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| 1 | Catalytic alkane dehydrogenations显示文摘Olefins find widespread applications in the synthesis of polyolefins and fine chemicals. With an increasing demand for olefins, the technologies for alkane dehydrogenation have drawn much attention. Several types of heterogeneous catalysts have found applications in industry for the dehydrogenation of light alkanes, mainly ethane, propane, and butane. In the past three decades, a number of transition-metal complexes,particularly pincer-ligated iridium complexes, have been developed as the homogeneous catalysts for alkane dehydrogenations. The homogeneous catalyst systems operate under much milder conditions compared with the heterogeneous systems, and some systems exhibit good activity and high regioselectivity in dehydrogenation of alkanes longer than butane. | Yuxuan Zhang Wubing Yao Huaquan Fang Aiguo Hu Zheng Huang | 2015 | Science Bulletin2015，60，15： | 4 |
| 2 | Optimization of the Ultrasonic-assisted Extraction Process for Protocatechuic Acid from Emilia sonchifolia DC by Response Surface Methodology显示文摘[Objectives] This study was conducted to optimize the extraction process of protocatechuic acid from Emilia sonchifolia DC. [Methods] The optimal extraction conditions were determined by single factor,response surface analysis and variance analysis,and the content of protocatechuic acid was determined by HPLC. [Results] The protocatechuic acid standard curve equation was: y = 1 435 x + 8 403,R^2= 0. 999 8,indicating a good linear relationship. The optimal extraction conditions were as follows: a temperature at 80 ℃,an extraction time of 1 h,a material-to-liquid ratio at 1:10 and an ultrasonic power of 600 W,and the content of protocatechuic acid extracted was 1. 93 mg/g. The method showed a RSD of 0. 41%,less than 2%,and the detection limit was 0. 0000047261 g/ml.The experimental sample X1 was the low-level 0. 1 mg/ml standard solution,which showed recovery of protocatechuic acid between 100.8% and 105.2%,with a RSD of 0. 013%;and the sample X2 was the high-level 1. 0 mg/ml standard solution,which exhibited recovery between 100. 6% and 102. 2%,with a RSD of 0.076%. Thus,the recovery was high,and the requirements of the performance index were met. [Conclusions] The detection method is stable and reliable and can produce satisfactory results. | Wen CHEN Xiangjun WANG Lingyan LI Zhewen ZHAI Xiaoling HUANG Wubing RAO Chenghan ZOU Tengtong LI | 2020 | Agricultural Biotechnology2020，9，3： | 3 |
| 3 | Experimental and numerical study on instability structure of the supersonic mixing layer(M_c = 0.5)显示文摘The parameters of instability wave of supersonic mixing layer(Mc=0.5,M1=3.5/M2=1.4) are measured by flow visualization and calculated by means of two-dimensional direct numerical simulaitons of the compressible Navier-Stokes equations.In both cases of the mixing layer with harmonic disturbance or not,the comparative results indicate that the wavelength of the two-dimensional wave is equal to the vortex spacing in the streamwise direction because the difference between them is less than 1%.However,the measured convective velocity of the large-scale structure deviates from the theoretical isentropic prediction about 10%.Here the measured value confirms that Mc,2 | YANG WuBing ZHUANG FengGan SHEN Qing GUAN FaMing WANG Qiang YI ShiHe ZHAO YuXin HE Lin TIAN LiFeng | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，10： | 2 |
| 4 | Design, synthesis and antimycobacterial activities of 1-methyl-2- alkenyl-4(1H)-quinolones 显示文摘 | Wube A A Htifner A Thomaschitz C | 2011 | Bioorg Med Chem2011，19，1： | 1 |
| 5 | Antimalarial compounds from Kniphofia foliosa roots显示文摘 | Wube A A Bucar F Asres K | 2005 | Phyto- therapy Research2005，19，6： | 1 |
| 6 | Design, synthesis and antimycobacterial activities of l-methyl-2-alkenyl-4 ( 1H ) - quinolones显示文摘 | Wube A A Hfifner A Thomaschitz C | 2011 | Bioorg Med Chem2011，19，1： | 1 |
