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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Correlation of serum concentrations of cystatin C and creatinine to inulin clearance in liver cinhosis显示文摘 | Woitas RP Stoffel-Wagner B Flommersfeld S | | 0，，05： | 1 |
| 3 | N-terminal pro-B-type natriureticpeptide and mortality in coronary heart disease显示文摘 | P(o)ge U Gerhardt TM Woitas RP | | 0，，19： | 1 |
| 4 | Correlation of serum concentrations of cystatin C and creatinine to inulin clearance in liver cirhosis显示文摘 | Woitas RP Stoffel-Wagner B Flommersfeld S | 2000 | Clin Chem2000，46，5： | 1 |
| 5 | De-creased frequency of HCV core-specific peripheral blood mononuclear cells with type 1cytokine se-cretion in chronic hepatitis C显示文摘 | Lechmann M Woita P Langhans B | 1999 | J Hepatol1999，31，6： | 1 |
| 6 | lower-molecular weight proteins as markers for glomerular filtration rate显示文摘 | Woitas RP Stoffel-Wagner B Poege U Schieldermaier P Spengler u Sauerbruch T | 2001 | Clin Chem2001，47，724： | 1 |
| 7 | Antigen-specific cytokine response to hepatitis C virus core in HIV/hepatitis C virus-coinfected patients显示文摘 | ROCKSTROH J K BEIER I | 1999 | AIDS1999，13，21： | 1 |
| 8 | Correla- tion of serum concentrations of cystatin C and creatinine to inu- lin clearance in liver cirrhosis 显示文摘 | Woitas RP Stoffel-Wagner B Flommersfeld S | 2000 | Clin Chem2000，46，5： | 1 |
| 9 | Beta-trace protein-based equations for calculation of GFR in renal trans plant recipients显示文摘 | Po'ge U Gerhardt T Stoffe]- Wagner B Palmedo H Klehr HU Sauerbruch T Woitas RP | 2008 | Am J Transplan2008，8，： | 1 |
| 10 | Correlation of serum concentrations of cystatin C and creatinine to inulin clearance in liver cirrhosis显示文摘 | Woitas RP Stoffel--Wagner B Flommersfeld S | 2000 | Clin Chem2000，46，5： | 1 |
| 11 | Correlation of serum concentrations of cystatin C and creatinine to inulin clearance in liver cirrhosis显示文摘 | Woitas RP Stoffel-Wagner B Flommersfeld S | 2000 | Clin Chem2000，46，5： | 1 |
| 12 | Clinical real-time monitoring of gaseous mioroemboli in pediatric cardiopulmonary bypass 显示文摘 | Wang S Woitas K Clark YI3 | 2009 | Artif Organs2009，33，11： | 1 |
| 13 | Correlation of serum concentrations of cystation C and creatinine to inulin clearance in liver cirehosis显示文摘 | Woitas RP Stoffel-Wagner B Flommersfeld S | 2000 | Clin Chem2000，46，5： | 1 |
| 14 | Decreased frequency of HCV core-specific peripheral blood mononuclear cells with type 1 cytokine secretion in chronic hepatitis C显示文摘 | Martin Lechmann Rainer P Woitas Bettina Langhans Rolf Kaiser Hans Georg Ihlenfeldt Günther Jung Tilman Sauerbruch Ulrich Spengler | 1999 | Journal of Hepatology1999，，6： | 1 |
| 15 | Correlation of serum concentrations of cystatin C and creatinine to inulin clearance in liver cirrhosis显示文摘 | Woitas RP Stoffel-Wagner B Flommersfeld S | 2000 | Clin Chem2000，46，5： | 1 |
| 16 | Renal functional reserve is well maintained in patients with advanced liver cirrhosis and ascites显示文摘 | Woitas RP Flommersfeld S Stoffel-Wagner B | 2002 | Scand J Gastroenterol2002，37，11： | 1 |
| 17 | Correlation of serum concentrations of cystatin C and creatinine to inulin clearance in liver cirrhosis显示文摘 | Woitas RP Stoffel Wagner B Flommersfeld S | 2000 | Clin Chem2000，46，71： | 1 |
| 18 | Correlation of serum concentrations of cystatin C and creatinine to inulin to inulin clearance in liner cinhosis显示文摘 | Woitas RP StoffeL-Wagner B Flommersfeld S | 2000 | Clin Chem2000，46，5： | 1 |
| 19 | Correlation of serum concentrations of cystatin C and creatinine to inulin clearance in liver cirrhosis显示文摘 | Woitas RP Stoffel-Wagner B Flommersfeld S | 2000 | Clin Chem2000，46，5： | 1 |
| 20 | Correlation of serum concentrations of cystatin C and creatinine to inulin clearance in liver cirrhosis显示文摘 | Woitas RP Stoffel-Wagner B Flommersfeld S Poege U Schiedermaier P Klehr HU Spengler U Bidlingmaier F Sauerbruch T | 2000 | Clin Chem2000，46，5： | 1 |
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