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| 1 | Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors显示文摘 | Zhu, Jie Ming, Chang Fu, Xin Duan, Yaou Duc Anh Hoang Rutgard, Jeffrey Zhang, Runze Wang, Wenqiu Hou, Rui Zhang, Daniel Zhang, Edward Zhang, Charlotte Hao, Xiaoke Xiong, Wenjun Zhang, Kang | 2017 | Cell Research2017，27，6： | 11 |
| 2 | Mechanical properties and microstructure of an α+β titanium alloy with high strength and fracture toughness显示文摘The Ti-Al-Sn-Zr-Cr-Mo-V-Si (Ti-62A) alloy, an alpha-beta alloy with high strength and fracture toughness, is currently used as an advanced structural material in aerospace and non-aerospace applications. Thermo-mechanical processes can be used to optimize the relationship between its strength and fracture toughness. A Ti-62A alloy bar can be machined through a transus β-forged plus α+β solution treated and aged specimen with a lamellar alpha microstructure. The effects of heat treatment on the mechanical properties were discussed. Heat treatment provided a practical balance of strength, fracture toughness, and fatigue crack growth resistance. A comparison of the Ti-62A alloy with the Ti-62222S alloy under the same thermo-mechanical processing conditions showed that their properties are at the same level. | YU Yang HUI Songxiao YE Wenjun XIONG Baiqing | 2009 | Rare Metals2009，28，4： | 8 |
| 3 | Dynamic fracture toughness of TA15ELI alloy studied by instrumented impact test显示文摘The dynamic fracture toughness of TA15ELI alloy with two types of microstructures was studied by instrumented impact test.Charpy specimens with both the 0.2 mm U-notch and the a/W = 0.2 pre-crack were adopted to compare notch sensitivity in the two microstructures.The result shows that the specimen with Widmanst?tten microstructure exhibits a better dynamic fracture toughness and lower notch sensitivity than that with lath-like microstructure.Fracture surfaces in the case of the two microstructures are analyzed to have a ductile and brittle mixed feature under dynamic loading.The fracture surface of lath-like microstructure is composed of dimples and tear ridges,while that of Widmanst?tten microstructure is covered with rough block-like facets and dimples and tear ridges.The α phase boundaries and α/β interfaces act as locations for void nucleation and crack arrest and deviation.The decrease in width of α phase lamellae leads to the increase in the amount of boundaries and interfaces,which causes the increase in the consumption of impact energy and results in the improvement in dynamic fracture toughness. | LIU Rui,HUI Songxiao,YE Wenjun,XIONG Baiqing,YU Yang,and FU Yanyan State Key Laboratory for Fabrication & Processing of Nonferrous Metals,General Research Institute for Nonferrous Metals,Beijing 100088,China | 2010 | Rare Metals2010，29，6： | 6 |
| 4 | Histone Deacetylase AtSRT1 Links Metabolic Flux and Stress Response in Arabidopsis显示文摘怎么种新陈代谢的流动,改变基因表示优化植物生长,对应力的反应仍然保持大部分不清楚。这里,我们报导 Arabidopsis thaliana NAD +-dependent histone deacetylase AtSRT1 否定地调整植物公差到应力和 glycolysis,但是刺激 mitochondrial 呼吸。我们发现 AtSRT1 与 Arabidopsis cMyc 有约束力的蛋白质 1 交往(AtMBP-1 ) ,一个 transcriptional 抑压者由 cytosolic glycolytic enolase 基因 LOS2/ENO2 的其他的翻译生产了。我们证明 AtSRT1 能与 AtMBP-1 目标 LOS2/ENO2 和 STZ/ZAT10 的染色质联系,哪个编码关键压力管理者,并且在这些基因减少 H3K9ac 层次镇压他们的抄写。AtSRT1 和 AtMBP-1 的 Overexpression 在 glycolytic 基因的表示上有 synergistic 效果, glycolytic 酶的活动,和 mitochondrial 呼吸。而且,我们发现 AtMBP-1 是 lysine-acetylated 并且对 proteasomal 蛋白质降级脆弱,当 AtSRT1 能移开它的离氨酸 acetylation 并且显著地提高它的稳定性在时 ? vivo。一起拿,这些结果显示 AtSRT1 在 Arabidopsis 由 epigenetic 规定和 AtMBP-1 transcriptional 活动的调整调整主要新陈代谢和压力反应。 | Xiaoyun Liu Wei Wei Wenjun Zhu Lufang Su Zeyang Xiong Man Zhou Yu Zheng and Dao-Xiu Zhou | 2017 | Molecular Plant2017，10，12： | 6 |
