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| 1 | A Novel QTL qTGW3 Encodes the GSK3/ SHAGGY-Like Kinase OsGSK5/OsSK41 that Interacts with OsARF4 to Negatively Regulate Grain Size and Weight in Rice显示文摘谷物尺寸和形状在米饭是谷物重量和产量的重要决定因素。这里,我们报导一个新主要量的特点在米饭的地点(QTL ) , qTGW3,那种控制谷物尺寸和重量。这个地点, qTGW3,编码 OsSK41 (也作为 OsGSK5 知道) , GLYCOGEN SYNTHASE KINASE 3/SHAGGY-like 家庭的一个成员。带 OsSK41 的 loss-of-function 等位基因的瑞斯 near-isogenic 线增加了谷物长度和重量。我们证明那 OsSK41 交往与并且 phosphorylates 植物生长素反应因素 4 (OsARF4 ) 。有 OsARF4 的 OsSK41 的合作表示在米饭原物增加 OsARF4 的累积。OsARF4 的功能的损失导致更大的米饭谷物。定序 RNA 分析建议 OsARF4 和 OsSK41 镇压下游的基因的一个普通集合的表示, ? 包括一些植物生长素应答的基因,在米饭谷物开发期间。在 qTGW3 的 OsSK41 的 loss-of-function 形式代表没被指向的基因编辑或 QTL 节节上升广泛地在 OsSK41 功能的米饭 breeding.?Suppression 利用了的稀罕等位基因提高米饭谷物尺寸和重量。因此,我们的学习在米饭谷物开发揭示 OsSK41 的重要角色 ?? 并且在另外的谷物庄稼在米饭并且也许为谷物产量的基因改进提供新候选人基因。 | Zejun Hu Sun-Jie Lu Mei-Jing Wang Haohua He Le Sun Hongru Wang Xue-Huan Liu Ling Jiang Jing-Liang sun Xiaoyun Xin Wei Kong Chengcai Chu Hong-Wei Xue Jinshui Yang Xiaojin Luo Jian-Xiang Liu | 2018 | Molecular Plant2018，11，5： | 47 |
| 2 | Methanation of carbon dioxide on Ni/ZrO_2-Al_2O_3 catalysts:Effects of ZrO_2 promoter and preparation method of novel ZrO_2-Al_2O_3 carrier显示文摘The novel nickel-based catalysts with a nickel content of 12 wt% were prepared with the zirconia-alumina composite as the supports. The new carriers, ZrO2 improved alumina, were synthesized by three methods, i.e., impregnation-precipitation, co-precipitation, and impregnation method. The catalytic properties of these catalysts were investigated in the methanation of carbon dioxide, and the samples were characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscope (XPS), temperature-programmed reduction (TPR) and temperature-programmed desorption (TPD) techniques. The new catalysts showed higher catalytic activity and better stability than Ni/γ-Al2O3. Furthermore, as a support for new nickel catalyst, the ZrO2-Al2O3 composite prepared by the impregnation-precipitation method was more efficient than the other supports in the methanation of carbon dioxide. The highly dispersed zirconium oxide on the surface of γ-Al2O3 inhibited the formation of nickel aluminate-like phase, which was responsible for the better dispersion of Ni species and easier reduction of NiO species, leading to the enhanced catalytic performance of corresponding catalyst. | Mengdie Cai Jie Wen Wei Chu Xueqing Cheng Zejun Li | 2011 | Journal of Natural Gas Chemistry2011，20，3： | 33 |
| 3 | Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)显示文摘In recent years,as living standards have continued to improve,the number of diabetes patients in China,along with the incidence of complications associated with the disease,has been increasing.Among these complications,diabetic foot disease is one of the main causes of disability and death in diabetic patients.Due to the differences in economy,culture,religion and level of medical care available across different regions,preventive and treatment methods and curative results for diabetic foot vary greatly.In multidisciplinary models built around diabetic foot,the timely assessment and diagnosis of wounds and appropriate methods of prevention and treatment with internal and external surgery are key to clinical practice for this pathology.In 2019,under the leadership of the Jiangsu Medical Association and Chinese Diabetes Society,the writing group for the Guidelines on multidisciplinary approaches for the prevention and management of diabetic foot disease(2020 edition)was established with the participation of scholars from the specialist areas of endocrinology,burn injury,vascular surgery,orthopedics,foot and ankle surgery and cardiology.Drawing lessons from diabetic foot guidelines from other countries,this guide analyses clinical