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| 1 | Urban energy consumption and related carbon emission estimation: a study at the sector scale显示文摘与快速的经济开发和精力消费生长,中国在世界上成为了最大的精力消费者。由广泛的国际担心推动了,有迫切需要分析精力消费和相关的碳排放的特征与节省精力的目的,减少碳排放,并且减少环境影响。集中于城市的生态系统,最大的精力消费者,为估计精力消费的一个方法和相关的碳排放在这份报纸在城市的部门规模被建立。为 19962010 基于数据,建议方法在案例研究被用于北京分析不同精力资源的消费(即,煤,油,气体,和电)并且在不同扇区的相关的碳排放(即,农业,工业,建设,交通,家庭,和服务性行业)。结果证明煤和油在学习时期期间在不同精力资源之中最作出贡献到精力消费和碳排放,当工业部门消费了大多数精力并且在不同部门之中射出大多数碳时。建议在北京为精力保存和排放减小被提出。在部门规模的精力消费和相关的碳排放的分析对实际精力在城市的生态系统节省和排放减小有用。 | Weiwei LU Chen CHEN Meirong SU Bin CHEN Yanpeng CAI Tao XING | 2013 | Frontiers of Earth Science2013，7，4： | 5 |
| 2 | Memristive Artificial Synapses for Neuromorphic Computing显示文摘Neuromorphic computing simulates the operation of biological brain function for information processing and can potentially solve the bottleneck of the von Neumann architecture.This computing is realized based on memristive hardware neural networks in which synaptic devices that mimic biological synapses of the brain are the primary units.Mimicking synaptic functions with these devices is critical in neuromorphic systems.In the last decade,electrical and optical signals have been incorporated into the synaptic devices and promoted the simulation of various synaptic functions.In this review,these devices are discussed by categorizing them into electrically stimulated,optically stimulated,and photoelectric synergetic synaptic devices based on stimulation of electrical and optical signals.The working mechanisms of the devices are analyzed in detail.This is followed by a discussion of the progress in mimicking synaptic functions.In addition,existing application scenarios of various synaptic devices are outlined.Furthermore,the performances and future development of the synaptic devices that could be significant for building efficient neuromorphic systems are prospected. | Wen Huang Xuwen Xia Chen Zhu Parker Steichen Weidong Quan Weiwei Mao Jianping Yang Liang Chu Xing’ao Li | 2021 | Nano-Micro Letters2021，13，5： | 4 |
| 3 | Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field. | Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 4 | The calmodulin-dependent protein kinase II inhibitor KN-93 protects rat cerebral cortical neurons from N-methyl-D-aspartic acid-induced injury显示文摘In this study, primary cultured cerebral cortical neurons of Sprague-Dawley neonatal rats were treated with 0.25, 0.5, and 1.0 μM calmodulin-dependent protein kinase II inhibitor KN-93 after 50 μM N-methyl-D-aspartic acid-induced injury. Results showed that, compared with N-methyl-D-aspartic acid-induced injury neurons, the activity of cells markedly increased, apoptosis was significantly reduced, leakage of lactate dehydrogenase decreased, and intracellular Ca(2+) concentrations in neurons reduced after KN-93 treatment. The expression of caspase-3, phosphorylated calmodulin-dependent protein kinase II and total calmodulin-dependent protein kinase II protein decreased after KN-93 treatment. And the effect was apparent at a dose of 1.0 μM KN-93. Experimental findings suggest that KN-93 can induce a dose-dependent neuroprotective effect, and that the underlying mechanism may be related to the down-regulation of caspase-3 and calmodulin-dependent protein kinase II expression. | Xuewen Liu Cui Ma Ruixian Xing Weiwei Zhang Buxian Tian Xidong Li Qiushi Li Yanhui Zhang | 2013 | Neural Regeneration Research2013，8，2： | 3 |
| 5 | Effects of hepatocyte growth factor overexpressed bone marrow‐derived mesenchymal stem cells on prevention from left ventricular remodelling and functional improvement in infarcted rat hearts显示文摘 | Shenxu Wang Xing Qin Dongdong Sun Yunfang Wang Xiaoyan Xie Weiwei Fan Yabin Wang Dong Liang Xuetao Pei Feng Cao | 2012 | Cell Biochem Funct2012，，7： | 2 |