| 5 | Microstructure and cutting performance of Ti(C, N)-based cermets heat-treated in nitrogen显示文摘Ti(C, N)-based cermets were treated using hot isostatic pressing (HIP) at 1423 K in nitrogen. The microstructures compared with the as-sintered cermets were investigated using X-ray diffraction, scanning electron microscopy, transmis- sion electron microscopy, energy-dispersive X-ray analysis, and electron microprobe analysis. It was found that high nitro- gen activity in the surface zone resulted in the formation of gradient structure. Approximately 20-μm-deep, nitrogen-rich and titanium-rich hard surface zone was introduced by the heat treatment. The nitrogen activity was the driving force that caused the transportation of the atoms through the binder, titanium towards the surface, and tungsten and molybdenum in- wards. In the surface zone, the particle size became fine, the inner rim disappeared, and the volume fraction of the outer rim and the binder phase considerably reduced. Small grains of TiN, WC, Mo2C, and nitrogen-rich carbonitride phases formed in the surface zone during the heat treatment, improving the tribological property of the heat-treated cermet. | LIU Wenjun XIONG Weihao ZHENG Yong SHI Zengmin YE Jiajian | 2007 | Rare Metals2007，26，4： | 4 |
| 6 | Substantial transition to clean household energy mix in rural China显示文摘The household energy mix has significant impacts on human health and climate,as it contributes greatly to many health-and climate-relevant air pollutants.Compared to the well-established urban energy statistical system,the rural household energy statistical system is incomplete and is often associated with high biases.Via a nationwide investigation,this study revealed high contributions to energy supply from coal and biomass fuels in the rural household energy sector,while electricity comprised∼20%.Stacking(the use of multiple sources of energy)is significant,and the average number of energy types was 2.8 per household.Compared to 2012,the consumption of biomass and coals in 2017 decreased by 45%and 12%,respectively,while the gas consumption amount increased by 204%.Increased gas and decreased coal consumptions were mainly in cooking,while decreased biomass was in both cooking(41%)and heating(59%).The time-sharing fraction of electricity and gases(E&G)for daily cooking grew,reaching 69%in 2017,but for space heating,traditional solid fuels were still dominant,with the national average shared fraction of E&G being only 20%.The non-uniform spatial distribution and the non-linear increase in the fraction of E&G indicated challenges to achieving universal access to modern cooking energy by 2030,particularly in less-developed rural and mountainous areas.In some non-typical heating zones,the increased share of E&G for heating was significant and largely driven by income growth,but in typical heating zones,the time-sharing fraction was<5%and was not significantly increased,except in areas with policy intervention.The intervention policy not only led to dramatic increases in the clean energy fraction for heating but also accelerated the clean cooking transition.Higher income,higher education,younger age,less energy/stove stacking and smaller family size positively impacted the clean energy transition. | Guofeng Shen Rui Xiong Yanlin Tian Zhihan Luo Bahabaike Jiangtulu Wenjun Meng Wei Du Jing Meng Yuanchen Chen Bing Xue Bin Wang Yonghong Duan Jia Duo Fenggui Fan Lei Huang Tianzhen Ju Fenggui Liu Shunxin Li Xianli Liu Yungui Li Mu Wang Ying Nan Bo Pan Yanfang Pan Lizhi Wang Eddy Zeng Chao Zhan Yilin Chen Huizhong Shen Hefa Cheng Shu Tao | 2022 | National Science Review2022，9，7： | 4 |
| 7 | Safety and efficacy of Compound Huangdai Tablets combined with all-trans retinoic acid for treatment of acute promyelocytic leukemia:Clinical evidence and potential mechanisms显示文摘Objective:To evaluate the safety and efficacy of Compound Huangdai Tablets(Realgar-Indigo Naturalis formula,RIF)combined with all-trans retinoic acid(ATRA)to treat acute promyelocytic leukemia(APL).Methods:This study was registered in PROSPERO(CRD42018108118).The relevant literatures on RIF treatment of APL were systematically searched in the following databases:China National Knowledge Infrastructure,Wanfang,VIP Medical Information System,Chinese Biomedical Database,EMBASE,Cochrane Library,and PubMed.The quality of the included studies was evaluated and Review Manager 5.3 software and Stata 13.0 software were used to perform the Meta-analysis.In addition,this study used the method of network pharmacology to conduct a preliminary exploration of the mechanism of RIF on APL.Results:The study included 12 studies involving 775 APL patients.The Meta-analysis showed that there was no significant difference(P>0.05)between the RIF group and the arsenic trioxide(ATO)group for primary outcomes,secondary outcomes apart from liver dysfunction.The incidence of liver dysfunction(P=0.006)in