practices for diabetic foot,queries the theoretical basis and grades and gives recommendations based on the characteristics of the pathology in China.This paper begins with assessments and diagnoses of diabetic foot,then describes treatments for diabetic foot in detail,and ends with protections for high-risk feet and the prevention of ulcers.This manuscript covers the disciplines of internal medicine,surgical,nursing and rehabilitation and describes a total of 50 recommendations that we hope will provide procedures and protocols for clinicians dealing with diabetic foot. | Aiping Wang Guozhong Lv Xingbo Cheng Xianghua Ma Wei Wang Jianchao Gui JiHu Meng Lu Guoping Chu Jin’an Chen Hao Zhang Yiqiu Jiang Yuedong Chen Wengbo Yang Lin Jiang Houfa Geng Rendong Zheng Yihui Li Wei Feng Boey Johnson Wenjuan Wang Dalong Zhu Yin Hu | 2020 | Burns & Trauma2020，8，1： | 34 |
| 4 | Genome-wide Targeted Mutagenesis in Rice Using the CRISPR/Cas9 System显示文摘 | Lu, Yuming Ye, Xiao Guo, Renming Huang, Jing Wang, Wei Tang, Jiuyou Tan, Longtao Zhu, Jian-kang Chu, Chengcai Qian, Yangwen | 2017 | Molecular Plant2017，10，9： | 28 |
| 5 | A new interpretation of the tectonic setting and age of meta-basic volcanics in the Ondor Sum Group, Inner Mongolia显示文摘The Ondor Sum Group in the central Inner Mongolia is mainly composed of meta-basic volcanics intercalated with ferruginous quartzite and quartz schist,and has been interpreted as slices of oceanic crust or an ophiolite suite of the Early Paleozoic or much older ages.This paper presents new LA-ICP-MS zircon U-Pb dating and geochemical data for the meta-basic volcanics.The results show that zircons in the meta-basic volcanics were derived from complicated sources,most of which may be captured by basic magma from the country rocks or other sources.They yield a large age range from the Late Archean to Early Mesozoic with the youngest age group between 246 and 261 Ma,constraining the protolith of the meta-basic volcanics formed in the Late Permian to Early Triassic.The meta-basic volcanics have an affinity to E-MORB in geochemistry,and also a similarity toward OIB,representing a tectonic setting of limited intra-continental ocean basin.This limited basin might have been related to the continuous extension of the area since the Early Permian and finally closed in the Early Mesozoic. | CHU Hang ZHANG JinRui WEI ChunJing WANG HuiChu REN YunWei | 2013 | Chinese Science Bulletin2013，58，28： | 25 |
| 6 | Late Mesozoic extensional tectonics of the Liaodong Peninsula massif:Response of crust to continental lithosphere destruction of the North China Craton显示文摘Unlike most Precambrian cratons that have thick sub-continental lithospheric roots,the Archean lithosphere beneath the North China Craton is thin (reduced from 200 km to about 80 km),and has been replaced by a geochemically juvenile lithospheric mantle.This is a unique regional geological event,which has attracted worldwide attention.In the North China Block,Late Mesozoic extensional tectonics is evident by low-angle detachment faults,syntectonic plutons bounded by ductile faults,metamorphic core complexes (MCC) and widespread Jurassic to Cretaceous half-grabens filled by continental terrigenous deposits and volcanic rocks.At a regional scale,these structures share the same NW-SE extensional direction,while maintaining their own individual kinematics.In other words,the MCC feature a top-to-the-NW sense of shear,and syntectonic plutons are typified by a top-to-the-SE shearing deformations.Geochronological results indicate that the extensional structures were formed between 130-120 Ma.These extensional events lead to magmatic rock emplacement,distributed at the footwall of the detachment faults.Two different exhumation stages can be identified based on