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| 1 | Resin infiltration of deproteinised natural occlusal subsurface lesions improves initial quality of fissure sealing显示文摘The aim of this ex vivo study was to evaluate the infiltration capability and rate of microleakage of a low-viscous resin infiltrant combined with a flowable composite resin(RI/CR) when used with deproteinised and etched occlusal subsurface lesions(International Caries Detection and Assessment System code 2). This combined treatment procedure was compared with the exclusive use of flowable composite resin(CR) for fissure sealing. Twenty premolars and 20 molars revealing non-cavitated occlusal carious lesions were randomly divided into two groups and were meticulously cleaned and deproteinised using Na OCl(2%). After etching with HCl(15%), 10 premolar and 10 molar lesions were infiltrated(Icon/DMG; rhodamine B isothiocyanate(RITC)-labelled) followed by fissure sealing(G-?nial Flo/GC; experimental group, RI/CR). In the control group(CR), the carious fissures were only sealed. Specimens were cut perpendicular to the occlusal surface and through the area of the highest demineralisation(DIAGNOdent pen, Ka Vo). Using confocal laser-scanning microscopy, the specimens were assessed with regard to the percentage of caries infiltration, marginal adaption and internal integrity. Within the CR group, the carious lesions were not infiltrated. Both premolar(57.9% ± 23.1%) and molar lesions(35.3% ± 22.1%) of the RI/CR group were uniformly infiltrated to a substantial extent, albeit with significant differences(P = 0.034). Moreover, microleakage(n = 1) and the occurrence of voids(n = 2) were reduced in the RI/CR group compared with the CR group(5 and 17 specimens,respectively). The RI/CR approach increases the initial quality of fissure sealing and is recommended for the clinical control of occlusal caries. | Andrej M Kielbassa Ina Ulrich Rita Schmidl Christoph Schuller Wilhelm Frank Vanessa D Werth | 2017 | International Journal of Oral Science2017，9，2： | 4 |
| 2 | Efficacy of SpyGlass^(TM)-directed biopsy compared to brush cytology in obtaining adequate tissue for diagnosis in patients with biliary strictures显示文摘AIM: To evaluate the diagnostic yield(inflammatory activity) and efficiency(size of the biopsy specimen) of SpyGlassTM-guided biopsy vs standard brush cytology in patients with and without primary sclerosing cholangitis(PSC).METHODS: At the University Medical Center Mainz, Germany, 35 consecutive patients with unclear biliarylesions(16 patients) or long-standing PSC(19 patients) were screened for the study. All patients underwent a physical examination, lab analyses, and abdominal ultrasound. Thirty-one patients with non-PSC strictures or with PSC were scheduled to undergo endoscopic retrograde cholangiography(ERC) and subsequent per-oral cholangioscopy(POC). Standard ERC was initially performed, and any lesions or strictures were localized. POC was performed later during the same session. The Boston Scientific SpyGlass SystemTM(Natick, MA, United States) was used for choledochoscopy. The biliary tree was visualized, and suspected lesions or strictures were biopsied, followed by brush cytology of the same area. The study endpoints(for both techniques) were the degree of inflammation, tissue specimen size, and the patient populations(PSC vs non-PSC). Inflammatory changes were divided into three categories: none, low activity, and high activity. The specimen quantity was rated as low, moderate, or sufficient.RESULTS: SpyGlassTM imaging and brush cytology with material retrieval were performed in 29 of 31(93.5%) patients(23 of the 29 patients were male). The median patient age was 45 years(min, 20 years; max, 76 years). Nineteen patients had known PSC, and 10 showed non-PSC strictures. No procedure-related complications were encountered. However, for both methods, tissues could only be retrieved from 29 pa-tients. In cases of inflammation of the biliary tract, the diagnostic yield of the SpyGlassTM-directed biopsies was greater than that using brush cytology. More tissue material was obtained for the