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| 1 | Heme oxygenase-1 overexpression increases liver injury after bile duct ligation in rats显示文摘AIM: To investigate the effects of heme oxygenase-1 (HO-1) against oxidant-induced injury caused by bile duct ligation (BDL). METHODS: Either cobalt protoporphyrin (CoPP), a HO-1 inducer, or saline were injected intraperitoneally in male SD-rats. Three days later, BDL or sham-operations were performed. Rats were sacrificed 3 wk after BDL and livers were harvested for histology. Fibrosis was evaluated by sirius red staining and image analysis. Alpha-smooth muscular actin, which indicates activation of stellate cells, was detected by immunohistochemical staining, and cytokine and collagen-Ⅰα (Col-Ⅰα) mRNA expression was detected using RNase protection assays. RESULTS: Serum alanine transaminase increased 8-fold above normal levels one day after BDL. Surprisingly, enzyme release was not reduced in rats receiving CoPP. Liver fibrosis was evaluated 3 wk after BDL and the sirius red-positive area was found to be increased to about 7.8%. However, in CoPP pretreated rats sirius red- positive areas were increased to about 11.7% after BDL. Collagen-Ⅰα and TGF-β mRNA increased significantly by BDL. Again, this effect was increased by HO-1 overexpression.CONCLUSION: Hepatic fibrosis due to BDL is not reduced by the HO-1 inducer CoPP. In contrast, HO-1 overexpression increases liver injury in rats under conditions of experimental chronic cholestasis. | Matthias Froh Lars Conzelmann Peter Walbrun Susanne Netter Reiner Wiest Michael D Wheeler Mark Lehnert Takehiko Uesugi Jurgen Scholmerich Ronald G Thurman | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 2 | Case report prolonged remission of recurrent metastatic placental site trophoblastic tumor after chemotherapy显示文摘 | Coukos G Wheeler JE | 2000 | Gynecol Oncol2000，76，： | 1 |
| 3 | The removal of uranium from mining wastewater using algal/microbial biomass 显示文摘 | Margarete Kalin W N Wheeler G Meinrath | 2005 | Journal of Environmental Radioactivity2005，，78： | 1 |
| 4 | A microcomputer based system for computer-aided wood identification显示文摘 | Lapasha C A Wheeler E G | 1987 | IAWA Bull1987，8，： | 1 |
| 5 | Cloned transgenic cattle produce milk with higher levels of casein and casein显示文摘 | Brophy B Smolenski G Wheeler T | 2003 | Nat Biotechnol2003，21，： | 1 |
| 6 | Genetic variation in anti-herbivore chemical defenses in an invasive plant显示文摘 | Wang Y Siemann E Wheeler G S Zhu L Gu X Ding J | | 0，，： | 1 |
| 7 | The cartilage specific microRNA-140 targets histone deacetylate 4 in mouse cells显示文摘 | Tuddenham L Wheeler G Ntounia-Fousara S | | 0，，： | 1 |
| 8 | Phase-field model for isothermal phase transitions in binary alloys显示文摘 | Wheeler A A Bottinger W J McFadden G B | | 0，，11： | 1 |
| 9 | Career planning and develop- ment for nurses: the time has eome显示文摘 | Donner G J Wheeler M M | 2001 | Int Nurs Rev2001，48，2： | 1 |
| 10 | Serum uric acid and coronary heart disease in 9 458 incident cases and 155 084 controls: prospective study and meta-analysis显示文摘 | Jeremy G Wheeler Kelsey D M Juzwishin | 2005 | Plos Med2005，2，3： | 1 |
| 11 | C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease显示文摘 | Danesh J Wheeler J G Hirschfield G M | 2004 | N Engl J Med2004，350，： | 1 |
| 12 | Genetic evidence for the role of GDP-mannose in plant ascorbic acid biosynthesis显示文摘 | CONKLIN NORRIS S R WHEELER G L | 1999 | PNAS1999，96，： | 1 |
| 13 | Optimum Ackerman for improved steering axle tire wear on trucks 显示文摘 | Miller G Reed R Wheeler F | 1991 | Transactions of Society of Automotive Engineers1991，2，： | 1 |
| 14 | Competition belwl~nhydrilla vertieillata and vallisneria Americana as influenced by soil fertility显示文摘 | Van T K Wheeler G S Center T D | 1999 | Aquatic Botany1999，11，6： | 1 |
| 15 | Glycine bemine accumulation, ionic and water relations of red-beet at contrasting levels of sodium supply显示文摘 | Subbarao G V Wheeler R M Levine L H | 2001 | J Plant Physiol2001，158，： | 1 |
| 16 | The removal of uranium from mining waste water using algal/microbial biomass显示文摘 | Kalin M Wheeler W N Meinrath G | 2004 | Journal of Environmental Radioactivity2004，78，2： | 1 |
| 17 | C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease显示文摘 | DANESH J WHEELER J G HIRSCHFIELD G M | 2004 | N Engl J Med2004，350，： | 1 |
| 18 | What do we want and what do we get from not-for-profit hospitals 显示文摘 | Clement Jan p Smith Dean G Wheeler John R C | 1994 | Hospital & Health Services Administration1994，39，2： | 1 |
| 19 | GM-CSF and wound healing 显示文摘 | Wheeler G Brodie G N | 1998 | Med J Aust1998，168，11： | 1 |
| 20 | The expression and func- tion of micro RNAs in chondrogenesis and osteoarthfitis显示文摘 | Swingler TE Wheeler G Carmont V | 2012 | Arthritis Rheum2012，6，： | 1 |
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