regional structural and magmatic interpretation:a Jurassic slow or negligible exhumation and a Cretaceous fast one assisted by normal faulting.These two cooling stages correspond to distinct geodynamic processes that occurred during the Jurassic and Cretaceous.Extensional tectonics appear to have been insignificant before the Early Cretaceous,and the process may be demonstrated by partial melting of the crust.The second stage,dominated by an extensional regime,developed after ca 120 Ma,and is tentatively correlated with crustal extension caused by lithospheric removal of the North China Craton. | LIN Wei WANG QingChen WANG Jun WANG Fei CHU Yang CHEN Ke | 2011 | Science China Earth Sciences2011，54，6： | 24 |
| 7 | Root microbiota shift in rice correlates with resident time in the field and developmental stage显示文摘Land plants in natural soil form intimate relationships with the diverse root bacterial microbiota. A growing body of evidence shows that these microbes are important for plant growth and health. Root microbiota composition has been widely studied in several model plants and crops; however, little is known about how root microbiota vary throughout the plant's life cycle under field conditions. We performed longitudinal dense sampling in field trials to track the time-series shift of the root microbiota from two representative rice cultivars in two separate locations in China. We found that the rice root microbiota varied dramatically during the vegetative stages and stabilized from the beginning of the reproductive stage, after which the root microbiota underwent relatively minor changes until rice ripening. Notably, both rice genotype and geographical location influenced the patterns of root microbiota shift that occurred during plant growth. The relative abundance of Deltaproteobacteria in roots significantly increased overtime throughout the entire life cycle of rice, while that of Betaproteobacteria, Firmicutes, and Gammaproteobacteria decreased. By a machine learning approach, we identified biomarker taxa and established a model to correlate root microbiota with rice resident time in the field(e.g., Nitrospira accumulated from 5 weeks/tillering in field-grown rice). Our work provides insights into the process of rice root microbiota establishment. | Jingying Zhang Na Zhang Yong-Xin Liu Xiaoning Zhang Bin Hu Yuan Qin Haoran Xu Hui Wang Xiaoxuan Guo Jingmei Qian Wei Wang Pengfan Zhang Tao Jin Chengcai Chu Yang Bai | 2018 | Science China(Life Sciences)2018，61，6： | 24 |
| 8 | Field released transgenic papaya effect on soil microbial communities and enzyme activities显示文摘Soil properties, microbial communities and enzyme activities were stud ied in soil amended with replicase (RP)-transgenic or non-transgenic papaya unde r field conditions. Compared with non-transgenic papaya, significant differences (P<0.05) were observed in total nitrogen in soils grown with transgenic papaya. There were also significant differences (P<0.05) in the total number of colony forming units (CFUs) of bacteria, actinomycetes and fungi between soils amended with RP-transgenic plants and non-transgenic plants. Compared with non-transgen ic papaya, the total CFUs of bacteria, actinomycetes and fungi in soil with tran sgenic papaya increased by 0.43—1.1, 0.21—0.80 and 0.46—0.73 times respective ly. Significantly higher (P<0.05) CFUs of bacteria, actinomycetes and fungi res istant to kanamycin (Km) were obtained in soils with RP-transgenic papaya than t hose with non-transgenic papaya in all concentrations of Km. Higher resistance q uotients for Kmr (kanamycin resistant) bacteria, actinomycetes and fungi were fo und in soil planted with RP-transgenic papaya, and the resistance quotients for Kmr bacteria, actinomycetes and fungi in soils with