biopsy method than for the brush cytology method(P = 0.021). The biopsies showed significantly more inflammatory characteristics and greater inflammatory activity compared to the cy-tological investigation(P = 0.014). The greater quantity of tissue samples proved useful for both PSC and non-PSC patients.CONCLUSION: SpyGlassTM imaging can be recom-mended for proper inflammatory diagnosis in PSC pa-tients. However, its value in diagnosing dysplasia wasnot addressed in this study and requires further investi-gation. | Johannes Wilhelm Rey Torsten Hansen Sebastian Dümcke Achim Tresch Katja Kramer Peter Robert Galle Martin Goetz Marcus Schuchmann Ralf Kiesslich Arthur Hoffman | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 3 | Adipocytokine signaling is altered in Flinders sensitive line rats, and adiponectin correlates in humans with some symptoms of depression 显示文摘 | Wilhelm C J Choi D Huckans M | 2013 | Pharmacology Biochemistry Behavior2013，103，3： | 1 |
| 4 | Functionalanalysisofthe SRY-KRAB interaction in mouse sex determination显示文摘 | Polanco JC Wilhelm D Mizusaki H etal | 2009 | Biol Cell2009，101，1： | 1 |
| 5 | Lossy image compression for digital medical imaging systems显示文摘 | Wilhelm P Haynor D R Kim Y | 1991 | Opt Eng1991，30，10： | 1 |
| 6 | Fish antioxidant defenses-a comparative approach显示文摘 | WILHELM F D | 1996 | Braz J M ed Biol Res1996，29，12： | 1 |
| 7 | Recovery of Hesperodiaptomus population from diapausing eggs following elimination by stocked salmonids显示文摘 | Parker B R Wilhelm F M Schindler D W | 1996 | Can J Zool1996，74，： | 1 |
| 8 | Sox genes and cancer显示文摘 | Dong C Wilhelm D Koopman P | 2004 | Cy- togenet Genome Res2004，105，24： | 1 |
| 9 | Endopolyploidization of mesoeotyls in Nebraska maize populations selected for cold tolerance 显示文摘 | Wilhelm E d Biradar D P Bullock D G | 1995 | Crop Science1995，35，： | 1 |
| 10 | Conservative treatment of ectopic pregnancy in a cesarean section scar with methotrexate:a case report显示文摘 | Nanrroth F Foth D Wilhelm L | 2001 | Eur J Obstet Gynecol Reprod Biol2001，99，1： | 1 |
| 11 | Conservative treatment of ectopic pregnancy in a cesarean section scar with methotrexate:a case report显示文摘 | Nawroth F Foth D Wilhelm L | 2001 | Eur J Obstet Gynecol Reprod Biol2001，99，1： | 1 |
| 12 | pH sensor based on differential measurements on one pH-FET chip显示文摘 | Wilhelm D Voigt H Treichel W | 1991 | Sensors and Actuators B1991，4，： | 1 |
| 13 | Expression of distinct RNAs from 3' untranslated regions 显示文摘 | Mercer T R Wilhelm D Dinger ME | 2011 | Nucleic Acids Res2011，39，6： | 1 |
| 14 | Modeling dissolved gas supersaturation below spillway plunge pools显示文摘 | Geldert D A Gulliver J S Wilhelms S C | 1998 | Journal of Hydraulic Engineering1998，124，5： | 1 |
| 15 | BA Y 439006 exhibits broad spec?trum oral antitumor activity and targets the RAF / MEK/ERK pathway and receptor tyrosine kinases in?volved in tumor progression and angiogenesis显示文摘 | Wilhelm S M Carter C Tang L Wilkie D McNabola A Rong H | 2004 | Cane?er Res2004，64，70： | 1 |
| 16 | Combined laparoscopic-endoscopic resections of colorectal polyps:10-year experience and follow-up显示文摘 | Wilhelm D von Delius S Weber L | 2009 | Surg Endosc2009，23，4： | 1 |
| 17 | The game plan: Cellular and molecular mechanisms of mammalian testis develop- ment 显示文摘 | Wainwright E N Wilhelm D | 2010 | Organogenesis in Development2010，90，： | 1 |
| 18 | Comparative evaluation of HD 2D/3D laparoscopic monitors and benchmarking to a theoretically ideal 3D pseudodisplay:even well-experienced laparoscopists perform better with 3D显示文摘 | Wilhelm D Reiser S Kohn N | 2014 | Surg Endosc2014，28，8： | 1 |
| 19 | Conservative treatment of ectopic pregnancy in a cesarean section scar with methotrexate :a case re- port显示文摘 | Nawroth F Foth D Wilhelm L | 2001 | Eur J Obstet Gynecol Reprod Biol2001，99，1： | 1 |
| 20 | Comparative evaluation of HD 2D/3D laparoscopic monitors and benchmarking to a theoretically ideal 3D pseudodisplay: even well-experienced laparoscopists per- form better with 3D显示文摘 | Wilhelm D Reiser S Kohn N | 2014 | Sm''g Endosc2014，28，8： | 1 |
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