| 7 | In vitro 12( S )-HETE inhibitory activities of naphthoquinones isolated from the root bark of Euclea racemosa ssp. schimperi显示文摘 | Abraham Abebe Wube Bernhard Streit Simon Gibbons Kaleab Asres Franz Bucar | 2005 | Journal of Ethnopharmacology2005，，2： | 1 |
| 8 | A porcine collagen-derived matrix as a carrier for recombinant human bone morphogenetic protein-2 enhances spinal fusion in rats显示文摘 | Masashi Miyazaki Yuichiro Morishita Wubing He Ming Hu Chananit Sintuu Henry J. Hymanson Jonathan Falakassa Hiroshi Tsumura Jeffrey C. Wang | 2009 | The Spine Journal2009，，1： | 1 |
| 9 | ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells显示文摘Programmed DNA recombination in mammalian cells occurs predominantly in a directional manner.While random DNA breaks are typically repaired both by deletion and by inversion at approximately equal proportions,V(D)J and class switch recombination(CSR)of immunoglobulin heavy chain gene overwhelmingly delete intervening sequences to yield productive rearrangement.What factors channel chromatin breaks to deletional CSR in lymphocytes is unknown.Integrating CRISPR knockout and chemical perturbation screening we here identify the Snf2-family helicase-like ERCC6L2 as one such factor.We show that ERCC6L2 promotes double-strand break end-joining and facilitates optimal CSR in mice.At the cellular levels,ERCC6L2 rapidly engages in DNA repair through its C-terminal domains.Mechanistically,ERCC6L2 interacts with other end-joining factors and plays a functionally redundant role with the XLF end-joining factor in V(D)J recombination.Strikingly,ERCC6L2 controls orientation-specific joining of broken ends during CSR,which relies on its helicase activity.Thus,ERCC6L2 facilitates programmed recombination through directional repair of distant breaks. | Xiaojing Liu Tingting Liu Yafang Shang Pengfei Dai Wubing Zhang Brian J.Lee Min Huang Dingpeng Yang Qiu Wu Liu Daisy Liu Xiaoqi Zheng Bo O.Zhou Junchao Dong Leng-Siew Yeap Jiazhi Hu Tengfei Xiao Shan Zha Rafael Casellas X.Shirley Liu Fei-Long Meng | 2020 | Cell Research2020，30，9： | 1 |
| 10 | Effect of lumbar angular motion on central canal diameter: positional MRI study in 491 cases显示文摘背景腰部的针的狭窄是与新奇治疗过程的来临正在收到注意的一个普通问题。优先的位置的 MRI 研究与屈曲和延期表明了腰部的运河直径变化。没有任何研究相对尖运动的数量检验针的运河直径变化的数量。这研究的目的是评估在腰部的运河直径变化和尖运动 quantitatively.Methods 之间的关联位置的包括 310 男性和 181 女性( 16 years-85 岁),为 491 个病人的 MRI ( pMRI )图象在容纳屈曲 40 度与这些题目一起被获得,笔直地,并且与在 0.6 T 位置的 MRI 扫描仪以内的 10 度的扩展。运河直径和在 sagittal 中线飞机的每水平的部分角度的量的大小为每个位置被获得。然后,直径变化和尖运动与腰部的部分角度是的线性回归 analysis.Results 在屈曲和延期期间为关联被检验在除了在屈曲的 L1-2 的所有位置脊柱前凸。运河直径的变化统计上在屈曲和延期期间与部分尖运动被相关(P < 0.001 ) 。运河直径变化的数量与尖变化的数量相关并且被表示为比率。结论位置的 MRI 表明了统计上在屈曲和延期期间与脊骨的部分尖运动被相关的针的运河直径变化的数量。当 interspinous 设备或位置的变化被用来对待针的狭窄和增加的运河空间的数量时,这些结果可以被用来预言运河直径变化的程度可以与脊骨的尖或位置的变化的数量被预言。这可以与征兆的地势相关并且允许在针的狭窄的处理的改进成功。 | WEI Feng Jeffrey Wang Jun Zou Soon-woo Hong Haihong Zhang Wubing He Masashi Miyazaki Sang-hun Lee Ahmet Alanay | 2010 | Chinese Medical Journal2010，，11： | 0 |
| 11 | Recent Advances in the Theoretical and Applied Study on Compressible Turbulent Flow over Aerospace Vehicles显示文摘This paper focused on the fundamental and applied research of turbulent flows encountered in the hypersonic flight of aerospace vehicles,which take place in the boundary layer and mixing layer.As to the plate boundary layer,LES approach has been used to simulate the flows over compression corners and incident shock waves,revealing that turbulent flows would significantly inhibit the boundary layer separation caused by shock wave-boundary layer interaction(SWBLI).The boundary layer transition over a circular cone has been analyzed through stability analysis and wind-tunnel test,by which the angle-of-attack effect in case of small angle of attack has been studied.Non-linear evolution process and secondary instability structure in the supersonic mixing layer(Mc=0.5) were initially figured out through the study of mixing