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| 1 | Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells显示文摘AIM: To investigate the intracellular apoptotic signals engaged by resveratrol in three gastric adenocarcinoma cancer cell lines, two of which (AGS and SNU-1) express p53 and one (KATO-Ⅲ) with deleted p53. METHODS: Nuclear fragmentation was used to quanti- tate apoptotic cells; caspase activity was determined by photometric detection of cleaved substrates; formation of oxidized cytochrome C was used to measure cytochrome C activity, and Western blot analysis was used to determine protein expression. RESULTS: Gastric cancer cells, irrespective of their p53 status, responded to resveratrol with fragmentation of DNA and cleavage of nuclear lamins A and B and PARP. Resveratrol, however, has no effect on mitochondria-associated apoptotic proteins Bcl-2, Bcl- xl, Bax, Bid or Smac/Diablo, and did not promote sub- cellular redistribution of cytochrome C, indicating that resveratrol-induced apoptosis of gastric carcinoma cells does not require breakdown of mitochondrial membrane integrity. Resveratrol up-regulated p53 protein in SNU-1 and AGS cells but there was a difference in response of intracellular apoptotic signals between these cell lines. SNU-1 cells responded to resveratrol treatment with down-regulation of survivin, whereas in AGS and KATO- Ⅲ cells resveratrol stimulated caspase 3 and cytochrome C oxidase activities. CONCLUSION: These findings indicate that even within a specific cancer the intracellular apoptotic signals engaged by resveratrol are cell type dependent and suggest that such differences may be related to differentiation or lack of differentiation of these cells. | William L Riles Jason Erickson Sanjay Nayyar Mary Jo Atten Bashar M Attar Oksana Holian | 2006 | World Journal of Gastroenterology2006，12，35： | 8 |
| 2 | Insights into gastric neuroendocrine tumors burden显示文摘Type 1 gastric neuroendocrine tumors(g NETs)are usually small lesions,restricted to mucosal and sub-mucosal layers of corpus and fundus,with low aggressive behavior,for the majority of cases.Nevertheless,some cases present aggressive behavior.The increasing incidence of g NETs brings together a new relevant problem:how to identify potentially aggressive type 1 g NETs.The challenging problem seems to be finding out signs or features able to predict potentially aggressive cases,allowing a tailored approach,since the involved societies dedicated to provide guidelines for management of these neoplasms apparently failed in producing staging systems able to accurately predict prognosis of these tumors.Additionally,it is also important to try to find out explanations for increasing incidence,as well as to identify potential targets aiming to reach better control of this neoplasia.Here,we discuss potential pathways implicated in aggressive behavior,as well as new strategies to improve clinical management of these tumors. | Taíssa Maíra Thomaz Araújo Williams Fernandes Barra André Salim Khayat Paulo Pimentel de Assumpcao | 2017 | Chinese Journal of Cancer Research2017，29，2： | 7 |
| 3 | Novel fibrin-fibronectin matrix accelerates mice skin wound healing显示文摘Plasma fibrinogen(F1)and fibronectin(pFN)polymerize to form a fibrin clot that is both a hemostatic and provisional matrix for wound healing.About 90%of plasma F1 has a homodimeric pair ofγchains(γγF1),and 10%has a heterodimeric pair ofγand more acidicγ′chains(γγ′F1).We have synthesized a novel fibrin matrix exclusively from a 1:1(molar ratio)complex ofγγ′F1 and pFN in the presence of highly active thrombin and recombinant Factor XIII(rFXIIIa).In this matrix,the fibrin nanofibers were decorated with pFN nanoclusters(termedγγ′F1:pFN fibrin).In contrast,fibrin made from 1:1 mixture ofγγF1 and pFN formed a sporadic distribution of“pFN droplets”(termedγγF1+pFN fibrin).Theγγ′F1:pFN fibrin enhanced the adhesion of primary human umbilical vein endothelium cells(HUVECs)relative to theγγF1+FN fibrin.Three dimensional(3D)culturing showed that theγγ′F1:pFN complex fibrin matrix enhanced the proliferation of both HUVECs and primary human fibroblasts.HUVECs in the 3Dγγ′F1:pFN fibrin exhibited a starkly enhanced vascular morphogenesis while an apoptotic growth profile was observed in theγγF1+pFN fibrin.Relative toγγF1+pFN fibrin,mouse dermal wounds that were sealed byγγ′F1:pFN fibrin exhibited accelerated and enhanced healing.This study suggests that a 3D pFN presentation on a fibrin matrix promotes wound healing. | Carlos Poblete Jara Ou Wang Thais Paulino do Prado Ayman Ismail Frank Marco Fabian Han Li Licio A.Velloso Mark A.Carlson William Burgess Yuguo Lei William H.Velander Eliana P.Araújo | 2020 | Bioactive Materials2020，5，4： | 5 |