transgenic papaya increased 1.6—4.46, 0.63—2.5 and 0.75—2.30 times. RP-transgenic papaya and non-transg enic papaya produced significantly different enzyme activities in arylsulfatase (5.4—5.9x), polyphenol oxidase (0.7—1.4x), invertase (0.5—0.79x), cellulase ( 0.23—0.35x) and phosphodiesterase (0.16—0.2x). The former three soil enzymes appeared to be more sensitive to the transgenic papaya than the others, and cou ld be useful parameters in assessing the effects of transgenic papaya. Transgen ic papaya could alter soil chemical properties, enzyme activities and microbial communities. | WEI Xiang-dong ZOU Hui-ling CHU Lee-min LIAO Bin YE Chang-min LAN Chong-yu | 2006 | Journal of Environmental Sciences2006，18，4： | 22 |
| 9 | Immunogenicity noninferiority study of 2 doses and 3 doses of an Escherichia coli-produced HPV bivalent vaccine in girls vs.3 doses in young women显示文摘A new HPV-16/18 bivalent vaccine expressed by the Escherichia coli has been proven to be efficacious in adult women.A randomized,immunogenicity noninferiority study of this candidate vaccine was conducted in December 2015 in China.Girls aged 9–14 years were randomized to receive 2 doses at months 0 and 6(n=301)or 3 doses at months 0,1 and 6(n=304).Girls aged 15–17 years(n=149)and women aged 18–26 years(n=225)received 3 doses.The objectives included noninferiority analysis of the IgG geometric mean concentration(GMC)ratio(95%CI,lower bound>0.5)to HPV-16 and HPV-18 at month 7 in girls compared with women.In the per-protocol set,the GMC ratio of IgG was noninferior for girls aged 9–17 years receiving 3 doses compared with women(1.76(95%CI,1.56,1.99)for HPV-16 and 1.93(95%CI,1.69,2.21)for HPV-18)and noninferior for girls aged 9–14 years receiving 2 doses compared with women(1.45(95%CI,1.25,1.62)for HPV-16 and 1.17(95%CI,1.02,1.33)for HPV-18).Noninferiority was also demonstrated for neutralizing antibodies.The immunogenicity of the HPV vaccine in girls receiving 3 or 2 doses was noninferior compared with that in young adult women. | Yue-Mei Hu Meng Guo Chang-Gui Li Kai Chu Wen-Gang He Jing Zhang Jian-Xiang Gu Juan Li Hui Zhao Xiang-Hong Wu Bi-Zhen Lin Zhi-Jie Lin Xing-Mei Yao Ya-Fei Li Fei-Xue Wei Yue Huang Ying-Ying Su Feng-Cai Zhu Shou-Jie Huang Hui-Rong Pan Ting Wu Jun Zhang Ning-Shao Xia | 2020 | Science China(Life Sciences)2020，63，4： | 19 |
| 10 | Investigation of quality of life in patients with lung cancer by the EORTC QLQ-C30(V3.0) Chinese version显示文摘Objective To explore quality of life(QOL) and its influencing factors in patients with lung cancer.Methods A QOL questionnaire(European Organization for Research and Treatment of Cancer [EORTC] Quality of Life Questionnaire-Core 30 [QLQ-C30] Chinese version) was used with 138 patients with lung cancer participating in the study. A statistical description of the general characteristics of the patients with lung cancer was performed. The patients' QLQ-C30 scores were compared with the reference value for each dimension. To analyze the influence of QOL in different genders, age groups, and cancer stages, ttests and rank sum tests were used to compare the differences in QOL using a 5% significance level. Results The QLQ-C30 function scores in PF(physical functioning), EF(emotional functioning), SF(social functioning), and GH(global functioning), and symptom scales in NV(nausea and vomiting), DY(dyspnea), SL(insomnia), and FI(financial difficulties) were significantly different(P < 0.05) in comparison to the reference values. Female patients were worse than males(P < 0.05) in EF, NV, and DI(diarrhea). The later the stage of lung cancer, the worse the quality of life became; the functional scales in RF(role functioning), EF, CF, SF, and GH, and symptom scales in PA(pain), AP(appetite), and SL differences were statistically significant(P < 0.05). Conclusion This study aids understanding of the status of the quality of life of Chinese patients with cancer and might be useful for clinical work, theory research, and health policymakers. | Jun Li Xiaoguang Xiao Yao Wei Yang Li Man Zou Shiying Yu Yuan Chen Qian Chu | 2015 | Oncology and Translational Medicine2015，1，3： | 18 |
