|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Sequential comparisons of one-month and three-month depot leuprolide regimens in central precocious puberty 显示文摘 | Badaru A Wilson DM Bachrach LK | 2006 | J Clin Endocrinol Metab2006，91，： | 1 |
| 3 | Predictive value of regression and theoretical IOL formulas in pediatric intraocular lens implantation显示文摘 | Andreo LK Wilson ME Saunders RA | 1997 | J Prdiatr Ophthalmol Strbismus1997，34，4： | 1 |
| 4 | Antifungal sus- ceptibilities of Cryptococcus neo-formans 显示文摘 | Archibald LK Tuohy MY Wilson DA | 2004 | Emerg Infect Dis2004，10，1： | 1 |
| 5 | Building capacity to imple-ment cognitive pharmaceutical services:Quantifying the needsof community pharmacies显示文摘 | Feletto E Wilson LK Roberts AS | 2010 | Res Social Adm Pharm2010，6，3： | 1 |
| 6 | Implantation of vascular grafts lined with genetically modified endothelial cells 显示文摘 | Wilson JM Birinyi LK Salomon RN | 1989 | Science1989，244，4910： | 1 |
| 7 | Airway remodelling in asthma: current understanding and implications for future therapies 显示文摘 | Tang LK Wilson JW Stewart AG | 2006 | Pharmacol Ther2006，112，2： | 1 |
| 8 | Nicotine patches in Alzheimer' s disease: pilot study on learning, memory,and safety显示文摘 | Langley LK Monley J | 1995 | Pharmacol Biochem Behav1995，51，： | 1 |
| 9 | The structure, organization, activation and plasticity of the erythropoietin re- ceptor显示文摘 | Wilson IA Jolliffe LK | 1999 | Curr Opin Struct Biol1999，9，6： | 1 |
| 10 | Predictive value of regression and theoretical IOL formulas in pediatric intraocular lens implantation显示文摘 | Andreo LK Wilson ME Saunders RA | 1997 | J Pediatr Ophthalmol Strabismus1997，34，4： | 1 |
| 11 | Measuring organizational flexibility in community pharmacy:building the capacity to implement cognitive pharmaceutical services显示文摘 | Feletto E Wilson LK Roberts AS | 2011 | Research in Social and Administrative Pharmacy2011，7，1： | 1 |
| 12 | Implantation of vascular grafts lined with genetically modified endothelial cells 显示文摘 | Birinyi LK Salomon RN | 1989 | Science1989，，： | 1 |
| 13 | Measuring organ- izational flexibility in community pharmacy: Building the capacity to implement cognitive pharmaceutical serviees 显示文摘 | Feletto E Wilson LK Roberts AS | 2011 | Res Social adm Pharm2011，7，1： | 1 |
| 14 | Sequential comparisons of one-month and three-month depot leuprolide regimens in central precocious puberty 显示文摘 | Badaru A Wilson DM Bachrach LK | 2006 | J Clin Endocrinol Metab2006，91，5： | 1 |
| 15 | Enhanced EGF mitogenic response is associated with enhanced tyrosine phosphorylation of specific cellular proteins in fibroblasts overexpressing c - src显示文摘 | Wilson LK Parsons SJ | 1990 | Oncogene1990，5，10： | 1 |
| 16 | Single - sample, subcutaneous gonadotropin - releasing hormone test for central precocious puberty 显示文摘 | Ecken KL Wilson DM Bachrach LK | 1996 | Pediatrics1996，，97： | 1 |
| 17 | Two patients with the yon Szily reaction:herpetic keratitis and contralateral retinal necrosis显示文摘 | Smith LK Kurz PA Wilson D J | 2007 | Am J Ophthalmol2007，143，： | 1 |
| 18 | Devel- opment of an interactive anatomical three-dimensional eye model显示文摘 | ALLEN LK BHATTACHARYYA S WILSON TD | 2015 | Anat Sci Educ2015，8，3： | 1 |
| 19 | Rat hepatocyte engraftment in severe combined immunodeficient x beige mice using mouse-specific anti-fas antibody 显示文摘 | Wilson J H Paturzo FX Johnson LK | 2006 | Xenotransplantation2006，13，1： | 1 |
| 20 | Implantation of vascular grafts lined with genetically modified endothelial cells显示文摘 | Wilson JM Birinyi LK Salomon RN | 1989 | Science1989，244，4910： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员