| 6 | Microenvironment regulation of M-N-C single-atom catalysts towards oxygen reduction reaction显示文摘The development of cost-effective,robust,and durable electrocatalysts to replace the expensive Pt-based catalysts towards oxygen reduction reaction(ORR)is the trending frontier research topic in renewable energy and electrocatalysis.Particular attention has been paid to metal-nitrogen-carbon(M-N-C)single atom catalysts(SACs)due to their maximized atom utilization efficiency,biomimetic active site,and distinct electronic structure.More importantly,their catalytic properties can be further tailored by rationally regulating the microenvironment of active sites(i.e.,M-N coordination number,heteroatom doping and substitution.Herein,we present a comprehensive summary of the recent advancement in the microenvironment regulation of MN-C SACs towards improved ORR performance.The coordination environment manipulation regarding central metal and coordinated atoms is first discussed,focusing on the structure-function relationship.Apart from the near-range coordination,longrange substrate modulation including heteroatom doping,defect engineering is discussed as well.Besides,the synergy mechanism of nanoparticles and single atom sites to tune the electron cloud density at the active sites is summarized.Finally,we provide the challenges and outlook of the development of M-N-C SACs. | Li Zhang Qinglei Meng Ruixue Zheng Liuqing Wang Wei Xing Weiwei Cai Meiling Xiao | 2023 | Nano Research2023，16，4： | 2 |
| 7 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 8 | Stress rupture properties and deformation mechanisms of K4750 alloy at the range of 650℃ to 800℃显示文摘The stress rupture properties and deform ation mechanism s of K4750 alloy at 650 ℃, 700 ℃, 750 ℃ and 800 ℃ were investigated. As the decrease of tem perature and stress, the stress rupture life gradually increased. A Larson-Miller Parameter (LMP) method was used for analyzing the stress rupture life under different conditions. The linear fitting formula between stress (σ) and LMP was derived as σ= 3166.455-119.969 ×LMP and the fitting coefficient w as 0.98. After testing, the dislocation configurations of all stress rupture samples w ere investigated by transm ission electron microscopy (TEM). The tem perature and stress had a significant impact on the deform ation m echanism, thereby affected the stress rupture life of K4750 alloy. As the increasing stress at a given tem perature, the deform ation m echanism gradually transform ed from Orowan looping to stacking fault shearing. Based on experim ental results, the threshold stress at 650 ℃, 700 ℃, 750 ℃ and 800 ℃ for the transition of deformation mechanism was estimated to be about 650 MPa, 530 MPa, 430 MPa and 350 MPa, respectively. Below the threshold stress,γ phase effectively hindered dislocation motion by Orowan looping mechanism, K4750 alloy had along stress rupture life. Slightly above the threshold stress, Orowan looping combining stacking fault shearing was the dom inant mechanism ,the stress rupture life decreased. As the further increase of stress, stacking fault shearing acted as the dominant deformation mechanism , the resistance to dislocation motion decreased rapidly, so the stress rupture life reduced significantly. | Meiqiong Ou Yingche Ma Weiwei Xing Xianchao Hao Bo Chen Leilei Ding Kui Liu | 2019 | Journal of Materials Science & Technology2019，35，7： | 2 |
| 9 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 10 | Esterification of Acetic Acid and n - Propanol with Vapor Permeation Using NaA Zeolite Membrane 显示文摘 | Li Weixing Liu Weiwei Xing Weihong | 2013 | Indutrial & Engineering Chemis- try Research2013，52，： | 1 |
| 11 | Expression of CENH3 alleles in synthesized allopolyploid Oryza species显示文摘Synthesized allopolyploids are valuable materials for comparative analyses of two or more distinct genomes, such as the expression changes (activation, inactivation or differential expression) of orthologous genes following allopolyploidization. CENH3 is a centromere specific histone H3 variant and has been regarded as a central component in kinetochore formation and centromere function. In this study, interspecific hybrids of Oryza genus (AA × CC, AA × CCDD) and their backcross progenies were produced, and the genome constitutions were identified as AC, ACC, ACD, AACD, or AA(CD) by Genomic in situ hybridization (GISH). We further cloned and sequenced the CENH3 genes from O. sativa (AA), O. officinalis (CC) and O. latifolia (CCDD). Sequencing of RT-PCR products revealed that CENH3_C2 and CENH3_D, the two CENH3 alleles from O. latifolia, showed