| 11 | Regional differences in crustal structure of the North China Craton from receiver functions显示文摘Moho depth and crustal average Poisson's ratio for 823 stations are obtained by H-? stacking of receiver functions. These, together with topography and receiver function amplitude information, were used to study the crustal structure beneath the North China Craton(NCC). The results suggest that modified and preserved crust coexist beneath the craton with generally Airy-type isostatic equilibrium. The equilibrium is relatively low in the eastern NCC and some local areas in the central and western NCC, which correlates well with regional geology and tectonic features. Major differences in the crust were observed beneath the eastern, central, and western NCC, with average Moho depths of 33, 37, and 42 km and average Poisson's ratios of 0.268, 0.267 and 0.264, respectively. Abnormal Moho depths and Poisson's ratios are mainly present in the rift zones, the northern and southern edges of the central NCC, and tectonic boundaries. The crust beneath Ordos retains the characteristics of typical craton. Poisson's ratio increases roughly linearly as Moho depth decreases in all three parts of the NCC with different slopes. Receiver function amplitudes are relatively large in the northern edge of the eastern and central NCC, and small in and near the rifts. The Yanshan Mountains and southern part of the Shanxi rift show small-scale variations in the receiver-function amplitudes. These observations suggest that overall modification and thinning in the crust occurred in the eastern NCC, and local crustal modification occurred in the central and western NCC. Different crustal structures in the eastern, central, and western NCC suggest different modification processes and mechanisms. The overall destruction of the crustal structure in the eastern NCC is probably due to the westward subduction of the Pacific Plate during the Meso-Cenozoic time; the local modifications of the crust in the central and western NCC may be due to repeated reactivations at zones with a heterogeneous structure by successive thermal-tectonic events during the long-term evolution of the NCC. | WEI ZiGen CHU RiSheng CHEN Ling | 2015 | Science China Earth Sciences2015，58，12： | 18 |
| 12 | Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats显示文摘瞄准: 在老鼠,和与 5-lipoxygenase 抑制的可能的关系在焦点的服的局部缺血以后在早、推迟的损害上调查咖啡酸的效果。方法:短暂焦点的服的局部缺血被中间的服的动脉吸藏在 Sprague-Dawley 老鼠导致。咖啡酸(10 和 50 mg/kg ) 是在局部缺血以后为 5 d 注射的 ip。脑损伤被观察,并且 cysteinyl leukotrienes 的层次和在大脑织物的 leukotriene B4 被测量。结果:咖啡酸(50 mg/kg ) 改善了神经病学的机能障碍和神经原损失,和减少的梗塞体积在局部缺血以后的 24 h;它稀释了大脑萎缩,梗塞体积,并且特别地在局部缺血以后的星形细胞增长 14 d。另外,它减少了 leukotrienes (5-lipoxygenase 代谢物) 的生产在是化学家半球在局部缺血以后的 3 h 和 7 d。结论:咖啡酸在老鼠在焦点的服的局部缺血以后在早、推迟的损害上有保护的效果;并且这效果可以部分联系抑制到 5-lipoxygenase。 | Yu ZHOU San-hua FANG Yi-lu YE Li-sheng CHU Wei-ping ZHANG Meng-ling WANG Er-qing WEI | 2006 | Acta Pharmacologica Sinica2006，27，9： | 17 |
| 13 | Minocycline inhibits 5-lipoxygenase activation and brain inflammation after focal cerebral ischemia in rats显示文摘目的:决定 minocycline onpostis化学家大脑损害的反煽动性的效果是否被 5-lipoxygenase (5哈鱼)的抑制调停在 rats.Methods 的表示 andenzymatic 激活:焦点的服的局部缺血与 middlecerebral 动脉吸藏为 30 min 被导致,由 reperfusion.The ischemic 损害列在后面,内长的 IgG 渗出, neutrophils 和 macrophage/microglia 的 theaccumulation ,和5哈鱼 mRNA 表示被决定 72 hafter reperfusion.5哈鱼代谢物( | Li-sheng CHU San-hua FANG Yu ZHOU Guo-liang YU Meng-ling WANG Wei-ping ZHANG Er-qing WEI | 2007 | Acta Pharmacologica Sinica2007，28，6： | 16 |