layer,and knowledge of the flow control mechanism of the boundary layer and mixing enhancement mechanism of the mixing layer has been obtained through this research.Artificial boundary-layer transition technique based on subharmonic resonance has been proposed and applied to the flow control in a scramjet inlet,inhibiting the flow separation of the boundary layer while improving the inlet performance.To guarantee the mixing of kerosene and supersonic airflow in the scramjet combustor,the mixing enhancement method based on subharmonic resonance has been adopted and a concept of combustor with smooth wall and low internal drag has been proposed for ignition and stable combustion.Finally,future turbulence research and technological development of aerospace vehicles is predicted. | SHEN Qing LI Feng YANG Wubing WANG Qiang | 2016 | Aerospace China2016，17，1： | 0 |
| 12 | Lipopolysaccharide/Toll-like receptor 4 signaling pathway involved Qingdu decoction treating severe liver injury merging with endotoxemia显示文摘OBJECTIVE: To investigate the protective effects and underlying mechanism of Qingdu decoction(QDD) on experimental rats with severe liver injury induced by thioacetamide(TAA).METHODS: A total of 40 Wistar rats were randomly divided into normal group(n = 10) and experimental group(n = 30). Rats were administrated the same content of saline in normal group. The rats inthe experimental group were pretreated with TAA at dose of 12 mg/kg lasting 8 weeks, and from 9th week to 12 th week, with TAA at concentration of 36mg/kg. During the 9th week to 12 th week period,the rats were randomly divided into three subgroups(n = 10 each) simultaneously based on the treatment categories: model group, lactulose(LA,3.5 m L/kg) group and QDD(5.95 g/kg) group, orally once per day respectively. At the 12 th week, the content of serum alanine transaminase(ALT), aspartate transaminase(AST), total bilirubin(TBIL), endotoxin(ET) and tumor necrosis factor α(TNF-α) was detected by automatic biochemical analyzer. The plasma prothrombin time(PT), prothrombin time-international normalized ratio(PTR) and prothrombin time activity(PTA) were measured by automatic coagulation analyzer. The level of lipopolysaccharide(LPS)-binding protein(LBP), cluster differentiation 14(CD14) and Toll-like receptor 4(TLR4) expressions was measured by both western blot(WB) and real-time polymerase chain reaction(real-time PCR).RESULTS: Compared with the model group, hepatic morphology in the QDD group was improved under light microscope and transmission electron microscope; at the same time, the contents of serum ALT, AST, TBIL, ET and TNF-α, and level of LBP, CD14 and TLR4 expressions in liver tissues were significantly decreased compared with the model group(P < 0.05), while PTA in the QDD group was enhanced(P < 0.05).CONCLUSION: QDD has the functional effect on improving the injured liver through inhibiting the LPS/TLR4 signaling pathway thus decreasing the level of the inflammatory medicators. | Cao Wubing Du Yuqiong Gao Lianyin Che Niancong Zhang Qiuyun Fu Xiuwen Luo Jiajia Wang Rongbing | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 0 |
| 13 | Machine Learning Modeling of Protein-intrinsic Features Predicts Tractability of Targeted Protein Degradation显示文摘Targeted protein degradation(TPD)has rapidly emerged as a therapeutic modality to eliminate previously undruggable proteins by repurposing the cell’s endogenous protein degradation machinery.However,the susceptibility of proteins for targeting by TPD approaches,termed“degradability”,is largely unknown.Here,we developed a machine learning model,model-free analysis of protein degradability(MAPD),to predict degradability from features intrinsic to protein targets.MAPD shows accurate performance in predicting kinases that are degradable by TPD compounds[with an area under the precision–recall curve(AUPRC)of 0.759 and an area under the receiver operating characteristic