polymophism in several sites, while CENH3_C2 and CENH3_C1 from O. officinalis were different at only two amino acids positions. Moreover, we found that the CENH3 genes from both parents are expressed in interspecific hybrids and their progenies. Specifically, based on our cDNA sequencing data, the ratio of expression level between CENH3_A and CENH3_C1 was approximately 1 in AC and 0.5 in ACC genomes, respectively. As a result, the CENH3 expression patterns shed more light on the inter-coordination between varied centromeric DNA sequences and highly conserved kinetochore protein in synthesized allopolyploids of Oryza genus. | Hui Li Li Lu Yanfang Heng Rui Qin Yongzhong Xing Weiwei Jin | 2010 | Journal of Genetics and Genomics2010，37，10： | 1 |
| 12 | Reform and Practice on International Software Talent Training Mode显示文摘In view of the increasingly rapid development of global economic integration and combined with the existing modes of training international software engineering talents in China,this paper deeply analyzes and obtains the existing problems in the current teaching process,and proposes various teaching reform measures under the guidance of CDIO higher engineering education thought.Through many years of teaching practice experience,we can find that our reform has achieved remarkable results. | Weiwei Xing Wei Lu Jie Yao | 2020 | 计算机教育2020，，12： | 1 |
| 13 | Soil-atmosphere exchange potential of NO and N2O in different land use types of Inner Mongolia as affected by soil temperature, soil moisture, freeze-thaw, and drying-wetting events显示文摘 | Yao Zhisheng Wu Xing Wolf Benjamin Dannenmann Michael Butterbach-Bahl Klaus Brüggemann Nicolas Chen Weiwei Zheng Xunhua | 2010 | Atmospheres2010，，17： | 1 |
| 14 | Real contribution of formic acid in direct formic acid fuel cell: Investigation of origin and guiding for micro structure design显示文摘 | Weiwei Cai Liang Liang Yuwei Zhang Wei Xing Changpeng Liu | 2013 | International Journal of Hydrogen Energy2013，，1： | 1 |
| 15 | Competitive Expression of Endogenous Wheat CENH3 May Lead to Suppression of Alien ZmCENH3 in Transgenic Wheat × Maize Hybrids显示文摘Uniparental chromosome elimination in wheat maize hybrid embryos is widely used in double haploid production of wheat. Several explanations have been proposed for this phenomenon, one of which is that the lack of cross-species CENH3 incorporation may act as a barrier to interspecies hybridization. However, it is unknown if this mechanism applies universally. To study the role of CENH3 in maize chromosome elimination of wheat maize hybrid embryos, maize Zm CENH3 and wheat aT a CENH3-B driven by the constitutive Ca MV35 S promoter were transformed into wheat variety Yangmai 158. Five transgenic lines for Zm CENH3 and six transgenic lines for aT a CENH3-B were identified. RT-PCR analysis showed that the transgene could be transcribed at a low level in all Zm CENH3 transgenic lines, whereas transcription of endogenous wheat CENH3 was significantly up-regulated. Interestingly, the expression levels of both wheat CENH3 and Zm CENH3 in the Zm CENH3 transgenic wheat maize hybrid embryos were higher than those in the non-transformed Yangmai 158 maize hybrid embryos. This indicates that the alien Zm CENH3 in wheat may induce competitive expression of endogenous wheat CENH3, leading to suppression of ZmCENH3 over-expression. Eliminations of maize chromosomes in hybrid embryos of Zm CENH3 transgenic wheat maize and Yangmai 158 maize were compared by observations on micronuclei presence, by marker analysis using maize SSRs(simple sequence repeats), and by FISH(fluorescence in situ hybridization) using 45 S r DNA as a probe. The results indicate that maize chromosome elimination events in the two crosses are not significantly different. Fusion protein Zm CENH3-YFP could not be detected in Zm CENH3 transgenic wheat by either Western blotting or immnunostaining, whereas accumulation and loading of the a Ta CENH3-B-GFP fusion protein was normal in aT a CENH3-B transgenic lines. As Zm CENH3-YFP did not accumulate after AM114 treatment, we speculate that low levels of Zm CENH3 protein in transgenic wheat may be one of the factors that lead to failure of suppression of maize chromatin elimination in Zm CENH3 transgenic wheat maize hybrids. | Wei Chen Qilin Zhu Haiyan Wang Jin Xiao Liping Xing Peidu Chen Weiwei Jin Xiu-E.Wang | 2015 | Journal of Genetics and Genomics2015，42，11： | 1 |