| 14 | Effects of continuously regenerating diesel particulate filters on regulated emissions and number-size distribution of particles emitted from a diesel engine显示文摘The effects of continuously regenerating diesel particulate filter (CRDPF) systems on regulated gaseous emissions, and number-size distribution and mass of particles emanated from a diesel engine have been investigated in this study. Two CRDPF units (CRDPF-1 and CRDPF-2) with different specifications were separately retrofitted to the engine running with European steady-state cycle (ESC). An electrical low pressure impactor (ELPI) was used for particle number-size distribution measurement and mass estimation. The conversion/reduction rate (R CR ) of hydrocarbons (HC) and carbon monoxide (CO) across CRDPF-1 was 83% and 96.3%, respectively. Similarly, the R CR of HC and CO and across CRDPF-2 was 91.8% and 99.1%, respectively. The number concentration of particles and their concentration peaks; nuclei mode, accumulation mode and total particles; and particle mass were highly reduced with the CRDPF units. The nuclei mode particles at downstream of CRDPF-1 and CRDPF-2 decreased by 99.9% to 100% and 97.8% to 99.8% respectively; and the particle mass reduced by 73% to 92.2% and 35.3% to 72.4%, respectively, depending on the engine conditions. In addition, nuclei mode particles increased with the increasing of engine speed due to the heterogeneous nucleation initiated by the higher exhaust temperature, while accumulation mode particles were higher at higher loads due to the decrease in the air-to-fuel ratio (A/F) at higher loads. | Zhihua Liu Asad Naeem Shah Yunshan Ge Yan Ding, Jianwei Tan Lei Jiang Linxiao Yu Wei Zhao Chu Wang Tao Zeng | 2011 | Journal of Environmental Sciences2011，23，5： | 15 |
| 15 | Scutellaria barbata D.Don Inhibits Colorectal Cancer Growth via Suppression of Wnt/β-Catenin Signaling Pathway显示文摘Objective: To investigate the effect of the ethanol extract of Scutellaria barbata D. Don(EESB) on colorectal cancer(CRC) growth and Wnt/β-catenin signaling pathway in vivo and in vitro. Methods: In vivoexperiment, CRC xenograft mouse model was constructed with injection of HT-29 cells. Following xenograft implantation, twenty mice were randomly divided into EESB-treated group(n=10) and control group(n=10) by a random number table, and were given with intra-gastric administration of 2 g/kg EESB or saline, 5 days a week for 16 days, respectively. At the end of experiment, tumors were removed and weighed by electronic scales. The proliferation biomarker Ki-67 of tumor was evaluated by immunohistochemistry(IHC) assay. In vitro study, HT-29 cells were treated with 0, 0.5, 1.5, 2.5 mg/m L EESB for 24 h. At the end of the treatment, the viability and survival of HT-29 cells were determined by methylthiazolyldiphenyl-tetrazolium bromide(MTT) assay and colony formation assay, respectively. The m RNA expression of c-Myc, Survivin and adenomatous polyposis coli(APC) was examined by reverse transcription-polymerase chain reaction(RT-PCR) both in tumor tissues of CRC xenograft mice and HT-29 cells. Protein expression of c-Myc, Survivin, APC, and β-catenin as well as β-catenin phosphorylation level were evaluated by IHC assay or Western blotting. Results: EESB significantly reduced tumor weight in CRC xenografts mice, compared with the control group(P<0.05). IHC assay showed that EESB significantly inhibited protein expression of Ki-67 in tumor tissues(P<0.05). MTT assay showed that EESB significantly reduced HT-29 cell viability in a dose-dependent manner(P<0.05). Colony formation assay showed that EESB dose-dependently decreased the survival of HT-29 cells(P<0.05). In addition, RT-PCR