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| 1 | 塞来昔布治疗骨关节炎的随机对照试验显示文摘目的 :比较塞来昔布、萘普生以及安慰剂在治疗膝关节骨关节炎时的疗效、安全性。方法 :10 0 3名有症状的膝关节骨关节炎患者随机接受塞来昔布 5 0 ,10 0 ,2 0 0mg ,bid ;萘普生 5 0 0mg ,bid或安慰剂 12周。患者在停用既往NSAID药或止痛治疗后 2~ 7d以及服用受试药物治疗后 2 ,6 ,12周 ,根据标准疗效判定方法进行评估。结果 :塞来昔布在改善骨关节炎的症状和体征上有显著效果。在治疗后的 2d内疼痛明显缓解 ,最大抗炎和镇痛作用出现在 2周内并持续至 12周。各剂量的塞来昔布与安慰剂比较均有效 ,但 5 0mg ,bid的剂量效果较差 ;较大剂量的塞来昔布 (10 0和 2 0 0mg ,bid)疗效相似 ,所观察到的改善程度与萘普生 5 0 0mg ,bid相当。各剂量的塞来昔布和萘普生均有良好的耐受性。结论 :COX 2抑制剂塞来昔布是治疗骨关节炎的有效药物 ,对骨关节炎临床症状和体征的改善与萘普生相当。 | Bensen WG Fiechtner JJ Mcmillen JI Zhao WW Yu SS Woods EM Hubbard RC Isakson PC Verburg KM Geis GS | 2000 | 中国新药杂志2000，9，8： | 17 |
| 2 | Cytomegalovirus in pregnancy:to screen or not to screen显示文摘 | Walker SP Palma-Dias R Wood EM | 2013 | BMCPregnancy Childbirth2013，13，： | 1 |
| 3 | Transfusing blood safelyand appropriately显示文摘 | Murphy MF Waters JH Wood EM | 2013 | BMJ2013，347，： | 1 |
| 4 | Transfusing blood safely and appropriately 显示文摘 | Murphy MF Waters JH Wood EM | 2013 | BMJ2013，347，： | 1 |
| 5 | Cytomegalovirus in pregnancy:to screen or not to screen显示文摘 | Walker SP Palma-Dias R Wood EM | 2013 | BMC Pregnancy Childbirth2013，13，： | 1 |
| 6 | Clinical transfu- sion practice update : haemovigilance, complications, patient blood management and national standards 显示文摘 | Engelbrecht S Wood EM Cole- Sinclair MF | 2013 | Med J Aust2013，199，6： | 1 |
| 7 | cAMP-dependent phosphorylation of the tetrodotoxinresistant voltage-dependent sodium channel SNS显示文摘 | Fitzgerald EM Okuse K Wood JN Dolphin AC Moss SJ | 1999 | J Physiol1999，516，2： | 1 |
| 8 | Efficacy of celecoxib, a COX-2 specific inhibitor, in osteoarthritis of the hip 显示文摘 | Geis GS Hubbard RC Woods EM | 1999 | Arthritis Rheum1999，，： | 1 |
| 9 | TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions显示文摘 | Grossman M Wood EM Moore P | 2007 | Arch Neurol2007，64，10： | 1 |
| 10 | Effects of thedelta-opioid receptor agonist SNC80 on learning relative to its antidepressant-like effects in rats显示文摘 | Jutkiewicz EM Rice KC Woods JH | 2003 | Behav Pharmacol2003，14，7： | 1 |
| 11 | Rec- ognition acuity, grating acuity, contrast sensitivity, and visual fields in 5-year-old children 显示文摘 | Hargadon DD Wood J Twelker JD Harvey EM Dobson V | 2010 | Arch Ophthalmol2010，128，1： | 1 |
| 12 | Clinical,genetic,and patho-logic characteristics of patients with frontotemporal dementia and pro-granulin mutations显示文摘 | Van Deerlin VM Wood EM Moore P | 2007 | Arch Neurol2007，64，8： | 1 |
| 13 | Comparison of family histo- ries in FTLD subtypes and related tauopathies 显示文摘 | Goldman JS Farmer JM Wood EM | 2005 | Neurology2005，65，11： | 1 |
| 14 | Determination of the stringency of DNA microsatellite marker genotypes for use in individual animal identification显示文摘 | Green RD Wood WO | 2000 | Animal G enetics2000，53，： | 1 |
| 15 | Lower serum ionized calcium and abnormal calciotropic hormone levels in preeclampsia显示文摘 | Seely EW Wood RJ Brown EM | 1992 | J Clin Endocrinol Metab1992，74，6： | 1 |
| 16 | Aripiprazole in thetreatment of the psychosis prodrome: an open - label pilotstudy显示文摘 | Woods SW Tully EM Walsh BC | 2007 | Br J Psychiatry2007，191，： | 1 |
| 17 | Cytomegalovirus in pregnancy:to screen or not to screen显示文摘 | Walker SP Palma-Dias R Wood EM | 2013 | BMC Pregnancy Childbirth2013，13，1： | 1 |
| 18 | Clinical transfusion practice update:haemovigilance,complications,patient blood management and national standards显示文摘 | Engelbrecht S Wood EM Cole-Sinclair MF | 2013 | Med J Aust2013，199，6： | 1 |
| 19 | Rec- ognition acuity, grating acuity, contrast sensitivity, and visual fields in 6-year-old children 显示文摘 | Hargadon DD Wood J Twelker JD Harvey EM Dobson V | 2010 | Arch Ophthalmol2010，128，1： | 1 |
| 20 | Prevention of monocyte adhesion and inflammatory cytokine production during blood platelet storage:An in vitro model with implications for prolonged platelet storage显示文摘 | Wood EM Colton E Yomtovian RA | 2000 | J Biomed Mater Res2000，51，2： | 1 |
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