| 16 | Cache Power Optimization Based on Compare-Based Adaptive Clock Gating and Its 65nm SoC Implementation显示文摘In most embedded microprocessor based System on chips(So Cs), cache has become a ma jor source of power consumption due to its increasing size and high access rate. Power optimization of cache based on Compare-based adaptive clock gating(CACG) is proposed to reduce the power waste due to cache idle. By detecting the cache's working state, the CACG can automatically turn off its clock when it is in idle state, saving a large percentage of dynamic power. Measurements of a real So C chip fabricated under TSMC 65 nm CMOS process show that an average of 30.3% power reduction is gained in Dhrystone test benchmark at a cost of negligible area overhead and no virtually performance loss. | LI Jie WAN Xing WU Jianbing SHAN Weiwei | 2017 | Chinese Journal of Electronics2017，26，1： | 1 |
| 17 | Registration of intervention trials of Traditional Chinese Medicine for four neurological diseases on Chinese Clinical Trial Registry and Clinical Trials.gov:a narrative review显示文摘OBJECTIVE:To analyze the current status of clinical trial registration of Traditional Chinese Medicine(TCM)for the treatment of neurological diseases.METHODS:Interventional clinical trials of TCM treatment for ischemic stroke,hemorrhagic stroke,vascular cognitive impairment,tension-type headache before September 22,2020 on the platform of Chinese Clinical Trial Registry(Chi CTR),and Clinical Trials.gov were searched.Two researchers independently selected the literature and extracted data.RESULTS:A total of 180 interventional clinical trials were included for analysis.Out of 180 trials,127 were from Chi CTR and 53 from Clinical Trials.gov.The countries primary sponsoring the included trials were China(176,97.8%),and the common categories of primary sponsors were hospital(131,72.8%).Among the study design,the largest proportion of allocation was randomized(172,95.6%),interventional model assignment was parallel(163,90.6%),masking was double blind 49(27.2%),and the sample size was≤400(144,80.0%).The trials were most carried out at a single center(102,56.7%).Among the included studies,112(62.2%)registered on Chi CTR attached the ethical approval documents.In terms of trial stages,50(27.7%)studies were in phaseⅣ.The mostly used intervention was Chinese herbal medicines(99,55%),acupuncture(68,37.8%)was the second.By searching the registration number on China National Knowledge Infrastructure Database and Pub Med,38(21.1%)registered trials were published,including 25 protocol studies and 14 research results with one(NCT02275949)published both the protocol and the results.CONCLUSIONS:Irregular and inadequate reporting,untimely update and publication,insufficient information on traditional medicine unique characteristics,and lack of international collaborations are the problems existing in the interventional clinical registration trials of traditional medicine treatment on neurological diseases.More efforts need to be made from the above aspects to standardize and improve the registration of traditional medicine trials. | WEI Jingjing GUO Rongjuan FU Guojing LIANG Xiao XU Zhenmin JIA Min ZENG Zixiu DU Wanqing JIAO Weiwei SUN Linjuan LIU Hongmei GUO Chunli TONG Chenguang ZHANG Yunling LIAO Xing | 2022 | Journal of Traditional Chinese Medicine2022，42，1： | 1 |
| 18 | Enhanced enzy- matic saccharification of rico straw by microwave pretrcat- ment 显示文摘 | Ma Huan Liu Weiwei Chen Xing | 2009 | Bioresource Technology2009，100，3： | 1 |
| 19 | Enhanced enzymatic saccharification of rice straw by microwave pretreatment 显示文摘 | Ma lluan Liu Weiwei Chen Xing | 2009 | Bioresource Technology2009，100，3： | 1 |
| 20 | PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis显示文摘 | Weiwei Yang Yan Xia David Hawke Xinjian Li Ji Liang Dongming Xing Kenneth Aldape Tony Hunter W.K. Alfred Yung Zhimin Lu | 2012 | Cell2012，，4： | 1 |
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