the RIF group were significantly lower than those in the ATO group.In addition,the cost of maintenance therapy in the RIF group was significantly lower(P<0.05)than the ATO group.Besides,the active ingredients in RIF mainly act on targets proteins such as ACHE,NCOA2,RXRA,and then play a role in the treatment of APL through regulating multiple molecular mechanisms,such as TP53 regulates transcription of cell cycle genes,nuclear receptor transcription pathway.Conclusion:There was no significant difference in efficacy of oral RIF combined with ATRA compared with intravenous ATO combined with ATRA for the treatment of APL.The oral RIF exposed patients to less risk,offered more convenience and had lower prices.RIF can treat APL by multi-target and multipathway interventions that inducing apoptosis of APL cells and inhibiting the proliferation of APL cells,and so on.Therefore,oral RIF in the treatment of APL is worthy of further research and development. | Qianqian Huang Tao Wang Yan Xiong Liping Qu Qiaozhi Yin Wenjun Zou | 2022 | Chinese Herbal Medicines2022，14，1： | 3 |
| 8 | Comparison of the fatigue and fracture of Ti–6Al–2Zr–1Mo–1V with lamellar and bimodal microstructures显示文摘 | Shikai Li Baiqing Xiong Songxiao Hui Wenjun Ye Yang Yu | 2007 | Materials Science & Engineering A2007，，： | 2 |
| 9 | Laparoscopic vs.open surgery for gastrointestinal stromal tumors of esophagogastric junction:A multicenter,retrospective cohort analysis with propensity score weighting显示文摘Objective:Laparoscopic resection is increasingly performed for gastrointestinal stromal tumors(GISTs).However,the laparoscopic approach for GISTs located in the esophagogastric junction(EGJ-GIST)is surgically challenging.This study compares the efficacy of laparoscopic surgery and the open procedure for EGJ-GIST through the propensity score weighting(PSW)method.Methods:Between April 2006 and April 2018,1,824 surgical patients were diagnosed with primary gastric GIST at four medical centers in South China.Of these patients,228 were identified as EGJ-GISTs and retrospectively reviewed clinicopathological characteristics,operative information,and long-term outcomes.PSW was used to create the balanced cohorts.Results:PSW was carried out in laparoscopic and open-surgery cohorts according to year of surgery,sex,age,body mass index(BMI),tumor size,mitotic rates and recurrence risk.After PSW,438 patients consisting of 213 laparoscopic(L group)and 225 open surgery(O group)patients were enrolled.After PSW,the following measures in the L group were superior to those in the O group:median operative time[interquartile range(IQR)]:100.0(64.5-141.5)vs.149.0(104.0-197.5)min,P<0.001;median blood loss(IQR):30.0(10.0-50.0)vs.50.0(20.0-100.0)mL,P=0.002;median time to liquid intake(IQR):3.0(2.0-4.0)vs.4.0(3.0-5.0)d,P<0.001;median hospital stay(IQR):6.0(4.0-8.0)vs.7.0(5.0-12.0)d,P<0.001;and postoperative complications(10.3%vs.22.7%,P=0.001).The median follow-up was 55(range,2-153)months in the entire cohort.No significant differences were detected in either relapse-free survival(RFS)[hazard ratio(HR):0.372,95%confidence interval(95%CI):0.072-1.910,P=0.236]or overall survival(OS)(HR:0.400,95%CI:0.119-1.343,P=0.138)between the two groups.Conclusions:Laparoscopic surgery for EGJ-GIST is associated with the advantages of shorter operative time,reduced blood loss,shorter time to liquid intake,and shorter length of stay,all without compromising postoperative outcomes and long-term survival. | Wenjun Xiong Yuting Xu Tao Chen Xingyu Feng Rui Zhou Jin Wan Yong Li Guoxin Li Wei Wang | 2021 | Chinese Journal of Cancer Research2021，33，1： | 2 |
| 10 | Effect of nano addition on the microstructure and mechanical properties of Ti(C,N)-based cermets显示文摘 | ZHENG Yong XIONG Weihao LIU Wenjun | 2005 | Ceram Int2005，31，3： | 1 |
| 11 | Effect of nano addition on the microstructures and mechanical properties of Ti(C,N)-based cermets显示文摘 | Zheng Yong Xiong Weihao Liu Wenjun | 2005 | Ceramics International2005，31，： | 1 |
