulletin2012，57，21： | 2 |
| 12 | Experimental and Numerical studies of injection molding with microfeatures显示文摘 | Guojun Xu Liyong Yu James Lee L | 2005 | Polymer Engineering and Science2005，7，45： | 1 |
| 13 | Brugada syndrome:a fatal disease with complex genetic etiologies–still a long way to go显示文摘Brugada syndrome(BrS)is an arrhythmogenic disorder which was first described in 1992.This disease is a channelopathy characterized by ST-segment elevations in the right precordial leads and is susceptible to sudden death.BrS is a fatal disease with gender and age preferences.It occurs mainly in young male subjects with a structurally normal heart and silently progresses to sudden death with no significant symptoms.The prevalence of BrS has been reported in the ranges of 5-20 per 10000 people.The disease is more prevalent in Asia.Nowadays,numerous variations in 23 genes have been linked to BrS since the first gene SCN5A has been associated with BrS in 1998.Not only can clinical specialists apply these discoveries in risk assessment,diagnosis and personal medicine,but also forensic pathologists can make full use of these variations to conduct death cause identification.However,despite the progress in genetics,these associated genes can only account for approximately 35%of the BrS cases while the etiology of the remaining BrS cases is still unexplained.In this review,we discussed the prevalence,the genes associated with BrS and the application of molecular autopsy in forensic pathology.We also summarized the present obstacles,and provided a new insight into the genetic basis of BrS. | Yeda Wu Mei Ai Adham Sameer A.Bardeesi Lunwu Xu Jingjing Zheng Da Zheng Kun Yin Qiuping Wu Liyong Zhang Lei Huang Jianding Cheng | 2017 | Forensic Sciences Research2017，2，3： | 1 |
| 14 | Climate change impacts on crop yield and quality with CO<sub>2</sub> fertilization in China显示文摘 | Erda Lin Wei Xiong Hui Ju Yinlong Xu Yue Li Liping Bai Liyong Xie | 2005 | Philosophical Transactions of The Royal Society B2005，，1463： | 1 |
| 15 | Climate change impacts on crop yield and quality with CO2 fertilization in China显示文摘 | Erda Lin Wei Xiong Hui Ju Yinlong Xu Yue Li Liping Bai Liyong Xie | 2005 | Philosophical Transactions of The Royal Society B2005，，1463： | 1 |
| 16 | Downregulation of S100A4 expression by RNA interference suppresses cell growth and invasion in human colorectal cancer cells 显示文摘 | Liyong HUANG Ye XU Guoxiang CAI | 2012 | Oncology reports2012，27，4： | 1 |
| 17 | Experimental Study 18Ne(a,p)21Na of Key Astrophysical Reaction显示文摘 | Zhang Liyong He Jianjun Xu Shiwei H. Yamaguchi S. Kubono Y. Wakabayashi Chen Size Ma Peng Y. Togano T. Hashimoto D. Kahl T. Teranishi Chen Ruofu Wang Hongwei Tian Wendong Guo Bing S. Hayakawa N. Iwasa T. Yamada T. Komatsubara | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 18 | Leisure Education and Creative Thinking显示文摘There are two dimensions of creative thinking:a creative'state of mind'and creative'thinking tactics'.The former means clarity of mind which makes people always ready for truth,while the latter points to an effective way of creative thinking.The formation of creative thinking requires a leisurely mindset.Leisure education could help people make the best use of their leisure,let leisure wield a positive influence on creativity cultivation,and eliminate the downside of the current education,thereby rendering people’s efforts to cultivate creative thinking more effectively.The goal of leisure education is to achieve a creative'state of mind'required for creative thinking,while the content and approaches adopted by leisure education could provide inspiration for creative'thinking tactics'.To vigorously expand leisure education will be necessary in this creative age,especially for the cultivation of creative talents. | Pan Liyong Wu Xiaowei Xu Qingtong(译) | 2020 | Contemporary Social Sciences2020，5，1： | 0 |
| 19 | 2 - 30 Progress in Analyzing RIBLL1 17F+p Experimental Data显示文摘 | He Jianjun Hu Jun Xu Shiwei Chen Zhiqiang Zhang Xueying Wang Jiansong Yu Xiangqing Li Long Zhang Liyong Yang Yanyun Ma Peng Wang Hongwei Tian Wendong Zhang Xueheng Su Jun Li Ertao Hu Zhengguo Guo Zhongyan Xu Xing Yuan Xiaohua Lu Wan Lei Xiangguo Yu Yuhong Tang Shuwen Ye Ruiping Chen Jinda Jin Shilun Du Chengming Wang Shitao Ma Junbing Liu Longxiang Bai Zhen Sun Zhiyu Li Xiangqing Zhang Yuhu Zhou Xiaohong Xu Hushan | 2010 | IMP & HIRFL Annual Report2010，，1： | 0 |
| 20 | Hardware Circuit Implementation and Performance Analysis of Three-Slot NP-CSMA显示文摘The development of wireless communication technology has become increasingly important in the communications industry.How to allocate limited channel resources reasonably and reliably to each competing user is a problem that the access protocol of the MAC(Multiple Access Control)layer needs to solve.As an important way of random access,NP-CSMA(Non Persistent Carrier Sense Multiple Access)has a higher network throughput rate when the arrival rate is higher.This paper analyzes and improves the implemented NP-CSMA model,and obtains a three-slot NP-CSMA model.The mathematical tool MATLAB is used to analyze the network throughput,delay and energy efficiency of the model,and compare several random multiple access protocols adheres to the network throughput,they are NP-CSMA,Three-slot NP-CSMA,1-persistent CSMA,P-persistent CSMA,and concludes that the three-slot NP-CSMA is significantly letter than several other multiple access protocols.Finally,using Quartus to design the three-slot NP-CSMA circuit,the statistical value of the circuit system is compared with the theoretical value of the model,and the error is less than 0.01,which proves that the system is reasonable in design and can be applied to wireless communication networks. | Xu Lu Hongwei Ding Zejun Han Zhijun Yang Liqing Wang Liyong Bao | 2019 | Computer Modeling in Engineering & Sciences2019，，6： | 0 |
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