| 4 | Hereditary gastric cancer:Three rules to reduce missed diagnoses显示文摘Gastric cancer remains one of the most lethal cancers.The incidence and mortality rates are quite similar.The main reason for the high mortality is diagnosis at advanced stages of disease,when treatment options are poor.One of the supposed strategies to overcome late-stage diagnosis is identifying people at high risk with the aim of establishing rigorous clinical control,including routine endoscopy and biopsies.Hereditary gastric cancer(HGC)syndromes,though representing a sizeable group to monitor for prevention or,at least,for early diagnosis,are apparently extremely rare.The low rate of HGC diagnosis might be related to the low rates of suspicion,insufficient familiarity about clinical diagnosis criteria,and the supposed conditional necessity of a molecular diagnosis.In this review,we will discuss simple measures to increase HGC diagnosis by applying three rules that might provide an opportunity for precision care to benefit the families affected by this disease. | Paula Assumpcao Taíssa Araújo André Khayat Geraldo Ishak Sidney Santos Williams Barra Joao Felipe Acioli Benedito Rossi Paulo Assumpcao | 2020 | World Journal of Gastroenterology2020，26，13： | 3 |
| 5 | ASGE guideline: the role of endoscopy in the surveillance of premalignant conditions of the upper GI tract显示文摘 | William K. Hirota Marc J. Zuckerman Douglas G. Adler Raquel E. Davila James Egan Jonathan A. Leighton Waqar A. Qureshi Elizabeth Rajan Robert Fanelli Jo Wheeler-Harbaugh Todd H. Baron Douglas O. Faigel | 2006 | Gastrointestinal Endoscopy2006，，4： | 2 |
| 6 | ASGE Guideline: the role of endoscopy in the patient with lower-GI bleeding显示文摘 | Raquel E. Davila Elizabeth Rajan Douglas G. Adler James Egan William K. Hirota Jonathan A. Leighton Waqar Qureshi Marc J. Zuckerman Robert Fanelli Jo Wheeler-Harbaugh Todd H. Baron Douglas O. Faigel | 2005 | Gastrointestinal Endoscopy2005，，： | 2 |
| 7 | ASGE guideline: the role of ERCP in diseases of the biliary tract and the pancreas显示文摘 | Douglas G. Adler Todd H. Baron Raquel E. Davila James Egan William K. Hirota Jonathan A. Leighton Waqar Qureshi Elizabeth Rajan Marc J. Zuckerman Robert Fanelli Jo Wheeler-Harbaugh Douglas O. Faigel | 2005 | Gastrointestinal Endoscopy2005，，1： | 2 |
| 8 | ASGE guideline: the role of ERCP in diseases of the biliary tract and the pancreas显示文摘 | Douglas G. Adler Todd H. Baron Raquel E. Davila James Egan William K. Hirota Jonathan A. Leighton Waqar Qureshi Elizabeth Rajan Marc J. Zuckerman Robert Fanelli Jo Wheeler-Harbaugh Douglas O. Faigel | 2005 | Gastrointestinal Endoscopy2005，，1： | 1 |
| 9 | International analysis of the frequen- cy and outcomes of NKJT-cell lymphomas 显示文摘 | William BM Armitage JO | 2013 | Best Pract Res Clin Haematol2013，26，1： | 1 |
| 10 | Endometrial thickness is avalidmoni- toting parameter in cycles of ovula-tionin duction with menotropins alone 显示文摘 | Isaacs JO Wel|s CS Williams DB | 1996 | Fertil Steril1996，65，2： | 1 |
| 11 | Duration of smoking absti- nence as a predictor for non-small-cell lung cancer survival in women显示文摘 | Ebbert JO Williams BA Sun Z | 2005 | Lung Cancer2005，47，2： | 1 |
| 12 | Anisotropic elastic properties of cancellous bone from a human edenttrlous mmldible显示文摘 | O'Mahony AM Williams JL Katz JO | 2000 | Clin Oral Implants Res2000，11，5： | 1 |
| 13 | Anisotropic elastic properties of cancellous bone from a human edentulous mandible显示文摘 | Williams JL Katz JO | 2000 | Clin Oral Implants Res2000，11，5： | 1 |
| 14 | Guidelines for Antibiotic Prophylaxis for GI Endoscopy显示文摘 | William K. Hirota Kathryn Petersen Todd H. Baron Jay L. Goldstein Brian C. Jacobson Jonathan A. Leighton J.Shawn Mallery J.Patrick Waring Robert D. Fanelli Jo Wheeler-Harbough Douglas O. Faigel | 2003 | Gastrointestinal Endoscopy2003，，4： | 1 |
| 15 | ASGE Guideline: the role of endoscopy in the patient with lower-GI bleeding显示文摘 | Raquel E. Davila Elizabeth Rajan Douglas G. Adler James Egan William K. Hirota Jonathan A. Leighton Waqar Qureshi Marc J. Zuckerman Robert Fanelli Jo Wheeler-Harbaugh Todd H. Baron Douglas O. Faigel | 2005 | Gastrointestinal Endoscopy2005，，5： | 1 |
| 16 | Anisotropic elastic properties of cancellous bone from a human dentulous mandible显示文摘 | O'Mahony AM Williams JL Katz JO | 2000 | Clin Oral Implants Res2000，11，5： | 1 |
| 17 | Epidemiology of hospitalizations and deaths from heat illness in soldiers from 1980 through 2002显示文摘 | Carter R 3rd Cheuvront SN Williams JO | 2005 | Med Sei Sports Exerc2005，37，8： | 1 |
| 18 | Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial 显示文摘 | Bailey RC Moses S Parker CB Agot K Maclean I Krieger JN Williams CF Campbell RT Ndinya-Achola JO | 2007 | Lancet2007，369，9562： | 1 |
| 19 | ASGE Guideline: the role of endoscopy in the management of variceal hemorrhage, updated July 2005显示文摘 | Waqar Qureshi Douglas G. Adler Raquel Davila James Egan William Hirota Jonathan Leighton Elizabeth Rajan Marc J. Zuckerman Robert Fanelli Jo Wheeler-Harbaugh Todd H. Baron Douglas O. Faigel | 2005 | Gastrointestinal Endoscopy2005，，5： | 1 |
| 20 | Enhanced nutrient removal in high-rate ponds显示文摘 | YAKUP N WILLIAM JO | 1995 | Water Science and Technology1995，31，12： | 1 |
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