assay showed that EESB decreased the m RNA expression of c-Myc and Survivin and increased APC expression, both in tumor tissues of CRC xenograft mice and HT-29 cells(P<0.05). IHC assay or Western blotting showed that EESB decreased protein expression of β-catenin, c-Myc and Survivin, as well as increased APC expression and β-catenin phosphorylation in tumor tissues or HT-29 cells(P<0.05). Conclusions: EESB significantly reduced tumor growth in CRC xenografts mice, and inhibited the viability and survival of HT-29 cells. EESB could suppress the activation of the Wnt/β-catenin pathway, which might be one of the mechanisms whereby Scutellaria barbata D. Don exerts its anticancer activity. | WEI Li-hui LIN Jiu-mao CHU Jian-feng CHEN Hong-wei LI Qing-yu PENG Jun | 2017 | Chinese Journal of Integrative Medicine2017，23，11： | 14 |
| 16 | Responses of Soil Acid Phosphomonoesterase Activity to Simulated Nitrogen Deposition in Three Forests of Subtropical China显示文摘Soil acid phosphomonoesterase activity (APA) plays a vital role in controlling phosphorus (P) cycling and reflecting the current degree of P limitation. Responses of soil APA to elevating nitrogen (N) deposition are important because of their potential applications in addressing the relationship between N and P in forest ecosystems. A study of responses of soil APA to simulated N deposition was conducted in three succession forests of subtropical China. The three forests include a Masson pine (Pinus massoniana) forest (MPF)-pioneer community, a coniferous and broad-leaved mixed forest (MF)-transition community and a monsoon evergreen broad-leaved forest (MEBF)-climax community. Four N treatments were designed for MEBF: control (without N added), low-N (50 kg N ha-1 year-1), and medium-N (100 kg N ha-1 year-1) and high-N (150 kg N ha-1 year-1), and only three N treatments (i.e., control, low-N, medium-N) were established for MPF and MF. Results showed that soil APA was highest in MEBF, followed by MPF and MF. Soil APAs in both MPF and MF were not influenced by low-N treatments but depressed in medium-N treatments. However, soil APA in MEBF exhibited negative responses to high N additions, indicating that the environment of enhanced N depositions would reduce P supply for the mature forest ecosystem. Soil APA and its responses to N additions in subtropical forests were closely related to the succession stages in the forests. | HUANG Wen-Juan ZHANG De-Qiang LI Yue-Lin LU XianKai ZHANG Wei HUANG Juan D.OTIENO Z.H.XU LIU Ju-Xiu LIU Shi-Zhong CHU Guo-Wei | 2012 | Pedosphere2012，22，5： | 13 |
| 17 | Effect of MgO content in sinter on the softening–melting behavior of mixed burden made from chromium-bearing vanadium–titanium magnetite显示文摘The effect of sinter with different MgO contents on the softening–melting behavior of mixed burden made from chromium-bearing vanadium–titanium magnetite was investigated. The results show that with increasing MgO content in the sinter, the softening interval and melting interval increased and the location of the cohesive zone shifted downward slightly and became moderately thicker. The softening–melting characteristic value was less pronounced when the MgO content in the sinter was 2.98wt%–3.40wt%. Increasing MgO content in the sinter reduced the content and recovery of V and Cr in the dripped iron. In addition, greater MgO contents in the sinter resulted in the generation of greater amounts of high-melting-point components, which adversely affected the permeability of the mixed burden. When the softening–melting behavior of the mixed burden and the recovery of valuable elements were taken into account, proper MgO contents in the sinter and slag ranged from 2.98wt% to 3.40wt% and from 11.46wt% to 12.72wt%, respectively, for the smelting of burden made from chromium-bearing vanadium–titanium magnetite in a blast furnace. | Zheng-gen Liu Man-sheng Chu Hong-tao Wang Wei Zhao Xiang-xin Xue | 2016 | International Journal of Minerals,Metallurgy and Materials2016，23，1： | 13 |