curve(AUROC)of 0.775]and is likely generalizable to independent non-kinase proteins.We found five features with statistical significance to achieve optimal prediction,with ubiquitination potential being the most predictive.By structural modeling,we found that E2-accessible ubiquitination sites,but not lysine residues in general,are particularly associated with kinase degradability.Finally,we extended MAPD predictions to the entire proteome to find964 disease-causing proteins(including proteins encoded by 278 cancer genes)that may be tractable to TPD drug development. | Wubing Zhang Shourya S.Roy Burman Jiaye Chen Katherine A.Donovan Yang Cao Chelsea Shu Boning Zhang Zexian Zeng Shengqing Gu Yi Zhang Dian Li Eric S.Fischer Collin Tokheim X.Shirley Liu | 2022 | Genomics, Proteomics & Bioinformatics2022，20，5： | 0 |
| 14 | Study of full waveform inversion based on L-BFGS algorithm显示文摘Full waveform inversion is mainly used to obtain high resolution velocity models of subsurface. The size of full waveform inversion will lead to a gigantic computation cost. Under the available computer resource and the limitation of full waveform inversion,the authors propose L-BFGS algorithm as the optimization method to solve this problem. In order to demonstrate the flexibility of the method,three different numerical experiments have been done to analyze the properties of full waveform inversion based on L-BFGS. | DENG Wubing HAN Liguo ZHANG Bo HUANG Fei HAN Miao | 2012 | Global Geology2012，15，2： | 0 |
| 15 | Differential impacts of adult trees on offspring and non-offspring recruits in a subtropical forest显示文摘An important mechanism promoting species coexistence is conspecific negative density dependence(CNDD),which inhibits conspecific neighbors by accumulating host-specific enemies near adult trees.Natural enemies may be genotype-specific and regulate offspring dynamics more strongly than non-offspring,which is often neglected due to the difficulty in ascertaining genetic relatedness.Here,we investigated whether offspring and non-offspring of a dominant species,Castanopsis eyrei,suffered from different strength of CNDD based on parentage assignment in a subtropical forest.We found decreased recruitment efficiency(proxy of survival probability)of offspring compared with non-offspring near adult trees during the seedling-sapling transition,suggesting genotype-dependent interactions drive tree demographic dynamics.Furthermore,the genetic similarity between individuals of same cohort decreased in late life history stages,indicating genetic-relatedness-dependent tree mortality throughout ontogeny.Our results demonstrate that within-species genetic relatedness significantly affects the strength of CNDD,implying genotype-specific natural enemies may contribute to population dynamics in natural forests. | Fang Wang Xiangcheng Mi Lei Chen Wubing Xu Walter Durka Nathan GSwenson Daniel JJohnson Samantha JWorthy Jianhua Xue Yan Zhu Bernhard Schmid Yu Liang Keping Ma | 2022 | Science China(Life Sciences)2022，65，10： | 0 |
| 16 | Analysis on secondary instability of shear layer based on the concept of phase synchronization显示文摘A concept of phase synchronization point is proposed, and then a model is built using this concept to explain secondary instabilities. This model has been used to determine the conditions of K- and H-type secondary instabilities, which are coincident with the conditions published in literatures. It also can be used to analyze other secondary instability phenomena. For example, the numerical results validate the analysis results in the case of 1/3rd subharmonic mode secondary instability. Furthermore, the numerical results indicate that the spanwise wave number of 3D disturbance has significant effect on the secondary instability. | Wubing Yang Qing Shen Qiang Wang Xiangjiang Yu | 2014 | Theoretical & Applied Mechanics Letters2014，4，6： | 0 |
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