| 12 | Standardization of tritiated water by the CIEMAT/NIST and TDCR methods显示文摘The activity of tritiated water has been standardized by two liquid scintillation counting methods:The CIEMAT/NIST method with the54Mn-standard efficiency tracing and the triple-to-double coincidence ratio(TDCR)method.The samples were prepared with Ultima Gold TM AB liquid scintillation cocktail in low-potassium glass vials.In the application of the CIEMAT/NIST method,the computer program EMILIA was used to calculate the efficiency of3H and54Mn according to the KL1L2L3M atomic rearrangement model.And the detection efficiency of the TDCR counter was calculated using TDCR07 code,which makes it possible to allow for the potential asymmetry between the three photomultiplier tubes.The influence of stopping power and k B factor is discussed in the paper.When a power approach is adopted for the stopping power for electrons below 1ke V and k B is chosen to be 0.0075 cm/Me V,the relative deviation will be only 0.3%between the two methods. | WU YongLe LIU HaoRan LIANG JunCheng LIU JiaCheng XIONG WenJun YUE HuiGuo LIU SenLin YANG YuanDi YUAN DaQing | 2015 | Science China(Technological Sciences)2015，58，3： | 1 |
| 13 | PGE geo- chemistry and Re-Os dating of massive sulfide ores from the Baimazhai Cu-Ni deposit, Yunnan Province, China 显示文摘 | Sun Xiaoming Wang Shengwei Sun Weidong Shi Guiyong Sun Yali Xiong Dexin Qu Wenjun Du Andao | 2008 | Lithos2008，105，12： | 1 |
| 14 | Improved Delay-Partitioning Method to Stability Analysis for NeuralNetworks with Discrete and Distributed Time-Varying Delays 显示文摘 | TIAN Junkang XIONG Wenjun XU Fang | 2014 | Applied Mathematics and Computation2014，233，： | 1 |
| 15 | Differential DNA methylation profiles of human B lymphocytes and Epstein-Barr virus-immortalized B lymphocytes显示文摘Objective: This study aimed to comprehensively assess Epstein-Barr virus(EBV)-induced methylation alterations of B cell across whole genome.Methods: We compared DNA methylation patterns of primary B cells and corresponding lymphoblastoid cell lines(LCLs) from eight participants. The genome-wide DNA methylation profiles were compared at over 850,000 genome-wide methylation sites.Results: DNA methylation analysis revealed 87,732 differentially methylated Cp G sites, representing approximately 12.41% of all sites in LCLs compared to primary B cells. The hypermethylated and hypomethylated Cp G sites were about 22.75% or 77.25%, respectively. Only 0.8% of hypomethylated sites and 4.5% of hypermethylated sites were located in Cp G islands, whereas 8.0% of hypomethylated sites and 16.3% of hypermethylated sites were located in shore(N_shore and S_shore). Using principal component analysis of the DNA methylation profiles, primary B cells and LCLs could be accurately predicted. Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis of differently methylated genes revealed that most of the top GO biological processes were related to cell activation and immune response, and some top enrichment pathways were related with activation and malignant transformation of human B cells.Conclusions: Our study demonstrated genome-wide DNA methylation variations between primary B cells and corresponding LCLs, which might yield new insight on the methylation mechanism of EBV-induced immortalization. | Chaoting Zhang Rui Zhang Zhiqiang Chen Jing Chen Jigang Ruan Zheming Lu Hongchao Xiong Wenjun Yang | 2018 | Chinese Journal of Cancer Research2018，30，1： | 1 |
| 16 | Improved delay-partitioning method to stability analysis for neural networks with discrete and distributed time-varying delays显示文摘 | Tian Junkang Xiong Wenjun Xu Fang | 2014 | Applied Mathematics and Computation2014，233，： | 1 |
| 17 | Effect of nano addition on the microstructures and mechanical properties of Ti(C, N)-based cermets显示文摘 | Yong Zheng Weihao Xiong Wenjun Liu Wen Lei Quan Yuan | 2004 | Ceramics International2004，，1： | 1 |
| 18 | Effect of WC content on the microstructure and mechanical properties of Ti(C 0.5 N 0.5 )–WC–Mo–Ni cermets显示文摘 | Jun Qu Weihao Xiong Dameng Ye Zhenghua Yao Wenjun Liu Shaojiang Lin | 2009 | International Journal of Refractory Metals and Hard Materials2009，，2： | 1 |
| 19 | Optimal reactive power compensation planning with improving voltage stability margin in deregulated environment显示文摘 | Xiong Hugang Cheng Haozhong Zhang Wenjun | 2006 | WSEAS Transactions on Circuits and Systems2006，5，1： | 1 |
| 20 | Effect of nano addition on the microstructures and mechanical properties of Ti (C,N)-based cermets显示文摘 | Yong Zheng Weihao Xiong Wenjun Liu | 2005 | Ceramics International2005，31，： | 1 |
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