| 18 | Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice显示文摘瞄准:最近的研究证明中国植物 Polygalae 根值的摘录在老鼠和人施加提高认知的行动。这研究的目的是描绘从 Polygalae Radix.Methods 提取的活跃混合物的药理学侧面:二部分 P3 和 P6 和二混合物 PTM-15 和 polygalasaponin XXXII (PGS32 ) 被准备。Neuroprotective 效果在暴露于高集中 glutamate,浆液缺乏或 H 2 O 2 。反痴呆行动用走彻底地回避测试和隧道水迷宫测试在老鼠在导致莨菪胺的健忘被估计。在进行隧道水迷宫测试以后,在老鼠马头鱼尾的怪兽的 TrkB phosphorylation 用西方的弄污被检测。长期的 potentiation (LTP ) 在成年老鼠在有牙齿的回转被导致;PGS32 (5 μ L 400 μ mol/L ) 被注入侧面的服的室在高频率刺激(HFS ) 以后的 20 min .Results:在老鼠在导致莨菪胺的健忘比作部分 P6,显示出的更突出的 neuroprotective 在 vitro 完成的部分 P3 和提高认知的效果。在部分 P3 的一活跃复合 PGS32 施加了有势力提高认知的行动:PGS32 的口头的管理(0.125 mg·为 19 天的 kg −1·d−1) 在老鼠废除了导致莨菪胺的记忆缺陷。而且, PGS32 (0.5 和 2 mg· kg −1·d−1) 显著地在马头鱼尾的怪兽刺激了 TrkB 的 phosphorylation。PGS32 的 Intracerebroventricular 注射显著地在 rats.Conclusion 的有牙齿的回转提高了导致 HFS 的 LTP:PGS32 在老鼠稀释导致莨菪胺的认知缺陷,建议它有为认知机能障碍和痴呆的处理的一个潜力。 | Heng ZHOU Wei XUE Shi-feng CHU Zhen-zhen WANG Chuang-jun LI Yi-na JIANG Lin-ming LUO Piao LUO Gang LI Dong-ming ZHANG Nai-hong CHEN | 2016 | Acta Pharmacologica Sinica2016，37，8： | 12 |
| 19 | Qingxuan Jiangya Decoction(清眩降压汤) Prevents Blood Pressure Elevation and Ameliorates Vascular Structural Remodeling via Modulating TGF-β 1/Smad Pathway in Spontaneously Hypertensive Rats显示文摘Objective:To elevate the effects of Qingxuan Jiangya Decoction(清眩降压汤,QXJYD)on hypertension and vascular structural remodeling(VSR)in spontaneously hypertensive rats(SHRs),and investigate the underlying mechanisms.Methods:SHRs(n=8)were given intra-gastric administration with 60 mg/kg of QXJYD or saline,daily for 8 weeks,while rats in SHR-control(n=8)and WKY(n=8)groups were received equal volumes of saline solution.Systolic blood pressures(SBP),diastolic blood pressures(DBP)and mean blood pressures(MBP)were measured once a week.The levels of angiotensinⅡ(AngⅡ),endothelin 1(ET-1)and plasma renin activity(PRA)were tested by enzyme-linked immunosorbent assay(ELISA)and radioimmunoassay,respectively.The effect of QXJYD on VSR was determined by examining the media thickness and the ex vivo contractility of thoracic aortic.The proliferation and fibrosis of vascular smooth muscle cells(VSMCs)were examined via immunohistochemical(IHC)staining for proliferating cell nuclear antigen(PCNA),collagen Ⅰ and collagen Ⅲ,respectively.The mRNA and protein expressions of transforming growth factor β1(TGF-β1),Smad3 and phosphorylation of Smad3 in thoracic aorta tissues were determined by real-time polymerase chain reaction(PCR)and Western blot assay,respectively.Results:QXJYD treatment led to a significant decrease of the elevation of blood pressure in SHRs and reduced the levels of AngⅡ,ET-1 and PRA in the serum(P<0.05).In addition,QXJYD treatment remarkably ameliorated VSR and vascular function in SHRs.Moreover,QXJYD inhibited VSMC proliferation and fibrosis by suppressing the expression of PCNA,collagen Ⅰ and collagen Ⅲ in thoracic aortic.Furthermore,QXJYD inhibited the expression of TGF-β1,Smad3 and the phosphorylation of Smad3,respectively(P<0.05).Conclusion:QXJYD reversed VSR by inhibiting VSMC proliferation and collagen deposition via regulation of TGF-β1/Smad signaling pathway,which may,in part,illuminate its anti-hypertensive activities. | HE Fei CHU Jian-feng CHEN Hong-wei LIN Wei LIN Shan CHEN You-qin PENG Jun CHEN Ke-ji | 2020 | Chinese Journal of Integrative Medicine2020，26，3： | 12 |
| 20 | Role of diffusion-weighted imaging in early ankylosing spondylitis显示文摘 | PAN Chu HU Dao-yu ZHANG Wei LI Xiao-ming | 2013 | Chinese Medical Journal2013，，4： | 12 |
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